In this review, we preliminarily looked into the various roles that the EMT-associated miRNAs play in the stem-like nature of malignant cells. Then we reviewed the interaction between drug resistance and EMT-associated miRNAs with elaborated signal pathways, especially the opposite roles in various cancer types. We finally arrived at a conclusion concerning the relationship between EMT, stemness and drug resistance and discussed the potential application of miRNA therapy for malignant tumors.

We aimed to explore whether other pathogenic variants for hereditary cancer genes are present in Lynch syndrome patients, to have a more comprehensive view of the genetic architecture for cancer risk. We found five families (6%) with at least two pathogenic variant in high- and/or moderate-risk-associated cancer genes. However, in most cases, no clinical manifestations associated with the secondary pathogenic variants were evidenced.

This study revealed that ISL1 modulates tumorigenesis and glycolysis in GC, wherein GLUT4 plays pivotal roles. Moreover, ISL1 and GLUT4 are predictive markers of a poor prognosis in patients with GC, which might hold therapeutic potential for this lethal malignancy.