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    Hepatology: Volume 67, Issue 6

    2065-2484
    June 2018
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Cover Image

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Cover Image

  • First Published: 21 May 2018

Issue Information

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Masthead

  • First Published: 21 May 2018
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Table of contents

  • First Published: 21 May 2018

Hepatology Highlights

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Hepatology Highlights

Nicholas Russo,  Robert S. Brown Jr,  Shirley Cohen-Mekelburg,  Robert E. Schwartz,  Vikas Gupta,  Joseph F. Pisa,  Russell Rosenblatt,  Aleksey Novikov, 
  • Pages: 2065-2067
  • First Published: 21 May 2018

Comments from the Editors

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Time to step-up the fight against NAFLD

Xiao-Jing Zhang Ph.D.,  Zhi-Gang She M.D., Ph.D.,  Hongliang Li M.D., Ph.D., 
  • Pages: 2068-2071
  • First Published: 16 February 2018

Editorials

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Two drinks per day does not take your fatty liver away

Stefano Bellentani M.D., Ph.D.,  Giorgio Bedogni M.D.,  Claudio Tiribelli M.D., Ph.D., 
  • Pages: 2072-2073
  • First Published: 21 December 2017
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Gut–liver axis alterations in alcoholic liver disease: Are bile acids the answer?

Jasmohan S. Bajaj M.D., F.A.A.S.L.D.,  Phillip B. Hylemon Ph.D., 
  • Pages: 2074-2075
  • First Published: 22 December 2017
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Staging for hepatocellular carcinoma in light of tumor heterogeneity: Time to change or update?

Do Young Kim M.D.,  Kwang-Hyub Han M.D., 
  • Pages: 2076-2078
  • First Published: 21 December 2017
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Dual ablation of β- and γ-catenin: Critical regulators of junctions and their functions

Heather Francis Ph.D.,  Lindsey Kennedy B.S.,  Gianfranco Alpini Ph.D., 
  • Pages: 2079-2081
  • First Published: 22 December 2017
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Is miR-21 a potent target for liver fibrosis?

Sanchuan Lai M.D.,  Yasuko Iwakiri Ph.D., 
  • Pages: 2082-2084
  • First Published: 08 January 2018

Rapid Communication

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Transplanting hepatitis C virus–positive livers into hepatitis C virus–negative patients with preemptive antiviral treatment: A modeling study

Jagpreet Chhatwal,  Sumeyye Samur,  Emily D. Bethea,  Turgay Ayer,  Fasiha Kanwal,  Chin Hur,  Mark S. Roberts,  Norah Terrault,  Raymond T. Chung, 
  • Pages: 2085-2095
  • First Published: 09 December 2017

Original Articles

VIRAL HEPATITIS

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The RNA genome of hepatitis E virus robustly triggers an antiviral interferon response

Wenshi Wang,  Yijin Wang,  Changbo Qu,  Shan Wang,  Jianhua Zhou,  Wanlu Cao,  Lei Xu,  Buyun Ma,  Mohamad S. Hakim,  Yuebang Yin,  Tiancheng Li,  Maikel P. Peppelenbosch,  Jingmin Zhao,  Qiuwei Pan, 
  • Pages: 2096-2112
  • First Published: 01 December 2017
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Elbasvir/grazoprevir and sofosbuvir for hepatitis C virus genotype 3 infection with compensated cirrhosis: A randomized trial

Graham R. Foster,  Kosh Agarwal,  Matthew E. Cramp,  Sulleman Moreea,  Stephen Barclay,  Jane Collier,  Ashley S. Brown,  Stephen D. Ryder,  Andrew Ustianowski,  Daniel M. Forton,  Ray Fox,  Fiona Gordon,  William M. Rosenberg,  David J. Mutimer,  Jiejun Du,  Christopher L. Gilbert,  Ernest Asante-Appiah,  Janice Wahl,  Michael N. Robertson,  Eliav Barr,  Barbara Haber, 
  • Pages: 2113-2126
  • First Published: 23 February 2018
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Nucleic acid polymer REP 2139 and nucleos(T)ide analogues act synergistically against chronic hepadnaviral infection in vivo in Pekin ducks

Jonathan Quinet,  Catherine Jamard,  Madeleine Burtin,  Matthieu Lemasson,  Sylviane Guerret,  Camille Sureau,  Andrew Vaillant,  Lucyna Cova, 
  • Pages: 2127-2140
  • First Published: 18 December 2017

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population

Fredrik Åberg,  Jaana Helenius-Hietala,  Pauli Puukka,  Martti Färkkilä,  Antti Jula, 
  • Pages: 2141-2149
  • First Published: 22 November 2017
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Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

