48/2004

Killing Resistant Germs
Paromomycin derivative as a potential drug against multiple-resistant Staphylococci (PDF)

Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site

Stephen Hanessian, Univ. Montréal (Canada)

47/2004

Detachable Nanoglue
Nanoscopic gold spheres can be reversibly bound to DNA strands (PDF)

Reversible Switching of DNA–Gold Nanoparticle Aggregation

Christoph M. Niemeyer, Univ. Dortmund (Germany)

46/2004

Protein with Pores
"Biozeolites": Peptides as a new class of microporous organic solids (PDF)

Dipeptides as Microporous Materials

Dimitriy V. Soldatov / John A. Ripmeester, Russian Academy of Sciences, Novosibirsk / Steacie Inst. of Molecular Sciences, Ottawa (Canada)

45/2004

Watch your Step!
Aligned nanowires: carbon nanotubes grow along atomic steps on sapphire surfaces (PDF)

Atomic-Step-Templated Formation of Single Wall Carbon Nanotube Patterns

Ernesto Joselevich, Weizmann Institute of Science, Rehovot (Israel)

44/2004

Uncovered by Weight Gain
Enzyme tests with peptide chips and mass spectrometry (PDF)

Profiling Kinase Activities by Using a Peptide Chip and Mass Spectrometry

Milan Mrksich, University of Chicago (USA)

43/2004

Solution to a Mystery
The structure of a polymeric carbon suboxide is finally cleared up (PDF)

Analysis of Poly(carbon suboxide) by Small-Angle X-ray Scattering

Matthias Ballauf, Universität Bayreuth (Germany)

42/2004

Copying Mother Nature
Organic molecules spontaneously organize themselves into large spherical structures (PDF)

Finite, Spherical Coordination Networks that Self-Organize from 36 Small Components

Makoto Fujita, University of Tokyo (Japan)

41/2004

Toy from the Molecular Construction Set
A molecule that looks like a toy top can serve as a motor for nanoscale components (PDF)

Molecular Gyroscopes: {Fe(CO)₃}- and {Fe(CO)₂(NO)}⁺ Rotators Encased in Three-Spoke Stators; Facile Assembly by Alkene Metatheses

John A. Gladysz, Universität Erlangen-Nürnberg (Germany)

40/2004

Nano-flares
A new method for coating individual luminous nanocrystals (quantum dots) with silicon dioxide (PDF)

Single Quantum Dots in Spherical Silica Particles

Thomas Nann, Universität Freiburg (Germany)

39/2004

Nanoneedle for the Injection of Genes?
Carbon nanotubes slip DNA into cells—a new approach to gene therapy? (PDF)

Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery

Alberto Bianco, CNRS, IBMC Strasbourg (France)

38/2004

Lord of the Rings—Chemical magic tricks
Selective formation of cross-catenanes—pairs of different interlocking molecular rings (PDF)

Kinetic Self-Assembly: Selective Cross-Catenation of Two Sterically Differentiated Pd^II-Coordination Rings

Makoto Fujita, The University of Tokyo (Japan)

37/2004

Nanotram
Autonomous nanomachine: a DNA fragment moves along a self-organized DNA track (PDF)

A Unidirectional DNA Walker That Moves Autonomously along a Track

Hao Yan, Duke University, Durham, NC (USA)

36/2004

Scaring off Mosquitoes
Total synthesis of gaur acid reveals the spatial structure of this proposed yellow-fever mosquito repellant (PDF)

Stereodivergent Construction of Cyclic Ethers by a Regioselective and Enantiospecific Rhodium-Catalyzed Allylic Etherification: Total Synthesis of Gaur Acid

P. Andrew Evans, Indiana University, Bloomington, IN (USA)

35/2004

Cancer Drug from Sea Sponges?
Two research teams succeed in synthesizing Dictyostatin—confirming the proposed structure of this natural product (PDF)

Total Synthesis and Configurational Assignment of (-)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin; Total Synthesis of (-)-Dictyostatin: Confirmation of Relative and Absolute Configurations

Ian Paterson / Dennis P. Curran , Universities of Cambridge (UK) / Pittsburgh (USA)

34/2004

More Potential Side-Effects than Previously Thought
Does the activity of chromium in "slimming agents" stem from the formation of cancer-causing substances? (PDF)

Biomimetic Oxidation of Chromium(III): Does the Antidiabetic Activity of Chromium(III) Involve Carcinogenic Chromium(VI)?

