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Synthetic Mushroom Toxin
New synthetic route for amanitin, a therapeutically interesting mushroom toxin.
The death cap mushroom is highly toxic. However, some of its toxins can also be healing: amanitins are potential components for antibody-based cancer treatments. In the journal Angewandte Chemie, German scientists have now introduced a new synthetic route for α-amanitin. Their method seems suitable for production on a larger scale, finally making enough of the toxin available for further research.
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Date | Press Release | Original Communication |
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February 4, 2020 |
Synthetic Mushroom Toxin New synthetic route for amanitin, a therapeutically interesting mushroom toxin (PDF) |
Roderich Süssmuth, Technische Universität Berlin (Germany) |
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January 31, 2020 |
Safe Potassium-Ion Batteries Nonflammable electrolyte for high-performance potassium batteries (PDF) |
An Intrinsically Non-flammable Electrolyte for High-Performance Potassium Batteries Zaiping Guo, University of Wollongong (Australia) |
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January 23, 2020 |
Taking Aim at Gastric Cancer New approach to selective chemotherapy (PDF) |
FerriIridium: A Lysosome-Targeting Iron(III)-Activated Iridium(III) Prodrug for Chemotherapy in Gastric Cancer Cells Hui Chao, Sun Yat-Sen University (China) |
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January 16, 2020 |
Lights on for Germ-Free Wound Dressings Biomimetic hydrogel with photodynamic antimicrobial effect (PDF) |
Biomimetic Networks with Enhanced Photodynamic Antimicrobial Activity from Conjugated Polythiophene/Polyisocyanide Hybrid Hydrogels Chengfen Xing, Hebei University of Technology (China) |
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January 15, 2020 |
Imprinted Color Patterns Azopolymer material allows light-assisted imprinting of nanostructures for structurally colored surfaces (PDF) |
Athermal and Soft Multi-Nanopatterning of Azopolymers: Phototunable Mechanical Properties Haifeng Yu, Peking University (China) |
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January 9, 2020 |
Sensing Protein Wellbeing Molecular probe maps misfolded proteome state in live cells (PDF) |
A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment Yuning Hong, La Trobe University (Australia) |
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December 11, 2019 |
Pathways toward Post-Petrochemistry Electroreduction of carbon monoxide for the highly selective production of ethylene (PDF) |
Highly Selective Production of Ethylene by the Electroreduction of Carbon Monoxide Dehui Deng, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (China) |
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December 9, 2019 |
Separating Drugs with MagLev Magneto-Archimedes levitation for identification of illicit drugs in powdered mixtures (PDF) |
Analysis of Powders Containing Illicit Drugs Using Magnetic Levitation George M. Whitesides, Harvard University (USA) |
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November 29, 2019 |
Providing Safe, Clean Water Magnetic nanoparticles with ionic liquids for water purification (PDF) |
Water Purification and Microplastics Removal using Magnetic Polyoxometalate-Supported Ionic Liquid Phases (magPOM-SILPs) Carsten Streb, Universität Ulm (Germany) |
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November 4, 2019 |
Post-Lithium Technology High-energy-density polymeric cathode for fast-charge sodium- and multivalent-ion batteries (PDF) |
A Pyrazine-Based Polymer for Fast-Charge Batteries Chunsheng Wang, University of Maryland (USA) |
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October 25, 2019 |
Immune System Upgrade Catalytic immunotherapy for cancer: nanoparticles act as artificial enzymes (PDF) |
Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR-II Light You-Nian Liu, Central South University (China) |
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October 18, 2019 |
Electric Cloth Flexible, wearable supercapacitors based on porous nanocarbon nanocomposites (PDF) |
Hierarchical Micro-Mesoporous Carbon-Framework-Based Hybrid Nanofibres for High-Density Capacitive Energy Storage Su Chen, Nanjing Tech University (China) |
