Recent Advances in Chemistry Technologies and Applications to Medicinal Chemistry
Methods in Drug Discovery and Discovering Lead Molecules
Andrew R. Bogdan,
Nathan J. Gesmundo,
Matthew P. Webster,
Ying Wang,
Anil Vasudevan,
Andrew R. Bogdan
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorNathan J. Gesmundo
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorMatthew P. Webster
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorYing Wang
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorAnil Vasudevan
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorAndrew R. Bogdan,
Nathan J. Gesmundo,
Matthew P. Webster,
Ying Wang,
Anil Vasudevan,
Andrew R. Bogdan
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorNathan J. Gesmundo
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorMatthew P. Webster
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorYing Wang
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorAnil Vasudevan
Discovery Platform Technologies, AbbVie Inc., North Chicago, IL, USA
Search for more papers by this authorFirst published: 28 April 2021
Abstract
Successful drug discovery is a team sport, wherein several disciplines contribute customized scholarship toward the common goal of delivering medications that can have a remarkable impact on patients' lives. In the realm of medicinal chemistry, there have been significant advances in molecular-/structure-based design, organic synthesis, and chemistry technologies, the interplay of all of which can have a significant impact on reducing cycle times, cost of goods, and improving the probability of technical success of drug discovery. This article covers the evolution and application of some of the newer chemistry technologies in medicinal chemistry.
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