Virtual Issues
List of EJHF Virtual Issues
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Spotlight on Asia: highlighting recent heart failure articles with relevance to Asia
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Top cited articles: Celebrating 5 years as Editor-in-Chief of EJHF
Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology
Maria G. Crespo‐Leiro Marco Metra Lars H. Lund Davor Milicic Maria Rosa Costanzo Gerasimos Filippatos Finn Gustafsson Steven Tsui Eduardo Barge‐Caballero Nicolaas De Jonge Maria Frigerio Righab Hamdan Tal Hasin Martin Hülsmann Sanem Nalbantgil Luciano Potena Johann Bauersachs Aggeliki Gkouziouta Arjang Ruhparwar Arsen D. Ristic Ewa Straburzynska‐Migaj Theresa McDonagh Petar Seferovic Frank Ruschitzka
Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology
Petar M. Seferović Mark C. Petrie Gerasimos S. Filippatos Stefan D. Anker Giuseppe Rosano Johann Bauersachs Walter J. Paulus Michel Komajda Francesco Cosentino Rudolf A. de Boer Dimitrios Farmakis Wolfram Doehner Ekaterini Lambrinou Yuri Lopatin Massimo F. Piepoli Michael J. Theodorakis Henrik Wiggers John Lekakis Alexandre Mebazaa Mamas A. Mamas Carsten Tschöpe Arno W. Hoes Jelena P. Seferović Jennifer Logue Theresa McDonagh Jillian P. Riley Ivan Milinković Marija Polovina Dirk J. van Veldhuisen Mitja Lainscak Aldo P. Maggioni Frank Ruschitzka John J.V. McMurray
Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology
Thomas M. Gorter Dirk J. van Veldhuisen Johann Bauersachs Barry A. Borlaug Jelena Celutkiene Andrew J.S. Coats Marisa G. Crespo‐Leiro Marco Guazzi Veli‐Pekka Harjola Stephane Heymans Loreena Hill Mitja Lainscak Carolyn S.P. Lam Lars H. Lund Alexander R. Lyon Alexandre Mebazaa Christian Mueller Walter J. Paulus Burkert Pieske Massimo F. Piepoli Frank Ruschitzka Frans H. Rutten Petar M. Seferovic Scott D. Solomon Sanjiv J. Shah Filippos Triposkiadis Rolf Wachter Carsten Tschöpe Rudolf A. de Boer
Left ventricular assist device therapy in advanced heart failure: patient selection and outcomes
Finn Gustafsson Joseph G. Rogers
Role of cardiopulmonary exercise testing in clinical stratification in heart failure. A position paper from the Committee on Exercise Physiology and Training of the Heart Failure Association of the European Society of Cardiology
Ugo Corrà Pier Giuseppe Agostoni Stefan D. Anker Andrew J.S. Coats Maria G. Crespo Leiro Rudolph A. de Boer Veli‐Pekka Harjola Loreena Hill Mitja Lainscak Lars H. Lund
Comprehensive in‐hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Veli‐Pekka Harjola John Parissis Hans‐Peter Brunner‐La Rocca Jelena Čelutkienė Ovidiu Chioncel Sean P. Collins Daniel De Backer Gerasimos S. Filippatos Etienne Gayat Loreena Hill Mitja Lainscak Johan Lassus Josep Masip Alexandre Mebazaa Òscar Miró Andrea Mortara Christian Mueller Wilfried Mullens Markku S. Nieminen Alain Rudiger Frank Ruschitzka Petar M. Seferovic Alessandro Sionis Antoine Vieillard‐Baron Jean Marc Weinstein Rudolf A. de Boer Maria G. Crespo‐Leiro Massimo Piepoli Jillian P. Riley
Heart and brain interaction in patients with heart failure: overview and proposal for a taxonomy. A position paper from the Study Group on Heart and Brain Interaction of the Heart Failure Association
Wolfram Doehner Dilek Ural Karl Georg Haeusler Jelena Čelutkienė Reinaldo Bestetti Yuksel Cavusoglu Marco A. Peña‐Duque Duska Glavas Massimo Iacoviello Ulrich Laufs Ricardo Marmol Alvear Amam Mbakwem Massimo F. Piepoli Stuart D. Rosen Georgios Tsivgoulis Cristiana Vitale M. Birhan Yilmaz Stefan D. Anker Gerasimos Filippatos Petar Seferovic Andrew J.S. Coats Frank Ruschitzka
Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Veli‐Pekka Harjola Wilfried Mullens Marek Banaszewski Johann Bauersachs Hans‐Peter Brunner‐La Rocca Ovidiu Chioncel Sean P. Collins Wolfram Doehner Gerasimos S. Filippatos Andreas J. Flammer Valentin Fuhrmann Mitja Lainscak Johan Lassus Matthieu Legrand Josep Masip Christian Mueller Zoltán Papp John Parissis Elke Platz Alain Rudiger Frank Ruschitzka Andreas Schäfer Petar M. Seferovic Hadi Skouri Mehmet Birhan Yilmaz Alexandre Mebazaa
Employment status at time of first hospitalization for heart failure is associated with a higher risk of death and rehospitalization for heart failure
Rasmus Rørth Emil L. Fosbøl Ulrik M. Mogensen Kristian Kragholm Anna‐karin Numé Gunnar H. Gislason Pardeep S. Jhund Mark C. Petrie, John J.V. McMurray, Christian Torp‐Pedersen, Lars Køber and Søren L. Kristensen
Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with ivabradine: findings from SHIFT
Michael Böhm, Michel Komajda, Jeffrey S. Borer, Ian Ford, Christoph Maack, Luigi Tavazzi, Aurélie Moyne and Karl Swedberg on behalf of the SHIFT Investigators
Extending survival by reducing sudden death with implantable cardioverter‐defibrillators: a challenging clinical issue in non‐ischaemic and ischaemic cardiomyopathies
Giuseppe Boriani and Vincenzo Livio Malavasi
Clinical characteristics of patients from the worldwide registry on peripartum cardiomyopathy (PPCM)
Karen Sliwa, Alexandre Mebazaa, Denise Hilfiker‐Kleiner, Mark C. Petrie, Aldo P. Maggioni, Cecile Laroche, Vera Regitz‐Zagrosek, Maria Schaufelberger, Luigi Tavazzi, Peter van der Meer, Jolien W. Roos‐Hesselink, Petar Seferovic, Karin van Spandonck‐Zwarts, Amam Mbakwem, Michael Böhm, Frederic Mouquet, Burkert Pieske, Roger Hall, Piotre Ponikowski and Johann Bauersachs
Left ventricular assist device therapy in advanced heart failure: patient selection and outcomes
Finn Gustafsson and Joseph G. Rogers
Heart rate and its reduction in chronic heart failure and beyond
Aleksandra Nikolovska Vukadinović, Davor Vukadinović, Jeffrey Borer, Martin Cowie, Michel Komajda, Mitja Lainscak, Karl Swedberg and Michael Böhm
New York Heart Association functional class, QRS duration, and survival in heart failure with reduced ejection fraction: implications for cardiac resychronization therapy
Frieder Braunschweig, Cecilia Linde, Lina Benson, Marcus Ståhlberg, Ulf Dahlström and Lars H. Lund
C. Pacho, M. Domingo, R. Nunez, J. Lupon, E. Revuelta, J. Barallat, P. Moliner, B. Gonzalez, M. Rodriguez, C. Rivas, V. Diaz, J. Santesmases, M. De Antonio, J. Tor, A. Bayes-Genis
Early post-discharge ST2 and NTproBNP for predicting 30-day heart failure readmission in a very old and co-morbid population with predominantly HFpEF, p. 201 in Special Issue: Abstracts of the World Congress on Acute Heart Failure, Paris, France, 29 April-2 May 2017
Thirty‐year trends in heart failure hospitalization and mortality rates and the prognostic impact of co‐morbidity: a Danish nationwide cohort study
Morten Schmidt, Sinna Pilgaard Ulrichsen, Lars Pedersen, Hans Erik Bøtker and Henrik Toft Sørensen
The real‐world evidence of heart failure: findings from 41 413 patients of the ARNO database
Aldo P. Maggioni, Francesco Orso, Silvia Calabria, Elisa Rossi, Elisa Cinconze, Samuele Baldasseroni and Nello Martini on behalf of the ARNO Observatory
Echocardiographic screening for non‐ischaemic stage B heart failure in the community
Hong Yang, Kazuaki Negishi, Ying Wang, Mark Nolan, Makoto Saito and Thomas H. Marwick
Geographic variation in heart failure—a matter of celebration or condemnation?
Pardeep S. Jhund
Clinical characteristics, management, and outcomes of acute heart failure patients: observations from the Gulf acute heart failure registry (Gulf CARE)
Kadhim Sulaiman, Prashanth Panduranga, Ibrahim Al‐Zakwani, Alawi A. Alsheikh‐Ali, Khalid F. AlHabib, Jassim Al‐Suwaidi, Wael Al‐Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al‐Motarreb, Mustafa Ridha, Bassam Bulbanat, Mohammed Al‐Jarallah, Nooshin Bazargani, Nidal Asaad and Haitham Amin
Global variation in clinical profile, management, and post‐discharge outcomes among patients hospitalized for worsening chronic heart failure: findings from the ASTRONAUT trial
Stephen J. Greene, Gregg C. Fonarow, Scott D. Solomon, Haris Subacius, Aldo P. Maggioni, Michael Böhm, Eldrin F. Lewis, Faiez Zannad and Mihai Gheorghiade for the ASTRONAUT Investigators and Coordinators
International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT‐HF): rationale for and design of a global registry
Gerasimos Filippatos, Sadiya Sana Khan, Andrew P. Ambrosy, John G.F. Cleland, Sean P. Collins, Carolyn S.P. Lam, Christiane E. Angermann, Georg Ertl, Ulf Dahlström, Dayi Hu, Kenneth Dickstein, Sergio V. Perrone, Mathieu Ghadanfar, Georgina Bermann, Adele Noe, Anja Schweizer, Thomas Maier and Mihai Gheorghiade
Which heart failure patients profit from natriuretic peptide guided therapy? A meta‐analysis from individual patient data of randomized trials
Hans‐Peter Brunner‐La Rocca, Luc Eurlings, A. Mark Richards, James L. Januzzi, Matthias E. Pfisterer, Ulf Dahlström, Yigal M. Pinto, Patric Karlström, Hans Erntell, Rudolf Berger, Hans Persson, Christopher M. O'Connor, Deddo Moertl, Hanna K. Gaggin, Christopher M. Frampton, M. Gary Nicholls and Richard W. Troughton
Do patients have worse outcomes in heart failure than in cancer? A primary care‐based cohort study with 10‐year follow‐up in Scotland
Mamas A. Mamas, Matthew Sperrin, Margaret C. Watson, Alasdair Coutts, Katie Wilde, Christopher Burton, Umesh T. Kadam, Chun Shing Kwok, Allan B. Clark, Peter Murchie, Iain Buchan, Philip C. Hannaford and Phyo K. Myint
Prognostic value of long‐term blood pressure changes in patients with chronic heart failure
Florian A. Schmid, Oliver Schlager, Philipp Keller, Burkhardt Seifert, Ruizhu Huang, Georg M. Fröhlich, Thomas F. Lüscher, Frank Ruschitzka and Frank Enseleit
In Memoriam: Mihai Gheorghiade
Mihai Gheorghiade sadly passed away on 28 August 2017. His contributions to the understanding of heart failure and improving patients’ symptoms and outcomes endures and will be forever acknowledged. He was also extremely active with HFA and our journal both as an enthusiastic researcher and organizer and as an Author, a Reviewer and an Editor. As tribute to Mihai and in recognition of his work, this virtual issue is a selection of his publications in the European Journal of Heart Failure.
