Notice to Authors

Angewandte Chemie (version 07/25)

Quick Checklist: Submission

i.

Select your article type and prepare your manuscript, in English, in the associated Microsoft Word article template (length from the abstract to the conclusion, inclusive):

Communications (typically 2500 words),

Research Articles (typically 5000 words),

Reviews (max. 12000 words; submit a Review Proposal),

Minireviews (max. 5000 words; submit a Review Proposal),

Scientific Perspectives (typically 5000 words),

Viewpoint Articles (typically 3000 words),

Highlights (max. 600 words, or 4500 characters),

Note

that a general purpose LaTeX template is also provided.

ii.

Include all text, Schemes, Figures, Tables, and the Table of Contents text and image at the appropriate position (not separately) in a single manuscript file (a Word file prepared in one of our templates is preferred). Each Scheme and Figure should be embedded as a single image (see Section 3.3). Embed all chemical structures in a ChemDraw format (.cdx, ChemDraw template) and all other images as high-resolution (300 dpi) .jpeg, .tif, .png, or similar in the manuscript text file. Check that your Word file saves with high fidelity (File > Options > Advanced > Image Size and Quality > Default resolution: High fidelity; image compression must be turned off).

iii.

Include Supporting Information (where applicable) as a separate PDF file and media and data files as appropriate. See Section 3 for details.

iv.

Upload the manuscript file as a Word file (.doc, .docx) and Supporting Information (where applicable; as a PDF) as separate files through the "Manuscripts for Production" menu on your personal homepage in Editorial Manager. The Word file (.doc, .docx) is used for preparation of the proof and the EarlyView article (see Section 4). Please provide short and informative descriptions with each uploaded Supporting Information file; e.g., "Spreadsheet for data in Figure 1". After uploading these files, the next opportunity to make changes will be when you receive the proofs for correction.

v.

Include a short cover letter in which the relevance and importance of the work are succinctly outlined. The cover letter should be addressed to Dr. Nathalie Weickgenannt and Dr. Frank Maaß as the Editors-in-Chief of the journal.

vi.

Include your suggestions for impartial reviewers to assess your manuscript and note those with whom you have a conflict of interest.

vii.

Inform us if you have a related paper in submission/peer review/publishing elsewhere.

viii.

Inform us if the manuscript has previously been submitted to another Wiley journal and/or if you have a related paper in submission/peer review/publishing elsewhere.

ix.

Inform us of any corresponding preprint(s) posted.

x.

Inform us if the manuscript has been professionally edited by a service such as Wiley Editing Services.

xi.

If relevant, upload a Data Reporting Checklist that aligns with the subject matter of the manuscript.

Quick Checklist: Manuscript Contents

i.

Abstract (max. 200 words).

ii.

Supporting Information, including the Experimental Section and characterization data (see Sections 3.2 and 3.4).

iii.

Table of Contents graphic with an accompanying text up to 50 words (max. 450 characters with spaces) and an appropriate image (5.5×5.0 cm (max. width × height) or 11.5×2.5 cm (max. width × height), min. font size: 6–7 points); see Sections 3.3, Section 5.6, and the Graphics Guidelines).

iv.

Keywords in alphabetical order including at least two from the core keyword list (see Section 3.6).

v.

Declaration of approval for animal, human, or tissue experiments in the Editorial Manager submission form AND in the Experimental Section of the manuscript/Supporting Information (see Section 5.1.2).

vi.

For Reviews and Minireviews: a frontispiece image (18.5×18.5 cm; Graphics Guidelines), biographies (70–100 words; max. 560 characters with spaces), and passport-style photographs of the authors.

vii.

For Scientific Perspectives and Viewpoint Articles: Biographies (70–100 words; max. 560 characters with spaces) and passport-style photographs of the corresponding authors may be submitted.

Optional

i.

Suggest a cover image (16.5×16.5 cm) without a white background, which adheres to Section 5.6 and the Graphics Guidelines.

About the Journal

Angewandte Chemie International Edition (in English) and Angewandte Chemie (in German) are owned by Gesellschaft Deutscher Chemiker (GDCh; the German Chemical Society) and are published by Wiley-VCH.

"Angewandte Chemie" is synonymous with leading chemical research across all fields of chemistry and adjacent disciplines. Angewandte Chemie International Edition and Angewandte Chemie publish 52 issues in print and online (in the Wiley Online Library) per year and all articles are available online weeks before they appear in an issue.

Angewandte Chemie International Edition and Angewandte Chemie publish: Communications, Research Articles, Reviews, Minireviews, Scientific Perspectives, Viewpoint Articles, and Highlights.

Authors are requested to submit their manuscripts through our online submission service, Editorial Manager; please note that ORCID registration and authentication is required for submission of the manuscript, and the submitting author must be a corresponding author. The submitting author can follow the progress of the manuscript on their personal homepage (Editorial Manager), which is created upon initial registration. Submissions to the journal should be in British or American English.

All articles are published in English in the German edition of Angewandte Chemie; however, authors who are fluent in German may also supply a translation of their manuscript. The main correspondence author will receive page proofs (in English and, if applicable, in German). After the article has been published in an issue, authors can share a read-only version of their article for free using the Wiley Article Share service. For more information on sharing published articles, please refer to the Article Sharing Policy. Please see the Copyright Transfer Agreement for terms of use of the Final Published Version. In addition, reprints and high-resolution PDFs can be ordered for a reasonable price, and ideally when submitting the galley proof corrections.

To make sure that references to these journals are correctly recorded and resolved (e.g., in CrossRef, PubMed, or ISI Web of Knowledge), please use the following abbreviated title in any citations: Angewandte Chemie International Edition is "Angew. Chem. Int. Ed."

Please cite the International Edition only; e.g.:

[1] A. Author, B. Smith, C. Brown, “Total Synthesis of …” Angew. Chem. Int. Ed. 2022, 61, e202116340.

[2] A. Author, B. Smith, C. Brown, “Total Synthesis of …” Angew. Chem. Int. Ed. 2019, 58, 14–20.

We recommend that authors provide a link to their publication on their homepage through the Digital Object Identifier (DOI).

Queries regarding manuscripts should be sent to [email protected].

1. Editorial Policies

1.1. Submission Considerations

Angewandte Chemie will consider submitted papers that have been previously 1) posted as a preprint on a community-trusted, subject-based preprint server such as ChemRxiv, bioRxiv, and arXiv (see the preprint guidelines). Or 2) published as a thesis prepared toward completion of a graduate degree at a university or technical institute of learning. Only the original submitted version of a manuscript is allowed to be posted as a preprint. Manuscripts previously published in other contexts will not be considered, at the discretion of the editor.

The authors must inform the Editor of manuscripts submitted, soon to be submitted, in press or published at other journals or posted on any preprint server, that have a bearing on the manuscript being submitted to Angewandte Chemie.

In the case of preprints, journals require that the material is not communicated with the media prior to publication of the paper.

If the manuscript is a revised or extended version of a manuscript previously rejected by Angewandte Chemie, the author must inform the editor about the previous submission in the cover letter and explain in detail which changes have been made. The journal may examine the prior history of manuscripts submitted to, but not accepted in, other Wiley-VCH journals, including Chemistry and Materials journals. The prior history of a manuscript can include reviewer reports obtained during prior peer review at another Wiley-VCH journal and, depending on the circumstances, the editor may take such reports into consideration (e.g., to ensure that an author has carried out relevant revisions). To facilitate administration and evaluation, authors are encouraged to disclose such prior submissions in their cover letter and to address any reviewer comments, when applicable. Submissions to Angewandte Chemie may not be under evaluation at any other journal at the time of submission.

