• Issue

    Hepatology: Volume 66, Issue 3

    683-1013
    September 2017
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Issue Information

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Masthead

  • First Published: 24 August 2017
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Table of contents

  • First Published: 24 August 2017

Hepatology Highlights

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Hepatology Highlights

Robert E. Schwartz,  Jennifer Batisti,  Robert S. Brown Jr.,  Zaid Tafesh,  Nicole Shen,  Nicholas Russo,  Russell Rosenblatt,  Emily Schonfeld,  Shirley Cohen-Mekelburg,  Vikas Gupta, 
  • Pages: 683-685
  • First Published: 24 August 2017

Message from the President

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Society Leadership and Diversity: Hail to the Women!

Anna Lok M.D., DS.c., FAASLD, AGAF (AASLD President),  Carol A. Burke M.D., FACG, FASGE, AGAF, FACP (ACG President),  Sheila E. Crowe M.D., FRCPC, FACP, FACG, AGAF (AGA President),  Karen L. Woods M.D., FASGE (ASGE President), 
  • Pages: 686-690
  • First Published: 15 August 2017

Editorials

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Toward novel immunocompetent animal models for hepatitis B virus infection

Laurent Mailly Ph.D.,  Mirjam B. Zeisel Pharm.D., Ph.D.,  Thomas F. Baumert M.D., 
  • Pages: 691-693
  • First Published: 03 May 2017
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Why is the female population more susceptible to cholestasis-induced liver injury—Could it be long noncoding RNA H19?

Grace L. Guo M.B.B.S., Ph.D., 
  • Pages: 694-696
  • First Published: 15 May 2017
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Statins in cirrhosis—Ready for prime time

Emmanuel A. Tsochatzis M.D., Ph.D.,  Jaime Bosch M.D., Ph.D., 
  • Pages: 697-699
  • First Published: 22 May 2017
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SIRT3 as a regulator of hepatic autophagy

Chun-Seok Cho Ph.D.,  David B. Lombard M.D., Ph.D.,  Jun Hee Lee Ph.D., 
  • Pages: 700-702
  • First Published: 18 May 2017

Original Articles

VIRAL HEPATITIS

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Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

Florian A. Lempp,  Ellen Wiedtke,  Bingqian Qu,  Pierre Roques,  Isabelle Chemin,  Florian W. R. Vondran,  Roger Le Grand,  Dirk Grimm,  Stephan Urban, 
  • Pages: 703-716
  • First Published: 13 February 2017
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Human embryonic stem cell–derived hepatoblasts are an optimal lineage stage for hepatitis C virus infection

Fang Yan,  Yi Wang,  Wencheng Zhang,  Mingyang Chang,  Zhiying He,  Jinbo Xu,  Changzhen Shang,  Tao Chen,  Jiang Liu,  Xin Wang,  Xuetao Pei,  Yunfang Wang, 
  • Pages: 717-735
  • First Published: 25 February 2017
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Elbasvir/Grazoprevir for Patients With Hepatitis C Virus Infection and Inherited Blood Disorders: A Phase III Study

Christophe Hézode,  Massimo Colombo,  Marc Bourlière,  Ulrich Spengler,  Ziv Ben-Ari,  Simone I. Strasser,  William M. Lee,  Leslie Morgan,  Jingjun Qiu,  Peggy Hwang,  Michael Robertson,  Bach-Yen Nguyen,  Eliav Barr,  Janice Wahl,  Barbara Haber,  Robert Chase,  Rohit Talwani,  Vito Di Marco,  on behalf of the C-EDGE IBLD Study Investigators , 
  • Pages: 736-745
  • First Published: 03 March 2017
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Hepatitis C virus–induced CCL5 secretion from macrophages activates hepatic stellate cells

Reina Sasaki,  Pradip B. Devhare,  Robert Steele,  Ranjit Ray,  Ratna B. Ray, 
  • Pages: 746-757
  • First Published: 20 March 2017
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Ginsenoside Rg3 restores hepatitis C virus–induced aberrant mitochondrial dynamics and inhibits virus propagation