Protein turnover in the failing heart: an ever-changing landscape
Baljash S. Cheema, Hani N. Sabbah, Stephen J. Greene and Mihai Gheorghiade
Clinical profiles in acute heart failure: one size fits all or not at all?
Andrew P. Ambrosy and Mihai Gheorghiade
Clinical trials in acute heart failure: beginning of the end or end of the beginning?
Andrew P. Ambrosy, Javed Butler and Mihai Gheorghiade
Patient-reported outcomes in the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED ejection fraction (SOCRATES-PRESERVED) study
Gerasimos Filippatos, Aldo P. Maggioni, Carolyn S.P. Lam, Elisabeth Pieske-Kraigher, Javed Butler, John Spertus, Piotr Ponikowski, Sanjiv J. Shah, Scott D. Solomon, Andrea-Viviana Scalise, Katharina Mueller, Lothar Roessig, Luke Bamber, Mihai Gheorghiade and Burkert Pieske
Influence of atrial fibrillation on post-discharge natriuretic peptide trajectory and clinical outcomes among patients hospitalized for heart failure: insights from the ASTRONAUT trial
Stephen J. Greene, Gregg C. Fonarow, Scott D. Solomon, Haris P. Subacius, Andrew P. Ambrosy, Muthiah Vaduganathan, Aldo P. Maggioni, Michael Böhm, Eldrin F. Lewis, Faiez Zannad, Javed Butler, Mihai Gheorghiade and for the ASTRONAUT Investigators and Coordinators
Moving away from symptoms-based heart failure treatment: misperceptions and real risks for patients with heart failure
Javed Butler, Mihai Gheorghiade and Marco Metra
Spectrum of epidemiological and clinical findings in patients with heart failure with preserved ejection fraction stratified by study design: a systematic review
Muthiah Vaduganathan, Alexander Michel, Kathryn Hall, Claire Mulligan, Savina Nodari, Sanjiv J. Shah, Michele Senni, Marco Triggiani, Javed Butler and Mihai Gheorghiade
In-hospital worsening heart failure
Javed Butler, Mihai Gheorghiade, Anita Kelkar, Gregg C. Fonarow, Stefan Anker, Stephen J. Greene, Lampros Papadimitriou, Sean Collins, Frank Ruschitzka, Clyde W. Yancy, John R. Teerlink, Kirkwood Adams, Gadi Cotter, Piotr Ponikowski, G. Michael Felker, Marco Metra and Gerasimos Filippatos
Heart failure at the crossroads: moving beyond blaming stakeholders to targeting the heart
Michele Senni, Antonello Gavazzi, Mihai Gheorghiade and Javed Butler
Agents with vasodilator properties in acute heart failure: how to design successful trials
Alexandre Mebazaa, Dan Longrois, Marco Metra, Christian Mueller, Arthur Mark Richards, Lothar Roessig, Marie France Seronde, Naoki Sato, Norman L. Stockbridge, Wendy Gattis Stough, Angeles Alonso, Robert J. Cody, Nancy Cook Bruns, Mihai Gheorghiade, Johannes Holzmeister, Said Laribi and Faiez Zannad
Length of hospital stay and 30-day readmission following heart failure hospitalization: insights from the EVEREST trial
Hassan Khan, Stephen J. Greene, Gregg C. Fonarow , Andreas P. Kalogeropoulos, Andrew P. Ambrosy, Aldo P. Maggioni, Faiez Zannad, Marvin A. Konstam, Karl Swedberg, Clyde W. Yancy, Mihai Gheorghiade, Javed Butler and on behalf of the EVEREST Trial Investigators
Global variation in clinical profile, management, and post-discharge outcomes among patients hospitalized for worsening chronic heart failure: findings from the ASTRONAUT trial
Stephen J. Greene, Gregg C. Fonarow, Scott D. Solomon, Haris Subacius, Aldo P. Maggioni, Michael Böhm, Eldrin F. Lewis, Faiez Zannad, Mihai Gheorghiade and for the ASTRONAUT Investigators and Coordinators
Rationale and design of a randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of oral rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery disease following an exacerbation of heart failure: the COMMANDER HF trial
Faiez Zannad, Barry Greenberg, John G.F. Cleland, Mihai Gheorghiade, Dirk J. van Veldhuisen, Mandeep R. Mehra, Stefan D. Anker, William M. Byra, Min Fu and Roger M. Mills
International REgistry to assess medical Practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry
Gerasimos Filippatos, Sadiya Sana Khan, Andrew P. Ambrosy, John G.F. Cleland, Sean P. Collins, Carolyn S.P. Lam, Christiane E. Angermann, Georg Ertl, Ulf Dahlström, Dayi Hu, Kenneth Dickstein, Sergio V. Perrone, Mathieu Ghadanfar, Georgina Bermann, Adele Noe, Anja Schweizer, Thomas Maier and Mihai Gheorghiade
Clinical profile and prognostic significance of natriuretic peptide trajectory following hospitalization for worsening chronic heart failure: findings from the ASTRONAUT trial
Stephen J. Greene, Aldo P. Maggioni, Gregg C. Fonarow, Scott D. Solomon, Michael Böhm, Albert Kandra, Margaret F. Prescott, Bernard Reimund, Tsushung A. Hua, Anastasia Lesogor, Faiez Zannad, Mihai Gheorghiade and for the ASTRONAUT Investigators and Coordinators
Decongestion in acute heart failure
Robert J. Mentz, Keld Kjeldsen, Gian Paolo Rossi, Adriaan A. Voors, John G.F. Cleland, Stefan D. Anker, Mihai Gheorghiade, Mona Fiuzat, Patrick Rossignol, Faiez Zannad, Bertram Pitt, Christopher O'Connor and G. Michael Felker
Association of low body temperature and poor outcomes in patients admitted with worsening heart failure: a substudy of the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) trial
Saeed Payvar, John A. Spertus, Alan B. Miller, S. Ward Casscells, Peter S. Pang, Faiez Zannad, Karl Swedberg, Aldo P. Maggioni, Kimberly J. Reid, Mihai Gheorghiade and for the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) Investigators
Haemoconcentration, renal function, and post-discharge outcomes among patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial
Stephen J. Greene, Mihai Gheorghiade, Muthiah Vaduganathan, Andrew P. Ambrosy, Robert J. Mentz, Haris Subacius, Aldo P. Maggioni, Savina Nodari, Marvin A. Konstam, Javed Butler, Gerasimos Filippatos and on behalf of the EVEREST Trial investigators
Serum aldosterone is associated with mortality and re-hospitalization in patients with reduced ejection fraction hospitalized for acute heart failure: analysis from the EVEREST trial
Nicolas Girerd, Peter S. Pang, Karl Swedberg, Angela Fought, Mary J. Kwasny, Haris Subacius, Marvin A. Konstam, Aldo Maggioni, Mihai Gheorghiade, Faiez Zannad and for the EVEREST investigators
Clinical outcome endpoints in heart failure trials: a European Society of Cardiology Heart Failure Association consensus document
Faiez Zannad, Angeles Alonso Garcia, Stefan D. Anker, Paul W. Armstrong, Gonzalo Calvo, John G.F. Cleland, Jay N. Cohn, Kenneth Dickstein, Michael J. Domanski, Inger Ekman, Gerasimos S. Filippatos, Mihai Gheorghiade, Adrian F. Hernandez, Tiny Jaarsma, Joerg Koglin, Marvin Konstam, Stuart Kupfer, Aldo P. Maggioni, Alexandre Mebazaa, Marco Metra, Christina Nowack, Burkert Pieske, Ileana L. Piña, Stuart J. Pocock, Piotr Ponikowski, Giuseppe Rosano, Luis M. Ruilope, Frank Ruschitzka, Thomas Severin, Scott Solomon, Kenneth Stein, Norman L. Stockbridge, Wendy Gattis Stough, Karl Swedberg, Luigi Tavazzi, Adriaan A. Voors, Scott M. Wasserman, Holger Woehrle, Andrew Zalewski and John J.V. McMurray
Haemodynamic effects, safety, and pharmacokinetics of human stresscopin in heart failure with reduced ejection fraction
Mihai Gheorghiade, Stephen J. Greene, Piotr Ponikowski, Aldo P. Maggioni, Jerzy Korewicki, Cezar Macarie, Marco Metra, Jacek Grzybowski, Serban-Ion Bubenek-Turconi, Waldemar Radziszewski, Allan Olson, Orlando F. Bueno, Atalanta Ghosh, Lawrence I. Deckelbaum, Lilian Y. Li, Ayan R. Patel, Andreas Koester and Marvin A. Konstam
Effect of oral digoxin in high-risk heart failure patients: a pre-specified subgroup analysis of the DIG trial
Mihai Gheorghiade, Kanan Patel, Gerasimos Filippatos, Stefan D. Anker, Dirk J. van Veldhuisen, John G.F. Cleland, Marco Metra, Inmaculada B. Aban, Stephen J. Greene, Kirkwood F. Adams, John J.V. McMurray and Ali Ahmed
Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial
Satyam Sarma, Robert J. Mentz, Mary J. Kwasny, Angela J. Fought, Mark Huffman, Haris Subacius, Savina Nodari, Marvin Konstam, Karl Swedberg, Aldo P. Maggioni, Faiez Zannad, Robert O. Bonow, Mihai Gheorghiade and on behalf of the EVEREST investigators
Influence of documented history of coronary artery disease on outcomes in patients admitted for worsening heart failure with reduced ejection fraction in the EVEREST trial
Robert J. Mentz, Bradley D. Allen, Mary J. Kwasny, Marvin A. Konstam, James E. Udelson, Andrew P. Ambrosy, Angela J. Fought, Muthiah Vaduganathan, Christopher M. O'Connor, Faiez Zannad, Aldo P. Maggioni, Karl Swedberg, Robert O. Bonow and Mihai Gheorghiade
Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes
Mihai Gheorghiade, Stephen J. Greene, Gerasimos Filippatos, Erland Erdmann, Roberto Ferrari, Phillip D. Levy, Aldo Maggioni, Christina Nowack, Alexandre Mebazaa and on behalf of the COMPOSE Investigators and Coordinators
Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial
Andrew P. Ambrosy, Muthiah Vaduganathan, Mark D. Huffman, Sadiya Khan, Mary J. Kwasny, Angela J. Fought, Aldo P. Maggioni, Karl Swedberg, Marvin A. Konstam, Faiez Zannad, Mihai Gheorghiade and on behalf of the EVEREST trial investigators
Targeting myocardial substrate metabolism in heart failure: potential for new therapies
Hossein Ardehali, Hani N. Sabbah, Michael A. Burke, Satyam Sarma, Peter P. Liu, John G.F. Cleland, Aldo Maggioni, Gregg C. Fonarow, E. Dale Abel, Umberto Campia and Mihai Gheorghiade
Clinical trials in acute heart failure: simpler solutions to complex problems. Consensus document arising from a European Society of Cardiology cardiovascular round-table think tank on acute heart failure, 12 May 2009
Theresa A. McDonagh, Michel Komajda, Aldo P. Maggioni, Faiez Zannad, Mihai Gheorghiade, Marco Metra and Henry J. Dargie
Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine
Mihai Gheorghiade, Ferenc Follath, Piotr Ponikowski, Jeffrey H. Barsuk, John E.A. Blair, John G. Cleland, Kenneth Dickstein, Mark H. Drazner, Gregg C. Fonarow, Tiny Jaarsma, Guillaume Jondeau, Jose Lopez Sendon, Alexander Mebazaa, Marco Metra, Markku Nieminen, Peter S. Pang, Petar Seferovic, Lynne W. Stevenson, Dirk J. van Veldhuisen, Faiez Zannad, Stefan D. Anker, Andrew Rhodes, John J.V. McMurray and Gerasimos Filippatos
OPTIME in CHF trial: rethinking the use of inotropes in the management of worsening chronic heart failure resulting in hospitalization
Mihai Gheorghiade, Wendy A. Gattis and Liviu Klein
European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions
Maria G. Crespo-Leiro, Stefan D. Anker, Aldo P. Maggioni, Andrew J. Coats, Gerasimos Filippatos, Frank Ruschitzka, Roberto Ferrari, Massimo Francesco Piepoli, Juan F. Delgado Jimenez, Marco Metra, Candida Fonseca, Jaromir Hradec, Offer Amir, Damien Logeart, Ulf Dahlström, Bela Merkely, Jaroslaw Drozdz, Eva Goncalvesova, Mahmoud Hassanein, Ovidiu Chioncel, Mitja Lainscak, Petar M. Seferovic, Dimitris Tousoulis, Ausra Kavoliuniene, Friedrich Fruhwald, Emir Fazlibegovic, Ahmet Temizhan, Plamen Gatzov, Andrejs Erglis, Cécile Laroche, Alexandre Mebazaa and on behalf of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
