New 8th Edition - April 2021

In April 2021, to correspond with the publication of the eighth edition of Burger's Medicinal Chemistry, Drug Discovery and Development in print, the following new chapters were added online:

Methods in Drug Discovery and Discovering Lead Molecules   

Automated Synthesis 
Thierry Masquelin, Andreas Kaerner, Ryan J. Bernhardt, Jibo Wang, Christos A. Nicolaou 

Computational Chemistry Tools 
Rainer Metcalf, Kenyon Daniel, Wesley Brooks, Wayne Guida 

Cryo Electron Microscopy in Drug Discovery and Development: Opportunities and Challenges 
Yacob Gomez-Llorente, Chuan Hong, Giovanna Scapin 

Docking, Scoring and Virtual Screening in Drug Discovery 
Francesca Spyrakis, Aurijit Sarkar, Glen E. Kellogg 
 
Drug Discovery beyond the Rule of Five 
David A. DeGoey, Philip B. Cox 

Enzymes as Drug Targets 
Thomas D. Meek 
 
Fragment-Based Lead Discovery 
Roderick E. Hubbard 

Ion Channels as Therapeutic Drug Targets  
Maria L. Garcia, Gregory J. Kaczorowski 

Medicinal Chemical Biology 
Lyn H. Jones 

Recent Advances in Chemistry Technologies and Applications to Medicinal Chemistry 
Andrew R. Bogdan, Nathan J. Gesmundo, Matthew P. Webster, Ying Wang, Anil Vasudevan 

Structure-Based Drug Design for G Protein-Coupled Receptors 
Miles Congreve, John A. Christopher, Chris de Graaf

The Design and Application of Bioisosteres in Drug Design 
Nicholas Meanwell 

Drug Development   
 
A Brief Primer on Project Leadership, Project Management and Cross-Functional Teams 
Michael Myers 

Clinical Development - A Primer 
Siddharth Chachad 

Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery 
Ronald E. Dolle 

FDA-Approved Medicines 
Michael Kinch 

Health Outcomes Research 
Pat McCollam,  Julie Birt,  Theresa Hunter

Preparative Chromatography for Production 
Olivier Dapremont 

Quality Assurance  
Harjinder Brar, Jude Vethanayagam

Toxicology and Nonclinical Safety Assessment in Pharmaceutical Discovery and Development 
Vincent L. Reynolds,  Matthew M. Abernathy,  Ronee B. Baracani,  Javed A. Bhalli,  LaRonda Morford,  Meredith A. Steeves,  Wei Wang

Translational Pharmaceutics and Early Phase Clinical Development 
Shobha N. Bhattachar,  Jeffrey S. Tan,  Stephen Dion Stamatis,  Jon Hilden

Cardiovascular, Endocrine and Metabolic Diseases   
 
Recent Advances Toward New Small Molecule Therapies for Heart Failure  
David St. Jean, Justin Malinowski,  Antonio Romero
 
Sodium Glucose Co-Transporter Inhibitors for the Treatment of Diabetes  
Ana R. Jesus,  Bryce A. Harrison,  Timothy M. Dore

Therapeutic Strategies for the Treatment of Sickle Cell Disease 
Martin K. Safo,  Anfal Aljahdali,  James Burnett,  Donald J. Abraham,  Osheiza Abdulmalik

Treatments for Non-Alcoholic Steatohepatitis (NASH) 
Ralf Glatthar, Robert H. Arch 

Pulmonary, Bone, Immunology, Vitamins and Autocoid Therapeutic Agents   
 
Eicosanoid Pathway Modulators: Prostaglandins, Prostacyclins and Thromboxanes  
Liudmila L. Mazaleuskaya,  Emanuela Ricciotti

JAK Family Inhibitors for Autoimmune Diseases 
Robert M. Borzilleri,  Amy C. Hart,  Ryan Moslin,  John S. Tokarski,  Stephen T. Wrobleski

Cancer   
 
Angiogenesis Inhibitors 
Shi Lei 

Cancer Targets Involving the Ubiquitin Proteasome System 
Erika Araujo 

The Design and Development of Antibody-Drug Conjugates (ADCs) for the Treatment of Cancer 
L. Nathan Tumey 

Immuno-oncology 
Andrew Buesking, Patrick A. Mayes,  Andrew P. Combs 

Small-Molecule Effectors of DNA Repair Proteins: applications for development of cancer therapeutics and research  
Pratik Chheda,  Maria Spies, M. Ashley Spies 

Tumor Metabolism: Focused on Tumor Glycolysis, Progress and Prospects in Cancer Therapy 
Atul Kumar,  Mamta Singh,  Dolly Sharma,  Vinit Kumar,  Reshma Rani 

Anti-Infectives   
 
Antiinfective Case Histories 
Roland E. Dolle 

Bacterial Efflux Pumps and Their Inhibitors 
Helen I. Zgurskaya,  Valentin V. Rybenkov,  John K. Walker,  Jerry M. Parks

Confronting the COVID-19 Pandemic: December 2019 – May 2020 
Roland E. Dolle,  Donald J. Abraham,  Bryan Norman,  Michael Kinch

Current Status of Approaches to Eradicate HIV Infection 
Scott E. Wolkenberg,  Abdellatif El Marrouni,  Antonella Converso,  David M. Tellers,  Richard J. O. Barnard,  Tracy L. Diamond

The Gut Microbiome 
Cassandra Francella,  Jane A. Foster

Polymyxins as Antibacterials and Antibiotic Potentiators 
Mike Dawson, Troy Lister 

CNS Disorders   
 
The Blood-brain Barrier and CNS Drug Delivery 
William Banks