The contributions of each author should be specified as "Contributor Roles" when all other information on the author is entered into Editorial Manager. Authors are encouraged to use Contributor Roles Taxonomy (CRediT) to define their contributions to a paper by allocating one (or more) of 14 possible roles to each author. CRediT is accessible during submission of a manuscript via the Editorial Manager submission system under "Contributor Roles” (further instructions are provided in the Editorial Manager submission system); Contributor Roles appear in the online article as a pop-up when clicking on the name of the author. Every author must be informed about the submission and must have agreed to the submitted version. Honorary authorship is forbidden.

Pending Patent Filings and Media Embargoes: On submission of a manuscript, authors confirm that any patent filings related to the content are complete and there are no media or other embargoes. Wiley will proceed with publication of accepted articles without delay or liability related to pending patent filings or embargoes. This policy applies even if any representative of Wiley, including employees or contractors, provides alternative guidance to the author.

Artificial Intelligence Generated Content tools—such as ChatGPT and others based on large language models—cannot be considered capable of initiating an original piece of research without direction by human authors. They also cannot be accountable for a published work or for research design, which is a generally held requirement of authorship, nor do they have legal standing or the ability to hold or assign copyright. Therefore—in accordance with Wiley′s Best Practice Guidelines on Research Integrity and Publishing Ethics and COPE′s position statement on AI tools—these tools cannot fulfill the role of, nor be listed as, an author of an article. If an author has used this kind of tool to develop any portion of a manuscript, its use must be described, transparently and in detail, in the Methods or Acknowledgements section (tools that are used to improve spelling, grammar, and general editing are exempted). The author is fully responsible for the accuracy of any information provided by the tool and for correctly referencing any supporting work on which that information depends. The final decision about whether use of an Artificial Intelligence Generated Content tool is appropriate or permissible in the circumstances of a submitted manuscript or a published article lies with the journal′s editor or other party responsible for the publication′s editorial policy. While use of AI-generated text is subject to further evaluation and approval, use of images generated by AI platforms is prohibited according to company guidelines (e.g., DALL-E, Midjourney, Craiyon, and Stability/Stable Diffusion). See the Graphics Guidelines.

For detailed advice about the Legal and Ethical Responsibilities of authors, including ethical declarations relating to human and animal experiments, conflict of interest, and copyright, see Section 5, the Graphics Guidelines, and the ethical guidelines.

1.2. Editorial Evaluation, Peer Review, and Manuscript Transfer

Submissions are evaluated by professional editors and, those manuscripts deemed suitable for the journal in terms of scope, quality, and novelty, are subject to peer review. Contributions that are not considered suitable for the journal are returned to the author(s) without external review; the editor may recommend transferal to an appropriate sister journal simultaneously. When a manuscript is sent for external review, the editor will avoid any known conflict of interest. Reviewers suggested by the author(s) may or may not be invited, at the editor′s discretion; the editor will exclude named opposed reviewers, subject to the ethical guidelines. The editorial assessment of submitted manuscripts will be handled by editors unaffiliated with the author or institution, and monitored carefully to ensure there is no peer review bias. Angewandte Chemie operates a strict single-anonymous peer-review process. After peer review, a decision of accept, reject, or revision is made on the basis of the reviewers′ comments and the judgment of the editor. Revised manuscripts are evaluated by the editor and, if required, by reviewers. In case of ambiguity, a board member or a top adjudicative reviewer is consulted for advice. All invited and transferred manuscripts, as well as contributions by the journal′s International Advisory Board and Scientific Advisory Committee members, undergo the same peer-review process (as outlined above) as unsolicited manuscripts. The final decision to accept or reject a manuscript rests with the editor. For information on how to appeal an editorial decision, see the journal′s Appeals Policy.

Angewandte Chemie participates in Wiley′s Refer & Transfer program. If your manuscript is not accepted, you may receive a recommendation to transfer your manuscript to another suitable Wiley journal, either through a referral from the journal′s editor or through our Transfer Desk Assistant. If authors choose to pursue this option, their manuscript along with the reviewer reports is transferred to the receiving journal to expedite any further evaluation and the editor′s decision. The primary objective of this collaboration is to reduce the incidence of redundant reviews, thus lessening the burden on the already overstretched community of reviewers. For further information about the transfer system, visit the Manuscript Transfer Guidelines.

To aid transparency during the peer-review process, reviewers may access reports associated with a manuscript they have peer reviewed by logging onto the journal′s Editorial Manager manuscript submission site and viewing the reviewer comments under their completed assignments. Reviewers also have the option to view their own reviewing history. Reports are presented anonymously to protect the identity of all reviewers. Reviewers can record reviewing activities as they submit their report through Editorial Manager (i.e., not retroactively). This function links up to ORCID, provider of persistent digital identifiers for researchers, and Web of Science Researcher Profiles, a commercial peer-review tracker. Both sites log peer-review activity at specific journals in the form of an authenticated, anonymized list that can be included in a researcher′s résumé.

1.3. Links to Policy Documents

The editorial office maintains policies on a range of publishing matters. For a list of up-to-date guidelines please browse this Notice to Authors and explore content in the following list.

i.

Ethical Guidelines

ii.

Graphics Guidelines

iii.

Manuscript Transfer Guidelines

iv.

Preprint Guidelines

v.

Reviewer Guidelines

vi.

Data Reporting Checklists

2. Article Types

Angewandte Chemie publishes the following article types: Communications, Research Articles, Reviews, Minireviews, Scientific Perspectives, Viewpoint Articles, Highlights, Correspondences, and Corrigenda. Please note that all article types are screened in-house for inappropriate content before external peer review, such as that which contravenes the journal′s commitment to diversity, equity, and inclusivity (e.g., discriminatory content; see Section 5.7 "Unbiased Language").

For detailed information on Manuscript Preparation see Section 3.

All templates are compiled under "Author Guidelines" on the journal′s webpage.

Communications and Research Articles present the results of experimental or theoretical studies of general interest or great importance to the development of a specific area of research. A short cover letter justifying why the manuscript should appear in the journal should be submitted. A Communication is typically 2500 words long and a Research Article no longer than 5000 words, where the length is determined from the start of the abstract to the end of the conclusion (references not included). Pertinent chemical formulae, Figures, Schemes, and Tables may be included in the primary article, whereas detailed experimental methods and full characterization data must be included in the Supporting Information.

Reviews (length up to max. 12000 words, from the start of the abstract to the end of the conclusion (references not included)) should be written by leading experts and deal with topics of high current interest in any area of chemistry. Rather than an assembly of detailed information with a complete literature survey, a critically selected treatment of the material is desired; unsolved problems and possible developments should also be discussed. Reviews should be divided into numbered sections. The Review starts with an Abstract (length up to 200 words, no references) that should summarize the contents of the article and stimulate the readers′ interest. The Introduction should introduce non-specialists to the subject in a clear manner. A Review should conclude with a section titled "Summary and Outlook", in which the achievements and new challenges of the subject are presented succinctly. Biographical sketches (maximum length 84 words, max. 560 characters with spaces) and passport-style photographs of the correspondence authors should be submitted.

If you are interested in submitting a Review to Angewandte Chemie, please first Submit a Review Proposal form for consideration by the editorial office.

Minireviews (length up to max. 5000 words, from the start of the abstract to the end of the conclusion (references not included)) should present current topics in a concise Review style. Minireviews offer the flexibility to treat topics at a time when a Review would still be premature or inappropriate. The general format is the same as that outlined for Reviews (above).

If you are interested in submitting a Minireview to Angewandte Chemie, please first Submit a Review Proposal form for consideration by the editorial office.

Scientific Perspectives (typically 5000 words, from the start of the abstract to the end of the conclusion (references not included)) are written by experts and they outline contemporary scientific best practice in the chemical sciences. They distill constructive insights and advice on concepts, techniques, and phenomena, as well as emerging practices, topics, and themes that are of importance to chemical researchers. Such articles aspire to become references of lasting benefit to the chemical community. Scientific Perspectives are founded on experimental and/or theoretical evidence, which is endorsed by leaders in the discipline or field of the article. Use of unpublished results from original research should be limited. The presentation should be supplemented with instructive graphical material. Biographies (70–100 words; max. 560 characters with spaces) and passport-style photographs of the corresponding authors may be submitted.