Peter A. Lay, University of Sydney (Australia)

33/2004

Plastic with a Lotus Effect
It's in the combination: a super-water-repellent polystyrene film made of microspheres and nanothreads (PDF)

A Lotus-Leaf-like Superhydrophobic Surface: A Porous Microsphere/Nanofiber Composite Film Prepared by Electrohydrodynamics

Lei Jiang, Chinese Academy of Sciences, Beijing (China)

32/2004

Phosphorus Nanorods
Two new forms of elemental phosphorus: rod-shaped molecular chains of phosphorus cages (PDF)

Phosphorus Nanorods—Two Allotropic Modifications of a Long-Known Element

Arno Pfitzner, Univ. Regensburg (Germany)

31/2004

Breakwater against Diabetes
A new approach to type II diabetes? "Beta-breaker" should break up incorrectly folded, destructive protein structures (PDF)

Inhibition of Amyloid Fibril Formation by Peptide Analogues Modified with α-Aminoisobutyric Acid

Ehud Gazit, Tel Aviv University (Israel)

30/2004

Rare Sugar
Unusual carbohydrate structure in the cell walls of tuberculosis bacteria—a new point of attack for drugs? (PDF)

Identification of the 5-Methylthiopentosyl Substituent in Mycobacterium tuberculosis Lipoarabinomannan

Achim Treumann, Royal College of Surgeons, Dublin (Ireland)

29/2004

Reinforcing the Immune System
Small difference, large effect: fully synthetic drug is orders of magnitude more effective than naturally occurring analogue (PDF)

The C-Glycoside Analogue of the Immunostimulant α-Galactosylceramide (KRN7000): Synthesis and Striking Enhancement of Activity

Richard W. Franck, City University of New York (USA)

28/2004

Will Computers Think, Machines Invent, and Humans Live Forever?
Harvard Chemist G. Whitesides on the Future (PDF)

Assumptions: Taking Chemistry in New Directions

George M. Whitesides, Harvard Univ., Cambridge (USA)

28/2004

Platonic Gold
Producing Gold nanocrystals with defined geometric shapes (PDF)

Platonic Gold Nanocrystals

Peidong Yang, UC Berkeley (USA)

I/2004

Piecing together the Natural Product Puzzle
Structure determination and synthesis of the mussel toxin azaspiracid (PDF)

Structural Revision and Total Synthesis of Azaspiracid-1 (Part I+II)

K. C. Nicolaou, The Scripps Research Institute, La Jolla, CA (USA)

27/2004

Molecular Hand
DNA-based molecular machine that reversibly grabs and then releases thrombin (PDF)

A DNA-Based Machine That Can Cyclically Bind and Release Thrombin

Friedrich C. Simmel, Univ. München (Germany)

26/2004

Open and shut detection
Electrochemical sensor for the uncomplicated detection of "hits" on DNA chips (PDF)

Label-Free Electrochemical Recognition of DNA Hybridization by Means of Modulation of the Feedback Current in SECM

Wolfgang Schuhmann, Univ. Bochum (Germany)

25/2004

DNA as a Template for Minerals
Copying DNA structures with silicates— a step toward ordered synthetic inorganic materials? (PDF)

Sol–Gel Reaction Using DNA as a Template: An Attempt Toward Transcription of DNA into Inorganic Materials

Seiji Shinkai, Kyushu University (Japan)

24/2004

Bottle Brushes Tête à Tête
Copolymers made of one coil- and one rod-shaped block congregate in giant micelles (PDF)

Micelle Formation from Amphiphilic "Cylindrical Brush"—Coil Block Copolymers Prepared by Metallocene Catalysis

Manfred Schmidt, Univ. Mainz (Germany)

23/2004

Fishing for Proteins
Magnetic gold and nickel nanorods for the separation of biomolecules (PDF)

Multicomponent Magnetic Nanorods for Biomolecular Separations

Chad A. Mirkin, Northwestern University, Evanston, IL (USA)

22/2004

A Goblet for Gases
Calixarene crystals as new absorption agents for the purification of hydrogen (PDF)

A New Type of Material for the Recovery of Hydrogen from Gas Mixtures

Leonard J. Barbour, University of Stellenbosch (South Africa)

21/2004

Finely Divided
New process for the production of efficient catalyst systems for the synthesis of methanol (PDF)

MOCVD-Loading of Mesoporous Siliceous Matrices with Cu/ZnO: Supported Catalysts for Methanol Synthesis

Roland A. Fischer, Ruhr-Universität Bochum (Germany)

20/2004

Thought Experiment with Golden Balls
Computer calculations predict an unusual gold cluster: a fullerene made of 32 gold atoms (PDF)

Au₃₂: A 24-Carat Golden Fullerene

Mikael P. Johansson, University of Helsinki (Finland)

19/2004

Crystals by the Drop
High-throughput process for the optimization of crystallization conditions for proteins (PDF)

A Droplet-Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor-Diffusion Methods with On-Chip X-Ray Diffraction

Rustem Ismagilov, University of Chicago (USA)

18/2004

Responsibility for the Weaker
Environmental protection and chemical security in developing countries—a mutual burden (PDF)

Chemical Safety in a Vulnerable World—A Manifesto

C. Djerassi, Stanford University (USA)

17/2004

"Drawing" with Nanoparticles
Defined patterns of gold nanoparticles in transparent materials—optoelectronic building blocks of the future? (PDF)

Manipulation of Gold Nanoparticles inside Transparent Materials

Colored butterfly

Jianrong Qiu, Shanghai Institute of Optics and Fine Mechanics (China)

