The cover image is based on the Full Paper Metal–organic frameworks as catalysts for fructose conversion into 5-hydroxymethylfurfural: Catalyst screening and parametric study by Noor Aljammal et al., https://doi.org/10.1002/aoc.6419.

Palladium-catalysed Stille couplings has got greater attention owing to their applicability in the construction of heavily functionalised C–C adducts, which are significant in natural product synthesis and other related fields. Non-palladium Stille couplings are a better choice for organic synthesis since they are more cost-effective, less toxic, and some having superior catalytic efficiency compared with conventional techniques utilising Pd. In the present review, we focus on the developments in non-palladium Stille couplings until 2021.

Catalytic reactions are of great interest in the field of synthetic reactions as they save energy and produce only low amounts of side products which are harmless for environment. This review gives an overview of iron-catalyzed N-alkylation reactions.

The Ag/TiO₂/Fe₃O₄@MWCNTs MNCs as a high performance catalyst were employed for the preparation of a new family of substituted spiropyridine employing the one-pot condensation reactions of acetophenones, diethyloxalate, ammonium acetate, isatin, malononitrile, and electron-deficient acetylenic compounds in water at room temperature. Investigation of antioxidant and antimicrobial property of some synthesized compounds is another purpose in this research work.

M@B₄₀ (M = Na and Ca) introduced as promising carriers for melphalan (MP) drug. It strongly interacts with Metal@B₄₀ fullerenes in water phase. Remarkable solubility in the aqueous medium is observed for M@B₄₀-6MP systems. It is found that the release of the MP drug from the surface of the introduced carriers could be occurred in the vicinity of the cancer cells upon the protonation is feasible. To sum up, theses fullerenes might be innovative boron-based candidates as drug delivery systems.  

New non-platinum metal complexes derived from four Schiff bases whose structures contain combination of 3-fluorophenylazo, sulfonamide, and/or thiazole moieties are synthesized, characterized, and screened for their antimicrobial and anticancer activities. Interestingly, docking simulation predicted good propensity to bind with the breast cancer protein 3s7s in case of L⁴ and its complex. The antiproliferative action against three cancer cell lines demonstrated their high inhibition efficacy as candidates for newly antitumor agents.

An ion liquid magnetic nanocomposite catalyst containing a mineral acid was synthesized. It exhibited a mild, fast, cost-effective, and environmentally friendly procedure for a one-pot preparation of paracetamol and aspirin drugs.

A novel 1D Cd-MOC showed perfect performance for detecting p-nitrophenol, metronidazole, ornidazole, and dimethylimidazole. The limit of detection (LOD) of them are 0.04, 0.02, 0.07, and 0.08 μM, respectively. The synthesized complex can maintain high recyclability after 5 cycles of the test substance. In summary, due to the strong stability, high sensitivity, and excellent selectivity of the synthesized complex, it provides a convenient method for the development of an analytical platform for detecting water pollutants.

In this paper, we have prepared highly dispersible, recyclable, and reusable based on iron and carbon nanostructures (graphene/carbon nanotubes) with a simple process and analyzed by various analytical methods. These catalysts were magnetically active, so due to their magnetic iron oxide nanoparticles, carbon nanostructure, and palladium metal, they were a great potential application for catalysis. The response surface methodology with Box–Behnken design was used to determine a feasible experimental design to optimize the coupling conditions of the Suzuki–Miyaura reactions.

The present research work reports a novel, agro-waste-derived nanosilica-supported six-coordinated Cu(II) complex with Se–N–Se pincer ligand. This catalyst was screened in the oxidation of alcohols, and we found several advantages such as short reaction time, environmentally benign mild reaction conditions, good to excellent yields, and good stability. The catalyst could be easily separated from the reaction products and reused for at least five successive runs effectively.

Platinum group metals (PGMs) recovered from a spent catalytic converter were loaded into specially designed mesoporous silica by complexation with mercapto groups. The resulted material is a heterogeneous hydrosilylation and oxidation catalyst. The scrap cordierite after PGMs extraction finds use as crosslinking catalyst and filler for high permittivity silicone composites and in removal of organic pollutants from water.

The preparation of an organometallic compound in sustainable deep eutectic solvent (DES) has been performed for the first time, using, for that purpose, indium metal. The nucleophilic allylation reaction of carbonyl compounds showed a linear relationship with the density of DES.

MOF-based catalysts were used for the selective conversion of fructose to 5-HMF. Catalytic performance of each MOF is tested in a microwave-assisted reactor. Over sulfonated MIL-101 in DMSO, 5-HMF yield was 90%. Unsaturated metal node sites show strong relationship with catalyst superior performance. Sulfonated MIL-101 was reusable for at least three cycles without deactivation.

