Framework of individualized and computer-aided elective neck irradiation. Firstly, we proposed individual elective neck irradiation schemes for head and neck squamous cell carcinoma. based on the actual incidence of lymph nodes metastasis and the tumor characteristics. Secondly, we developed a publicly available online tool to facilitate the widespread clinical use of these schemes. By inputting the characteristics of the primary tumor and metastatic LNs on this online tool, elective irradiation schemes for the right and left sides of the neck were recommended and delineated based on a set of CT scans.

We provide a mechanism by which the tumor suppressor JUP interact with the HIF2α transcription factor in ccRCC cells. JUP downregulation is likely to trigger the aberrant upregulation of HIF2α stability and transactivity, which further exerts effects on tumorigenesis in ccRCC. These results have important implications in both the diagnosis and treatment of RCC.