• Issue

    Hepatology: Volume 67, Issue 5

    1647-2063
    May 2018
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Cover Image

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Cover Image

  • First Published: 18 April 2018

Issue Information

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Masthead

  • First Published: 18 April 2018
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Table of contents

  • First Published: 18 April 2018

Hepatology Highlights

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Hepatology Highlights

Shirley Cohen-Mekelburg,  Robert E. Schwartz,  Russell Rosenblatt,  Robert S. Brown Jr,  Zaid H. Tafesh,  Clara Tow,  Nicholas Russo,  Yecheskel Schneider,  Vikas Gupta,  Saurabh Mukewar,  Nicole T. Shen,  Aleksey Novikov, 
  • Pages: 1647-1650
  • First Published: 18 April 2018

Editorials

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Regression of HCV cirrhosis: Time will tell

Guadalupe Garcia-Tsao M.D., 
  • Pages: 1651-1653
  • First Published: 09 December 2017
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Bringing the cell nucleus in the focus of NAFLD

Kurt Zatloukal M.D., 
  • Pages: 1654-1656
  • First Published: 01 December 2017
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Nonalcoholic fatty liver disease, metabolic syndrome, and the fight that will define clinical practice for a generation of hepatologists

Elliot B. Tapper M.D.,  Rohit Loomba M.D., M.H.Sc., 
  • Pages: 1657-1659
  • First Published: 09 December 2017
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Pyroptosis, A novel player for alcoholic hepatitis?

Shaogui Wang Ph.D.,  Hua Wang,  Wen-Xing Ding Ph.D., 
  • Pages: 1660-1662
  • First Published: 09 December 2017
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Breaking Kuhn's paradigm in advanced hepatocellular carcinoma

David J. Pinato M.D., M.Res., M.R.C.P., Ph.D., 
  • Pages: 1663-1665
  • First Published: 08 December 2017
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Evolving role of obeticholic acid in primary biliary cholangitis

Cynthia Levy M.D., 
  • Pages: 1666-1668
  • First Published: 09 December 2017

Introducing the AASLD President

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Introducing Ronald J. Sokol, M.D.—our 2018 AASLD president

Cara L. Mack M.D., 
  • Pages: 1669-1672
  • First Published: 21 February 2018

Rapid Communication

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Hepatitis C transmission from seropositive, nonviremic donors to non–hepatitis C liver transplant recipients

Khurram Bari,  Keith Luckett,  Tiffany Kaiser,  Tayyab Diwan,  Madison Cuffy,  Michael R. Schoech,  Kamran Safdar,  Jason T. Blackard,  Senu Apewokin,  Flavio Paterno,  Kenneth E. Sherman,  Stephen D. Zucker,  Nadeem Anwar,  Shimul A. Shah, 
  • Pages: 1673-1682
  • First Published: 02 December 2017

Original Articles

VIRAL HEPATITIS

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Portal pressure and liver stiffness measurements in the prediction of fibrosis regression after sustained virological response in recurrent hepatitis C

Ezequiel Mauro,  Gonzalo Crespo,  Carla Montironi,  Maria-Carlota Londoño,  Virginia Hernández-Gea,  Pablo Ruiz,  Lydia Sastre,  Julissa Lombardo,  Zoe Mariño,  Alba Díaz,  Jordi Colmenero,  Antoni Rimola,  Juan Carlos Garcia-Pagán,  Mercé Brunet,  Xavier Forns,  Miquel Navasa, 
  • Pages: 1683-1694
  • First Published: 27 September 2017
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Global microRNA expression profiling in the liver biopsies of hepatitis B virus–infected patients suggests specific microRNA signatures for viral persistence and hepatocellular injury

Avishek Kumar Singh,  Sheetalnath Babasaheb Rooge,  Aditi Varshney,  Madavan Vasudevan,  Ankit Bhardwaj,  Senthil Kumar Venugopal,  Nirupama Trehanpati,  Manoj Kumar,  Robert Geffers,  Vijay Kumar,  Shiv Kumar Sarin, 
  • Pages: 1695-1709
  • First Published: 30 November 2017