Phillipp Hartmann,  Katrin Hochrath,  Angela Horvath,  Peng Chen,  Caroline T. Seebauer,  Cristina Llorente,  Lirui Wang,  Yazen Alnouti,  Derrick E. Fouts,  Peter Stärkel,  Rohit Loomba,  Sally Coulter,  Christopher Liddle,  Ruth T. Yu,  Lei Ling,  Stephen J. Rossi,  Alex M. DePaoli,  Michael Downes,  Ronald M. Evans,  David A. Brenner,  Bernd Schnabl, 
  • Pages: 2150-2166
  • First Published: 21 November 2017
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11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis

Xiantong Zou,  Prakash Ramachandran,  Timothy J. Kendall,  Antonella Pellicoro,  Elena Dora,  Rebecca L. Aucott,  Kajal Manwani,  Tak Yung Man,  Karen E. Chapman,  Neil C. Henderson,  Stuart J. Forbes,  Scott P. Webster,  John P. Iredale,  Brian R. Walker,  Zoi Michailidou, 
  • Pages: 2167-2181
  • First Published: 18 December 2017
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Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride

Stefan Stender,  Eriks Smagris,  Bo K. Lauridsen,  Klaus F. Kofoed,  Børge G. Nordestgaard,  Anne Tybjærg-Hansen,  Len A. Pennacchio,  Diane E. Dickel,  Jonathan C. Cohen,  Helen H. Hobbs, 
  • Pages: 2182-2195
  • First Published: 21 December 2017
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Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein

Elisabetta Morello,  Salvatore Sutti,  Beatrice Foglia,  Erica Novo,  Stefania Cannito,  Claudia Bocca,  Martina Rajsky,  Stefania Bruzzì,  Maria Lorena Abate,  Chiara Rosso,  Cristina Bozzola,  Ezio David,  Elisabetta Bugianesi,  Emanuele Albano,  Maurizio Parola, 
  • Pages: 2196-2214
  • First Published: 21 December 2017

HEPATOBILIARY MALIGNANCIES

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External validation of the ITA.LI.CA prognostic system for patients with hepatocellular carcinoma: A multicenter cohort study

Mauro Borzio,  Elena Dionigi,  Angelo Rossini,  Massimo Marignani,  Rodolfo Sacco,  Ilario De Sio,  Emanuela Bertolini,  Giampiero Francica,  Anna Giacomin,  Giancarlo Parisi,  Susanna Vicari,  Anna Toldi,  Andrea Salmi,  Sergio Boccia,  Mario Mitra,  Fabio Fornari, 
  • Pages: 2215-2225
  • First Published: 22 November 2017
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Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice

Jei-Ming Peng,  Rabindranath Bera,  Chih-Yung Chiou,  Ming-Chin Yu,  Tse-Chin Chen,  Chia-Wei Chen,  Tsung-Rui Wang,  Wan-Ling Chiang,  Shin-Pei Chai,  Yongkun Wei,  Huamin Wang,  Mien-Chie Hung,  Sen-Yung Hsieh, 
  • Pages: 2226-2243
  • First Published: 23 November 2017
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The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study

Darrick K. Li,  Yanjie Ren,  Daniel S. Fierer,  Stephanie Rutledge,  Obaid S. Shaikh,  Vincent Lo Re III,  Tracey Simon,  Abdul-Badi Abou-Samra,  Raymond T. Chung,  Adeel A. Butt, 
  • Pages: 2244-2253
  • First Published: 02 December 2017
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RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

Mengnuo Chen,  Lai Wei,  Cheuk-Ting Law,  Felice Ho-Ching Tsang,  Jialing Shen,  Carol Lai-Hung Cheng,  Long-Hin Tsang,  Daniel Wai-Hung Ho,  David Kung-Chun Chiu,  Joyce Man-Fong Lee,  Carmen Chak-Lui Wong,  Irene Oi-Lin Ng,  Chun-Ming Wong, 
  • Pages: 2254-2270
  • First Published: 24 November 2017
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Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross-talk in hepatocellular carcinoma

Hong Zhang,  Xiao-Xing Li,  Yang Yang,  Yanjie Zhang,  Hui-Yun Wang,  X.F. Steven Zheng, 
  • Pages: 2271-2286
  • First Published: 08 December 2017
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Capicua suppresses hepatocellular carcinoma progression by controlling the ETV4–MMP1 axis