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September 30, 2019 |
Strained, Symmetric, and New Tetravinylallene, a small but powerful molecule, has been synthesized for the first time (PDF) |
Tetravinylallene Michael Sherburn, Australian National University (Australia) |
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September 11, 2019 |
Little Heaps of Silver, All Wrapped Up Determination of the crystal structure of a DNA-stabilized silver nanocluster (PDF) |
Crystal structure of a NIR-Emitting DNA-Stabilized Ag16 Nanocluster Jiro Kondo, Sophia University (Japan) |
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August 28, 2019 |
Colorful Microreactors Utilize Sunlight Energy-Efficient Solar Photochemistry with Luminescent Solar Concentrators (PDF) |
Energy-Efficient Solar Photochemistry with Luminescent Solar-Concentrator-Based Photomicroreactors Timothy Noel, Eindhoven University of Technology (Netherlands) |
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August 16, 2019 |
Doped Photovoltaics Organic dye in zinc oxide interlayer stabilizes and boosts the performance of organic solar cells (PDF) |
Tetrahydroxy-Perylene Bisimide Embedded in Zinc Oxide Thin Film as Electron Transporting Layer for High Performance Non-Fullerene Organic Solar Cells Frank Würthner, Universität Würzburg (Germany) |
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August 8, 2019 |
Analysis and Detoxification in One Step A smart chemoenzymatic method detects and removes hazardous phenols (PDF) |
A Chemo-Enzymatic Cascade for the Smart Detection of Nitro- and Halogenated Phenols Pimchai Chaiyen, Vidyasirimedhi Institute of Science and Technology (Thailand) |
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August 7, 2019 |
Enhanced Glow Direct detection of circulating tumor cells in blood samples (PDF) |
Direct Detection of Circulating Tumor Cells in Whole Blood Using Time-Resolved Luminescent Lanthanide Nanoprobes Xueyuan Chen, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences (China) |
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August 6, 2019 |
Striped Glow Sticks Heterostructure crystals could light the way to optical circuits (PDF) |
Engineering Donor–Acceptor Heterostructure Metal–Organic Framework Crystals for Photonic Logic Computation Xian-He Bu, Nankai University (China) |
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July 31, 2019 |
Actively Swimming Gold Nanoparticles Chemotactic movement on the macroscale by a swarm of bacteria-mimicking nanoswimmers (PDF) |
Macroscale Chemotaxis from a Swarm of Bacteria-Mimicking Nanoswimmers Qiang He, Harbin Institute of Technology (China) |
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July 18, 2019 |
The Art of Sensing within the Skin Dermal tattoo sensors for the detection of blood pH change and metabolite levels (PDF) |
Dermal Tattoo Biosensors for Colorimetric Metabolite Detection Ali Yetisen, Technische Universitüt München (Germany) |
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July 3, 2019 |
Imprinted Spheres Fight Breast Cancer Inhibition of HER2 on tumor cells by molecularly imprinted nanoparticles (PDF) |
Inhibition of HER2-Positive Breast Cancer Growth by Blocking the HER2 Signaling Pathway with HER2-Glycan-Imprinted Nanoparticles Zhen Liu, Nanjing University (China) |
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July 2, 2019 |
Glow Reveals Dangerous Bacteria Chemiluminescence probes for the rapid and sensitive detection of salmonella and listeria (PDF) |
Ultrasensitive Detection of Salmonella and Listeria monocytogenes by Small-Molecule Chemiluminescence Probes Doron Shabat, Tel Aviv University (Israel) |
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May 27, 2019 |
Antibiotic Ornament Clasp Chemical synthesis demonstrates that antibiotic from the human nose works by proton translocation (PDF) |
Synthetic Lugdunin Analogues Reveal Essential Structural Motifs for Antimicrobial Action and Proton Translocation Capability Stephanie Grond, Eberhard-Karls-Universität Tübingen (Germany) |
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May 16, 2019 |
Microglia Turned On Visualizing microglia in brain tissue with a fluorescence turn-on substrate (PDF) |
Visualizing Microglia with a Fluorescence Turn-On Ugt1a7c Substrate Young-Tae Chang, POSTECH (Rep. Korea) |
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May 13, 2019 |