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease

Graham F. Brady,  Raymond Kwan,  Peter J. Ulintz,  Phirum Nguyen,  Shirin Bassirian,  Venkatesha Basrur,  Alexey I. Nesvizhskii,  Rohit Loomba,  M. Bishr Omary, 
  • Pages: 1710-1725
  • First Published: 13 September 2017
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Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study

Alina M. Allen,  Terry M. Therneau,  Joseph J. Larson,  Alexandra Coward,  Virend K. Somers,  Patrick S. Kamath, 
  • Pages: 1726-1736
  • First Published: 23 September 2017
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Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients

Elena Khanova,  Raymond Wu,  Wen Wang,  Rui Yan,  Yibu Chen,  Samuel W. French,  Cristina Llorente,  Stephanie Q. Pan,  Qihong Yang,  Yuchang Li,  Raul Lazaro,  Charles Ansong,  Richard D. Smith,  Ramon Bataller,  Timothy Morgan,  Bernd Schnabl,  Hidekazu Tsukamoto, 
  • Pages: 1737-1753
  • First Published: 06 November 2017
Open Access

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

Scott L. Friedman,  Vlad Ratziu,  Stephen A. Harrison,  Manal F. Abdelmalek,  Guruprasad P. Aithal,  Juan Caballeria,  Sven Francque,  Geoffrey Farrell,  Kris V. Kowdley,  Antonio Craxi,  Krzysztof Simon,  Laurent Fischer,  Liza Melchor-Khan,  Jeffrey Vest,  Brian L. Wiens,  Pamela Vig,  Star Seyedkazemi,  Zachary Goodman,  Vincent Wai-Sun Wong,  Rohit Loomba,  Frank Tacke,  Arun Sanyal,  Eric Lefebvre, 
  • Pages: 1754-1767
  • First Published: 17 August 2017
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Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis

Chune Liu,  Zhihong Yang,  Jianguo Wu,  Li Zhang,  Sangmin Lee,  Dong-Ju Shin,  Melanie Tran,  Li Wang, 
  • Pages: 1768-1783
  • First Published: 15 November 2017

HEPATOBILIARY MALIGNANCIES

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Patients with advanced hepatocellular carcinoma need a personalized management: A lesson from clinical practice

Edoardo Giovanni Giannini,  Laura Bucci,  Francesca Garuti,  Matteo Brunacci,  Barbara Lenzi,  Matteo Valente,  Eugenio Caturelli,  Giuseppe Cabibbo,  Fabio Piscaglia,  Roberto Virdone,  Martina Felder,  Francesca Ciccarese,  Francesco Giuseppe Foschi,  Rodolfo Sacco,  Gianluca Svegliati Baroni,  Fabio Farinati,  Gian Lodovico Rapaccini,  Andrea Olivani,  Antonio Gasbarrini,  Maria Di Marco,  Filomena Morisco,  Marco Zoli,  Alberto Masotto,  Franco Borzio,  Luisa Benvegnù,  Fabio Marra,  Antonio Colecchia,  Gerardo Nardone,  Mauro Bernardi,  Franco Trevisani,  for the Italian Liver Cancer (ITA.LI.CA) group , 
  • Pages: 1784-1796
  • First Published: 21 November 2017
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Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies

Tracey G. Simon,  Lindsay Y. King,  Dawn Q. Chong,  Long H. Nguyen,  Yanan Ma,  Trang VoPham,  Edward L. Giovannucci,  Charles S. Fuchs,  Jeffrey A. Meyerhardt,  Kathleen E. Corey,  Hamed Khalili,  Raymond T. Chung,  Xuehong Zhang,  Andrew T. Chan, 
  • Pages: 1797-1806
  • First Published: 20 November 2017
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β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET

