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Well Connected through Amides
Efficient formation of amide bonds under mild conditions.
Linking molecular components through amide bonds is one of the most important reactions in research and the chemical industry. In the journal Angewandte Chemie, scientists have now introduced a new type of reaction for making amide bonds. Called an ASHA ligation, this reaction is fast, efficient, works under mild aqueous conditions, and is broadly applicable.
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January 27, 2021 |
Well Connected through Amides
Efficient formation of amide bonds under mild conditions (PDF) |
Chemoselective Amide-Forming Ligation Between Acylsilanes and Hydroxylamines Under Aqueous Conditions Rajavel Srinivasan, Tianjin University (China) |
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January 25, 2021 |
Fighting Cancer from a Chair
Platinum complex inhibits metastasis through conformational modulation of heparan sulfate (PDF) |
Conformational Modulation of Iduronic Acid-Containing Sulfated Glycosaminoglycans by a Polynuclear Platinum Compound and Implications for Development of Antimetastatic Platinum Drugs Susan J. Berners-Price, Griffith University (Australia) |
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January 22, 2021 |
Cargo Delivery by Polymers
Degradable sugar-based polymers may store and release useful molecular freight (PDF) |
Sugar-Based Polymers from D-Xylose: Living Cascade Polymerization, Tunable Degradation, and Small Molecule Release Tae-Lim Choi, Seoul National University (Rep. Korea) |
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January 18, 2021 |
Purely Organic Hole Transporter
Dopant-free, humidity-stable organic layers give perovskite solar cells 21% efficiency (PDF) |
A Coplanar π-Extended Quinoxaline Based Hole-Transporting Material Enabling over 21 % Efficiency for Dopant-Free Perovskite Solar Cells Yongzhen Wu, East China University of Science and Technology (China) |
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December 21, 2020 |
Inhibitor in a Tunnel
New method for the development of choline acetyltransferase inhibitors (PDF) |
In Situ Assembly of Choline Acetyltransferase Ligands by a Hydrothiolation Reaction Reveals Key Determinants for Inhibitor Design Fredrik Ekström, Swedish Defence Research Agency (Sweden) |
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December 18, 2020 |
Inverted Fluorescence
Discovery of chromophores that emit light in the ultraviolet region when excited with visible light (PDF) |
Discovery of Key TIPS-Naphthalene for Efficient Visible-to-UV Photon Upconversion under Sunlight and Room Light Nobuhiro Yanai, Kyushu University (Japan) |
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December 7, 2020 |
Useful “Fake” Peptides
Oligourea foldamers mimic peptides’ alpha-helices and effectively bind to drug targets (PDF) |
Structural Basis for α-Helix Mimicry and Inhibition of Protein–Protein Interactions with Oligourea Foldamers Gilles Guichard, CNRS, Université de Bordeaux (France) |
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November 24, 2020 |
Defined Blockade
Enzymatic photocaging for the study of gene regulation through DNA methylation (PDF) |
Engineered SAM Synthetases for Enzymatic Generation of AdoMet Analogues with Photocaging Groups and Reversible DNA Modification in Cascade Reactions Andrea Rentmeister, Universität Münster (Germany) |
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November 13, 2020 |
Anions Matter
Zinc-ion hybrid capacitors with ideal anions in the electrolyte show extra-long performance (PDF) |
Chunyi Zhi, City University of Hong Kong |
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November 2, 2020 |
Root Bacterium to Fight Alzheimer's
Rhizolutin dissociates β and tau aggregates (PDF) |
Rhizolutin, a Novel 7/10/6-Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease YoungSoo Kim, Yonsei University (Republic of Korea) |
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October 30, 2020 |
Well Oriented
Catalysts for isotactic polar polypropylenes (PDF) |
Expedient Synthetic Identification of a P-Stereogenic Ligand Motif for the Palladium-Catalyzed Preparation of Isotactic Polar Polypropylenes Kyoko Nozaki, The University of Tokyo (Japan) |
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October 27, 2020 |
Ultraheavy Precision Polymers
Controlled photoenzymatic RAFT polymerization of nonconjugated polymers (PDF) |
Achieving Ultrahigh Molecular Weights with Diverse Architectures for Unconjugated Monomers through Oxygen-Tolerant Photoenzymatic RAFT Polymerization Zesheng An, Jilin University (China) |
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October 13, 2020 |
Combination Therapy against Cancer
Synergistic anticancer therapy with two cell killer agent systems in one nanocapsule (PDF) |
Synergistic Anticancer Therapy by Ovalbumin Encapsulation-Enabled Tandem Reactive Oxygen Species Generation Katharina Landfester, Max-Planck-Institut für Polymerforschung (Germany) |
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October 9, 2020 |
Palladium Catalysts Can Do It
Direct coupling of aryl halides and alkyllithium compounds by palladium catalysis (PDF) |
Efficient Pd-Catalyzed Direct Coupling of Aryl Chlorides with Alkyllithium Reagents Viktoria H. Gessner, Ruhr-Universität Bochum (Germany) |