To contribute a Scientific Perspective, please contact our editorial office in the first instance so that our team may assess the suitability of the proposal. Unsolicited submissions cannot be considered at this time.

Viewpoint Articles (typically 3000 words, from the start of the abstract to the end of the conclusion (references not included)) are carefully considered, opinion-based contributions on topics relevant to the culture of the chemistry community not directly related to scientific research. Articles may address (but are not limited to) topics such as the role and responsibilities of chemists in society; diversity, equity, and inclusion in science; energy, environment, and sustainable development; recognition mechanisms and their influence (funding, prizes, etc.); and modern science communication and outreach programs. Biographies (70–100 words; max. 560 characters with spaces) and passport-style photographs of the corresponding authors may be submitted.

Viewpoint Articles are written primarily by invitation; however, unsolicited contributions on suitable topics may be considered (please contact our editorial office in the first instance so that our team may assess the suitability of the proposal). It is the responsibility of the author(s) to present a balanced discussion. In all cases, the editorial office will remain closely involved in the development of Viewpoint Article content.

Highlights (length up to 600 words, from the start of the abstract to the end of the conclusion (references not included)) describe and discuss exceptional research results with long-term scientific impact, novelty, and importance (ideally published online within the last two months), by a third person, with a view to instruct and to highlight the significance of the findings. The results should be presented clearly and as succinctly as possible, without the comprehensive details required for an original article. A typical highlight usually consists of three paragraphs. The first paragraph discusses the context and background of the research field (e.g., the importance of the topic, the state of the art, and the challenges in this field). The second paragraph presents the key findings of the original paper. The third paragraph provides an evaluation of the work (e.g., its strengths and limitations) and future perspectives (e.g., potential challenges, opportunities, and future research directions). Highlights should include only essential formulae and Figures/Schemes, typically featuring only one graphical element (a scheme or figure is preferred over a table), and no more than five references. Highlights should have no more than three authors (at the discretion of the editor), who should not have affiliations with the author(s) of the work being highlighted.

All Highlights are written upon invitation by the editorial office. Unsolicited submissions or proposals cannot be considered at this time. If you are interested in becoming a Highlight author, please contact our editorial office.

Correspondences on publications in Angewandte Chemie are welcome if they contribute to the scientific discussion. The author of the publication to which the Correspondence pertains will have the opportunity to reply. This reply will be sent to the author of the Correspondence before publication.

Scientifically incorrect or incomplete information in published articles should be corrected in a Corrigendum, which is as short as possible. All corrigenda are subject to approval by the Editor, and minor corrections will not be published. We request that authors submit the Corrigendum electronically, like any other article, and that they cite the publication to be corrected, as well as its DOI. Please note: readers with questions or concerns about published articles should contact the corresponding author of the article directly. It is the author′s responsibility to formulate an appropriate response to such approaches.

3. Manuscript Preparation

Contributions should be in British or in American English. Authors should submit their manuscripts through the online submission service Editorial Manager, which can be accessed through the "Submit a Manuscript" tab under "Contribute" on the journal′s webpage. Please prepare two files (if applicable): one containing the main manuscript (single-spaced text) with all graphics and tables (and their captions) integrated into the text at the appropriate position; the other containing the Supporting Information (see Section 3.2).

Templates for all article types (Microsoft Word, ChemDraw, Endnote) are available on the journal homepage in the section "Author Guidelines". Templates help to judge the length (number of pages) of an article, but they do not reflect the exact final layout. Nonetheless, use of the provided templates is recommended as they provide authors and reviewers with a reasonable approximation of a published article, and they speed up the production process. Details for the preparation of the final revised version of accepted contributions ("Production Data") are provided in the checklist in the acceptance letter.

If you use LaTeX, please make use of the LaTeX template provided on the Author Guidelines page; please do not include your own style sheets or macros. Keep your file as simple as possible. It will not be used directly to typeset your manuscript, but will be converted prior to editing and typesetting (latex2rtf).

The ORCID identifier is required for the submitting correspondence author on submission of a manuscript. We encourage all authors to provide an ORCID for each co-author as well. ORCID is a non-profit registry that provides researchers with a unique digital identifier. Some funding agencies recommend, or even require, the inclusion of ORCID numbers in all published articles; authors should consult their funding agency guidelines for details. Registration is easy and free; for further information see orcid.org.

3.1. Style

Authors are asked to make their manuscripts suitable for a heterogeneous readership. Use a simple, clear style, and avoid jargon. In some cases, it might be helpful for manuscripts to be checked by a third party for correct language usage before submission. Wiley Editing Services offers expert help with English language editing, as well as translation, manuscript formatting, Figure illustration and formatting, and graphical abstract design.

If possible, the standard Symbol font should be used to create Greek letters, rather than special characters or graphics embedded in the text.

Nomenclature, symbols, and units: the rules and recommendations of the International Union of Pure and Applied Chemistry (IUPAC), the International Union of Biochemistry (IUB), and the International Union of Pure and Applied Physics (IUPAP) should be adhered to.

Abbreviations and acronyms should be used sparingly and consistently. Where they first appear in the text, the complete term—apart from the most common ones such as NMR, IR, and tBu—should also be given.

3.2. Structure of Articles

The Title of a publication is the key point of entry for readers, abstracting services, and search engines. Therefore, the Title should be informative, attract as many readers as possible to the work, and avoid acronyms and abbreviations if possible. The first few words of an article title are the most important for discoverability: use keywords that are specific to the study rather than generic words, and avoid metaphors and ambiguity; for Review-type articles, avoid starting titles with "(Recent) Advances/Progress/Development/Trends in …" or similar. The first letters of all words, except coordinating conjunctions, articles, and prepositions, should be capitalized. Please avoid chemical formulae in the Title—they may complicate retrieval of your article by search engines or databases. No references may be cited.

Authorship is listed with the full given name and surname of each author, and an asterisk to indicate each correspondence author. Co-first authors are acknowledged with a ⁺ symbol. Deceased or incapacitated persons who qualify for co-authorship, as determined by their co-authors and according to the journal′s authorship criteria, which can be found in our ethical guidelines, should retain authorship. Deceased authors can be indicated with a † symbol and a footnote with the (approximate) date of death. Co-authors must vouch for any potential conflicts of interest the deceased or incapacitated author may have had and declare these at the submission stage. If the deceased or incapacitated author was the corresponding author, all co-authors must agree on a new corresponding author. For other issues concerning deceased or incapacitated authors see Section 5.2 (conflict of interest) and Section 5.3.4 (copyright). Artificial Intelligence Generated Content tools cannot fulfill the role of, nor be listed as, an author of an article (i.e., ChatGPT and others based on large language models).

Authors have the option to include their names in non-Latin characters/alphabets (such as Asian characters) together with the English spelling in the HTML and PDF versions of their articles. Simply insert the non-Latin version in parentheses after the English version of each name in the author line of the manuscript.

The address field contains the names of all authors according to research group (with academic title and all first names as initials), the complete postal address (preferably in the country′s official language), and academic or institutional e-mail address(es) of the correspondence author(s). For the non-correspondence author(s), only the address of their academic institution or company is required. The correspondence author is welcome to include the web address for their research group.

A dedication line can be included, which should be used to acknowledge noteworthy occasions or people.

An Abstract presents the motivation for the work, the methods applied, the results, and the conclusions drawn. The Abstract:

1)

should reflect the contents of the paper, and the text should contain several keywords to aid retrieval of the paper online;

2)

must not contain graphics, compound numbers (please use compound names), or references, as the Abstract will be searchable independently from the rest of the manuscript (e.g., in databases);

3)

should be easily accessible and keep abbreviations to a minimum;

4)

should not be longer than a maximum of 200 words.