Yan Liang,  Yun Feng,  Min Zong,  Xu-Fu Wei,  Jin Lee,  Yukuan Feng,  Hairi Li,  Guang-Shun Yang,  Zhong-Jun Wu,  Xiang-Dong Fu,  Gen-Sheng Feng, 
  • Pages: 1807-1822
  • First Published: 20 November 2017
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High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis

Ruochan Chen,  Shan Zhu,  Xue-Gong Fan,  Haichao Wang,  Michael T. Lotze,  Herbert J. Zeh 3rd,  Timothy R. Billiar,  Rui Kang,  Daolin Tang, 
  • Pages: 1823-1841
  • First Published: 17 November 2017
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Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Shan Wan,  Anne-Sophie Meyer,  Sofia Maria Elisabeth Weiler,  Christian Rupp,  Marcell Tóth,  Carsten Sticht,  Stephan Singer,  Stefan Thomann,  Stephanie Roessler,  Marina Schorpp-Kistner,  Jennifer Schmitt,  Norbert Gretz,  Peter Angel,  Darjus Felix Tschaharganeh,  Jens Marquardt,  Peter Schirmacher,  Federico Pinna,  Kai Breuhahn, 
  • Pages: 1842-1856
  • First Published: 20 November 2017
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C/EBPα-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer

Ashley Cast,  Leila Valanejad,  Mary Wright,  Phuong Nguyen,  Anita Gupta,  Liqin Zhu,  Soona Shin,  Nikolai Timchenko, 
  • Pages: 1857-1871
  • First Published: 21 November 2017
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Hypoxia-inducible factor-1α/interleukin-1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic-inflammatory microenvironment

Jingying Zhang,  Qi Zhang,  Yu Lou,  Qihan Fu,  Qi Chen,  Tao Wei,  Jiaqi Yang,  Jinlong Tang,  Jianxin Wang,  Yiwen Chen,  Xiaoyu Zhang,  Jian Zhang,  Xueli Bai,  Tingbo Liang, 
  • Pages: 1872-1889
  • First Published: 23 November 2017

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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A randomized trial of obeticholic acid monotherapy in patients with primary biliary cholangitis

Kris V. Kowdley,  Velimir Luketic,  Roger Chapman,  Gideon M. Hirschfield,  Raoul Poupon,  Christoph Schramm,  Catherine Vincent,  Christian Rust,  Albert Parés,  Andrew Mason,  Hanns-Ulrich Marschall,  David Shapiro,  Luciano Adorini,  Cathi Sciacca,  Tessa Beecher-Jones,  Olaf Böhm,  Richard Pencek,  David Jones,  for the Obeticholic Acid PBC Monotherapy Study Group , 
  • Pages: 1890-1902
  • First Published: 10 October 2017
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β-Catenin and interleukin-1β–dependent chemokine (C-X-C motif) ligand 10 production drives progression of disease in a mouse model of congenital hepatic fibrosis

Eleanna Kaffe,  Romina Fiorotto,  Francesca Pellegrino,  Valeria Mariotti,  Mariangela Amenduni,  Massimiliano Cadamuro,  Luca Fabris,  Mario Strazzabosco,  Carlo Spirli, 
  • Pages: 1903-1919
  • First Published: 15 November 2017
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Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history

Carla F. Murillo Perez,  Jorn C. Goet,  Willem J. Lammers,  Aliya Gulamhusein,  Henk R. van Buuren,  Cyriel Y. Ponsioen,  Marco Carbone,  Andrew Mason,  Christophe Corpechot,  Pietro Invernizzi,  Marlyn J. Mayo,  Pier Maria Battezzati,  Annarosa Floreani,  Albert Pares,  Frederik Nevens,  Kris V. Kowdley,  Tony Bruns,  George N. Dalekos,  Douglas Thorburn,  Gideon Hirschfield,  Nicholas F. LaRusso,  Keith D. Lindor,  Kalliopi Zachou,  Raoul Poupon,  Palak J. Trivedi,  Xavier Verhelst,  Harry L.A. Janssen,  Bettina E. Hansen,  on behalf of the GLOBAL PBC Study Group , 
  • Pages: 1920-1930
  • First Published: 08 December 2017