Seong-Jun Kim,  Jae Young Jang,  Eun-Jung Kim,  Eun Kyung Cho,  Dae-Gyun Ahn,  Chonsaeng Kim,  Han Seul Park,  Soung Won Jeong,  Sae Hwan Lee,  Sang Gyune Kim,  Young Seok Kim,  Hong Soo Kim,  Boo Sung Kim,  Jihyung Lee,  Aleem Siddiqui, 
  • Pages: 758-771
  • First Published: 22 March 2017
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Monotherapy with tenofovir disoproxil fumarate for multiple drug-resistant chronic hepatitis B: 3-year trial

Young-Suk Lim,  Yung Sang Lee,  Geum-Youn Gwak,  Kwan Soo Byun,  Yoon Jun Kim,  Jonggi Choi,  Jihyun An,  Han Chu Lee,  Byung Chul Yoo,  So Young Kwon, 
  • Pages: 772-783
  • First Published: 30 March 2017
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Hepatitis C viral load, genotype, and increased risk of developing end-stage renal disease: REVEAL-HCV study

Tai-Shuan Lai,  Mei-Hsuan Lee,  Hwai-I Yang,  San-Lin You,  Sheng-Nan Lu,  Li-Yu Wang,  Yong Yuan,  Gilbert L'Italien,  Kuo-Liong Chien,  Chien-Jen Chen,  for the REVEAL-HCV Study Group , 
  • Pages: 784-793
  • First Published: 02 April 2017

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis

Biljana Atanasovska,  Sander S. Rensen,  Marijke R. van der Sijde,  Glenn Marsman,  Vinod Kumar,  Iris Jonkers,  Sebo Withoff,  Ronit Shiri-Sverdlov,  Jan Willem M. Greve,  Klaas Nico Faber,  Han Moshage,  Cisca Wijmenga,  Bart van de Sluis,  Marten H. Hofker,  Jingyuan Fu, 
  • Pages: 794-808
  • First Published: 10 January 2017
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SIRT1/HSF1/HSP pathway is essential for exenatide-alleviated, lipid-induced hepatic endoplasmic reticulum stress

Xiaobin Zheng,  Fen Xu,  Hua Liang,  Huanyi Cao,  Mengyin Cai,  Wen Xu,  Jianping Weng, 
  • Pages: 809-824
  • First Published: 25 April 2017
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How healthy are the “Healthy volunteers”? Penetrance of NAFLD in the biomedical research volunteer pool

Varun Takyar,  Anand Nath,  Andrea Beri,  Ahmed M. Gharib,  Yaron Rotman, 
  • Pages: 825-833
  • First Published: 03 May 2017
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The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance

Quan-Yu Zhang,  Ling-Ping Zhao,  Xiao-Xiang Tian,  Cheng-Hui Yan,  Yang Li,  Yan-Xia Liu,  Pi-Xiao Wang,  Xiao-Jing Zhang,  Ya-Ling Han, 
  • Pages: 834-854
  • First Published: 15 May 2017

HEPATOBILIARY MALIGNANCIES

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Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

Jae-Kyung Won,  Su Jong Yu,  Chae Young Hwang,  Sung-Hwan Cho,  Sang-Min Park,  Kwangsoo Kim,  Won-Mook Choi,  Hyeki Cho,  Eun Ju Cho,  Jeong-Hoon Lee,  Kyung Bun Lee,  Yoon Jun Kim,  Kyung-Suk Suh,  Ja-June Jang,  Chung Yong Kim,  Jung-Hwan Yoon,  Kwang-Hyun Cho, 
  • Pages: 855-868
  • First Published: 25 April 2017

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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The role of long noncoding RNA H19 in gender disparity of cholestatic liver injury in multidrug resistance 2 gene knockout mice

Xiaojiaoyang Li,  Runping Liu,  Jing Yang,  Lixin Sun,  Luyong Zhang,  Zhenzhou Jiang,  Puneet Puri,  Emily C. Gurley,  Guanhua Lai,  Yuping Tang,  Zhiming Huang,  William M. Pandak,  Phillip B. Hylemon,  Huiping Zhou, 
  • Pages: 869-884
  • First Published: 08 March 2017
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Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics

