One-pot sequential reaction combining bimetallic Cu/Ir-catalyzed asymmetric allylation of ketimine esters and (E)-4-indolyl allyl carbonates with acid-mediated Pictet-Spengler cyclization was successfully developed. This protocol enables stereodivergent access to four stereoisomers of indole-fused 9-azabicyclo[4.2.1]nonanes, containing an eight-membered ring system bearing one tertiary and two quaternary stereocenters. It features a remarkable step economy, broad substrate compatibility, and excellent stereoselective control. More details are discussed in the article by Wang et al. on pages 1223—1229.

Accurate prediction of chemical reaction performance is crucial for automated chemical synthesis. In this study, a novel multi-modal chemical reaction prediction model is proposed, using graph and textual information, eliminating the need for computationally intensive DFT parameters with capability to handling reactions involving a fluctuating number of molecules. This model outperforms at least 7 generalized methods on 4 datasets, while maintaining chemical interpretability towards atomic and feature importance. Further details are comprehensively discussed in the article by Li et al. on pages 1230—1238.

Bimetallic Cu/Ir catalyzed asymmetric allylation of ketimine esters and (E)-4-indolyl allyl carbonates followed by acid-promoted Pictet-Spengler cyclization sequences was developed, enabling stereodivergent synthesis of chiral indole fused 9-azabicyclo[4.2.1]nonanes containing an eight-membered ring with one tertiary and two quaternary stereogenic centers.

A novel multi-modal model called MMHRP-GCL is developed for predicting the homogeneous chemical reaction yield, enantioselectivity, and activation energy by fusing the information from the graph and text modalities. MMHRP-GCL reveals atomic importance and provides ideas for new catalytic designs.

A Pd(II)-catalyzed regioselective [4+2] benzannulation of 2-pyridones with electrondeficient alkenes was presented for diversity-oriented synthesis of quinolinone derivatives. The potential reaction mechanism involved a series of sequential C—H activation reactions or 6π electrocyclization and entailed dehydrogenative aromatization for the transformation from 2-pyridone into quinolinone.

The change of aortic polarity in atherosclerosis was measured for the first time. Cy7P-B had H₂O₂/lipid droplets dual-analytes sequential activation characteristics, and the up-regulation of lipid accumulation and oxidative stress were effectively detected in atherosclerotic plaques.

A nickel-catalyzed amide-directed carboxylation of aryl C—F bonds with CO₂ has been developed. The reaction is switchable controlled by LiCl to react with one or two molecules of CO₂ to afford valuable phthalimides or α-hydroxycarboxylic acid derivatives.

The Bi(OAc)₃/CPA catalyzed asymmetric allylation reactions of racemic aldehyde [n]cyclophanes via KR have been disclosed, in which planar-chiral [n]cyclophanes with carbon-centered chirality were synthesized with stereoselectivities. The versatility in substrate scope and potential for further transformations substantiate the significance of this methodology. Furthermore, theoretical calculations elucidate the origin of enantioselectivity.

Nickel-catalyzed asymmetric reductive 1,4-dicarbofunctionalization of 1,3-dienes and 1,5-dicarbofunctionalization of vinylcyclopropanes have been disclosed, providing a variety of chiral olefins bearing an allylic or a homoallylic stereogenic center in high regio-, diastereo-, and enantioselectivities.

Three Hofmann-type SCO-MOFs (1·Ph₂S, 1·Ph₂SO, 1·Ph₂SO₂) with sulfur-containing guests exhibit tunable spin-crossover behaviors, host-guest synergy, and photomagnetic effects, demonstrating the potential for fine-tuning SCO properties through guest oxidation states.

A gold/copper catalyst-controlled selective 6π-electrocyclization strategy of N-vinyl-α,β-unsaturated nitrones has been developed for the divergent synthesis of polysubstituted pyridines in moderate to good yields without column chromatography.

We developed a novel method for synthesizing ssDNA using fluoride-sensitive, triisopropylsilyl (TIPS)-protected phosphoramidite building blocks, achieving over 99% deprotection efficiency under mild, non-acidic conditions. Solid-phase synthesis of short ssDNA sequences yielded over 99% efficiency per cycle, demonstrating high specificity and efficiency.

We report a neutral chalcogen bonding-enabled cross-electrophile C-Ch coupling reaction between aryl iodides and selenosulfonates under visible light irradiation. Mechanistic analysis shows that the process involves the photogeneration of R-Se anions and α-aminoalkyl radicals, which facilitate the activation of aryl iodides via halogen atom transfer, ultimately leading to the formation of aryl radicals.

A systematic investigation of substituent effects on the RTP properties of TA revealed that substitution at the 2-position leads to a concurrent enhancement of RTP efficiency and emission lifetime. These optimized RTP materials hold promise for applications in information storage and time-dependent decryption.

Two donor-acceptor organic PCs based on pyrazino[2,3-f][1,10]phenanthroline were successfully used to achieve efficient visible light-driven dual photoredox/copper catalyzed atom transfer radical polymerization at ultra-low catalyst loadings.

Quinolinone is a widely found partially aromatic heterocycle that is present in numerous natural products and pharmaceutical compounds. This work presents an intermolecular palladium-catalyzed regioselective [4+2] benzannulation reaction capable of converting 2-pyridones into quinolinones using electron-deficient alkenes as two-carbon units. More details are discussed in the article by Xu et al. on pages 1239—1245.

The neutral chalcogen bonding interaction established between chalcogen electrophiles and alkyl amines facilitates the photogeneration of R-Se⁻ anions and α-aminoalkyl radicals via single electron transfer processes. The α-aminoalkyl radicals then abstract halogen atoms, leading to the formation of aryl radicals. Finally, a radical nucleophilic substitution drives the cross-electrophile C-Se coupling reaction. More details are discussed in the article by Chen et al. on pages 1299—1305.