Communications should not be divided into sections. In contrast, Research Articles include the following headings: Introduction (enables readers unfamiliar with the subject to become acquainted with the importance of the results presented; relevant references should be included), Results and Discussion (subheadings are permitted in this section; relevant references should be included), and a Conclusion (a succinct summary with reference to the significance of the findings and, if appropriate, to the remaining challenges).

Experimental or computational details can be summarized separately, in the Supporting Information, under the heading Experimental Section or Computational Methods.

Important, ancillary information, which is relevant to the parent article, should be presented as Supporting Information (a PDF document that may be accompanied by additional supporting materials). The Supporting Information must be presented succinctly, in English, and may comprise additional Tables, data sets, Figures, movie files, and so on. The materials in the Supporting Information must be original and not previously published; otherwise, appropriate citations must be given. The Supporting Information is subject to peer review, and the author is solely responsible for its contents; thus, the scientific quality of the Supporting Information and the preparation of the text and graphics should be of the same standard as that in the actual publication (see Section 3.4 for reporting Experimental Data, and Section 3.3 and the Graphics Guidelines for preparation of graphical materials). The Supporting Information should start with a table of contents, and the relationships between the sections of the main article and the Supporting Information should be readily apparent.

Angewandte Chemie expects that data supporting the results in the paper will be archived in an appropriate public repository. See the Appendix: Reporting Experimental Information and Data, Appendix G. Data Deposition for examples of trusted repositories and visit the Registry of Research Data Repositories or FAIRsharing to help identify registered and certified data repositories relevant to your subject area. Authors are required to provide a data availability statement to describe the availability or the absence of shared data. When data have been shared, authors are required to include in their data availability statement a link to the repository they have used, and to cite the data they have shared (see Section 3.5). Whenever possible the scripts and other artefacts used to generate the analyses presented in the paper should also be publicly archived. If sharing data compromises ethical standards or legal requirements then authors are not expected to share it.

Acknowledgments—especially for any financial support—are given as a separate paragraph at the end of the main text.

References to the literature are typed in square brackets as superscripts after punctuation. These are numbered consecutively and listed (with the numbers in square brackets) at the end of the main body of text. Each reference should contain only one literature citation, and not multiple sub-parts (a, b, c…). References should not contain comprehensive experimental details or long explanatory text. Authors must cite relevant resources; including but not limited to scientific journals, books, databases, preprints, websites, computer programs, and so on. From 2022, Wiley-VCH papers (including Angewandte Chemie and Angewandte Chemie International Edition) available online in Early View, or those published in issues in 2022, should be cited using the eLocator (the DOI or article number may be used to cite just accepted articles published by other publishers). See Section 3.5 for detailed formatting requirements. The reference list should be fair and informative but not excessive. Copies of cited publications not yet available publicly, and with particular significance to the contribution under consideration, should be submitted along with the manuscript. Unpublished results and lectures should only be cited in exceptional circumstances. Please double-check your references to ensure (online) links are correct; e.g., by using CrossRef.

In response to commentary from the research community, we recommend citation of references contained in the Supporting Information within their associated primary article. It is our intention to acknowledge the entire body of work referenced by each article, and in so doing, to ensure that all cited authors are appropriately recognized. All references cited within the Supporting Information, and not already appearing in the primary manuscript, may be included at the end of the reference section of the primary manuscript, and the number sequence for those additional references should continue on from those of the primary manuscript. The sub-section "Supporting Information" above "Acknowledgements" should bear the citation for the additional references (please see the article templates on the "Author Guidelines" page). The reference numbering within the Supporting Information itself may begin with [1].

Authors must provide a short Table of Contents graphical abstract and accompanying text on the last page of the manuscript with 1) a text of up to 50 words (max. 450 characters with spaces), 2) an appropriate image (5.5×5.0 cm (max. width × height) or 11.5×2.5 cm (max. width × height), min. font size: 6–7 points), and 3) a maximum of five alphabetized keywords in American English. At least two of the keywords should be taken from the "Keyword Catalogue" (see Section 3.6). The graphical abstract should stimulate curiosity and it should adhere to the journal′s legal and ethical requirements (see Section 5.6 Acceptable Graphics and the Graphics Guidelines). Repetition or paraphrasing of the Title and experimental details should be avoided; instead, authors should highlight the key findings and appeal of the work.

3.3. Graphics, Tables, and Multimedia

Please be aware of the ethical and copyright issues associated with production of graphical materials, including graphical abstracts and cover pictures (see Section 5 and the Graphics Guidelines).

3.4. Experimental Data

Detailed experimental requirements are accessible in the Appendix: Reporting Experimental Information and Data.

To allow plenty of room for illuminating discussion, Angewandte Chemie requests that detailed experimental methods and full characterization data are placed in the Supporting Information rather than in the primary Communication or Research Article.

The Experimental Section in the Supporting Information should give sufficient detail to enable others to repeat and compare your work. In theoretical papers, technical details such as computational methods should likewise be confined to an appropriately named section. Equipment, complete with make and model number, and conditions used for the measurement of physical data should be described at the beginning of the Experimental Section. If practical, authors should use a systematic name (IUPAC or Chemical Abstracts) for each title compound in the Experimental Section. Do not use computer programs to generate elaborate systematic names or use long, multiline compound names; in such cases general descriptors, such as compound 2, dendrimer 3, or alcohol 4, should be used. When preparing your manuscript and the Supporting Information, please ensure that the compound numbers used in both documents match.

Physical data should be given in the following order: R_f=0.38 (CHCl₃/MeOH 9:1); m.p./b.p. 20°C; [α]_D²⁰=−13.5 (c=0.2 in acetone); ¹H NMR (200 MHz, [D₈]THF, ppm): δ=7.64–7.48 (m, 6H; Ar-H), 1.33 (q, ³J_H,H=8 Hz, 2H; CH₂), 0.79 (s, 3H; CH₃); ¹³C NMR (75 MHz, CDCl₃, ppm): δ=72.5 (CCH), 26.8 (s; CH₃), 6.5 (d, ¹J_C,P=156.9 Hz; CHP); IR (Nujol, cm⁻¹): ν˜=1780 (vs), 1790 (s) (C=O); UV/Vis (n-hexane, nm (mol⁻¹dm³cm⁻¹)): λ_max (ε)=320 (5000), 270 (12000); fluorescence (CH₂Cl₂, nm): λ_ex=435.5 nm; λ_em=659, 726; MS (70 eV): m/z (%): 108 (20) [M]⁺[TR ion], 107 (60) [M−H]⁺, 91 (100) [C₇H₇]⁺; HRMS (ESI): m/z calcd for C₃₂H₄₇NO₅+Na⁺: 548.3352 [M+Na]⁺; found: 548.3331; elemental analysis calcd (%) for C₂₀H₃₂N₂O₅: C 63.14, H 8.48, N 7.36; found: C 62.88, H 8.41, N 7.44.

3.5. References

Each reference number should contain only one literature citation, and not multiple sub-parts (a, b, c…). In the list of references, the names of all authors should be given in upper- and lowercase, starting with the initial(s) of first name(s) followed by the full surname. The penultimate and last names should be separated by a comma (not by "and"). Please double-check your references to ensure online links are correct; e.g., by using CrossRef. For optimal presentation of your references, please:

1)

use an up-to-date version of your reference management software (e.g., Endnote 20);

2)

use up-to-date import filters to import downloaded citations into your reference library (e.g., see the Endnote downloads page);

3)

use the Angewandte Chemie output style;

4)

correct errors in your reference list, such as missing article numbers, incorrectly formatted references, or switched first and last names.

A summary of the formatting style for references is provided below.