A novel porous metal–organic framework Cu-BCPPy with two dimensions of 2D channels constructed by multiple helixes has been synthesized. It exhibits good performance for effective selective adsorption of large carcinogenic dyes compared with small molecular dyes, and iodine adsorption and release.

The highly stable mesoporous metal-organic frameworks, PCN-222(M), which can reduce CO² to the useful chemicals, have been introduced. The as-prepared metal–organic frameworks (MOFs) represent a remarkable efficacious approach for the performance of the metalloporphyrin framework to CO² capture capability and photocatalytic activity. The presence of the metal center of porphyrins promotes CO² adsorption and activation.

Poly(glycidylmethacrylate)@polyaniline microsphere-supported CuO nanoparticles show remarkable potential for photocatalytic degradation under visible light irradiation. Preliminary kinetic studies confer a pseudo-first-order kinetics. Poly(glycidylmethacrylate)@polyaniline/CuO nanocomposite can be recycled with a minimal deposited CuO release over five cycles.

Multi-SO₃H functionalized ionic liquid was synthesized into the porous structure of MIL-100(Fe) by ship-in-bottle strategy. The prepared Brønsted acidic MOF was utilized as catalyst for alcoholysis of epoxides under solvent-free conditions. The simple recovery of the catalyst made it possible to use it for up to four successive cycles.

In this work, highly efficient two- and three-component routes were developed toward 3,4-dihydro-2H-1,3-benzoxazine monomers. For the first time, N-alkyl imidazole-based homonuclear coordination complex including zinc metal effectively catalyzes the formation of the benzoxazine ring system. This neutral organocatalyst exhibited high catalytic activity in the preparation of various substituted benzoxazines with high yields under milder reaction conditions.

A new series of scaffolds, triazabenzo[b]cyclopenta[lm]fluorenes, are synthesized using efficient NiFe₂O₄@SiO₂–SO₃H nanocatalyst. Ultrasonication allowed very high yield percentage in short reaction time.

Three new isomorphic metal complexes [Nd₂(L)₃·H₂O]_n, [Eu₂(L)₃·H₂O]_n, [Sm₂(L)₃·H₂O]_n(H2L = 1,1′(1,4-phenylene-bis [methylene])-bis (pyridine-3-carboxy- licaicd are novel structures and have favorable ability to induce apoptosis of HeLa cells. They will be used as potential cancer drugs in practical applications to meet the requirements of certain fields.

New copper levofloxacin complexes with 2-aminopyridine and 2,2′-bipyridine nitrogen-based ligands with the following molecular structures; [Cu (levo)₂(2-ampy)].6.25H₂O (1) and [Cu (levo)(H₂O)(2,2-bipy)](NO₃).2.5H₂O (2) were synthesized and characterized. The crystal structure of complexes 1 and 2 were determined. The complexes were also evaluated for their antibacterial activity using in vitro agar diffusion method against four gram-negative bacteria and four gram-positive bacteria. In addition, MIC and MBC of the two complexes, their parent ligands, and free levofloxacin were also determined against various bacterial strains.

α,α'-Bis (imino)-2,3:5,6-bis (pentamethylene)pyridylcobalt precatalysts polymerize ethylene for highly linear polymers with high molecular weights, illustrating the higher molecular weights from the steric hindrance of substituents.

Four novel transition metal MOFs (1–4) have been successfully synthesized with the mixed-ligand strategy based on a predesigned functional flexible benzimidazole tetracarboxylic acid ligand (H₄L) and different N-donor ancillary ligands. Of these, Complex 2 can sensitively and selectively detect Fe³⁺ in aqueous systems, and the possible sensing mechanism has been investigated using UV–vis spectroscopy, and Complexes 3 and 4 show strong antiferromagnetic and ferromagnetic coupling through M–O–C–O–M (Co for 3, Ni for 4) interactions, respectively.

Ni-ion doped Birnessite@Cryptomelane (Ni²⁺/B@Cr) hybrid structure was synthesized as a bifunctional efficient catalyst for Oxygen Evolution Reaction (OER) in neutral media and degradation of dye pollutants. New hybrid catalyst exhibited high catalytic activity for OER process and degradation of organic dye contaminants.

A green method is presented here for the synthesis of benzofuran derivatives from a reaction between alkynes, aldehyde, and amine using choline chloride-ethylene glycol deep eutectic solvent as green media and CuI as catalyst. The employed method includes easy workup, and 12 different benzofuran derivatives have been prepared in 7 h at 80°C in good yields.

