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The gas-generating platforms for tumor therapy precisely have been as a green treatment method. We summarized a nice overview on the mechanism, the common gas release pathways of NO, O₂, CO, CO₂ under ultrasound, and their applications for tumor therapy. We believe this review could represent a new field on antitumor.

The cellular and molecular switches of vasculogenesis and angiogenesis are highlighted. The molecular players of tumor angiogenesis are enumerated. Tumor angiogenic therapy and future antitumor approaches are outlined.

Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiation Therapy (SBRT) have been increasingly utilized in Radiation Oncology to treat early stage tumors, metastatic targets, and retreatment of relapsed diseases due to its efficiency, treatment effect and cost effectiveness in the past two decades. SRS and SBRT both demand high specifications for their delivery machines as they deliver radiation doses with fewer treatment fractions and higher doses per fraction. Manufacturers have either invented specialized technologies solely or customized their existing machines for this purpose. In this paper, we review the major technologies and treatment machines for SRS and SBRT, describe their main features, and discuss the advantages and disadvantages.

This paper summarizes six recent technical advances in magnetic resonance imaging (MRI) for MRI-guided radiotherapy: MRI simulators, MRI-linear accelerator hybrid machines, MRI-only workflow, four-dimensional MRI, MRI-based radiomics, and magnetic resonance fingerprinting.

The aim of this review article is to discuss esophageal anastomotic leak, and describe modern treatment approaches. Endoluminal vacuum therapy (EVT, E-VAT)may be the most promising therapeutic strategy for the most dreaded complication. EVT (E-VAT) also has good commercial prospects.

This review summarizes the hallmarks of ferroptosis, discusses how ferroptosis can be modulated by multiple extrinsic or intrinsic stresses, and highlights the interconnection between ferroptosis and cancer therapy response. A better understanding of the complex regulatory networks of ferroptosis and its interplay with current therapies could ultimately help to develop novel therapeutic approaches against cancer

Recent technological advances of next-generation sequencing and bioinformatics have made it possible to discover more abundant and specific neoantigens encoded by tumor-specific somatic mutations. Precise cancer medicine of therapeutic vaccines designed from personalized neoantigens have been proven effective and safe in patients with melanoma, non-small cell lung cancer, and head and neck squamous carcinoma, and so forth. Discoveries of the phenotypes, functionality, and long-lasting memory potential of tumor-infiltrating lymphocytes trigger deeper evaluation of cancer vaccine study and vaccine-induced neoantigen-specific CD4+ and CD8+ T-cell adoptive transfer therapy, which is warranted to improve immunotherapeutic activity and optimize vaccination strategies.

Graphical Abstract: Human gut harbors complex microbiota ecosystem, and the multi-kingdom microbiota are critical in the development of CRC. Diet intervention and different therapies regulated multi-kingdom microbiota influencing the development of CRC.

Pancreatic tissues' tumors exhibited three different situations. (A) Several glandular tubular adenocarcinoma structures could be seen in pancreatic tissue. (B) Tubular area could be seen in the pancreas, exhibiting papillary growth in the area. (C) The ductal epithelium in the pancreas was replaced by high columnar mucous cells, which showed pseudostratified columnar epithelial cells.

This paper examines the impact of COVID-19 on colorectal cancer diagnosis and management in Australia and New Zealand by comparing patients receiving colorectal cancer surgery during the pandemic against averages from the same period over the preceding three years. The key findings are a significant reduction in total colorectal cancer operations, particularly in rectal cancers, cancers presented at a more advanced stage and operations were more likely to be emergencies. The response to COVID-19 has had measurably negative effects on the diagnosis and management of colorectal cancer in two countries that have had significantly fewer COVID-19 cases than many other countries.

Sarcopenia as assessed on computed tomography was investigated as a predictor of outcomes following colorectal cancer resection. Associations were found with length of stay, complications and recurrence at 1 year. Sarcopenia was found to be a better predictive factor for recurrence and morbidity than other traditional measures of nutrition.

Pictorial essay on MRI local staging of rectal carcinoma: An easy approach

Multiple effects of berberine (BBR) as a gastrointestinal (GI) cancer therapeutic agent. BBR acts as a potential anti-GI cancer agent by inducing apoptosis, autophagy, and cell-cycle arrest, as well as metastasis and angiogenesis inhibition. It plays an important role in suppressing GI cancer cells.

Prevalence of gastrointestinal cancers was positively correlated with national human development index levels, but negatively with hypertension and diabetes rates. Age-specific trends were observed in stomach cancer and esophagus cancer for incidence and in liver cancer and pancreatic cancer for mortality, as well as sex-specific trends for stomach cancer and pancreatic cancer in the elder.These findings suggest that future research has to focus on the specific etiology of gastrointestinal cancers behind these epidemiologic transitions and improve therapeutic strategies for patients with comorbid metabolic diseases.

We have performed subcloning of metastatic intestinal tumor-derived organoids from single cells. Notably, approximately 30% of subclones showed loss of metastatic ability associated with growth suppression, although driver mutations were not affected. The results suggest that cancer evolution is regulated not only by positive selection but also by negative selection.

RUVBL1 is a direct downstream target gene of SETD1A. High expression of both SETD1A and RUVBL1 is an independent prognostic factor not only for disease-free survival but also for overall survival.

Graphical Headlights

• Small extracellular vesicles (sEVs) released from pancreatic ductal carcinoma (PDAC) are enriched in pancreatic juice (PJ).
• PJ-derived sEVs are promising for the early diagnosis of PDAC.
• PJ-derived sEVs could be promising therapeutic targets.