Journal citations: Journal titles should be abbreviated in accordance with the "Chemical Abstracts Service Source Index" (CASSI; no commas appear in the journal names). The titles of cited articles must also appear, in quotes, after the author listing. Depending on the journal cited, it may be necessary to cite an eLocator, page numbers, an article number, or a DOI (see Section 3.2). Examples:

[1] R. Author, H. Jones, “Article Title” Chem. Eur. J 2022, 28, e202201000.

[2] W. Smith, R. Author, H. Jones, “Synthesis of …” Chem. Asian J. 2022, 17, e202202000.

[3] P. Davis, J. Carlson, “Electrochemical Evaluation of …” Angew. Chem. Int. Ed. 2022, 61, e202203000.

[4] S. Fairchild, Q. Jones, “Article Title” Angew. Chem. Int. Ed. 2021, 60, 30000.

[5] A. Kraft, “A Full-Length Structural Model of …” Chem. Commun. 1996, 77, and references therein.

[6] V. Findlay, G. Schwartz, “Article Title” Sci. Am. 1984, 250(4), 7.

[7] B. Krebs, H. U. Hürter, “Molecular Design …” Acta Crystallogr. Sect. A 1981, 37, 163.

[8] G. Eulenberger, “Article Title” Z. Naturforsch. B 1981, 36, 521.

[9] D. Bruss, “Biosynthetic Pathways …” Appl. Phys. B, DOI: 10.1007/s003409900185.

Preprint citations: S. McKechnie, J. M. Frost, D. Pashov, P. Azarhoosh, A. Walsh, M. Schilfgaarde, 2017, arXiv preprint arXiv:1711.00533 [cond-mat.mtrl-sci].

S. McKechnie, J. M. Frost, D. Pashov, P. Azarhoosh, A. Walsh, M. Schilfgaarde, 2017, arXiv preprint DOI: 10.48550/arXiv.1711.00533.

N. Duchemin, R. Buccafusca, M. Daumas, V. Ferey, S. Arseniyadis, 2019, ChemRxiv preprint DOI: 10.26434/chemrxiv.8091314.v1.

Z. Li, Z. Lin, C. F. Ibanez, 2021, bioRxiv preprint DOI: 10.1101/2021.05.02.442373.

Data citations: [dataset] Authors; Year; Dataset title; Data repository or archive; Version (if any); Persistent identifier (e.g., DOI).

Book citations: Books without editor: E. Wingender, Gene Regulation in Eukaryotes, VCH, Weinheim, 1993, p. 215. Books with editor: T. D. Tullius in Comprehensive Supramolecular Chemistry, Vol. 5 (Eds.: J. L. Atwood, J. E. D. Davies, D. D. MacNicol, F. Vögtle, K. S. Suslick), Pergamon, Oxford, 1996, pp. 317–343.

Patents: C. R. A. Botta (Bayer AG), DE-B 2235093, 1973 (in cases where the patent is not available online at the respective patent office the corresponding reference to Chemical Abstracts should be added).

Thesis: A. Student, PhD thesis, University of Newcastle (UK), 1991.

Book volumes: G. Maas, Methoden Org. Chem. (Houben-Weyl) 4th ed. 1952–, Vol. E 21/1, 1983, pp. 379–397. "Synthesis in Biochemistry": R. Robinson, J. Chem. Soc. 1936, 1079.

Internet sources: S. Novick, "Biography of Rotational Spectra for Weakly Bound Complexes", can be found under http://www.wesleyan.edu/chem/faculty/novick/vdw.html, 2005 (accessed 1 August 2022); YouTube. "The First Mentoring Talk by Professor Seth R. Marder", can be found under https://youtu.be/BESzfAItqeY (accessed 1 August 2022), uploaded 8 December 2016 by B. R. Kaafarani.

Programs: G. M. Sheldrick, SHELXS-96, Program for the Solution of Crystal Structures, University of Göttingen, Göttingen (Germany), 1996.

3.6. Basic Keyword List

An interjournal browsing facility (automatic links to lists of thematically related contributions with a click of the mouse) has been developed for readers of the journal. Refer to the common keyword catalogue in American English. At least two of the maximum of five keywords assigned to an article should come from this list, to enhance the discoverability of your content in Special Collections.

This keyword list is a "living" catalogue, which is flexible enough to absorb new developments in chemistry. We therefore welcome all suggestions from our readers and authors that might improve its user-friendliness.

4. Acceptance and Sharing Your Work

4.1. The Version of Record

Instructions for preparation of the edited and proofread Version of Record are provided in a separate e-mail to the author after acceptance of a manuscript. After copy-editing, the correspondence author will receive galley proofs. To speed up publication, the galley proof corrections should be returned to the editorial office as soon as possible. The Version of Record will be published online in Early View as soon as possible after editing and proofing. Readers should therefore obtain the Version of Record from the journal website to ensure accuracy of information.

Where a correction is required to the Version of Record after publication, authors should submit a Corrigendum (see Section 2). Please contact the editorial office in such cases.

In cases where authors wish to change their name following publication, the journal will update and republish the paper and redeliver the updated metadata to indexing services. Our editorial and production teams will use discretion in recognizing that name changes may be of a sensitive and private nature for various reasons, including (but not limited to) alignment with gender identity, or as a result of marriage, divorce, or religious conversion. Accordingly, to protect the author′s privacy, the journal will not publish a correction notice to the paper, and we will not notify co-authors of the change. Authors should contact the editorial office with their name change request.

4.2. Open Access

Angewandte Chemie supports Open Access publishing, whereby authors can make their publications freely available the moment that they are published.

Wiley-VCH publishes both fully (Gold) Open Access journals and journals that operate a hybrid model. In a hybrid journal, such as Angewandte Chemie, the author can decide to make their publication Open Access the moment that it is accepted; otherwise, the author transfers the copyright to the publisher and the article is published under the subscription model. When opting for Gold Open Access, the author pays an Article Publication Charge at acceptance of the article and the article is made freely available online for all to read, download, and share, while the authors retain copyright (see Section 5.3).

Wiley has a number of Open Access accounts that enable research institutions, funders, and corporations to financially support their authors to cover the Article Publication Charge. For more information, view the list of institutions and funders with a Wiley Open Access account or check your eligibility.

Transformational agreements allow researchers unlimited read access to a portfolio of journals, plus funding to cover Article Publication Charges when choosing to publish Open Access. See Enabling Open Access Through Transformational Agreements for a table of institutions and consortia that are covered by transformational agreements.

For specific information about Open Access publishing in Angewandte Chemie, including the current Article Publication Charges, see Open Access under Contribute on this webpage.

4.3. Self-Archiving and Sharing

The submitted version of a manuscript may be archived immediately on a preprint server, institutional or company repository, approved Scholarly Collaboration Networks, or personal homepage, regardless of the publication model of the journal.

All versions of articles published Open Access with a Creative Commons license can be archived and shared without restrictions.

In all archival scenarios, it is recommended that authors add a Digital Object Identifier (DOI) link back to the Version of Record published on Wiley Online Library. For more information on archiving of article versions, see Wiley′s Article Sharing Policy and Article Sharing Guidelines infographic.

4.4. Publicity

At acceptance, authors may provide information about their personal, group, and/or institutional accounts on X. If a custom text is preferred, a short text of up to 250 characters may also be proposed. Pending editorial evaluation, the article will then be promoted on our social media channels once it appears in “Early View”.

Professionally produced, custom Video Abstracts, containing voiceovers, animations, and images that are appealing to a general scientific audience, are available to authors of articles accepted in Angewandte Chemie. Learn more about Video Abstracts and purchase one for your article.

Angewandte Chemie issue press releases to promote the visibility of outstanding contributions. Authors are welcome to enhance the visibility of their article through press releases from their institution; however, the release must not precede the publication of the article in EarlyView (embargo date) and the journal′s editorial office should be informed.