A novel and well-characterized Cu–CA–MOF with a citric acid ligand was prepared. The Cu–CA–MOF has been applied as efficient catalyst in the Suzuki cross-coupling and oxidation of sulfides under mild conditions.

This work describes the synthesis of a tetranuclear palladium(II) complex from the ligand, 6-methyl-2-oxo-1,2-dihydroquinoline-3-carboxaldehyde-4(N)-phenylthiosemicarbazone and its application in Suzuki–Miyaura coupling reaction. When N-heterocyclic chlorides were taken as substrates, the reactions ended up in the formation of C-alkoxy products instead of the more expected C-arylated products.

Imidazole-modified chloromethylated polystyrene anchored vanadium complexes Ps-Im-[V^IVO(^tertacac)₂] (4), Ps-Im-[V^VO₂(dipd)₂] (5), and Ps-Im-[V^IVO(phbd)₂] (6) were prepared in a straightforward way. All the catalysts are effective and efficient towards a series of straight-chain primary aliphatic alcohols. High reactivity, green oxidant, uncomplicated synthesis, easy recovery, recyclability, broad substrate scope, and moderate reaction conditions are the main advantages of these catalysts.

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The novel ferrocenyl-based porphyrins were synthesized. The synthesized materials were characterized with required analyses. Optoelectronic behaviors of the synthesized compounds were investigated by CV and UV–vis spectroscopy.

Eight novel nanosized heteroleptic complexes of cocaine/TMEDA were synthesized and structurally characterized via different spectral and analytical tools. DFT and TD-DFT calculations were conducted to investigate geometry optimization, electronic structure, and molecular electrostatic potential maps. The antiproliferative activity of the prepared complexes on the HepG-2 and MCF-7 cancer cell lines was studied. Further molecular mechanistic studies were performed on the Cd(II) complex to investigate its influence on the different processes related to cancer pathophysiology in the MCF-7 cell line.

An efficient green protocol for the synthesis of the functionalised chromen-dihydropyridines employing a multicomponent one-pot condensation reaction of chromene-3-carbaldehyde, dimethyl acetylenedicarboxylate, malononitrile and different aromatic and heteroaryl amines was designed using a TiO₂/HAp as heterogeneous catalyst in the eco-compatible solvent. The yield was up to 97%, and the catalyst is economical, fully recyclable and reusable for over five runs while preserving its high activity.

Schiff base Cu (II) complex was synthesized and characterized by X-ray crystallography. Intermolecular interactions in the solid states were studied by Hirshfeld surface analysis. The molecular electrostatic potential map is survey for better understanding the sites active in electrophilic as well as nucleophilic reactions. Optimized structures as well as Fourier transform infrared spectroscopy (FT-IR) and UV–Vis spectra were studied by density functional theory (DFT) calculations. Ligand and Cu (II) complex showed significant anticancer activities against SW480 cell lines by the MTT assay. Docking calculations of these complexes were performed.

Ultrasmall palladium nanoparticles stabilized by polyimide nanofibers were readily prepared by electrospinning and thermal imidization. These composite nanofibers possessed superior thermal property and chemical resistance as well as mechanical properties. Moreover, the palladium nanoparticles inside the nanofibers exhibited excellent catalytic activity and stability for the Heck and Suzuki coupling reactions. Due to fibrous structure, these composite nanofibers could be easily separated from the reaction mixture and reused for 10 times.

Two sterically varied nickel NHC complexes wherein one is a mono-NHC and the other is a bis-NHC have been prepared and compared as electrocatalysts for glucose sensing applications. It was found that the mono-NHC nickel(II) complex exhibited superior glucose sensing activity. The addition of mesoporous carbon to the complexes was found to enhance the glucose sensing performance of the complexes with increased sensitivity, increased linear range and decreased limit of detection.

Chlorosilyl and boryl containing alkenylsilanes and N-trimethylsilylpyrazole and (N-trimethylsilyl)pyridine-2-amin serve as better candidates for the development of CSiNNB and C₂SiNNB heterocycles. The 1,2-hydroboration reaction is a key to the synthesis of this type of heterocycles.

The complex (2) shows very highly significance against S. aureus than free ligands. Also, the figure shows the octahedral structure of complex (1) by using DFT calculations.

Two new non-centrosymmetric biferrocenyl Schiff bases have been synthesized and studied by density functional theory to understand their nonlinear optical behavior. The synthesized compounds were characterized by FTIR and NMR. DNA binding potential of the derivatives was evaluated through UV–visible spectroscopy, cyclic voltammetry, and molecular docking. Results indicate that the substituted biferrocenyl Schiff bases show a substantial increase in first-order hyperpolarizability (44) times greater than the reference urea) attributed to intramolecular charge transfer.