Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4-phenylene-bis [methylene])-bis (pyridine-3-carboxylicaicd): Synthesis, structural characterization, and antitumor activity
Gongchi Liu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Data curation (lead), Investigation (lead), Methodology (lead)
Search for more papers by this authorShuangyan Wu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Resources (lead), Supervision (lead)
Search for more papers by this authorWei Liu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Software (equal)
Search for more papers by this authorGuoxu Gao
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Software (equal)
Search for more papers by this authorYing Zhang
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Resources (lead)
Search for more papers by this authorEnjun Gao
School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, China
Contribution: Funding acquisition (lead), Resources (lead)
Search for more papers by this authorCorresponding Author
Mingchang Zhu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Key Laboratory of Resource Chemical Technology and Materials, (Ministry of Education), Shenyang University Chemical Technology, Shenyang, China
Correspondence
Mingchang Zhu, International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
Email: [email protected]
Contribution: Funding acquisition (lead), Resources (lead)
Search for more papers by this authorGongchi Liu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Data curation (lead), Investigation (lead), Methodology (lead)
Search for more papers by this authorShuangyan Wu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Resources (lead), Supervision (lead)
Search for more papers by this authorWei Liu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Software (equal)
Search for more papers by this authorGuoxu Gao
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Software (equal)
Search for more papers by this authorYing Zhang
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Contribution: Resources (lead)
Search for more papers by this authorEnjun Gao
School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, China
Contribution: Funding acquisition (lead), Resources (lead)
Search for more papers by this authorCorresponding Author
Mingchang Zhu
International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, China
Key Laboratory of Resource Chemical Technology and Materials, (Ministry of Education), Shenyang University Chemical Technology, Shenyang, China
Correspondence
Mingchang Zhu, International Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, 110142, China.
Email: [email protected]
Contribution: Funding acquisition (lead), Resources (lead)
Search for more papers by this authorFunding information: the Natural Science Foundation of China, Grant/Award Number: No. U1608224 and 21171118; the Department of Education Project of Liaoning Province, Grant/Award Number: LQ2020005; the Department of Education Basic Research Project of Liaoning Province, Grant/Award Number: LJ2019010; the Distinguished Professor Project of Liaoning province, Liaoning Revitalization Talents Program, Grant/Award Number: XLYC1907047
Abstract
In this work, three new complexes [Ln2(L)3·H2O]n (where Ln = Nd(1)、Eu (2) and Sm (3)) have been synthesized by H2L (H2L = 1,1 ‘(1,4-phenylene- bis [methylene])-bis (pyridine-3-carboxylicaicd)) and were characterized by X-ray single crystal diffraction and PXRD. The interaction of these complexes with FS DNA (fish sperm DNA) and the DNA binding constants of the complexes were determined using UV spectroscopy, indicating their ability to bind to FS DNA. The DNA binding constants k of the three complexes were 1.0186 × 104, 5.047 × 103, and 5.115 × 103, respectively. The results of UV spectrum showed that the complex 1–3 was bound to DNA through hydrogen bonding. The interaction of the complexes with FS DNA was studied by fluorescence spectroscopy. The stern-volmer quenching values of complexes 1, 2, and 3 were 0.186, 0.093, and 0.114, respectively. Electrophoresis experiments showed that the three complexes could cleave DNA molecules. In addition, flow cytometry, and morphological apoptosis studies showed that the complex could induce apoptosis of HeLa tumor cells. Results all the three complexes had potential medicinal value.
Open Research
DATA AVAILABILITY STATEMENT
The data that supports the findings of this study are available in the supplementary material of this article.
Supporting Information
| Filename | Description |
|---|---|
| aoc6427-sup-0001-Supplementary Meterial.docxWord 2007 document , 229.3 KB |
Figure S3. (a-c) Powder X-ray diffraction patterns of Complex1–3 Table S2. Selected bond lengths (Å) of the complexes 1–3 Table S3. Selected bond angles (°) of the complexes 1–3 Table S4. Selected hydrogen-bond geometry for complexes 1–3. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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