Underwater Power Generation Energy from seawater: power generator autonomously switches between two functional modes (PDF) |
An Auto-Switchable Dual-Mode Seawater Energy Extraction System Enabled by Metal–Organic Frameworks Ming Hu, East China Normal University (China) |
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April 30, 2019 |
Tracking Small Things in Cells Small and tunable fluorophores for the imaging of metabolites in living cells (PDF) |
SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism Marc Vendrell, University of Edinburgh (United Kingdom) |
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April 29, 2019 |
Partitioning of Porous Materials Highly resorptive metal–organic frameworks can be constructed by a foresighted combination of two different synthetic principles (PDF) |
A Tale of Two Trimers from Two Different Worlds: A COF-Inspired Synthetic Strategy for Pore-Space Partitioning of MOFs Pingyun Feng, University of California, Riverside (USA) |
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April 24, 2019 |
A Close Look at Lithium Batteries Fluorescence probe shows the distribution of active lithium species on lithium metal anodes (PDF) |
Fluorescence Probing of Active Lithium Distribution in Lithium Metal Anodes Guanglei Cui, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences (China) |
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April 2, 2019 |
Golden Ball in a Golden Cage “Golden fullerene”: ligand-protected nanocluster made of 32 gold atoms (PDF) |
A Ligand-Protected Golden Fullerene: The Dipyridylamido Au328+ Nanocluster Quan-Ming Wang, Tsinghua University (China) |
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March 27, 2019 |
Fullerenes Bridge Conductive Gap in Organic Photovoltaics Efficient cathode interlayers made of ionene polymers refined with pendant fullerenes (PDF) |
Transforming Ionene Polymers into Efficient Cathode Interlayers with Pendent Fullerenes Thomas P. Russell, University of Massachusetts (USA) |
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March 12, 2019 |
Copying Made Easy A universal isothermal DNA amplification method (PDF) |
An RNA-Guided Cas9 Nickase-Based Method for Universal Isothermal DNA Amplification Bin-Cheng Yin, State Key Laboratory of Bioreactor Engineering (China) |
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March 7, 2019 |
Chemical Hydrogen Storage System Reversible liquid organic hydrogen carrier system made of simple organic chemicals (PDF) |
A Reversible Liquid Organic Hydrogen Carrier System Based on Methanol-Ethylenediamine and Ethylene Urea David Milstein, The Weizmann Institute of Science (Israel) |
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February 18, 2019 |
From Sea to Lab Total synthesis of marine antitumor agents trabectedin and lurbinectedin (PDF) |
A Scalable Total Synthesis of the Antitumor Agents Et-743 and Lurbinectedin Dawei Ma, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (China) |
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February 7, 2019 |
Finding Chemicals inside a Cell Chemical and topographical single-cell imaging at nanoscale resolution by near-field desorption mass spectrometry (PDF) |
Chemical and Topographical Single-Cell Imaging by Near-Field Desorption Mass Spectrometry Wei Hang, Xiamen University (China) |
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February 1, 2019 |
Optimized Binding Cavity Directed evolution of a designer enzyme with an unnatural catalytic amino acid (PDF) |
Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid Gerard Roelfes, Rijksuniversiteit Groningen (Netherlands) |
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January 30, 2019 |
Maestro’s Techniques Unusual plumbonacrite mineral resides in Rembrandt’s impasto, as seen by X-ray diffraction analysis (PDF) |
Identification of Unusual Plumbonacrite in Rembrandt's Impasto by Using Multimodal Synchrotron X-ray Diffraction Spectroscopy Victor Gonzalez, Technische Universiteit Delft (Netherlands) |
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January 24, 2019 |
Semiconductors Combine Forces in Photocatalysis Active photocatalyst: 2D/2D heterojunction of black phosphorus and bismuth tungstate (PDF) |
Z-Scheme 2D/2D Heterojunction of Black Phosphorus/Monolayer Bi2WO6 Nanosheets with Enhanced Photocatalytic Activities Jian-Mei Lu, Soochow University (China) |
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