Toshihiro Tanaka,  Weici Zhang,  Ying Sun,  Zongwen Shuai,  Asiya Seema Chida,  Thomas P. Kenny,  Guo-Xiang Yang,  Ignacio Sanz,  Aftab Ansari,  Christopher L. Bowlus,  Gregory C. Ippolito,  Ross L. Coppel,  Kazuichi Okazaki,  Xiao-Song He,  Patrick S.C. Leung,  M. Eric Gershwin, 
  • Pages: 885-895
  • First Published: 03 May 2017

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Statins decrease the risk of decompensation in hepatitis B virus– and hepatitis C virus–related cirrhosis: A population-based study

Fu-Ming Chang,  Yen-Po Wang,  Hui-Chu Lang,  Chia-Fen Tsai,  Ming-Chih Hou,  Fa-Yauh Lee,  Ching-Liang Lu, 
  • Pages: 896-907
  • First Published: 20 March 2017

LIVER INJURY/REGENERATION

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PTEN Down-Regulation Promotes β-Oxidation to Fuel Hypertrophic Liver Growth After Hepatectomy in Mice

Ekaterina Kachaylo,  Christoph Tschuor,  Nicolas Calo,  Nathalie Borgeaud,  Udo Ungethüm,  Perparim Limani,  Anne-Christine Piguet,  Jean-Francois Dufour,  Michelangelo Foti,  Rolf Graf,  Pierre A. Clavien,  Bostjan Humar, 
  • Pages: 908-921
  • First Published: 24 April 2017
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Pentamidine blocks hepatotoxic injury in mice

Enpeng Zhao,  Ghulam Ilyas,  Francesca Cingolani,  Jae Ho Choi,  François Ravenelle,  Kathryn E. Tanaka,  Mark J. Czaja, 
  • Pages: 922-935
  • First Published: 03 May 2017

LIVER BIOLOGY/PATHOBIOLOGY

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Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity

Songtao Li,  Xiaobing Dou,  Hua Ning,  Qing Song,  Wei Wei,  Ximei Zhang,  Chen Shen,  Jiaxin Li,  Changhao Sun,  Zhenyuan Song, 
  • Pages: 936-952
  • First Published: 24 April 2017
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Pentraxin-3 modulates lipopolysaccharide-induced inflammatory response and attenuates liver injury

Luis Perea,  Mar Coll,  Lucia Sanjurjo,  Delia Blaya,  Adil El Taghdouini,  Daniel Rodrigo-Torres,  José Altamirano,  Isabel Graupera,  Beatriz Aguilar-Bravo,  Marta Llopis,  Julia Vallverdú,  Joan Caballeria,  Leo A. van Grunsven,  Maria-Rosa Sarrias,  Pere Ginès,  Pau Sancho-Bru, 
  • Pages: 953-968
  • First Published: 19 April 2017

Review

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Prevention and treatment of complications of selective internal radiation therapy: Expert guidance and systematic review

Bruno Sangro,  Diego Martínez-Urbistondo,  Lourens Bester,  Jose I. Bilbao,  Douglas M. Coldwell,  Patrick Flamen,  Andrew Kennedy,  Jens Ricke,  Ricky A. Sharma, 
  • Pages: 969-982
  • First Published: 13 April 2017

Hepatology Elsewhere

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Proapoptotic signaling induced by deletion of receptor-interacting kinase 1 and TNF receptor-associated factor 2 results in liver carcinogenesis

Petra Hirsova Ph.D.,  Maria Eugenia Guicciardi Ph.D.,  Gregory J. Gores M.D., 
  • Pages: 983-985
  • First Published: 18 May 2017

Clinical Observations in Hepatology

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Uncommon extrahepatic metastases from hepatocellular carcinoma

Luigia Florimonte,  Massimo Iavarone,  Massimo Castellani,  Mariagiulia Longo,  Francesco Pallotti,  Lorenzo Maffioli,  Eva Orunesu,  Riccardo Benti, 
  • Pages: 986-988
  • First Published: 10 March 2017
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Regression of hepatocellular adenomas and systemic inflammatory syndrome after cessation of estrogen therapy

Marie Sinclair,  Anthony Schelleman,  Daljean Sandhu,  Peter W. Angus, 
  • Pages: 989-991
  • First Published: 13 March 2017
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Unexpected viral relapses in hepatitis C virus–infected patients diagnosed with hepatocellular carcinoma during treatment with direct-acting antivirals