Wiley Editing Services offer professional video, design, and writing services to create shareable videos, infographics, conference posters, lay summaries, and research news stories for your research.

5. Legal and Ethical Responsibilities

Angewandte Chemie follows ethical guidelines. Please ensure that your manuscript is compliant.

When dealing with cases that result from possible violations of our guidelines, the journals follow procedures established by the Commission on Publication Ethics (COPE). Such violations include, but are not limited to, plagiarism, false declarations, and omission of relevant information. Note that 1) submitted manuscripts are subject to plagiarism checks using iThenticate plagiarism detection software, 2) all authors must qualify for authorship, and 3) relevant precedent or work must be cited (e.g., journal articles, preprints, and so on).

5.1. Declarations

5.1.1. Funding

All authors must declare all sources of funding relating to their submission in the Section "Funding Information" in Editorial Manager.

5.1.2. Animal and Human Experiments

Animal or human experiments that require ethical statements:

1)

experiments or sampling done with high-order, vertebrate animals; including, mammals, reptiles, amphibians, birds, and fish. For invertebrates, only cephalopods are included (e.g., squid, octopus, or nautilus).

2)

experiments using humans as test subjects (e.g., for ingested, injected, inhaled, or topical treatments, use of superficial patches or sensors, wearable technology, or sensory evaluations).

3)

experiments using human samples of any kind (e.g., solid tissue samples, primary cell lines, bodily fluids such as blood, blood components, serum, urine, semen, or sweat).

EXCEPTIONS ARE use of 1) common stable cell lines (e.g., HeLa, NIH-3T3, HEK-293, Jurkat, COS-7) obtained commercially or from well-known bio banks; 2) commercially purchased samples. In these cases, the commercial or biobank sources should be stated in the Experimental Section.

For manuscripts describing experiments using animals, authors must ensure compliance with the ARRIVE guidelines and any applicable national regulations. Such manuscripts require a declaration in the Editorial Manager submission form AND in the Experimental Section of the manuscript/Supporting Information itself, as follows:

1)

a statement confirming that the experiments were approved by the relevant national, local, or institutional authority. Provide the approval or accreditation number of the laboratory, project, or investigator. If your country/institute does not provide such accreditation numbers, please mention this.

2)

if no such rules or permission are stipulated in your country, this must also be mentioned.

For manuscripts describing experiments with human subjects (including sensor or wearable technologies) or tissue samples from human subjects (including all bodily fluids), appropriate ethical committee approval must be secured. Such manuscripts require a declaration in the Editorial Manager submission form AND in the Experimental Section of the manuscript/Supporting Information itself, as follows:

1)

a statement that the experiments were approved by a pertinent national, local, or institutional ethical committee. Provide the approval or accreditation number of the laboratory, project, or investigator. If your country/institute does not provide such accreditation numbers, please mention this.

2)

a statement that informed consent of all participating subjects, or their next of kin, was obtained.

3)

if the human samples used were only obtained from a commercial or national repository, or any third-party repository, please state these sources.

For manuscripts that report phase II and III clinical trials, report on tumor marker studies, or describe human biospecimens, authors should refer to the relevant CONSORT statement, REMARK, or BRISQ guidelines, as appropriate.

Any work that involves the use of human subjects should be carried out in accordance with the World Medical Association′s Ethical Principles for Medical Research Involving Human Subjects (Declaration of Helsinki).

Note: evaluation of your manuscript will remain on hold until the required statements are supplied in both the Editorial Manager submission form and the Experimental Section of the manuscript/Supporting Information. Failure to respond within a reasonable timeframe could result in rejection of your manuscript without further evaluation.

5.1.3. Safety

Authors should highlight significant hazards (whether new or known) associated with their experimental work, when applicable. This information should be contained within the Experimental Section in the text of the article and/or the Supporting Information.

5.1.4. Computer-Aided Image Enhancement

Any electronic modification of images must be performed honestly and must be stated in the appropriate graphic caption. Refer to the Graphics Guidelines for further information.

5.2. Conflict of Interest

Authors must declare any conflict of interest in their letter to the editor; e.g., support of the research by companies who stand to profit from publication of the results. In the case of a deceased or incapacitated author, co-authors must vouch for any potential conflicts of interest and declare these at the submission stage. If the authors have no conflict of interest to declare, they must also state this at submission. It is the responsibility of the corresponding author to review this policy with all authors and to list all pertinent relationships in the online submission system. Should the manuscript be accepted, the information provided in the online submission system will be included in the published manuscript.

5.3. Copyright

Authors are entirely responsible for overlapping patent or intellectual property copyright issues relating to manuscripts submitted to this journal.

5.3.1. Copyright for Open Access Articles

All Open Access articles must be published under a Creative Commons license, whereby the author retains copyright, the public is allowed to reuse the content, and Wiley-VCH is granted a license to publish the article and identify as the original publisher. On acceptance of a manuscript for Open Access publication, the submitting corresponding author will receive an email prompting them to login to Author Services, where the Wiley Author Licensing Service will allow the author to complete an Open Access license agreement on behalf of all authors on the paper.

Reproduction of materials from an Open Access journal and/or article is permitted under the terms of the Creative Commons license. CC-BY content can be used without asking permission, but the source must be attributed; e.g., "Reproduced under terms of the CC-BY license.^[ref] Copyright 2018, The Authors, published by…" Content published under Creative Commons licenses where there is a "Non-Commercial" (NC), "No-Derivatives" (ND), or "Share-Alike" (SA) requirement cannot be used without first obtaining permission, for the following reasons:

•

NC: Re-use in our journals is classified as commercial use.

•

ND: The work in which the content is re-used is classified as a derivative work.

•

SA: The derivative work cannot be published under the same terms as the SA license.

In such cases authors should either replace the image with something suitable or gain permission directly from the copyright holder. Further information on licensing  is available.

5.3.2. Copyright for Subscription Articles

On acceptance of a manuscript, authors must either confirm the transfer of the rights to their publication to Wiley-VCH or choose to publish Open Access under a Creative Commons license to retain copyright (see Section 5.3.1.). When publication of a subscription article is preferred, the author must transfer the rights for the publication to Wiley-VCH. The submitting corresponding author will receive an email prompting them to login to Author Services, where the Wiley Author Licensing Service will allow the author to transfer the rights for the publication on behalf of all authors on the paper.

To reproduce materials from subscription articles, note that copyright is held by the Publisher in most cases. Where the RightsLink system is used to request re-use, permission is usually granted immediately. Specialized requests may take longer or need to be followed up with the Publisher′s rights and licenses department. Authors should confirm that they have received all permissions when they upload their production data. If excerpts from copyrighted works owned by third parties are included, credit must be given in the contribution. It is the author′s responsibility to obtain written permission for reproduction from the copyright owners; permissions must be obtained before the manuscript is submitted. Further information on licensing  is available.

5.3.3. Table of Contents and Cover Graphics

Where Table of Contents graphical abstracts and cover graphics are concerned, authors must ensure that the provided image(s) do not infringe on the copyright of another entity. Refer to the Graphics Guidelines for detailed information.

5.3.4. Copyright of Deceased or Incapacitated Authors

Copyright is considered personal property under law that transfers to the author′s inheritor upon death or to the author′s agent if they become incapacitated. If the deceased or incapacitated author has not yet signed a copyright transfer agreement, or granted a co-author the permission to do so on their behalf in writing, permission to sign the copyright transfer agreement must be obtained from the author′s inheritor (deceased author) or agent (incapacitated author) in writing.

5.4. Privacy

Authors must ensure that submission does not breach the confidence (whether spoken or unspoken) that they hold with another party (e.g., their employer and/or institute). A breach of confidence might include the disclosure of sensitive information without the express permission of the entity with whom a confidence (or expectation of privacy) is held.