Epidemiology of heart failure: the prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review
Evelien E.S. van Riet, Arno W. Hoes, Kim P. Wagenaar, Alexander Limburg, Marcel A.J. Landman and Frans H. Rutten
Heart failure epidemiology 2000–2013: insights from the German Federal Health Monitoring System br />Michael Christ, Stefan Störk, Marcus Dörr, Hans J. Heppner, Christian Müller, Rolf Wachter, Uwe Riemer and for the Trend HF Germany Project
National trends in heart failure hospitalization rates in Slovenia 2004–2012
Daniel Omersa, Jerneja Farkas, Ivan Erzen and Mitja Lainscak
Heart failure as a general pandemic in Asia
Hiroaki Shimokawa, Masanobu Miura, Kotaro Nochioka and Yasuhiko Sakata
Fruit and vegetable intake and rate of heart failure: a population-based prospective cohort of women
Susanne Rautiainen, Emily B. Levitan, Murray A. Mittleman and Alicja Wolk
Temporal trends in the epidemiology, management, and outcome of patients with cardiogenic shock complicating acute coronary syndromes
Leonardo De Luca, Zoran Olivari, Andrea Farina, Lucio Gonzini, Donata Lucci, Antonio Di Chiara, Gianni Casella, Francesco Chiarella, Alessandro Boccanelli, Giuseppe Di Pasquale, Stefano De Servi, Francesco Maria Bovenzi, Michele Massimo Gulizia and Stefano Savonitto
Cardiogenic shock in intensive care units: evolution of prevalence, patient profile, management and outcomes, 1997–2012
Etienne Puymirat, Jean Yves Fagon, Philippe Aegerter, Jean Luc Diehl, Alexandra Monnier, Caroline Hauw-Berlemont, Florence Boissier, Gilles Chatellier, Bertrand Guidet, Nicolas Danchin, Nadia Aissaoui and on behalf of the Collège des Utilisateurs de Bases de données en Réanimation (CUB-Réa Group [Intensive Care Database User Group])
Fifteen-year trends in the management of cardiogenic shock and associated 1-year mortality in elderly patients with acute myocardial infarction: the FAST-MI programme
Nadia Aissaoui, Etienne Puymirat, Yves Juilliere, Patrick Jourdain, Didier Blanchard, François Schiele, Pascal Guéret, Batric Popovic, Jean Ferrieres, Tabassome Simon and Nicolas Danchin
Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry
Ovidiu Chioncel, Mitja Lainscak, Petar M. Seferovic, Stefan D. Anker, Maria G. Crespo-Leiro, Veli-Pekka Harjola, John Parissis, Cecile Laroche, Massimo Francesco Piepoli, Candida Fonseca, Alexandre Mebazaa, Lars Lund, Giuseppe A. Ambrosio, Andrew J. Coats, Roberto Ferrari, Frank Ruschitzka, Aldo P. Maggioni and Gerasimos Filippatos
Associations with and prognostic impact of chronic kidney disease in heart failure with preserved, mid-range, and reduced ejection fraction
Ida Löfman, Karolina Szummer, Ulf Dahlström, Tomas Jernberg and Lars H. Lund
Do patients have worse outcomes in heart failure than in cancer? A primary care-based cohort study with 10-year follow-up in Scotland
Mamas A. Mamas, Matthew Sperrin, Margaret C. Watson, Alasdair Coutts, Katie Wilde, Christopher Burton, Umesh T. Kadam, Chun Shing Kwok, Allan B. Clark, Peter Murchie, Iain Buchan, Philip C. Hannaford and Phyo K. Myint
Incidence of cancer in patients with chronic heart failure: a long-term follow-up study
Ann Banke, Morten Schou, Lars Videbæk, Jacob E. Møller, Christian Torp-Pedersen, Finn Gustafsson, Jordi S. Dahl, Lars Køber, Per R. Hildebrandt and Gunnar H. Gislason
The association of chronic kidney disease and microalbuminuria with heart failure with preserved vs. reduced ejection fraction
Matthew Nayor, Martin G. Larson, Na Wang, Rajalakshmi Santhanakrishnan, Douglas S. Lee, Connie W. Tsao, Susan Cheng, Emelia J. Benjamin, Ramachandran S. Vasan, Daniel Levy, Caroline S. Fox and Jennifer E. Ho
Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non-vitamin K antagonist oral anticoagulant dose adjustment
Nathaniel M. Hawkins, Pardeep S. Jhund, Andrea Pozzi, Eileen O'Meara, Scott D. Solomon, Christopher B. Granger, Salim Yusuf, Marc A. Pfeffer, Karl Swedberg, Mark C. Petrie, Sean Virani and John J.V. McMurray
Outcomes in patients hospitalized for heart failure and chronic obstructive pulmonary disease: differences in clinical profile and treatment between 2002 and 2009
Lidia Staszewsky, Laura Cortesi, Mauro Tettamanti, Gabrio Andrea Dal Bo, Ida Fortino, Angela Bortolotti, Luca Merlino, Roberto Latini, Maria Carla Roncaglioni and Marta Baviera
Heart failure and risk of dementia: a Danish nationwide population-based cohort study
Kasper Adelborg, Erzsébet Horváth-Puhó, Anne Ording, Lars Pedersen, Henrik Toft Sørensen and Victor W. Henderson
The real-world evidence of heart failure: findings from 41 413 patients of the ARNO database
Aldo P. Maggioni, Francesco Orso, Silvia Calabria, Elisa Rossi, Elisa Cinconze, Samuele Baldasseroni, Nello Martini and on behalf of the ARNO Observatory
Prognostic burden of heart failure recorded in primary care, acute hospital admissions, or both: a population-based linked electronic health record cohort study in 2.1 million people
Stefan Koudstaal, Mar Pujades-Rodriguez, Spiros Denaxas, Johannes M.I.H. Gho, Anoop D. Shah, Ning Yu, Riyaz S. Patel, Chris P. Gale, Arno W. Hoes, John G. Cleland, Folkert W. Asselbergs and Harry Hemingway
Association between enrolment in a heart failure quality registry and subsequent mortality—a nationwide cohort study
Lars H. Lund, Juan-Jesus Carrero, Bahman Farahmand, Karin M. Henriksson, Åsa Jonsson, Tomas Jernberg and Ulf Dahlström
Cardiac device therapy in patients with left ventricular dysfunction and heart failure: ‘real-world’ data on long-term outcomes (mortality, hospitalizations, days alive and out of hospital)
Giuseppe Boriani, Elena Berti, Laura Maria Beatrice Belotti, Mauro Biffi, Rossana De Palma, Vincenzo L. Malavasi, Nicola Bottoni, Luca Rossi, Elia De Maria, Roberto Mantovan, Marco Zardini, Edoardo Casali, Marco Marconi, Alberto Bandini, Corrado Tomasi, Giulio Boggian, Gaetano Barbato, Tiziano Toselli, Mauro Zennaro, Biagio Sassone and on behalf of RERAI (Registry of Emilia Romagna on Arrhythmia Interventions) Investigators
Association between demographic, organizational, clinical, and socio-economic characteristics and underutilization of cardiac resynchronization therapy: results from the Swedish Heart Failure Registry
Lars H. Lund, Juan-Jesus Carrero, Bahman Farahmand, Karin M. Henriksson, Åsa Jonsson, Tomas Jernberg and Ulf Dahlström
Heart Failure Awareness Day Virtual Issue
From ESC Heart Failure
Heart failure awareness survey in Germany: general knowledge on heart failure remains poor
Christine Zelenak, Sara Radenovic, Lindy Musial-Bright, Elvis Tahirovic, Mesud Sacirovic, Chong-Bin Lee, Diana Jahandar-Lashki, Simone Inkrot, Tobias Daniel Trippel, Andreas Busjahn, Djawid Hashemi, Rolf Wachter, Sabine Pankuweit, Stefan Störk, Burkert Pieske, Frank Edelmann and Hans-Dirk Düngen
Sexual function of patients with heart failure: facts and numbers
Tiny Jaarsma
ESC Heart Failure, Volume 4, Issue 1, February 2017, Pages 3–7
Heart failure: preventing disease and death worldwide
Piotr Ponikowski, Stefan D. Anker, Khalid F. AlHabib, Martin R. Cowie, Thomas L. Force, Shengshou Hu, Tiny Jaarsma, Henry Krum, Vishal Rastogi, Luis E. Rohde, Umesh C. Samal, Hiroaki Shimokawa, Bambang Budi Siswanto, Karen Sliwa and Gerasimos Filippatos
ESC Heart Failure, Volume 1, Issue 1, September 2014, Pages 4–25
Relationship of physical activity and healthy eating with mortality and incident heart failure among community-dwelling older adults with normal body mass index
Ahmed Abdelmawgoud, Cynthia J. Brown, Xuemei Sui, Gregg C. Fonarow, Peter F. Kokkinos, Vera Bittner, Wilbert S. Aronow, Raya E. Kheirbek, Ross D. Fletcher, Steven N. Blair and Ali Ahmed
ESC Heart Failure, Volume 2, Issue 1, March 2015, Pages 20–24
Obesity paradox in heart failure: a heavy matter
Vijaiganesh Nagarajan, Luke Kohan, Eric Holland, Ellen C. Keeley and Sula Mazimba
ESC Heart Failure, Volume 3, Issue 4, December 2016, Pages 227–234
Acute heart failure facts and numbers: acute heart failure populations
Julia Searle, Johann Frick and Martin Möckel
ESC Heart Failure, Volume 3, Issue 2, June 2016, Pages 65–70
The effect of exercise training on biventricular myocardial strain in heart failure with preserved ejection fraction
Siddhartha S. Angadi, Catherine L. Jarrett, Moustafa Sherif, Glenn A. Gaesser and Farouk Mookadam
From European Journal of Heart Failure
What does the lay public know about heart failure? Findings from the Heart Failure Awareness Day Initiative
Stefan Störk, Ausra Kavoliuniene, Dragos Vinereanu, Rafael Ludwig, Petar Seferovic, Kenneth Dickstein, Stefan D. Anker, Gerasimos Filippatos, Pjotr Ponikowski and Mitja Lainscak
ExtraHF survey: the first European survey on implementation of exercise training in heart failure patients
Massimo F. Piepoli, Simone Binno, Ugo Corrà, Petar Seferovic, Viviane Conraads, Tiny Jaarsma, Jean-Paul Schmid, Gerasimos Filippatos, Piotr P. Ponikowski and on behalf of the Committee on Exercise Physiology & Training of the Heart Failure Association of the ESC
Adherence to a Mediterranean diet is associated with reduced risk of heart failure in men
Thanasis G. Tektonidis, Agneta Åkesson, Bruna Gigante, Alicja Wolk and Susanna C. Larsson
Fruit and vegetable intake and rate of heart failure: a population-based prospective cohort of women
Susanne Rautiainen, Emily B. Levitan, Murray A. Mittleman and Alicja Wolk
Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial
Angeliki Papadaki, Miguel Ángel Martínez-González, Angel Alonso-Gómez, Javier Rekondo, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, José Lapetra, Antonio García-Rodriguez, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Monica Bulló, Mercè Serra-Mir, Jose V. Sorlí and Fernando Arós
Influence of cigarette smoking on cardiac biomarkers: the Atherosclerosis Risk in Communities (ARIC) Study
Wilson Nadruz Jr, Alexandra Gonçalves, Brian Claggett, Gabriela Querejeta Roca, Amil M. Shah, Susan Cheng, Gerardo Heiss, Christie M. Ballantyne and Scott D. Solomon
Heart Failure Conference Reads
From ESC Heart Failure
Cardiac and peripheral autonomic control in restrictive cardiomyopathy
Ana Luiza C. Sayegh, Marcelo R. dos Santos, Adriana O. Sarmento, Francis R. de Souza, Vera M.C. Salemi, Viviane T. Hotta, Akothirene Cristhina D.B. Marques, Heidrum H. Krämer, Ivani C. Trombetta, Charles Mady and Maria Janieire de Nazaré Nunes Alves
Translational Registry for CardiomyopatHies (TORCH) – rationale and first results
Claudia Seyler, Benjamin Meder, Tanja Weis, Thea Schwaneberg, Kerstin Weitmann, Wolfgang Hoffmann, Hugo A. Katus and Andreas Dösch
Palliative care in heart failure: facts and numbers
Jillian P. Riley and James M. Beattie
Who are patients classified within the new terminology of heart failure from the 2016 ESC guidelines?