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Bleeding complications in acute liver failure

R. Todd Stravitz,  Caitlyn Ellerbe,  Valerie Durkalski,  Michael Schilsky,  Robert J. Fontana,  Carolyn Peterseim,  William M. Lee,  and the Acute Liver Failure Study Group , 
  • Pages: 1931-1942
  • First Published: 01 December 2017

LIVER INJURY/REGENERATION

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CD36 deficiency attenuates immune-mediated hepatitis in mice by modulating the proapoptotic effects of CXC chemokine ligand 10

Che Xu,  Chen Zhang,  Jie Ji,  Chao Wang,  Jing Yang,  Biao Geng,  Ting Zhao,  Hong Zhou,  Xianmin Mu,  Jinshun Pan,  Shi Hu,  Yuanfang Lv,  Xingguo Chen,  Hao Wen,  Qiang You, 
  • Pages: 1943-1955
  • First Published: 08 December 2017
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Decellularized human placenta supports hepatic tissue and allows rescue in acute liver failure

Zurab Kakabadze,  Ann Kakabadze,  David Chakhunashvili,  Lia Karalashvili,  Ekaterine Berishvili,  Yogeshwar Sharma,  Sanjeev Gupta, 
  • Pages: 1956-1969
  • First Published: 06 December 2017

LIVER BIOLOGY/PATHOBIOLOGY

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B lymphocytes limit senescence-driven fibrosis resolution and favor hepatocarcinogenesis in mouse liver injury

Francesca Faggioli,  Eleonora Palagano,  Luca Di Tommaso,  Matteo Donadon,  Veronica Marrella,  Camilla Recordati,  Stefano Mantero,  Anna Villa,  Paolo Vezzoni,  Barbara Cassani, 
  • Pages: 1970-1985
  • First Published: 03 November 2017
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Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

Banishree Saha,  Fatemeh Momen-Heravi,  Istvan Furi,  Karen Kodys,  Donna Catalano,  Anwesha Gangopadhyay,  Reka Haraszti,  Abhishek Satishchandran,  Arvin Iracheta-Vellve,  Adeyinka Adejumo,  Scott A. Shaffer,  Gyongyi Szabo, 
  • Pages: 1986-2000
  • First Published: 18 December 2017

Special Article

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Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science

Mohammad Shadab Siddiqui,  Stephen A. Harrison,  Manal F. Abdelmalek,  Quentin M. Anstee,  Pierre Bedossa,  Laurent Castera,  Lara Dimick-Santos,  Scott L. Friedman,  Katherine Greene,  David E. Kleiner,  Sophie Megnien,  Brent A. Neuschwander-Tetri,  Vlad Ratziu,  Elmer Schabel,  Veronica Miller,  Arun J. Sanyal,  on behalf of the Liver Forum Case Definitions Working Group , 
  • Pages: 2001-2012
  • First Published: 23 October 2017

Reviews

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New insights into the role and mechanism of c-Jun-N-terminal kinase signaling in the pathobiology of liver diseases

Sanda Win,  Tin Aung Than,  Jun Zhang,  Christina Oo,  Robert Win Maw Min,  Neil Kaplowitz, 
  • Pages: 2013-2024
  • First Published: 30 November 2017
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Advance care planning (ACP) for specialists managing cirrhosis: A focus on patient-centered care

Amanda Brisebois,  Kathleen P. Ismond,  Michelle Carbonneau,  Jan Kowalczewski,  Puneeta Tandon, 
  • Pages: 2025-2040
  • First Published: 18 December 2017

Hepatology Elsewhere

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Exercise alters the hepatic immunophenotype to protect against inflammatory liver disease