Eunjeong Kim,  Donghyo Kim,  Jeon-Soo Lee,  Jeehyun Yoe,  Jongmin Park,  Chang-Jin Kim,  Dongjun Jeong,  Sanguk Kim,  Yoontae Lee, 
  • Pages: 2287-2301
  • First Published: 18 December 2017
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Increased expression of GATA zinc finger domain containing 1 through gene amplification promotes liver cancer by directly inducing phosphatase of regenerating liver 3

Wei Sun,  Yanquan Zhang,  Ka Chun Wong,  Ken Liu,  Yidong Yang,  Bin Wu,  Joanna H.M. Tong,  Anthony W.H. Chan,  Henry L.Y. Chan,  Jun Yu, 
  • Pages: 2302-2319
  • First Published: 21 December 2017

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis

Tirthadipa Pradhan-Sundd,  Lili Zhou,  Ravi Vats,  An Jiang,  Laura Molina,  Sucha Singh,  Minakshi Poddar,  Jacquelyn Russell,  Donna B Stolz,  Michael Oertel,  Udayan Apte,  Simon Watkins,  Sarangarajan Ranganathan,  Kari N. Nejak-Bowen,  Prithu Sundd,  Satdarshan Pal Monga, 
  • Pages: 2320-2337
  • First Published: 10 October 2017
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Surveillance for hepatobiliary cancers in patients with primary sclerosing cholangitis

Ahmad Hassan Ali,  James H. Tabibian,  Navine Nasser-Ghodsi,  Ryan J. Lennon,  Thomas DeLeon,  Mitesh J. Borad,  Moira Hilscher,  Marina G. Silveira,  Elizabeth J. Carey,  Keith D. Lindor, 
  • Pages: 2338-2351
  • First Published: 15 December 2017
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Wnt/β-catenin signaling controls intrahepatic biliary network formation in zebrafish by regulating notch activity

Juhoon So,  Mehwish Khaliq,  Kimberley Evason,  Nikolay Ninov,  Benjamin L. Martin,  Didier Y.R. Stainier,  Donghun Shin, 
  • Pages: 2352-2366
  • First Published: 21 December 2017

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis

Jacqueline G. O'Leary,  K. Rajender Reddy,  Guadalupe Garcia-Tsao,  Scott W. Biggins,  Florence Wong,  Michael B. Fallon,  Ram M. Subramanian,  Patrick S. Kamath,  Paul Thuluvath,  Hugo E. Vargas,  Benedict Maliakkal,  Puneeta Tandon,  Jennifer Lai,  Leroy R. Thacker,  Jasmohan S. Bajaj, 
  • Pages: 2367-2374
  • First Published: 08 January 2018
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Patient-reported outcomes in cirrhosis: A scoping review of the literature

Elliot B. Tapper,  Fasiha Kanwal,  Sumeet K. Asrani,  Chanda Ho,  Nadia Ovchinsky,  John Poterucha,  Avegail Flores,  Judith E. Smith,  Victor Ankoma-Sey,  Bruce Luxon,  Michael L. Volk, 
  • Pages: 2375-2383
  • First Published: 22 December 2017

LIVER INJURY/REGENERATION

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Chitinase 3-like-1 promotes intrahepatic activation of coagulation through induction of tissue factor in mice

Zhao Shan,  Xiaodong Liu,  Yuan Chen,  Meng Wang,  Yue Rachel Gao,  Liangguo Xu,  Wasim A. Dar,  Chun Geun Lee,  Jack Angel Elias,  Pavel Davizon Castillo,  Jorge Di Paola,  Cynthia Ju, 
  • Pages: 2384-2396
  • First Published: 18 December 2017

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Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury

Yu Sun,  Terytty Yang Li,  Lintao Song,  Cixiong Zhang,  Jingyi Li,  Zhi-Zhong Lin,  Sheng-Cai Lin,  Shu-Yong Lin, 
  • Pages: 2397-2413
  • First Published: 22 December 2017

LIVER BIOLOGY/PATHOBIOLOGY

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MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis

Jorge Matias Caviglia,  Jun Yan,  Myoung-Kuk Jang,  Geum-Youn Gwak,  Silvia Affo,  Lexing Yu,  Peter Olinga,  Richard A. Friedman,  Xin Chen,  Robert F. Schwabe, 
  • Pages: 2414-2429
  • First Published: 01 November 2017

Special Article

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Impact of hepatitis C virus polymorphisms on direct-acting antiviral treatment efficacy: Regulatory analyses and perspectives

Patrick R. Harrington,  Takashi E. Komatsu,  Damon J. Deming,  Eric F. Donaldson,  Julian J. O'Rear,  Lisa K. Naeger, 
  • Pages: 2430-2448
  • First Published: 01 December 2017

