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Synthetic Mushroom Toxin - New synthetic route for amanitin, a therapeutically interesting mushroom toxin

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Synthetic Mushroom Toxin

New synthetic route for amanitin, a therapeutically interesting mushroom toxin.
The death cap mushroom is highly toxic. However, some of its toxins can also be healing: amanitins are potential components for antibody-based cancer treatments. In the journal Angewandte Chemie, German scientists have now introduced a new synthetic route for α-amanitin. Their method seems suitable for production on a larger scale, finally making enough of the toxin available for further research.

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DatePress ReleaseOriginal Communication

February 4, 2020

Synthetic Mushroom Toxin
New synthetic route for amanitin, a therapeutically interesting mushroom toxin
(PDF)

Roderich Süssmuth, Technische Universität Berlin (Germany)


January 31, 2020

Safe Potassium-Ion Batteries
Nonflammable electrolyte for high-performance potassium batteries
(PDF)

An Intrinsically Non-flammable Electrolyte for High-Performance Potassium Batteries

Zaiping Guo, University of Wollongong (Australia)


January 23, 2020

Taking Aim at Gastric Cancer
New approach to selective chemotherapy
(PDF)

FerriIridium: A Lysosome-Targeting Iron(III)-Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells

Hui Chao, Sun Yat-Sen University (China)


January 16, 2020

Lights on for Germ-Free Wound Dressings
Biomimetic hydrogel with photodynamic antimicrobial effect
(PDF)

Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels

Chengfen Xing, Hebei University of Technology (China)


January 15, 2020

Imprinted Color Patterns
Azopolymer material allows light-assisted imprinting of nanostructures for structurally colored surfaces
(PDF)

Athermal and Soft Multi-Nanopatterning of Azopolymers: Phototunable Mechanical Properties

Haifeng Yu, Peking University (China)


January 9, 2020

Sensing Protein Wellbeing
Molecular probe maps misfolded proteome state in live cells
(PDF)

A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment

Yuning Hong, La Trobe University (Australia)


December 11, 2019

Pathways toward Post-Petrochemistry
Electroreduction of carbon monoxide for the highly selective production of ethylene
(PDF)

Highly Selective Production of Ethylene by the Electroreduction of Carbon Monoxide

Dehui Deng, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (China)


December 9, 2019

Separating Drugs with MagLev
Magneto-Archimedes levitation for identification of illicit drugs in powdered mixtures
(PDF)

Analysis of Powders Containing Illicit Drugs Using Magnetic Levitation

George M. Whitesides, Harvard University (USA)


November 29, 2019

Providing Safe, Clean Water
Magnetic nanoparticles with ionic liquids for water purification
(PDF)

Water Purification and Microplastics Removal using Magnetic Polyoxometalate-Supported Ionic Liquid Phases (magPOM-SILPs)

Carsten Streb, Universität Ulm (Germany)


November 4, 2019

Post-Lithium Technology
High-energy-density polymeric cathode for fast-charge sodium- and multivalent-ion batteries
(PDF)

A Pyrazine-Based Polymer for Fast-Charge Batteries

Chunsheng Wang, University of Maryland (USA)


October 25, 2019

Immune System Upgrade
Catalytic immunotherapy for cancer: nanoparticles act as artificial enzymes
(PDF)

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR-II Light

You-Nian Liu, Central South University (China)


October 18, 2019

Electric Cloth
Flexible, wearable supercapacitors based on porous nanocarbon nanocomposites
(PDF)

Hierarchical Micro-Mesoporous Carbon-Framework-Based Hybrid Nanofibres for High-Density Capacitive Energy Storage

Su Chen, Nanjing Tech University (China)


September 30, 2019

Strained, Symmetric, and New
Tetravinylallene, a small but powerful molecule, has been synthesized for the first time
(PDF)

Tetravinylallene

Michael Sherburn, Australian National University (Australia)


September 11, 2019

Little Heaps of Silver, All Wrapped Up
Determination of the crystal structure of a DNA-stabilized silver nanocluster
(PDF)

Crystal structure of a NIR-Emitting DNA-Stabilized Ag16 Nanocluster

Jiro Kondo, Sophia University (Japan)


August 28, 2019

Colorful Microreactors Utilize Sunlight
Energy-Efficient Solar Photochemistry with Luminescent Solar Concentrators
(PDF)

Energy-Efficient Solar Photochemistry with Luminescent Solar-Concentrator-Based Photomicroreactors

Timothy Noel, Eindhoven University of Technology (Netherlands)


August 16, 2019

Doped Photovoltaics
Organic dye in zinc oxide interlayer stabilizes and boosts the performance of organic solar cells
(PDF)

Tetrahydroxy-Perylene Bisimide Embedded in Zinc Oxide Thin Film as Electron Transporting Layer for High Performance Non-Fullerene Organic Solar Cells

Frank Würthner, Universität Würzburg (Germany)


August 8, 2019

Analysis and Detoxification in One Step
A smart chemoenzymatic method detects and removes hazardous phenols
(PDF)

A Chemo-Enzymatic Cascade for the Smart Detection of Nitro- and Halogenated Phenols

Pimchai Chaiyen, Vidyasirimedhi Institute of Science and Technology (Thailand)


August 7, 2019

Enhanced Glow
Direct detection of circulating tumor cells in blood samples
(PDF)

Direct Detection of Circulating Tumor Cells in Whole Blood Using Time-Resolved Luminescent Lanthanide Nanoprobes

Xueyuan Chen, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences (China)


August 6, 2019

Striped Glow Sticks
Heterostructure crystals could light the way to optical circuits
(PDF)

Engineering Donor–Acceptor Heterostructure Metal–Organic Framework Crystals for Photonic Logic Computation