Abhishek Chauhan BMedSci, MBChB,  David H. Adams M.D., MBChB, 
  • Pages: 2041-2043
  • First Published: 16 November 2017
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The role of genetics in hepatic fibrosis among hepatitis C virus patients

Heiyoung Park Ph.D.,  Thomas R. O’Brien M.D., M.P.H.,  Barbara Rehermann M.D., 
  • Pages: 2043-2045
  • First Published: 20 November 2017
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Scratching the surface of cholestatic itch treatments

Christopher L. Bowlus M.D., 
  • Pages: 2045-2048
  • First Published: 01 December 2017

Clinical Observations in Hepatology

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Sofosbuvir, pegylated interferon, and ribavirin for retreatment of hepatitis C virus genotype 1b following sofosbuvir and ledipasvir failure

Chetan Kalal,  Akash Shukla,  Ravi Mohanka,  Mihir Vora,  Priyesh Patel,  Samir Shah, 
  • Pages: 2049-2050
  • First Published: 20 November 2017
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Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient

Suzane Kioko Ono,  Leda Bassit,  Victor Van Vaisberg,  Venâncio Avancini Ferreira Alves,  Elia G. Caldini,  Brian D. Herman,  Reed Shabman,  Nadia B. Fedorova,  Denise Paranaguá-Vezozzo,  Caroline Torres Sampaio,  Rafael Bandeira Lages,  Débora Terrabuio,  Wellington Andraus,  Raymond F. Schinazi,  Flair José Carrilho, 
  • Pages: 2051-2054
  • First Published: 24 November 2017

Correspondence

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Targeting mitochondrial pyruvate carrier in nonalcoholic steatohepatitis: Growing evidence and future challenges

Giovanni Musso M.D.,  Roberto Gambino Ph.D., 
  • Page: 2055
  • First Published: 20 March 2017
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Reply

Kyle S. McCommis Ph.D.,  Jerry R. Colca Ph.D.,  Brian N. Finck Ph.D., 
  • Pages: 2055-2056
  • First Published: 20 March 2017
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Mesenchymal stromal cells in treatment of acute-on-chronic liver failure

Lin Wang Ph.D., 
  • Pages: 2056-2057
  • First Published: 20 November 2017
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Who should receive endoscopic variceal ligation after recovering from acute variceal bleeding?

Xingshun Qi M.D.,  Nahum Méndez-Sánchez M.D., MSc, Ph.D.,  Andrea Mancuso M.D.,  Fernando Gomes Romeiro,  Xiaozhong Guo M.D., 
  • Pages: 2057-2058
  • First Published: 24 November 2017
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A novel frailty index improves risk prediction of waitlist mortality over the model for end-stage liver disease score alone

Heng Fan Ph.D.,  Jian-hua Zhu Ph.D., 
  • Page: 2059
  • First Published: 29 January 2018
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Reply

Jennifer C. Lai M.D., M.B.A.,  Kenneth E. Covinsky M.D., MPH,  Jennifer L. Dodge M.P.H.,  W. John Boscardin Ph.D.,  Dorry L. Segev M.D., Ph.D.,  John P. Roberts M.D.,  Sandy Feng M.D., Ph.D., 
  • Pages: 2059-2060
  • First Published: 29 January 2018
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Von Willebrand factor for the liver: Friend or foe?

Qing Pang M.D., Ph.D.,  Huichun Liu M.D., Ph.D.,  Hao Jin M.D.,  Lei Zhou M.D.,  Zhongran Man M.D., 
  • Page: 2061
  • First Published: 29 January 2018
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Reply

David Pereyra,  Patrick Starlinger, 
  • Pages: 2061-2062
  • First Published: 29 January 2018

Correction

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Correction

  • Page: 2063
  • First Published: 26 March 2018

Issue Information

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Notices

  • First Published: 18 April 2018
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Instructions to authors and Information for readers

  • First Published: 18 April 2018