Review

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Toward the elimination of hepatitis C in the United States

Sammy Saab,  Long Le,  Satvir Saggi,  Vinay Sundaram,  Myron J. Tong, 
  • Pages: 2449-2459
  • First Published: 27 November 2017

Hepatology Elsewhere

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Gentle palpating liver sinusoidal endothelial cells reveals the dynamic behavior and formation of fenestrae: A new window for biomedical research

Filip Braet Ph.D.,  Eddie Wisse Ph.D., 
  • Pages: 2460-2461
  • First Published: 02 December 2017
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Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Tatyana V. Masyuk Ph.D.,  Anatoliy I. Masyuk Ph.D.,  Nicholas F. LaRusso M.D., 
  • Pages: 2462-2464
  • First Published: 06 December 2017
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Ectopic expansion of engineered human liver tissue seeds using mature cell populations

Raymond D. Hickey Ph.D.,  Willscott E. Naugler M.D., 
  • Pages: 2465-2467
  • First Published: 09 December 2017

Clinical Observations in Hepatology

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Chronic hepatitis E in patients with indolent lymphoma after treatment with rituximab and bendamustine

Khaled Alnuaimi,  Julie Lavolé,  Caroline Lascoux-Combes,  Anne-Marie Roque Afonso,  Philippe Sogni,  Stanislas Pol,  Vincent Mallet, 
  • Pages: 2468-2470
  • First Published: 01 December 2017
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Hepatocellular carcinoma due to a baffle obstruction after the mustard operation: A case report

Takeo Yoshihara,  Ryotaro Sakamori,  Kunimaro Furuta,  Minoru Shigekawa,  Ryoko Yamada,  Takahiro Kodama,  Hayato Hikita,  Takayuki Yakushijin,  Tomohide Tatsumi,  Yasushi Sakata,  Hidetoshi Eguchi,  Yoshiki Sawa,  Tetsuo Takehara, 
  • Pages: 2471-2473
  • First Published: 22 December 2017

Correspondence

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The association between nonalcoholic fatty liver disease and metabolic comorbidities

Qian Zhao M.D.,  Xinyue Tang M.D.,  Jiansheng Wu M.D., 
  • Page: 2474
  • First Published: 18 December 2017
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Are immunoglobulins against the HBsAg still needed in liver transplantation for hepatitis D?

Silvia Martini M.D.,  Lucio Caccamo M.D.,  Mario Rizzetto M.D., 
  • Pages: 2475-2476
  • First Published: 21 January 2018
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Knockout of ULK1/2 protects against acetaminophen-induced acute liver injury independent of autophagy?

Cuiqin Zhang M.M.,  Fuyong Song Ph.D., 
  • Pages: 2476-2477
  • First Published: 02 February 2018
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Reply

Yu Sun M.Sc.,  Shu-Yong Lin Ph.D., 
  • Page: 2477
  • First Published: 01 February 2018
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Should statins be discontinued in cirrhosis with decompensation?

William Carey M.D., M.A.C.G., F.A.A.S.L.D., 
  • Pages: 2477-2478
  • First Published: 14 February 2018
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Reply

Naga Chalasani M.D.,  on behalf of the Writing Group for the AASLD NAFLD Practice Gudiance , 
  • Pages: 2478-2479
  • First Published: 14 February 2018
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People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol

Stephen R. Atkinson M.B.B.S.,  Andrew McQuillin Ph.D.,  Marsha Y. Morgan M.D.,  Mark R. Thursz M.D., 
  • Pages: 2479-2480
  • First Published: 02 February 2018
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New biomarkers for drug-induced liver injury

James W. Dear Ph.D., F.R.C.P.(Edin), 
  • Pages: 2480-2481
  • First Published: 03 March 2018
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Reply

Rachel J. Church Ph.D.,  Paul B. Watkins M.D., 
  • Pages: 2481-2482
  • First Published: 05 March 2018
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Magic mirror on the wall: Which is the best biomarker for hepatocellular carcinoma?

Teh-Ia Huo M.D.,  Chia-Yang Hsu M.D., M.P.H.,  Po-Hong Liu M.D., M.P.H., 
  • Pages: 2482-2483
  • First Published: 05 March 2018
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Reply

Ping Luo Ph.D.,  Peiyuan Yin Ph.D.,  Guowang Xu Ph.D., 
  • Pages: 2483-2484
  • First Published: 05 March 2018

Issue Information

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Notices

  • First Published: 21 May 2018
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Instructions to authors and Information for readers

  • First Published: 21 May 2018