Benoit Delepaul, Guillaume Robin, Clément Delmas, Thomas Moine, Adrien Blanc, Pauline Fournier, Aénora Roger-Rollé, Guillaume Domain, Clémence Delon, Charles Uzan, Rabah Boudjellil, Didier Carrié, Jérôme Roncalli, Michel Galinier and Olivier Lairez
Serum albumin level and hospital mortality in acute non-ischemic heart failure
Arnaud Ancion, Sophie Allepaerts, Cécile Oury, Anne-Stephan Gori, Luc A. Piérard and Patrizio Lancellotti
Uric acid predicts mortality and ischaemic stroke in subjects with diastolic dysfunction: the Tromsø Study 1994–2013
Jon V. Norvik, Henrik Schirmer, Kirsti Ytrehus, Hilde M. Storhaug, Trond G. Jenssen, Bjørn O. Eriksen, Ellisiv B. Mathiesen, Maja-Lisa Løchen, Tom Wilsgaard and Marit D. Solbu
On admission serum sodium and uric acid levels predict 30 day rehospitalization or death in patients with acute decompensated heart failure
Ahmad Amin, Mitra Chitsazan, Fatemeh Shiukhi Ahmad Abad, Sepideh Taghavi and Nasim Naderi
Periodontitis and bone metabolism in patients with advanced heart failure and after heart transplantation
Ulrike Schulze-Späte, Iman Mizani, Kristina Rodriguez Salaverry, Jaime Chang, Christina Wu, Meaghan Jones, Peter J. Kennel, Danielle L. Brunjes, Tse-Hwei Choo, Tomoko S. Kato, Donna Mancini, John Grbic and P. Christian Schulze
Metabolic profiles in heart failure due to non-ischemic cardiomyopathy at rest and under exercise
Matthias Mueller-Hennessen, Johanna Sigl, Jens C. Fuhrmann, Henning Witt, Regina Reszka, Oliver Schmitz, Jürgen Kastler, Jenny J. Fischer, Oliver J. Müller, Evangelos Giannitsis, Tanja Weis, Norbert Frey and Hugo A. Katus
Immunosuppressive treatment in fulminant myocarditis and gene expression pattern associated with, but no histological confirmation of giant cell myocarditis
Friedrich Fruhwald, Dirk Lassner, Sonja Fruhwald, Ulrich M. Gross, Otto Dapunt and Heinz-Peter Schultheiss
Sexual function of patients with heart failure: facts and numbers
Tiny Jaarsma
Worse prognosis of real-world patients with acute heart failure from the Czech AHEAD registry in comparison to patients from the RELAX-AHF trial
Jindrich Spinar, Jiri Jarkovsky, Lenka Spinarova, Jiri Vitovec, Ales Linhart, Petr Widimsky, Roman Miklik, Kamil Zeman, Jan Belohlavek, Filip Malek, Cestmir Cihalik, Jiri Spac, Marian Felsoci, Petr Ostadal, Ladislav Dusek, Jiri Kettner, Jan Vaclavik, Simona Littnerova, Zdeněk Monhart, Josef Malek, Jiri Parenica and on behalf of the AHEAD registry investigators
Top Cited Papers 2015-16
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Piotr Ponikowski, Adriaan A. Voors, Stefan D. Anker, Héctor Bueno, John G. F. Cleland, Andrew J. S. Coats, Volkmar Falk, José Ramón González-Juanatey, Veli-Pekka Harjola, Ewa A. Jankowska, Mariell Jessup, Cecilia Linde, Petros Nihoyannopoulos, John T. Parissis, Burkert Pieske, Jillian P. Riley, Giuseppe M. C. Rosano, Luis M. Ruilope, Frank Ruschitzka, Frans H. Rutten, Peter van der Meer, Authors/Task Force Members and Document Reviewers
Recommendations on pre-hospital & early hospital management of acute heart failure: a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society of Emergency Medicine and the Society of Academic Emergency Medicine
Alexandre Mebazaa, M. Birhan Yilmaz, Phillip Levy, Piotr Ponikowski, W. Frank Peacock, Said Laribi, Arsen D. Ristic, Ekaterini Lambrinou, Josep Masip, Jillian P. Riley, Theresa McDonagh, Christian Mueller, Christopher deFilippi, Veli-Pekka Harjola, Holger Thiele, Massimo F. Piepoli, Marco Metra, Aldo Maggioni, John McMurray, Kenneth Dickstein, Kevin Damman, Petar M. Seferovic, Frank Ruschitzka, Adelino F. Leite-Moreira, Abdelouahab Bellou, Stefan D. Anker and Gerasimos Filippatos
Current state of knowledge on Takotsubo syndrome: a Position Statement from the Taskforce on Takotsubo Syndrome of the Heart Failure Association of the European Society of Cardiology
Alexander R. Lyon, Eduardo Bossone, Birke Schneider, Udo Sechtem, Rodolfo Citro, S. Richard Underwood, Mary N. Sheppard, Gemma A. Figtree, Guido Parodi, Yoshihiro J. Akashi, Frank Ruschitzka, Gerasimos Filippatos, Alexandre Mebazaa and Elmir Omerovic
Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease
Bertram Pitt, Stefan D. Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber, Henry Krum, Aldo P. Maggioni, Piotr Ponikowski, Adriaan A. Voors, Faiez Zannad, Christina Nowack, So-Young Kim, Alexander Pieper, Nina Kimmeskamp-Kirschbaum and Gerasimos Filippatos
MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
Chris J. Watson, Shashi K. Gupta, Eoin O'Connell, Sabrina Thum, Nadezhda Glezeva, Jasmin Fendrich, Joe Gallagher, Mark Ledwidge, Lea Grote-Levi, Kenneth McDonald and Thomas Thum
Heart failure with preserved ejection fraction: uncertainties and dilemmas
Roberto Ferrari, Michael Böhm, John G.F. Cleland, Walter J.S. Paulus, Burkert Pieske, Claudio Rapezzi and Luigi Tavazzi
Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction
Adriaan A. Voors, Mauro Gori, Licette C.Y. Liu, Brian Claggett, Michael R. Zile, Burkert Pieske, John J.V. McMurray, Milton Packer, Victor Shi, Martin P. Lefkowitz, Scott D. Solomon and for the PARAMOUNT Investigators
Heart failure as a general pandemic in Asia
Hiroaki Shimokawa, Masanobu Miura, Kotaro Nochioka and Yasuhiko Sakata
Clinical picture and risk prediction of short-term mortality in cardiogenic shock
Veli-Pekka Harjola, Johan Lassus, Alessandro Sionis, Lars Køber, Tuukka Tarvasmäki, Jindrich Spinar, John Parissis, Marek Banaszewski, Jose Silva-Cardoso, Valentina Carubelli, Salvatore Di Somma, Heli Tolppanen, Uwe Zeymer, Holger Thiele, Markku S Nieminen, Alexandre Mebazaa and for the CardShock study investigators and the GREAT network
Corrected by: Corrigendum to ‘Clinical picture and risk prediction of short-term mortality in cardiogenic shock’ [Eur J Heart Fail] 2015 May;17(5):501–9. doi: 10.1002/ejhf.260
Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction
Lee Lee Wong, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Dwi Setyowati Karolina, Kai Ying Lim, Jia Yuen Lim, Jenny P. C. Chong, Jessica Y. X. Ng, Yei-Tsung Chen, Michelle M. Y. Chan, Zhaojin Chen, Poh Shuan D. Yeo, Tze P. Ng, Lieng H. Ling, David Sim, Kui Toh G. Leong, Hean Y. Ong, Fazlur Jaufeerally, Raymond Wong, Ping Chai, Adrian F. Low, Carolyn S. P. Lam, Kandiah Jeyaseelan and Arthur Mark Richards
Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Frank Edelmann, Volker Holzendorf, Rolf Wachter, Kathleen Nolte, Albrecht G. Schmidt, Elisabeth Kraigher-Krainer, André Duvinage, Ines Unkelbach, Hans-Dirk Düngen, Carsten Tschöpe, Christoph Herrmann-Lingen, Martin Halle, Gerd Hasenfuss, Götz Gelbrich, Wendy Gattis Stough and Burkert M. Pieske
State of the Art: Newer biomarkers in heart failure
Rudolf A. de Boer, Lori B. Daniels, Alan S. Maisel and James L. Januzzi Jr
Antithrombotic/Anticoagulant papers in EJHF
Aspirin does not reduce the clinical benefits of the mineralocorticoid receptor antagonist eplerenone in patients with systolic heart failure and mild symptoms: an analysis of the EMPHASIS-HF study
Ken Lee Chin, Timothy J. Collier, Bertram Pitt, John J.V. McMurray, Karl Swedberg, Dirk J. van Veldhuisen, Stuart J. Pocock, John Vincent, Eva Turgonyi, Faiez Zannad, Henry Krum and for the EMPHASIS-HF Study Investigators
Stroke prevention in heart failure and sinus rhythm: where do we go from here?