16/2004

Needle in a Haystack
Magnetic-bioelectronic protein diagnosis is super-sensitive and has potential for use on lab-on-chips (PDF)

DNA-Based Amplified Bioelectronic Detection and Coding of Proteins

Joseph Wang, New Mexico State University (USA)

15/2004

Liberated Lithium Ions
Additive speeds the efficiency of lithium-ion accumulators (PDF)

A High Electrode-Reaction Rate for High-Power-Density Lithium-Ion Secondary Batteries by the Addition of a Lewis Acid

Masataka Wakihara, Tokyo Institute of Technology (Japan)

14/2004

Common Mushrooms as Synthetic Geniuses
Yellow pigments with unusual structures from common earthball and peppery bolete? (PDF)

Unusual Pulvinic Acid Dimers from the Common Fungi Scleroderma citrinum (Common Earthball) and Chalciporus piperatus (Peppery Bolete)

Wolfgang Steglich, Univ. München (Germany)

13/2004

Iron Complex with a Killer Instinct
Iron-containing nucleoside analogs kill tumor cells—organometallic compounds as a new class of drugs? (PDF)

Iron-Containing Nucleoside Analogues with Pronounced Apoptosis-Inducing Activity

Hans-Günter Schmalz, Univ. Köln (Germany)

12/2004

Three Colors: Green
Electrically conducting green polymer completes the three primary colors—a step toward a plastic display? (PDF)

A Red, Green, and Blue (RGB) Polymeric Electrochromic Device (PECD): The Dawning of the PECD Era

Fred Wudl, University of California, Los Angeles (USA)

11/2004

Rock ‘n’ Roll Down the Tubes
Metal-filled fullerenes are "hopping" inside of carbon nanotubes (PDF)

Molecular Motion of Endohedral Fullerenes in Single-Walled Carbon Nanotubes

Andrei N. Khlobystov, Oxford University (UK)

10/2004

Nano-mole
Platinum nanoparticles "burrow" into a zeolite support and form new pores (PDF)

Mesopores Created by Platinum Nanoparticles in Zeolite Crystals

Hitoshi Kato, Japan Fine Ceramics Center, Nagoya (Japan)

09/2004

Reactor made of Gold Tubes
Gold nanotubes in polycarbonate films for the investigation of catalytic reactions at gas-liquid phase boundaries (PDF)

Gold-Nanotube Membranes for the Oxidation of CO at Gas-Water Interfaces

James A. Dumesic, University of Wisconsin, Madison (USA)

08/2004

Cleaner Fuel
Removing nitrogen compounds from diesel by adsorption onto copper-containing zeolites (PDF)

Denitrogenation of Transportation Fuels by Zeolites at Ambient Temperature and Pressure

Ralph T. Yang, University of Michigan (USA)

07/2004

Winterproof Fish
Which structural characteristics make glycoproteins into good antifreezes? (PDF)

Antifreeze Glycoproteins: Elucidation of the Structural Motifs That Are Essential for Antifreeze Activity

Shin-Ichiro Nishimura, Hokkaido Univ. (Japan)

06/2004

Environmentally Friendly Silicon Production
Electrochemical extraction of silicon: new approach for a more environmentally friendly large-scale process? (PDF)

Electrochemical Preparation of Silicon and Its Alloys from Solid Oxides in Molten Calcium Chloride

George Z. Chen, University of Nottingham (UK)

05/2004

Wedged In
A jump in porosity: the incusion of small molecules changes the distance between layers in lamellar material (PDF)

Solid-State Reshaping of Crystals: Flash Increase in Porosity of Zirconium Phosphate-Hypophosphite That Contains Polyethylenoxa Diphosphonate Pillars

Ernesto Brunet, Universidad Autónoma de Madrid (Spain)

04/2004

Pocket-sized HIV-Diagnostic Lab
Affordable for developing countries too: Prototype of a portable detector for protein diagnosis (PDF)

An Integrated Approach to a Portable and Low-Cost Immunoassay for Resource-Poor Settings

George M. Whitesides, Harvard University (USA)

03/2004

Arsenic in Sheep’s Clothing
Organic arsenic-sulfur compound discovered in sheep urine—is arsenic metabolism more complex than expected? (PDF)

2-Dimethylarsinothioyl Acetic Acid Identified in a Biological Sample: The First Occurrence of a Mammalian Arsinothioyl Metabolite

Jörg Feldmann, Univ. Aberdeen (UK)

02/2004

Nanoscale Ladders
Synthesis of ladderlike molecules (ladderanes) by reaction in the solid state (PDF)

Supramolecular Construction of Molecular Ladders in the Solid State

Leonard R. MacGillivray, Univ. of Iowa (USA)

01/2004

Stacked Rosettes
Stepwise self-organization of molecules into hexameric rosettes and then into nanotubes (PDF)

π-Conjugated Oligo-(p-phenylenevinylene) Rosettes and Their Tubular Self-Assembly

E. W. Meijer, TU Eindhoven (The Netherlands)