Xian-He Bu, Nankai University (China)


July 31, 2019

Actively Swimming Gold Nanoparticles
Chemotactic movement on the macroscale by a swarm of bacteria-mimicking nanoswimmers
(PDF)

Macroscale Chemotaxis from a Swarm of Bacteria-Mimicking Nanoswimmers

Qiang He, Harbin Institute of Technology (China)


July 18, 2019

The Art of Sensing within the Skin
Dermal tattoo sensors for the detection of blood pH change and metabolite levels
(PDF)

Dermal Tattoo Biosensors for Colorimetric Metabolite Detection

Ali Yetisen, Technische Universitüt München (Germany)


July 3, 2019

Imprinted Spheres Fight Breast Cancer
Inhibition of HER2 on tumor cells by molecularly imprinted nanoparticles
(PDF)

Inhibition of HER2-Positive Breast Cancer Growth by Blocking the HER2 Signaling Pathway with HER2-Glycan-Imprinted Nanoparticles

Zhen Liu, Nanjing University (China)


July 2, 2019

Glow Reveals Dangerous Bacteria
Chemiluminescence probes for the rapid and sensitive detection of salmonella and listeria
(PDF)

Ultrasensitive Detection of Salmonella and Listeria monocytogenes by Small-Molecule Chemiluminescence Probes

Doron Shabat, Tel Aviv University (Israel)


May 27, 2019

Antibiotic Ornament Clasp
Chemical synthesis demonstrates that antibiotic from the human nose works by proton translocation
(PDF)

Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability

Stephanie Grond, Eberhard-Karls-Universität Tübingen (Germany)


May 16, 2019

Microglia Turned On
Visualizing microglia in brain tissue with a fluorescence turn-on substrate
(PDF)

Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate

Young-Tae Chang, POSTECH (Rep. Korea)


May 13, 2019

Underwater Power Generation
Energy from seawater: power generator autonomously switches between two functional modes
(PDF)

An Auto-Switchable Dual-Mode Seawater Energy Extraction System Enabled by Metal–Organic Frameworks

Ming Hu, East China Normal University (China)


April 30, 2019

Tracking Small Things in Cells
Small and tunable fluorophores for the imaging of metabolites in living cells
(PDF)

SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

Marc Vendrell, University of Edinburgh (United Kingdom)


April 29, 2019

Partitioning of Porous Materials
Highly resorptive metal–organic frameworks can be constructed by a foresighted combination of two different synthetic principles
(PDF)

A Tale of Two Trimers from Two Different Worlds: A COF-Inspired Synthetic Strategy for Pore-Space Partitioning of MOFs

Pingyun Feng, University of California, Riverside (USA)


April 24, 2019

A Close Look at Lithium Batteries
Fluorescence probe shows the distribution of active lithium species on lithium metal anodes
(PDF)

Fluorescence Probing of Active Lithium Distribution in Lithium Metal Anodes

Guanglei Cui, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences (China)


April 2, 2019

Golden Ball in a Golden Cage
“Golden fullerene”: ligand-protected nanocluster made of 32 gold atoms
(PDF)

A Ligand-Protected Golden Fullerene: The Dipyridylamido Au328+ Nanocluster

Quan-Ming Wang, Tsinghua University (China)


March 27, 2019

Fullerenes Bridge Conductive Gap in Organic Photovoltaics
Efficient cathode interlayers made of ionene polymers refined with pendant fullerenes
(PDF)

Transforming Ionene Polymers into Efficient Cathode Interlayers with Pendent Fullerenes

Thomas P. Russell, University of Massachusetts (USA)


March 12, 2019

Copying Made Easy
A universal isothermal DNA amplification method
(PDF)

An RNA-Guided Cas9 Nickase-Based Method for Universal Isothermal DNA Amplification

Bin-Cheng Yin, State Key Laboratory of Bioreactor Engineering (China)


March 7, 2019

Chemical Hydrogen Storage System
Reversible liquid organic hydrogen carrier system made of simple organic chemicals
(PDF)

A Reversible Liquid Organic Hydrogen Carrier System Based on Methanol-Ethylenediamine and Ethylene Urea

David Milstein, The Weizmann Institute of Science (Israel)


February 18, 2019

From Sea to Lab
Total synthesis of marine antitumor agents trabectedin and lurbinectedin
(PDF)

A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin

Dawei Ma, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (China)


February 7, 2019

Finding Chemicals inside a Cell
Chemical and topographical single-cell imaging at nanoscale resolution by near-field desorption mass spectrometry
(PDF)

Chemical and Topographical Single-Cell Imaging by Near-Field Desorption Mass Spectrometry

Wei Hang, Xiamen University (China)


February 1, 2019

Optimized Binding Cavity
Directed evolution of a designer enzyme with an unnatural catalytic amino acid
(PDF)

Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid

Gerard Roelfes, Rijksuniversiteit Groningen (Netherlands)


January 30, 2019

Maestro’s Techniques
Unusual plumbonacrite mineral resides in Rembrandt’s impasto, as seen by X-ray diffraction analysis
(PDF)

Identification of Unusual Plumbonacrite in Rembrandt's Impasto by Using Multimodal Synchrotron X-ray Diffraction Spectroscopy

Victor Gonzalez, Technische Universiteit Delft (Netherlands)


January 24, 2019

Semiconductors Combine Forces in Photocatalysis
Active photocatalyst: 2D/2D heterojunction of black phosphorus and bismuth tungstate
(PDF)

Z-Scheme 2D/2D Heterojunction of Black Phosphorus/Monolayer Bi2WO6 Nanosheets with Enhanced Photocatalytic Activities

Jian-Mei Lu, Soochow University (China)