Muthiah Vaduganathan, Ravi B. Patel and Clyde W. Yancy
CHA2DS2-VASc score and adverse outcomes in patients with heart failure with reduced ejection fraction and sinus rhythm
Siqin Ye, Min Qian, Bo Zhao, Richard Buchsbaum, Ralph L. Sacco, Bruce Levin, Marco R. Di Tullio, Douglas L. Mann, Patrick M. Pullicino, Ronald S. Freudenberger, John R. Teerlink, J.P. Mohr, Susan Graham, Arthur J. Labovitz, Conrado J. Estol, Dirk J. Lok, Piotr Ponikowski, Stefan D. Anker, Gregory Y.H. Lip, John L.P. Thompson, Shunichi Homma and on behalf of the WARCEF Investigators
Use of non-vitamin K antagonist oral anticoagulants in patients with heart failure and atrial fibrillation: does concomitant kidney disease change our practice?
Farhan Shahid, Eduard Shantsila and Gregory Y.H. Lip
Severity of renal impairment in patients with heart failure and atrial fibrillation: implications for non-vitamin K antagonist oral anticoagulant dose adjustment
Nathaniel M. Hawkins, Pardeep S. Jhund, Andrea Pozzi, Eileen O'Meara, Scott D. Solomon, Christopher B. Granger, Salim Yusuf, Marc A. Pfeffer, Karl Swedberg, Mark C. Petrie, Sean Virani and John J.V. McMurray
Efficacy and safety of edoxaban compared with warfarin in patients with atrial fibrillation and heart failure: insights from ENGAGE AF-TIMI 48
Giulia Magnani, Robert P. Giugliano, Christian T. Ruff, Sabina A. Murphy, Francesco Nordio, Marco Metra, Tiziano Moccetti, Veselin Mitrovic, Minggao Shi, Michele Mercuri, Elliott M. Antman and Eugene Braunwald
Non-vitamin K antagonist oral anticoagulants (NOACs) in patients with concomitant atrial fibrillation and heart failure: a systemic review and meta-analysis of randomized trials
Qinmei Xiong, Yee Cheng Lau, Keitaro Senoo, Deirdre A. Lane, Kui Hong and Gregory Y.H. Lip
Thromboembolic risk stratification of patients hospitalized with heart failure in sinus rhythm: a nationwide cohort study
Emil Wolsk, Morten Lamberts, Morten L. Hansen, Paul Blanche, Lars Køber, Christian Torp-Pedersen, Gregory Y. H. Lip and Gunnar Gislason
Prediction of thrombo-embolic risk in patients with hypertrophic cardiomyopathy (HCM Risk-CVA)
Oliver P. Guttmann, Menelaos Pavlou, Constantinos O'Mahony, Lorenzo Monserrat, Aristides Anastasakis, Claudio Rapezzi, Elena Biagini, Juan Ramon Gimeno, Giuseppe Limongelli, Pablo Garcia-Pavia, William J. McKenna, Rumana Z. Omar, Perry M. Elliott and for the Hypertrophic Cardiomyopathy Outcomes Investigators
Disrupting Virchow's triad: can factor X inhibition reduce risk of adverse outcomes in patients with ischaemic cardiomyopathy?
Tariq Ahmad and Javed Butler
Rationale and design of a randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of oral rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery disease following an exacerbation of heart failure: the COMMANDER HF trial
Faiez Zannad, Barry Greenberg, John G.F. Cleland, Mihai Gheorghiade, Dirk J. van Veldhuisen, Mandeep R. Mehra, Stefan D. Anker, William M. Byra, Min Fu and Roger M. Mills
Effect of warfarin on survival in patients with concomitant left ventricular systolic dysfunction and pulmonary hypertension: a population cohort study
Andrew Goudie, Douglas Elder, Harshal Deshmukh, Benjamin R Szwejkowski, Chim C Lang and Jacob George
New oral anticoagulants in heart failure
Isabelle C. Van Gelder, Dirk J. Van Veldhuisen and Gregory Y.H. Lip
Best Imaging papers of 2015 – EJHF and ESCHF
For the HFA Congress, Luigi Paolo Badano selected the best papers in the field of HF imaging from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt
The right heart in heart failure with preserved ejection fraction: insights from cardiac magnetic resonance imaging and invasive haemodynamics
Stefan Aschauer, Andreas A. Kammerlander, Caroline Zotter-Tufaro, Robin Ristl, Stefan Pfaffenberger, Alina Bachmann, Franz Duca, Beatrice A. Marzluf, Diana Bonderman and Julia Mascherbauer
Prognostic value of residual pulmonary congestion at discharge assessed by lung ultrasound imaging in heart failure
Stefano Coiro, Patrick Rossignol, Giuseppe Ambrosio, Erberto Carluccio1, Gianfranco Alunni, Adriano Murrone, Isabella Tritto, Faiez Zannad and Nicolas Girerd
Best Biomarkers papers of 2015 – EJHF and ESCHF
For the HFA Congress, Stephan von Haehling selected the best papers in the field of HF biomarkers from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt
Prospective study on changes in blood variables in pregnant women at higher risk of peripartum cardiomyopathy
Takeshi Umazume, Takahiro Yamada, Satoshi Ishikawa, Takashi Yamada, Takahiro Koyama, Itsuko Furuta, Mamoru Morikawa, Satoshi Yamada and Hisanori Minakami
Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials
Hans-Peter Brunner-La Rocca, Luc Eurlings, A. Mark Richards, James L. Januzzi, Matthias E. Pfisterer, Ulf Dahlström, Yigal M. Pinto, Patric Karlström, Hans Erntell, Rudolf Berger, Hans Persson, Christopher M. O'Connor, Deddo Moertl, Hanna K. Gaggin, Christopher M. Frampton, M. Gary Nicholls and Richard W. Troughton
Plasma kidney injury molecule-1 in heart failure: renal mechanisms and clinical outcome
Johanna E. Emmens, Jozine M. ter Maaten, Yuya Matsue, Marco Metra, Christopher M. O'Connor, Piotr Ponikowski, John R. Teerlink, Gad Cotter, Beth Davison, John G. Cleland, Michael M. Givertz, Daniel M. Bloomfield, Howard C. Dittrich, John Todd, Dirk J. van Veldhuisen, Hans L. Hillege, Kevin Damman, Peter van der Meer and Adriaan A. Voors
Detection of muscle wasting in patients with chronic heart failure using C-terminal agrin fragment: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF)
Lisa Steinbeck, Nicole Ebner, Miroslava Valentova, Tarek Bekfani, Sebastian Elsner, Pius Dahinden, Stefan Hettwer, Nadja Scherbakov, Jörg C. Schefold, Anja Sandek, Jochen Springer, Wolfram Doehner, Stefan D. Anker and Stephan von Haehling
Prevalence and prognostic impact of frailty and its components in non-dependent elderly patients with heart failure
María T. Vidán, Vendula Blaya-Novakova, Elísabet Sánchez, Javier Ortiz, José A. Serra-Rexach and Héctor Bueno
Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure
Sanjay S. Bhandari, Hafid Narayan, Donald J.L. Jones, Toru Suzuki, Joachim Struck, Andreas Bergmann, Iain B. Squire and Leong L. Ng
Increased mortality with elevated plasma endothelin-1 in acute heart failure: an ASCEND-HF biomarker substudy
Antonio L. Perez, Justin L. Grodin, Yuping Wu, Adrian F. Hernandez, Javed Butler, Marco Metra, G. Michael Felker, Adriaan A. Voors, John J. McMurray, Paul W. Armstrong, Randall C. Starling, Christopher M. O'Connor and W. H. Wilson Tang
Plasma amino-terminal pro B-type natriuretic peptide as a predictor of late cardiovascular mortality in patients with acute lung disorders: a prospective, observational cohort study
Heikki O. Koskela, Päivi H. Salonen, Jarkko Romppanen and Juha Hartikainen
Soluble neprilysin does not correlate with outcome in heart failure with preserved ejection fraction
Georg Goliasch, Noemi Pavo, Caroline Zotter-Tufaro, Andreas Kammerlander, Franz Duca, Julia Mascherbauer and Diana Bonderman
Changes in N-terminal pro-B-type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: an analysis of the I-Preserve study
Pardeep S. Jhund, Inder S. Anand, Michel Komajda, Brian L. Claggett, Robert S. McKelvie, Michael R. Zile, Peter E. Carson and John J.V. McMurray
Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Frank Edelmann, Volker Holzendorf, Rolf Wachter, Kathleen Nolte, Albrecht G. Schmidt, Elisabeth Kraigher-Krainer, André Duvinage, Ines Unkelbach, Hans-Dirk Düngen, Carsten Tschöpe, Christoph Herrmann-Lingen, Martin Halle, Gerd Hasenfuss, Götz Gelbrich, Wendy Gattis Stough and Burkert M. Pieske
Best Medical Therapy papers of 2015 – EJHF and ESCHF
For the HFA Congress, Adriaan Voors selected the best papers in the field of HF medical therapy from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt
Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 randomized, double-blind, placebo-controlled trial
Stefan D. Anker, Mikhail Kosiborod, Faiez Zannad, Ileana L. Piña, Peter A. McCullough, Gerasimos Filippatos, Peter van der Meer, Piotr Ponikowski, Henrik S. Rasmussen, Philip T. Lavin, Bhupinder Singh, Alex Yang and Prakash Deedwania
Effect of patiromer on reducing serum potassium and preventing recurrent hyperkalaemia in patients with heart failure and chronic kidney disease on RAAS inhibitors
Bertram Pitt, George L. Bakris, David A. Bushinsky, Dahlia Garza, Martha R. Mayo, Yuri Stasiv, Heidi Christ-Schmidt, Lance Berman and Matthew R. Weir
Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease
Natalie A. Bello, Eldrin F. Lewis, Akshay S. Desai, Inder S. Anand, Henry Krum, John J.V. McMurray, Kurt Olson, Scott D. Solomon, Karl Swedberg, Dirk J. van Veldhuisen, James B. Young and Marc A. Pfeffer
Renal effects of the angiotensin receptor neprilysin inhibitor LCZ696 in patients with heart failure and preserved ejection fraction
Adriaan A. Voors, Mauro Gori, Licette C.Y. Liu, Brian Claggett, Michael R. Zile, Burkert Pieske, John J.V. McMurray, Milton Packer, Victor Shi, Martin P. Lefkowitz, Scott D. Solomon and for the PARAMOUNT Investigators
Best Devices papers of 2015 – EJHF and ESCHF
For the HFA Congress, Kenneth Dickstein selected the best papers in the field of HF devices from EHJ, EJHF and ESCHF in 2015 and here we offer you free access to the papers from EJHF and ESCHF. The slides from the session can be found here: bit.ly/25Acrqt
Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction
Ofek Y. Hai, Robert J. Mentz, Faiez Zannad, Maurizio Gasparini, Gaetano M. De Ferrari, Jean-Claude Daubert, Johannes Holzmeister, Carolyn S.P. Lam, Thierry Pochet, Alphons Vincent and Cecilia Linde
Early intervention and long-term outcome with cardiac resynchronization therapy in patients without a history of advanced heart failure symptoms
Romana Herscovici, Valentina Kutyifa, Alon Barsheshet, Scott Solomon, Scott McNitt, Bronislava Polonsky, Andy Y. Lee, Wojciech Zareba, Arthur J. Moss and Ilan Goldenberg
Cardiac resynchronization therapy in mild heart failure should be reserved for true dyssynchronopathy
Alexander H. Maass and B. Daan Westenbrink
Cardiac resynchronization revisited: what is the next step?
