Polarity Sensitive and H2O2/Lipid Droplets Sequence-Activated Asymmetric Cyanine Probe Achieves Multi-marker Imaging of Atherosclerosis
Weihua Wang
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
These authors contributed equally to this work.
Search for more papers by this authorHan Zhu
Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071 China
These authors contributed equally to this work.
Search for more papers by this authorBo Gu
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorYongze Xie
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorXinlei Xu
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorCorresponding Author
Shu-Lin Liu
Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Heng Song
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Wuhan University Shenzhen Research Institute, Shenzhen, Guangdong, 518000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorWeihua Wang
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
These authors contributed equally to this work.
Search for more papers by this authorHan Zhu
Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071 China
These authors contributed equally to this work.
Search for more papers by this authorBo Gu
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorYongze Xie
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorXinlei Xu
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Search for more papers by this authorCorresponding Author
Shu-Lin Liu
Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Heng Song
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei, 430072 China
Wuhan University Shenzhen Research Institute, Shenzhen, Guangdong, 518000 China
E-mail: [email protected]; [email protected]Search for more papers by this authorComprehensive Summary
Atherosclerosis is a lipoprotein-driven disease. In-depth understanding of pathology and accurate identification are particularly important in clinical assessment and treatment due to the irreversibility of atherosclerotic plaque formation. Atherosclerosis is not only accompanied by lipid droplets accumulation but also closely related to inflammation, which is accompanied by excessive reactive oxygen species (ROS) and changes in microenvironment. However, there is still a lack of a simple and rapid detection platform to simultaneously evaluate multiple indicators of atherosclerosis in multiple channels. In this study, we propose a multicolor imaging probe Cy7P-B for polarity, H2O2 and lipid droplets to evaluate atherosclerotic plaques in vivo. Cy7P-B is sensitive to environmental polarity and can monitor polarity changes by near-infrared ratio. Moreover, Cy7P-B has H2O2/lipid droplets dual-analyte sequential activation characteristics. Based on the multifunctional properties of Cy7P-B, the classical biomarkers of atherosclerotic plaque, lipid accumulation and up-regulation of oxidative stress are effectively detected in atherosclerotic plaques, and more importantly, the change of aortic polarity in atherosclerosis was detected for the first time. This work provides a general molecular design approach for multi-species imaging of AS, which is helpful for effective cardiovascular disease stewardship.
Supporting Information
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Appendix S1: Supporting Information |
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