5.5. Data Security

By submitting a manuscript to, or reviewing for this journal, your name, e-mail address, and affiliation, and other contact details the publication might require, will be used for the regular operations of the journal, including, when necessary, sharing with the publisher (Wiley) and partners for production and publication. The journal and the publisher recognize the importance of protecting the personal information collected from users in the operation of these services, and have practices in place to ensure that steps are taken to maintain the security, integrity, and privacy of the personal data collected and processed. Learn more about the data protection policy of this journal.

5.6. Acceptable Graphics

5.6.1. Cover Pictures, Frontispieces, and Table of Contents Graphics

Graphical images used in journal Cover Pictures, Frontispieces, and Table of Contents Graphics must adhere to the Graphics Guidelines.

Graphics that do not adhere to the Graphics Guidelines will be recommended for revision or will not be accepted for publication.

5.6.2. Image Integrity of Scientific Figures

Before acceptance of a manuscript, figures/images undergo a final screening process to check their scientific validity and ensure that all final files comply with our ethical guidelines. See the Graphics Guidelines for more information.

5.7. Unbiased Language

Angewandte Chemie recognizes the author′s right to freedom of expression, with the condition that this right is exercised dutifully and responsibly. Authors must not use derogatory demographic descriptors or offensive language. Discriminatory or offensive content contravenes the journal′s commitment to diversity, equity, and inclusivity and will not be tolerated. Authors should base their discussion on facts, and any conclusions and opinions drawn by authors should be free of unsuitable language (e.g., discriminatory or defamatory statements about individuals, groups of people, enterprises, or institutes, etc.).

Appendix: Reporting Experimental Information and Data

The Experimental Section should give sufficient detail to enable others to repeat and compare your work. Equipment and conditions used for the measurement of physical data should be described at the beginning of the Experimental Section, and the make and model of instruments employed in the synthesis and characterization of compounds should be mentioned. Detailed guidance is provided below.

A. Synthetic Procedures

Literature references to known but non-commercial compounds should be given, and hazardous chemicals, equipment and techniques must be emphasized. If practical, authors should use a systematic name (IUPAC or Chemical Abstracts) for each title compound in the Experimental Section. Do not use computer programs to generate elaborate systematic names or use long, multiline compound names; in such cases general descriptors, such as compound 2, dendrimer 3, or alcohol 4, should be used.

New synthetic procedures should contain reactant quantities in weight or volume and molar units. Equipment details, such as reaction vessel, type of heating (conventional, microwave, or photoirradiation), irradiation wavelength, optical irradiance, cut-off filters, and details of purification techniques and solvents, among others, should be included. Yields of purified products should be in weight and percentage (e.g., 109 mg, 95%). Physical data should be quoted with decimal points and negative exponents (e.g., 25.8 JK⁻¹mol⁻¹). If chromatographic methods are used for purification, the nature of the stationary phase and thin-layer chromatography data/retention factor (e.g., R_f=0.38 (CHCl₃/MeOH 9:1)) should be provided. Please note that reactions following a new synthetic procedure can be conducted on a small scale, but at least one example should be at a scale of 1 mmol.

B. Characterization

B1. Characterization of Compounds and Materials

The structure and composition of all compounds and materials central to the manuscript must be disclosed in the main text or in the Supporting Information, including commercial and proprietary products, pure materials, and mixtures. Manuscripts reporting results using undisclosed material compositions may be returned without external review.

All new organic, organometallic, and inorganic compounds, and materials must be fully characterized by appropriate analytical methods with sufficient evidence for composition, structure, and purity (e.g., elemental analysis, ¹H and ¹³C NMR spectroscopies, high-resolution mass spectrometry, mass spectrometry, IR spectroscopy, specific rotation, physical state and melting point, X-ray crystallography, electron microscopy, X-ray diffraction, etc.). The identity and bulk purity of compounds and materials should be verified with elemental analysis or, in exceptional circumstances, by another appropriate method. For instance, when the compound is unstable or not available in sufficient quantities for complete analysis, the exact relative molecular mass obtained by high-resolution mass spectrometry and clean ¹H and ¹³C NMR spectra (appended to the Supporting Information for inspection by the referees) should be supplied. Reasons should be provided if a type of data could not be obtained for a compound or compound class.

In any cases where elemental analysis cannot be carried out (e.g., for air-sensitive compounds) an explanation for the omission or inaccuracy of this data should be given, alongside additional evidence for purity. HPLC or GC chromatograms are suitable, but other techniques (e.g., NMR spectroscopy or powder X-ray diffraction) will be considered.

For known organic, organometallic, and inorganic compounds, characterization by ¹H and ¹³C NMR spectroscopies and mass spectrometry is sufficient and purity should be verified. A reference to the fully characterized compound should be provided. Any soluble organometallic or inorganic diamagnetic compound with an organic fragment should be characterized using NMR spectroscopy (¹H, ¹³C, and any other appropriate nucleus) in the same manner as organic compounds. For soluble paramagnetic compounds (e.g., Cu^II complexes), paramagnetic NMR techniques are encouraged but not essential.

Reporting of single-crystal X-ray structures is encouraged for crystalline solids; however, such structures cannot be used as the only means of characterization as they do not necessarily represent the bulk material. Powder X-ray diffraction data can be submitted as evidence for the purity of a bulk material—ideally in comparison to a calculated diffraction pattern. For micro- and nanostructured materials, detailed information about both the composition and morphology (e.g., adsorption–desorption isotherms, surface area, porosity, etc.) should be provided.

Data collected for a sample may be subject to measurement variations (e.g., device settings, sample preparation, sample dimensions, etc.). In such cases authors must not only report the important settings of the measurement and data specific for the sample (e.g., sample dimensions or mass) but also make the data comparable. The technique and the parameters used for this purpose (e.g., normalization) must be reported.

B2. Characterization Techniques

Please note: manipulation of spectra to misrepresent data is unethical and will not be tolerated.

Nuclear magnetic resonance spectroscopy: Proton and carbon resonances must be provided for each new compound in the Experimental Section; solvent and instrument frequencies are required. Depending on the compound, other resonances, such as ¹⁹F, ²⁹Si, or ³¹P, should be added. NMR spectra should have sufficiently high signal-to-noise ratios so that all peaks can be adequately resolved.

¹H NMR resonances should be reported to the nearest 0.01 ppm. Multiplet abbreviations, number of atoms represented by each signal, and coupling constants should be provided; e.g., ¹H NMR (200 MHz, [D₈]THF, 25°C, TMS, ppm): δ=7.64–7.48 (m, 6H; Ar-H), 1.33 (q, J=8 Hz, 2H; CH₂). Mutually coupled protons in ¹H NMR spectra must be quoted with precisely matching J values to assist thorough interpretation. In instances where computer print-outs provide ambiguous readings, mean J values should be quoted that are rounded to the nearest decimal point.

¹³C NMR resonances should be reported to the nearest 0.1 ppm. Provide resonances with high precision only in case of closely spaced signals. The number of attached hydrogen atoms can also be included; e.g., ¹³C NMR (75 MHz, CDCl₃, 25°C, TMS, ppm): δ=72.5 (CCH), 26.8 (CH₃).

Copies of the ¹H and ¹³C NMR spectra of all key intermediates and all final products must be included in the Supporting Information. The spectra must be those resulting from the specific reactions reported in the manuscript and not copies from previous syntheses of the same compounds. Each spectrum must be legible and should be labeled with the compound number used in the manuscript and an image of the structure. The minimum chemical shift range for ¹H NMR spectra should be −1 to 10 ppm and for ¹³C NMR spectra −10 to 200 ppm. All peaks should be labeled and integrated.