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September 14, 2020 |
On the Road to Conductors of the Future
Superconductivity in hydrogen sulfide (PDF) |
A Boosted Critical Temperature of 166 K in Superconducting D3S Synthesized from Elemental Sulfur and Hydrogen Vasily S. Minkov, Max-Planck-Institut für Chemie (Germany) |
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September 8, 2020 |
Cascades with Carbon Dioxide
Making substances out of CO2 (PDF) |
Organocatalytic Trapping of Elusive Carbon-Dioxide-Based Heterocycles by a Kinetically Controlled Cascade Process Arjan Willem Kleij, Institute of Chemical Research of Catalonia (Spain) |
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August 28, 2020 |
Structural Colors from Cellulose-Based Polymers
Self-assembly of responsive photonic biobased materials in liquid marbles (PDF) |
Responsive Photonic Liquid Marbles Manos Anyfantakis, Université du Luxembourg (Luxembourg) |
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August 27, 2020 |
Trapping of Acetylene
Separation of Trace Acetylene from Ethylene in Ultramicroporous Metal–Organic Frameworks (PDF) |
Efficient Trapping of Trace Acetylene from Ethylene in an Ultramicroporous Metal–Organic Framework: Synergistic Effect of High-Density Open Metal and Electronegative Sites Dan Zhao, National University of Singapore (Singapore) |
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July 8, 2020 |
Mirror Image Tumor Treatment
Checkpoint blockade by a D-peptide for cancer immunotherapy (PDF) |
A Novel D-Peptide Identified by Mirror-Image Phage Display Blocks TIGIT/PVR for Cancer Immunotherapy Yanfeng Gao, Sun Yat-Sen University (China) |
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July 1, 2020 |
Well Packed
Architecture is key: Biomolecule metal–organic hybrids with high bioactivity (PDF) |
Embedding Functional Biomacromolecules within Peptide-Directed Metal–Organic Framework (MOF) Nanoarchitectures Enables Activity Enhancement Gangfeng Ouyang, Sun Yat-Sen University (China) |
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June 23, 2020 |
Sweet or Sour Natural Gas
Polyimide membranes for the purification of natural gas (PDF) |
Molecularly Engineered 6FDA-Based Polyimide Membranes for Sour Natural Gas Separation William J. Koros, Georgia Institute of Technology (USA) |
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June 18, 2020 |
Two-Dimensional Carbon Networks
Graphdiyne as a Functional Lithium-Ion Storage Material (PDF) |
Tuning the Properties of Graphdiyne by Introducing Electron-Withdrawing/Donating Groups Changshui Huang, The Qingdao Institute of Bioenergy and BioprocessTechnology, Chinese Academy of Science (China) |
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June 17, 2020 |
Better Than Cyclodextrins
Molecular Containers for the Sequestration of Neurotransmitter Drugs in Water (PDF) |
Pillar[n]MaxQ: A New High Affinity Host Family for Sequestration in Water Lyle Isaacs, University of Maryland, College Park (USA) |
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June 4, 2020 |
Fluorescence Bioimaging
Stable and Functional Dyes for Near-Infrared Fluorescence Imaging of Living Subjects (PDF) |
Sterically Shielded Heptamethine Cyanine Dyes for Bioconjugation and High-Performance Near-Infrared Fluorescence Imaging Bradley D. Smith, University of Notre Dame (USA) |
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March 25, 2020 |
Staining Cycles with Black Holes
Ultrafast repeated staining and destaining of cell samples for tumor diagnostics (PDF) |
Ultra-fast Cycling for Multiplexed Cellular Fluorescence Imaging Ralph Weissleder, Massachusetts General Hospital (USA) |
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March 16, 2020 |
Cancer Diagnostics
Amplification and imaging of microRNA as a biomarker to detect tumor development (PDF) |
A Smart, Autocatalytic, DNAzyme Biocircuit for In Vivo, Amplified, MicroRNA Imaging Shao Q. Yao, National University of Singapore (Singapore) |
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March 13, 2020 |
One Drug, Three Action Modes
Chemotherapy and photodynamic therapy combined in a single drug to fight resistant cancers (PDF) |
A Multi-action and Multi-target RuII–PtIV Conjugate Combining Cancer-Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers Gilles Gasser, Université PSL, Chimie ParisTech (France) |
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March 6, 2020 |
Making Puffer Fish Toxin in a Flask
Total synthesis of tetrodotoxin (PDF) |
Total Synthesis of Tetrodotoxin Satoshi Yokoshima, Nagoya University (Japan) |
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January 30, 2020 |
Autonomous Microtrap for Pathogens
Self-propelled onion-like microvehicle can attract, trap, and destroy biological threats (PDF) |
Onion-like Multifunctional Microtrap Vehicles for Attraction–Trapping–Destruction of Biological Threats Joseph Wang, University of California, San Diego (USA) |
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01/2020 |
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A Renal-Clearable Macromolecular Reporter for Near-Infrared Fluorescence Imaging of Bladder Cancer Kanyi Pu, Nanyang Technological University (Singapore) |
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IssueVolume 97, Issue 7