Cecilia Linde
Predicting outcomes following CRT: the quest continues
Camilla Normand and Kenneth Dickstein
Validation of a simple risk stratification tool for patients implanted with Cardiac Resynchronization Therapy: the VALID-CRT risk score
Maurizio Gasparini, Catherine Klersy, Cristophe Leclercq, Maurizio Lunati, Maurizio Landolina, Angelo Auricchio, Massimo Santini, Giuseppe Boriani, Alessandro Proclemer and Francisco Leyva
Reduced risk of life-threatening ventricular tachyarrhythmias with cardiac resynchronization therapy: relationship to left ventricular ejection fraction
Valentina Kutyifa, Arthur J. Moss, Scott D. Solomon, Scott McNitt, Mehmet K. Aktas, Alon Barsheshet, Bela Merkely, Wojciech Zareba and Ilan Goldenberg
Henry Krum left us in the last days of November 2015. Throughout his life, he made major contributions to science and, namely, to the understanding and treatment of heart failure. One demonstration of this is the remarkable number of articles published in our journal, the European Journal of Heart Failure. This virtual issue is a selection from the articles that he authored that were published in our journal; they allow us to retrace some of the major steps in our knowledge about heart failure. Scientific contributions allow investigators to survive their material life through the persistent legacy of their work, and it is my wish that this will be a small proof of how much Henry left to us.
Marco Metra, Editor-in-Chief - European Journal of Heart Failure
Increased risk of stroke with darbepoetin alfa in anaemic heart failure patients with diabetes and chronic kidney disease
Natalie A. Bello, Eldrin F. Lewis, Akshay S. Desai, Inder S. Anand , Henry Krum, John J.V. McMurray, Kurt Olson, Scott D. Solomon, Karl Swedberg, Dirk J. van Veldhuisen, James B. Young and Marc A. Pfeffer
Incidence of heart failure in 6083 elderly hypertensive patients: the Second Australian National Blood Pressure Study (ANBP2)
Berhe W. Sahle, Alice J. Owen, Henry Krum, Christopher M. Reid and on behalf of the Second Australian National Blood Pressure Study Management Committee
The Aliskiren Trial to Minimize OutcomeS in Patients with HEart failure trial (ATMOSPHERE): revised statistical analysis plan and baseline characteristics
Henry Krum, John J.V. McMurray, William T. Abraham, Kenneth Dickstein, Lars Køber, Akshay S. Desai, Scott D. Solomon, Yanntong Chiang, Claudio Gimpelewicz, Bernard Reimund, M. Atif Ali, Georgia Tarnesby, Barry M. Massie and on behalf of the ATMOSPHERE Committees and Investigators
Clinical outcomes according to QRS duration and morphology in the Eplerenone in Mild Patients: Hospitalization and SurvIval Study in Heart Failure (EMPHASIS-HF)
Jane A. Cannon, Timothy J. Collier, Li Shen, Karl Swedberg, Henry Krum, Dirk J. Van Veldhuisen, John Vincent, Stuart J. Pocock, Bertram Pitt, Faiez Zannad and John J.V. McMurray
Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study-Heart Failure (ARTS-HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease
Bertram Pitt, Stefan D. Anker, Michael Böhm, Mihai Gheorghiade, Lars Køber, Henry Krum, Aldo P. Maggioni, Piotr Ponikowski, Adriaan A. Voors, Faiez Zannad, Christina Nowack, So
Worsening heart failure, a critical event during hospital admission for acute heart failure: results from the VERITAS study
Gad Cotter, Marco Metra, Beth A. Davison, Stefanie Senger, Robert C. Bourge, John G.F. Cleland , Guillaume Jondeau, Henry Krum, Christopher M. O'Connor, John D. Parker, Guillermo Torre
Heart failure and dipeptidyl peptidase-4 inhibitors
Henry Krum, Marina Skiba, Shiying Wu and Ingrid Hopper
Worsening renal function during renin–angiotensin–aldosterone system inhibitor initiation and long-term outcomes in patients with left ventricular systolic dysfunction
Hannah Clark, Henry Krum and Ingrid Hopper
Interaction between baseline and early worsening of renal function and efficacy of renin–angiotensin–aldosterone system blockade in patients with heart failure: insights from the Val-HeFT study
Anastasia Lesogor, Jay N. Cohn, Roberto Latini, Gianni Tognoni, Henry Krum, Barry Massie, Andrew Zalewski, Albert Kand ra, Tsushung A. Hua and Claudio Gimpelewicz
Losing ALTITUDE? How should ASTRONAUT launch into ATMOSPHERE
Henry Krum, Barrie Massie, William T. Abraham, Kenneth Dickstein, Lars Kober, John J.V. McMurray and on behalf of the ATMOSPHERE Investigators
N-terminal B-type natriuretic peptide and the association with left ventricular diastolic function in a population at high risk of incident heart failure: results of the SCReening Evaluation of the Evolution of New-Heart Failure Study (SCREEN-HF)
Michele McGrady, Christopher M. Reid, Louise Shiel, Rory Wolfe, Umberto Boffa, Danny Liew, Duncan J. Campbell, David Prior and Henry Krum
Updated meta-analysis on antithrombotic therapy in patients with heart failure and sinus rhythm
Ingrid Hopper, Marina Skiba and Henry Krum
Impact of heart failure and changes to volume status on liver stiffness: non-invasive assessment using transient elastography
Ingrid Hopper, William Kemp, Pornwalee Porapakkham, Yusuke Sata, Eilis Condon, Marina Skiba, Lauren Farber, Pramote Porapakkham, Trevor J. Williams, Solomon Menahem, Stuart Roberts and Henry Krum
FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy
Yuan Zhang, Amand a J. Edgley, Alison J. Cox, Andrew K. Powell, Bing Wang, Andrew R. Kompa, David I. Stapleton, Steven C. Zammit, Spencer J. Williams, Henry Krum, Richard E. Gilbert and Darren J. Kelly
Aliskiren, ALTITUDE, and the implications for ATMOSPHERE
John J.V. McMurray, William T. Abraham, Kenneth Dickstein, Lars Køber, Barry M. Massie and Henry Krum
Short- and long-term outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trials
Hendrik Zimmet, Pramote Porapakkham, Pornwalee Porapakkham, Yusuke Sata, Steven Joseph Haas, Silviu Itescu, Andrew Forbes and Henry Krum
Impact of concomitant heart failure on outcomes in patients undergoing percutaneous coronary interventions: analysis of the Melbourne Interventional Group registry
Ken J. Lu, Bryan P. Yan, Andrew E. Ajani, William M. Wilson, Stephen J. Duffy, Ronen Gurvitch, David J. Clark, Angela Brennan, Christopher Reid, Nick Andrianopoulos, Henry Krum and on behalf of the Melbourne Interventional Group
Short- and long-term treatment of dilutional hyponatraemia with satavaptan, a selective arginine vasopressin V2-receptor antagonist: the DILIPO study
Doron Aronson, Joseph G. Verbalis, Matthias Mueller, Henry Krum and on behalf of the DILIPO investigators
Direct renin inhibition in addition to or as an alternative to angiotensin converting enzyme inhibition in patients with chronic systolic heart failure: rationale and design of the Aliskiren Trial to Minimize OutcomeS in Patients with HEart failuRE (ATMOSPHERE) study
Henry Krum, Barry Massie, William T. Abraham, Kenneth Dickstein, Lars Kober, John J.V. McMurray, Ashkay Desai, Claudio Gimpelewicz, Albert Kand ra, Bernard Reimund, Henning Rattunde, Juergen Armbrecht and on behalf of the ATMOSPHERE Investigators
Baseline factors associated with congestive heart failure in patients receiving etoricoxib or diclofenac: multivariate analysis of the MEDAL program
Henry Krum, Sean P. Curtis, Amarjot Kaur, Hongwei Wang, Steven S. Smugar, Matthew R. Weir, Loren Laine, D. Craig Brater and Christopher P. Cannon
Adherence, adaptation and acceptance of elderly chronic heart failure patients to receiving healthcare via telephone-monitoring
Robyn A. Clark, Julie J. Yallop, Leon Piterman, Joanne Croucher, Andrew Tonkin, Simon Stewart, Henry Krum and CHAT Study Team
Tolerability of beta-blockers in elderly patients with chronic heart failure: The COLA II study
Henry Krum, Julie Hill, Friedrich Fruhwald, Christine Sharpe, Gyorgy Abraham, Jun
Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: Putting guidelines into practice
John McMurray, Alain Cohen
Effect of valsartan added to background ACE inhibitor therapy in patients with heart failure: results from Val-HeFT
Henry Krum, Peter Carson, Csaba Farsang, Aldo P. Maggioni, Robert D. Glazer, Nora Aknay, Yann
NT-proBNP in severe chronic heart failure: rationale, design and preliminary results of the COPERNICUS NT-proBNP substudy
Franz Hartmann, Milton Packer, Andrew J.S. Coats, Michael B. Fowler, Henry Krum, Paul Mohacsi, Jean L. Rouleau, Michal Tendera, Alain Castaigne, Jürgen Trawinski, Ildiko Amann
Pharmacoeconomics of beta-blockers: effective and cost-effective therapy in chronic heart failure
Krum Henry and Lim Stephen
Heart Failure with Preserved Ejection Fraction (HFpEF)
Introduction
Heart failure with preserved ejection fraction (HFpEF) accounts for up to half of contemporary diagnoses of heart failure and is associated with similar adverse short- and long-term outcomes to heart failure with reduced ejection fraction (HFrEF). Notwithstanding, its diagnosis is still partially unsettled and no specific treatment has been shown as effective, yet. HFpEF has therefore drawn the attention of many outstanding researchers. This virtual issue collects and highlights some of the most recent articles published in this field by our journal.
1. Underlying biology/pathophysiology
Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle
Bowen, T. Scott; Rolim, Natale P. L.; Fischer, Tina; Baekkerud, Fredrik H.; Medeiros, Alessandra; Werner, Sarah; Bronstad, Eivind; Rognmo, Oivind; Mangner, Norman; Linke, Axel; Schuler, Gerhard; Silva, Gustavo J. J.; Wisloff, Ulrik; Adams, Volker
Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction
Gori, Mauro; Lam, Carolyn S. P.; Gupta, Deepak K.; Santos, Angela B. S.; Cheng, Susan; Shah, Amil M.; Claggett, Brian; Zile, Michael R.; Kraigher-Krainer, Elisabeth; Pieske, Burkert; Voors, Adriaan A.; Packer, Milton; Bransford, Toni; Lefkowitz, Martin; McMurray, John J. V.; Solomon, Scott D.
Changes of ventricular and peripheral performance in patients with heart failure and normal ejection fraction: insights from ergometry stress echocardiography
Wang, Jing; Fang, Fang; Yip, Gabriel Wai-Kwok; Sanderson, John E.; Lee, Pui-Wai; Feng, Wei; Xie, Jun-Min; Luo, Xiu-Xia; Lam, Yat-Yin
Impaired left atrial function in heart failure with preserved ejection fraction
Santos, Angela B. S.; Kraigher-Krainer, Elisabeth; Gupta, Deepak K.; Claggett, Brian; Zile, Michael R.; Pieske, Burkert; Voors, Adriaan A.; Lefkowitz, Marty; Bransford, Toni; Shi, Victor; Packer, Milton; McMurray, John J. V.; Shah, Amil M.; Solomon, Scott D.
Insulin resistance in heart failure: differences between patients with reduced and preserved left ventricular ejection fraction
Nadja Scherbakov, Maximiliane Bauer, Anja Sandek, Tibor Szabó, Agnieszka Töpper, Ewa A. Jankowska, Jochen Springer, Stephan von Haehling, Stefan D. Anker, Mitja Lainscak, Stefan Engeli, Hans-Dirk Düngen and Wolfram Doehner
2. Diagnosis/distinguishing HFpEF from HFrEF
The middle child in heart failure: heart failure with mid-range ejection fraction (40–50%)
Carolyn S.P. Lam, and Scott D. Solomon
3. Biomarkers
HFpEF vs. HFrEF: can microRNAs advance the diagnosis?