Alessandro Soria,  Massimiliano Fabbiani,  Giuseppe Lapadula,  Andrea Gori, 
  • Pages: 992-994
  • First Published: 30 March 2017
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Overt acute hepatitis B is more severe in female patients

Ming-Ling Chang,  Yun-Fan Liaw, 
  • Pages: 995-996
  • First Published: 02 April 2017

Correspondence

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Expansion and intensification of humoral autoimmune response in the transition from preclinical to full-blown primary biliary cholangitis

Alessandra Dellavance Ph.D.,  Maria L.G. Ferraz M.D., Ph.D.,  Eduardo L.R. Cançado M.D., Ph.D.,  Luís E.C. Andrade M.D., Ph.D., 
  • Page: 997
  • First Published: 16 May 2017
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Reply

Christophe Corpechot M.D.,  Géraldine Dahlqvist M.D.,  Olivier Chazouillères M.D.,  Catherine Johanet M.D., 
  • Page: 998
  • First Published: 16 May 2017
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Dual photon microscopy based quantitation of fibrosis-related parameters (q-FP) to model disease progression in steatohepatitis: Methodological issues

Saeid Safiri Ph.D,  Erfan Ayubi Ph.D., 
  • Pages: 998-999
  • First Published: 16 May 2017
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Reply

Yan Wang M.D., Ph.D.,  Arun J. Sanyal M.B.B.S., M.D., 
  • Pages: 999-1000
  • First Published: 16 May 2017
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Emphasis on harms of hepatocellular carcinoma surveillance: Just pretending innocence after taking advantage?

Zheng Wang M.D.,  Jun Han M.D.,  Han Zhang M.D.,  Meng-Chao Wu M.D.,  Tian Yang M.D., 
  • Pages: 1000-1001
  • First Published: 24 May 2017
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Unscheduled screening tests cannot be termed as surveillance

Xue-Jun Xu M.D.,  Huai-Zhi Wang M.D.,  Ping Bie M.D., 
  • Pages: 1001-1002
  • First Published: 24 May 2017
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Reply

Omair Atiq M.D.,  Jasmin Tiro Ph.D.,  Adam C. Yopp M.D.,  Adam Muffler M.D.,  Jorge A. Marrero M.D., M.S.,  Neehar D. Parikh M.D.,  Caitlin Murphy Ph.D.,  Katharine McCallister B.A.,  Amit G. Singal M.D., M.S., 
  • Pages: 1002-1003
  • First Published: 24 May 2017
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Optimal timing for hepatitis C antiviral therapy in the peritransplant period?

George Cholankeril M.D.,  Robert J. Wong M.D.,  Donghee Kim M.D., Ph.D.,  Aijaz Ahmed M.D., 
  • Page: 1004
  • First Published: 06 June 2017
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Reply

Jagpreet Chhatwal Ph.D.,  Sumeyye Samur Ph.D.,  Emily Bethea M.D.,  Raymond T. Chung M.D., 
  • Pages: 1005-1006
  • First Published: 06 June 2017
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Healthy controls in nonalcoholic fatty liver disease management: A biomedical research perspective

Saumya Pandey M.Sc., Ph.D., 
  • Pages: 1006-1007
  • First Published: 23 June 2017
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Reply

Varun Takyar M.D.,  Yaron Rotman M.D., M.Sc., 
  • Pages: 1007-1008
  • First Published: 23 June 2017
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Reliability and validity analyses are essential for questionnaire research

Hao Xing M.D.,  Lei Liang M.D.,  Zhen-Li Li M.D.,  Han Zhang M.D.,  Tian Yang M.D., 
  • Pages: 1008-1009
  • First Published: 30 May 2017
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Do we need vasoconstrictors up to 5 days after successful hemostasis by ligation of bleeding varices?

Gin-Ho Lo M.D., 
  • Page: 1009
  • First Published: 21 June 2017

Corrections

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Correction

  • Page: 1010
  • First Published: 01 August 2017

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Correction

  • Page: 1011
  • First Published: 31 July 2017

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Correction

  • Page: 1012
  • First Published: 31 July 2017

Issue Information

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Notices

  • Page: 1013
  • First Published: 24 August 2017
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Instructions to authors and Information for readers

  • First Published: 24 August 2017