Daniela Schmitter, Adriaan A. Voors, and Pim van der Harst
Circulating microRNAs in heart failure with reduced and preserved left ventricular ejection fraction
Wong, Lee Lee; Armugam, Arunmozhiarasi; Sepramaniam, Sugunavathi; Karolina, Dwi Setyowati; Lim, Kai Ying; Lim, Jia Yuen; Chong, Jenny P. C.; Ng, Jessica Y. X.; Chen, Yei-Tsung; Chan, Michelle M. Y.; Chen, Zhaojin; Yeo, Poh Shuan D.; Ng, Tze P.; Ling, Lieng H.; Sim, David; Leong, Kui Toh G.; Ong, Hean Y.; Jaufeerally, Fazlur; Wong, Raymond; Chai, Ping; Low, Adrian F.; Lam, Carolyn S. P.; Jeyaseelan, Kandiah; Richards, Arthur Mark
MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure
Watson, Chris J.; Gupta, Shashi K.; O'Connell, Eoin; Thum, Sabrina; Glezeva, Nadezhda; Fendrich, Jasmin; Gallagher, Joe; Ledwidge, Mark; Grote-Levi, Lea; McDonald, Kenneth; Thum, Thomas
Biomarkers of heart failure with normal ejection fraction: a systematic review
Cheng, Jin M.; Akkerhuis, K. Martijn; Battes, Linda C.; van Vark, Laura C.; Hillege, Hans L.; Paulus, Walter J.; Boersma, Eric; Kardys, Isabella
4. Exercise Testing
Exercise haemodynamics may unmask the diagnosis of diastolic dysfunction among patients with pulmonary hypertension
Maor, Elad; Grossman, Yoni; Balmor, Ronen Gingy; Segel, Michael; Fefer, Paul; Ben-Zekry, Sagit; Buber, Jonathan; DiSegni, Elio; Guetta, Victor; Ben-Dov, Issahar; Segev, Amit
Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Abudiab, Muaz M.; Redfield, Margaret M.; Melenovsky, Vojtech; Olson, Thomas P.; Kass, David A.; Johnson, Bruce D.; Borlaug, Barry A.
Normal resting pulmonary artery wedge pressure: a diagnostic trap for heart failure with preserved ejection fraction
Constantijn Franssen and Walter J. Paulus
A systematic review of diastolic stress tests in heart failure with preserved ejection fraction, with proposals from the EU-FP7 MEDIA study group
Erdei, Tamas; Smiseth, Otto A.; Marino, Paolo; Fraser, Alan G.
5. Prognosis/Outcomes
How do patients with heart failure with preserved ejection fraction die?
Chan, Michelle M. Y.; Lam, Carolyn S. P.
A prediction model for sudden cardiac death in patients with heart failure and preserved ejection fraction
Adabag, Selcuk; Rector, Thomas S.; Anand, Inder S.; McMurray, John J.; Zile, Michael; Komajda, Michel; McKelvie, Robert S.; Massie, Barry; Carson, Peter E.
Association between cardiovascular vs. non-cardiovascular co-morbidities and outcomes in heart failure with preserved ejection fraction
Lund, Lars H.; Donal, Erwan; Oger, Emmanuel; Hage, Camilla; Persson, Hans; Haugen-Lofman, Ida; Ennezat, Pierre-Vladimir; Sportouch-Dukhan, Catherine; Drouet, Elodie; Daubert, Jean-Claude; Linde, Cecilia
Prognostic value of N-terminal pro C-type natriuretic peptide in heart failure patients with preserved and reduced ejection fraction
Lok, Dirk J.; Klip, IJsbrand T.; Voors, Adriaan A.; Lok, Sjoukje I.; de la Porte, Pieta W. Bruggink-Andre; Hillege, Hans L.; Jaarsma, Tiny; van Veldhuisen, Dirk J.; van der Meer, Peter
C-reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction
Koller, L.; Kleber, M.; Goliasch, G.; Sulzgruber, P.; Scharnagl, H.; Silbernagel, G.; Grammer, T.; Delgado, G.; Tomaschitz, A.; Pilz, S.; Maerz, W.; Niessner, A.
Galectin-3 in patients with heart failure with preserved ejection fraction: results from the Aldo-DHF trial
Edelmann, Frank; Holzendorf, Volker; Wachter, Rolf; Nolte, Kathleen; Schmidt, Albrecht G.; Kraigher-Krainer, Elisabeth; Duvinage, Andre; Unkelbach, Ines; Duengen, Hans-Dirk; Tschoepe, Carsten; Herrmann-Lingen, Christoph; Halle, Martin; Hasenfuss, Gerd; Gelbrich, Goetz; Stough, Wendy Gattis; Pieske, Burkert M.
6. Treatment/Clinical Trials
Galectin-3 in heart failure with preserved ejection fraction
de Boer, Rudolf A.; Edelmann, Frank; Cohen-Solal, Alain; Mamas, Mamas A.; Maisel, Alan; Pieske, Burkert
N-terminal pro brain natriuretic peptide-guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF)
Maeder, Micha T.; Rickenbacher, Peter; Rickli, Hans; Abbuehl, Heidi; Gutmann, Marc; Erne, Paul; Vuilliomenet, Andre; Peter, Martin; Pfisterer, Matthias; Brunner-La Rocca, Hans-Peter
Independence of the blood pressure lowering effect and efficacy of the angiotensin receptor neprilysin inhibitor, LCZ696, in patients with heart failure with preserved ejection fraction: an analysis of the PARAMOUNT trial
Jhund, Pardeep S.; Claggett, Brian; Packer, Milton; Zile, Michael R.; Voors, Adriaan A.; Pieske, Burkert; Lefkowitz, Martin; Shi, Victor; Bransford, Toni; McMurray, John J. V.; Solomon, Scott D.
Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing
Yoshihisa, Akiomi; Suzuki, Satoshi; Yamaki, Takayoshi; Sugimoto, Koichi; Kunii, Hiroyuki; Nakazato, Kazuhiko; Suzuki, Hitoshi; Saitoh, Shu-ichi; Takeishi, Yasuchika
The sHunt for better breathing in heart failure with preserved ejection fraction
Barry A. Borlaug
Transcatheter treatment of heart failure with preserved or mildly reduced ejection fraction using a novel interatrial implant to lower left atrial pressure
Sondergaard, Lars; Reddy, Vivek; Kaye, David; Malek, Filip; Walton, Antony; Mates, Martin; Franzen, Olaf; Neuzil, Petr; Ihlemann, Nikolaj; Gustafsson, Finn
7. General
Heart failure with preserved ejection fraction: uncertainties and dilemmas
Roberto Ferrari, Michael Böhm, John G.F. Cleland, Walter J.S. Paulus, Burkert Pieske, Claudio Rapezzi and Luigi Tavazzi
Epidemiology and clinical course of heart failure with preserved ejection fraction
Lam, Carolyn S. P.; Donal, Erwan; Kraigher-Krainer, Elisabeth; Vasan, Ramachandran S.
HFA Heart Failure Awareness Days
The HFA’s Heart Failure Awareness Days are a Europe-wide initiative, taking place on the 8th, 9th and 10th of May. The aim is to raise awareness of the importance of recognising heart failure, getting an accurate diagnosis and receiving optimal treatment. Both European Journal of Heart Failure and ESC Heart Failure are dedicated towards advancing knowledge in the field of heart failure. In recognition of the Heart Failure Awareness days, the Editor-in-Chief of European Journal of Heart Failure, Marco Metra, and the Editor-in-Chief of ESC Heart Failure, Stefan Anker, have selected the following articles for this special virtual issue:
Organization of heart failure management in European Society of Cardiology member countries: survey of the Heart Failure Association of the European Society of Cardiology in collaboration with the Heart Failure National Societies/Working Groups
Seferovic PM, Stoerk S, Filippatos G, Mareev V, Kavoliuniene A, Ristic AD, Ponikowski P, McMurray J, Maggioni A, Ruschitzka F, van Veldhuisen DJ, Coats A, Piepoli M, McDonagh T, Riley J, Hoes A, Pieske B, Dobric M, Papp Z, Mebazaa A, Parissis J, Ben Gal T, Vinereanu D, Brito D, Altenberger J, Gatzov P, Milinkovic I, Hradec J, Trochu JN, Amir O, Moura B, Lainscak M, Comin J, Wikström G, Anker S; on behalf of the Committee of National Heart Failure Societies or Working Groups of the Heart Failure Association of the European Society of Cardiology
European Journal of Heart Failure, Volume 15, Issue 9, September 2013, pages: 947-959
EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)
Maggioni AP, Dahlström U, Filippatos G, Chioncel O, Crespo Leiro M, Drozdz J, Fruhwald F, Gullestad L, Logeart D, Fabbri G, Urso R, Metra M, Parissis J, Persson H, Ponikowski P, Rauchhaus M, Voors AA, Nielsen OW, Zannad F, Tavazzi L; Heart Failure Association of the European Society of Cardiology (HFA)
European Journal of Heart Failure, Volume 15, Issue 7, July 2013, pages: 808-817
Current aspects of the spectrum of acute heart failure syndromes in a real-life setting: the OFICA study
Logeart D, Isnard R, Resche-Rigon M, Seronde MF, de Groote P, Jondeau G, Galinier M, Mulak G, Donal E, Delahaye F, Juilliere Y, Damy T, Jourdain P, Bauer F, Eicher JC, Neuder Y, Trochu JN; and on behalf of the working group on Heart Failure of the French Society of Cardiology European Journal of Heart Failure, Volume 15, Issue 4, April 2013, pages: 465-476
Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey
van Deursen VM, Urso R, Laroche C, Damman K, Dahlström U, Tavazzi L, Maggioni AP, Voors AA
European Journal of Heart Failure, Volume 16, Issue 1, January 2014, pages: 103-111
Burden of new hospitalization for heart failure: a population-based investigation from Italy
Corrao G, Ghirardi A, Ibrahim B, Merlino L, Maggioni AP
European Journal of Heart Failure, Volume 16, Issue 7, July 2014, pages: 729-736
The epidemiology of heart failure, based on data for 2.1 million inhabitants in Sweden
Zarrinkoub R, Wettermark B, Wändell P, Mejhert M, Szulkin R, Ljunggren G, Kahan T
European Journal of Heart Failure, Volume 15, Issue 9, September 2013, pages: 995-1002
Heart failure: preventing disease and death worldwide
Piotr Ponikowski, Stefan D. Anker, Khalid F. AlHabib, Martin R. Cowie, Thomas L. Force, Shengshou Hu, Tiny Jaarsma, Henry Krum, Vishal Rastogi, Luis E. Rohde, Umesh C. Samal, Hiroaki Shimokawa, Bambang Budi Siswanto, Karen Sliwa and Gerasimos Filippatos
ESC Heart Failure, Volume 1, Issue 1, September 2014, pages: 4-25
Steps forward in regulatory pathways for acute and chronic heart failure
Luca Pani, Sergio Pecorelli, Giuseppe Rosano, Stefan D. Anker, Andrea Peracino, Laura Fregonese, Krishna Prasad, and Guido Rasi
ESC Heart Failure, Volume 1, Issue 2, December 2014, pages: 87-93
Ischemic stroke and heart failure: facts and numbers
Nadja Scherbakov, Karl Georg Haeusler, and Wolfram Doehner
ESC Heart Failure, Volume 2, Issue 1, March 2015, pages: 1-4
Altered myocardial force generation in end-stage human heart failure
Zoltán Papp, Jolanda van der Velden, Attila Borbély, István Édes and Ger J.M. Stienen
ESC Heart Failure, Volume 1, Issue 2, December 2014, pages: 160-165
Facts and numbers on epidemiology and pharmacological treatment of heart failure with preserved ejection fraction
Frank Edelmann
ESC Heart Failure, Volume 2, Issue 2, June 2015, pages: 41-45
Heart failure in Southeast Asia: facts and numbers
Carolyn S.P. Lam
ESC Heart Failure, Volume 2, Issue 2, June 2015, pages: 46-49
Top cited articles: Celebrating 5 years as Editor-in-Chief of EJHF
I took over as Editor-in-Chief of EJHF on 1 January 2010, and from the beginning, ‘doing’ the Journal in Groningen was a big source of inspiration and we enjoyed it enormously. I was very fortunate to be able to assign Professor Adriaan Voors and Professor Wiek van Gilst as Deputy Editors, and 15 Associate Editors from our department (14 in Cardiology and 1 in CardioThoracic Surgery) who were all dedicated to heart failure (more details are in the Editorial of the December 2014 issue of the Journal).
During our time on the Journal, we were privileged to see some excellent submissions from around the world that have driven forward our understanding of heart failure, and improved its treatment, so we are very proud to share with you now the most cited works from the 5 years of our tenure.
Dirk J. van Veldhuisen, EJHF Editor-in-Chief (2010-2014)
Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey
Van Deursen, Vm; Urso, R; Laroche, C; Damman, K; Dahlstrom, U; Tavazzi, L; Maggioni, Ap; Voors, Aa
Baseline characteristics and treatment of patients in Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
Mcmurray, Jjv; Packer, M; Desai, As; Gong, Jj; Lefkowitz, M; Rizkala, Ar; Rouleau, Jl; Shi, Vc; Solomon, Sd; Swedberg, K; Zile, Mr
The Chronic Kidney Disease Epidemiology Collaboration equation outperforms the Modification of Diet in Renal Disease equation for estimating glomerular filtration rate in chronic systolic heart failure
Valente, MAE; Hillege, HL; Navis, G; Voors, AA; Dunselman, PHJM; van Veldhuisen, DJ; Damman, K
Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Abudiab, MM; Redfield, MM; Melenovsky, V; Olson, TP; Kass, DA; Johnson, BD; Borlaug, BA
Effects of carvedilol on heart failure with preserved ejection fraction: the Japanese Diastolic Heart Failure Study (J-DHF)
Yamamoto, K; Origasa, H; Hori, M
EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot)
Maggioni, AP; Dahlstrom, U; Filippatos, G; Chioncel, O; Leiro, MC; Drozdz, J; Fruhwald, F; Gullestad, L; Logeart, D; Fabbri, G; Urso, R; Metra, M; Parissis, J; Persson, H; Ponikowski, P; Rauchhaus, M; Voors, AA; Nielsen, OW; Zannad, F; Tavazzi, L
Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin-converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM-HF)
McMurray, JJV; Packer, M; Desai, AS; Gong, J; Lefkowitz, MP; Rizkala, AR; Rouleau, J; Shi, VC; Solomon, SD; Swedberg, K; Zile, MR
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC
McMurray, JJV; Adamopoulos, S; Anker, SD; Auricchio, A; Bohm, M; Dickstein, K; Falk, V; Filippatos, G; Fonseca, C; Gomez-Sanchez, MA; Jaarsma, T; Kober, L; Lip, GYH; Maggioni, AP; Parkhomenko, A; Pieske, BM; Popescu, BA; Ronnevik, PK; Rutten, FH; Schwitter, J; Seferovic, P; Stepinska, J; Trindade, PT; Voors, AA; Zannad, F; Zeiher, A
MitraClip therapy in daily clinical practice: initial results from the German transcatheter mitral valve interventions (TRAMI) registry
Baldus, S; Schillinger, W; Franzen, O; Bekeredjian, R; Sievert, H; Schofer, J; Kuck, KH; Konorza, T; Mollmann, H; Hehrlein, C; Ouarrak, T; Senges, J; Meinertz, T
Serum levels of microRNAs in patients with heart failure
Goren, Y; Kushnir, M; Zafrir, B; Tabak, S; Lewis, BS; Amir, O
MitraClip (R) therapy in patients with end-stage systolic heart failure
Franzen, O; van der Heyden, J; Baldus, S; Schluter, M; Schillinger, W; Butter, C; Hoffmann, R; Corti, R; Pedrazzini, G; Swaans, MJ; Neuss, M; Rudolph, V; Surder, D; Grunenfelder, J; Eulenburg, C; Reichenspurner, H; Meinertz, T; Auricchio, A
Epidemiology and clinical course of heart failure with preserved ejection fraction
Lam, CSP; Donal, E; Kraigher-Krainer, E; Vasan, RS
Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy
Sliwa, K; Hilfiker-Kleiner, D; Petrie, MC; Mebazaa, A; Pieske, B; Buchmann, E; Regitz-Zagrosek, V; Schaufelberger, M; Tavazzi, L; van Veldhuisen, DJ; Watkins, H; Shah, AJ; Seferovic, PM; Elkayam, U; Pankuweit, S; Papp, Z; Mouquet, F; McMurray, JJV
Assessing and grading congestion in acute heart failure: a scientific statement from the Acute Heart Failure Committee of the Heart Failure Association of the European Society of Cardiology and endorsed by the European Society of Intensive Care Medicine
Gheorghiade, M; Follath, F; Ponikowski, P; Barsuk, JH; Blair, JEA; Cleland , JG; Dickstein, K; Drazner, MH; Fonarow, GC; Jaarsma, T; Jondeau, G; Sendon, JL; Mebazaa, A; Metra, M; Nieminen, M; Pang, PS; Seferovic, P; Stevenson, LW; van Veldhuisen, DJ; Zannad, F; Anker, SD; Rhodes, A; McMurray, JJV; Filippatos, G
2010 Focused Update of ESC Guidelines on device therapy in heart failure
Dickstein, K; Vardas, PE; Auricchio, A; Daubert, JC; Linde, C; McMurray, J; Ponikowski, P; Priori, SG; Sutton, R; van Veldhuisen, DJ
Sleep Apnoea / Sleep-disordered Breathing and Heart Failure
Papers selected by Professor Dr Dirk J van Veldhuisen
Introduction
Sleep apnoea (or sleep-disordered breathing), and in particular central sleep apnoea (CSA), is one of the more recent additions to the list of significant co-morbidities of heart failure; it is ‘the new kid on the block’. Prevalence levels of up to 60% have been reported in studies of patients with heart failure, and CSA has also been associated with increased mortality in some studies, perhaps as much as doubling the mortality risk of patients with heart failure.
To date, no interventional study has been able to improve outcome in these patients but a few studies are currently underway, the results of which are awaited with interest. We present here a collection of articles from EJHF spanning the prognostic impact, associations with other symptoms, and treatment of sleep apnoea in heart failure patients.
Comorbidities:
Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey
Vincent M. van Deursen, Renato Urso, Cecile Laroche, Kevin Damman, Ulf Dahlström, Luigi Tavazzi, Aldo P. Maggioni and Adriaan A. Voors European Journal of Heart Failure Volume 16, Issue 1, January 2014, pages: 103–111
Prognostic impact of sleep disordered breathing and its treatment in heart failure: an observational study
Clemens Jilek, Marion Krenn, Daniela Sebah, Ruth Obermeier, Astrid Braune, Victoria Kehl, Stephan Schroll, Sylvia Montalvan, Günter A.J. Riegger, Michael Pfeifer, and Michael Arzt
European Journal of Heart Failure Volume 13, Issue 1, January 2011, pages 68-75
Symptoms:
Central sleep apnoea and inflammation are independently associated with arrhythmia in patients with heart failure
Kan Sano, Eiichi Watanabe, Junichiro Hayano, Yuuki Mieno, Yoshihiro Sobue, Mayumi Yamamoto, Tomohide Ichikawa, Hiroki Sakakibara, Kazuyoshi Imaizumi, and Yukio Ozaki
European Journal of Heart Failure Volume 15, Issue 9, September 2013, pages 1003 – 1010
Study Designs
Rationale and design of the SERVE-HF study: treatment of sleep-disordered breathing with predominant central sleep apnoea with adaptive servo-ventilation in patients with chronic heart failure
Martin R. Cowie, Holger Woehrle, Karl Wegscheider, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita Simonds, Virend K. Somers, Faiez Zannad, and Helmut Teschler
European Journal of Heart Failure Volume 15, Issue 8 , August 2013, pages 937 - 943
Therapy
Adaptive servo-ventilation therapy improves cardiac sympathetic nerve activity in patients with heart failure
Takashi Koyama, Hiroyuki Watanabe, Yoshikazu Tamura, Yasunori Oguma, Toshimitsu Kosaka, and Hiroshi Ito
European Journal of Heart Failure Volume 15, Issue 8, August 2013, pages 902 – 909
Article
Association between sleep-disordered breathing, sleep–wake pattern, and cognitive impairment among patients with chronic heart failure
Carina Hjelm, Anna Strömberg, Kristofer Årestedt, and Anders Broström
European Journal of Heart Failure Volume 15, Issue 5, May 2013, pages 496-504
Treatment
Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing
Akiomi Yoshihisa, Satoshi Suzuki, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, and Yasuchika Takeishi
European Journal of Heart Failure Volume 15, Issue 5, May 2013 , pages 543-550
Comparison of acute and chronic impact of adaptive servo-ventilation on left chamber geometry and function in patients with chronic heart failure
Nobuhiko Haruki, Masaaki Takeuchi, Kyoko Kaku, Hidetoshi Yoshitani, Hiroshi Kuwaki, Masahito Tamura, Haruhiko Abe, Masahiro Okazaki, Akizumi Tsutsumi, and Yutaka Otsuji
European Journal of Heart Failure Volume 13, Issue 10, October 2011, pages 1140-1146
Impact of device-guided slow breathing on symptoms of chronic heart failure: a randomized, controlled feasibility study
Inger Ekman, Barbro Kjellström, Kristin Falk, Jonna Norman, and Karl Swedberg
European Journal of Heart Failure, Volume 1, Issue 9, September 2011, pages 1000-
Treatment of sleep-disordered breathing in heart failure: reduction of high ventricular wall stress should be a diagnostic and therapeutic target
Peter Alter and Heinz Rupp
European Journal of Heart Failure Volume 14, Issue 10, October 2013, page 1189
Prognosis:
Prognostic impact of sleep-disordered breathing and its treatment with nocturnal ventilation for chronic heart failure
Thibaud Damy, Laurent Margarit, Ala Noroc, Diane Bodez, Soulef Guendouz, Laurent Boyer, Xavier Drouot, Aurélia Lamine, Alexandra Paulino, Stéphane Rappeneau, Maria-Hermann Stoica, Jean-Luc Dubois-Randé, Serge Adnot, Luc Hittinger, and Marie Pia d'Ortho
European Journal of Heart Failure Volume 14, Issue 9, September 2012, pages 1009-1019
Editorial:
Adaptive servo-ventilation in heart failure associated with central sleep apnoea. Is it effective in both acute and chronic setting?
Joost M.A.A. van der Maaten and, Peter J. Wijkstra
European Journal of Heart Failure Volume 13, Issue 10, October, 2011, pages 1049-1051
Central sleep apnoea: another important comorbidity in heart failure?
Peter J. Wijkstra and Dirk J van Veldhuisen
European Journal of Heart Failure Volume 12, Issue 4, April 2010, pages 309-10
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Published on behalf of the Heart Failure Association of the European Society of Cardiology