Infrared spectroscopy: It is not necessary to provide a full list of IR stretches. Only those signals that are diagnostic of the compound′s functional groups need to be listed. The band frequencies should be given to the nearest 1 cm⁻¹ and their intensity should be provided (very strong (vs), strong (s), medium (m), weak (w), broad (br)); e.g., IR (KBr, cm⁻¹): ν˜=1780 (vs), 1790 (s) (C=O).

Mass spectrometry (MS): It is not necessary to provide a full list of MS peaks. Only those signals for which the molecular fragment can be identified need to be listed. Molecular ion peaks, and any other fragmentation peaks, should be reported in comparison to the calculated mass for the ion. Please use an ionization technique suitable for your compound. Relative intensities of the signals should be provided; e.g., MS (EI, 70 eV) m/z (%): 173 (32), 171 (100) [M+H]⁺.

Elemental analysis or high-resolution MS (HRMS): Evidence for elemental constitution should be provided by satisfactory elemental analysis, in which case duplicate analysis should be obtained and an average presented (both sets of data used to calculate the average should be provided). Elemental analysis; e.g., Elemental analysis calcd for C₂₀H₃₂N₂O₅: C 63.14, H 8.48, N 7.36, found: C 62.88, H 8.41, N 7.44. High-resolution mass spectrum; e.g., HRMS (ESI) m/z calcd for C₃₂H₄₇NO₅+Na⁺: 548.3352 [M+Na]⁺; found: 548.3331. For compounds where elemental analysis data is not provided, the HRMS data should be accompanied by NMR spectra with sufficiently high signal-to-noise ratios.

HRMS instrumentation should be properly calibrated, and we encourage authors to provide verification of resolution (high resolution being 5 ppm precision). Please include expected HRMS parameters (m/z range, resolution, mass accuracy) to minimize reporting of noise peaks or contamination that can appear in ESI/MS data.

Note that elemental analysis data must be provided for papers detailing the isolation and structure elucidation of natural products.

UV/Vis and fluorescence spectroscopy: If UV/Vis or fluorescence spectroscopy data are discussed in the manuscript, the following data should be provided in the Experimental Section of the Supporting Information, along with any copies of the corresponding spectra.

UV/Vis absorptions (peak, extinction coefficient); e.g., UV/Vis (n-hexane, nm (mol⁻¹dm³cm⁻¹)): λ_max (ε)=320 (5000), 270 (12000).

Fluorescence excitation and emission; e.g., fluorescence (CH₂Cl₂, nm): λ_ex=435.5 nm, λ_em=659, 726 nm.

X-ray absorption spectroscopy (XAS): Collection and treatment of XAS data require specialized knowledge. Please consult a beamline scientist or other experienced person to ensure the appropriate steps are taken to collect, process, and interpret XAS data correctly. The Athena User′s Guide provides general guidance for XAS data processing.

Specific rotation: Specific rotations following [α]=(100∙α)/(lc) should be provided for isolated and synthesized natural products as well as for other enantioenriched compounds; e.g., [α]_D²⁰=−13.5 (c=0.2 in acetone). For new compounds that are chiral, HPLC or GC traces should be included in the Supporting Information.

Physical state and melting point: A description of the physical state and color of a new compound should be given; e.g., yellow needle-like crystals. Melting point ranges should only be provided for crystalline compounds; e.g., mp: 90.2–91.2°C.

Isomeric mixtures: Where isomeric mixtures are reported, such as diastereomeric or enantioenriched mixtures, please provide percentage compositions and information about how these values were obtained (e.g., NMR spectroscopy, HPLC, etc.). If certain spectroscopic signals (e.g., NMR signals) can be attributed to either of the isomers, these data should be reported in separate lists and not in combined lists.

Microscopy images should be captured at an appropriate magnification to show a representative sample. When high-magnification images of selected particles are used they must be supplemented by low-magnification images of the broader sample, and the use of histograms and statistics to describe size and shape distributions is encouraged.

Powder X-ray diffraction data: XRD (Cu Kα1, 0.15406 nm, 2θ (°) (d (nm)): 5.2 (1.68), 10.1 (0.83).

Crystallographic data must be uploaded as Supporting Information and must be deposited using the joint Cambridge Crystallographic Data Centre (CCDC) and FIZ Karlsruhe deposition service (see Appendix G. Data Deposition). Authors must deposit their data before submitting their manuscript so that referees can retrieve the information directly from the data repository. Please use the free online service CheckCIF provided by the International Union of Crystallography to verify the quality of crystal structure analysis. Any ′level A′ alerts should be addressed before submission, or otherwise explained within the CIF using the Validation Reply Form (VRF). To aid data retrieval, please ensure that the name of the database and the deposition number(s) are stated in the part of the manuscript where the respective structure or sequence determination is described; please declare each deposition number, rather than a range, to ensure that the journal′s data feed back to the repository is complete. Crystallographic data must be uploaded as .cif files together with the manuscript to allow automated generation of CheckCIF files for the convenience of referees. All other supporting data should be included in the Supporting Information. If data are subsequently revised prior to publication, please ensure the latest version has been deposited and that the data deposited with the database are identical to those reported in the revised manuscript.

If a crystal structure analysis is not an essential part of the paper, only a footnote is required indicating where the detailed results can be found. Otherwise, all supporting data should be given in the Supporting Information: crystal dimensions, crystal system, space group, unit cell dimensions and volume, ρcalcd, 2θ_max, radiation, wavelength, scan mode, temperature of measurement, no. of measured and independent reflections, no. of reflections included in refinement, σ limits, whether and how Lorentzian polarization and absorption corrections were performed (μ, min/max transmission), method of structure solution and program, method of refinement and program, no. of parameters, treatment of H atoms. R, wR, whether refined against |F| or |F²|, residual electron density, and the database in which the detailed results are deposited. An ORTEP-type plot that merely confirms the structure of a synthetic intermediate should not be included.

B3. Cell Line Research

For papers containing cell lines the following information should be provided in the methods section.

The species, sex, tissue of origin, official cell line name, and Research Resource Identifier (RRID).

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Dates and timeline of described experiments, including passage number information (especially important for finite cell lines), may be requested.

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Avoid misspelled identifiers (e.g., the incorrect use of NKM45, in place of MKN45).

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Official name and RRID are not applicable to primary cells.

The source/supplier of the cell line and when it was obtained.

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Documentation of the origin may be requested, which should include details on the creation of in-house cell lines and where externally sourced cell lines were first established.

Confirmation that the cell line was authenticated for the described experiments (including the percent match result and method used) and has not been previously reported as misidentified or contaminated (see databases below).

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The expectation is that experiments were performed with verified cells (following STR profiling performed at the beginning and end of the described study), which are not listed within the databases below.

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Documentation for the percent match result and dates of testing may be requested.

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Additional information on in-house or external testing may be requested.

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If the cell line is listed within the databases below, the rationale for its use must be provided. The use of cross-contaminated cell lines is not expected to be justifiable.

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Established cell lines without reference profiles require authentication to demonstrate no matches to other cell lines or evidence of being problematic.

Confirmation that the cell line was free of mycoplasma contamination for the described experiments.

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The expectation is that experiments were performed with confirmed mycoplasma-free cells (this includes cell lines used for virus production etc). At least the latest passage of the cell line (when the cells were used) must have been tested using cell pellets or cell samples (not supernatant) and confirmed negative.

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Documentation for mycoplasma result and dates of testing may be requested.

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Additional information on in-house or external testing may be requested.

If one or more of the above are unknown, this must be stated and the rationale for the use of the cell line provided. Further guidance on misidentification and contamination is available from the International Cell Line Authentication Committee (ICLAC) register, the NCBI misidentified cell line database, and the Cellosaurus problematic cell line database.

C. Catalysis

Catalytic activity should be reported as turnover frequency (TOF) or mass-specific activity. For heterogeneous catalysts, surface-specific activity should be reported. Evidence of catalytic performance should be provided, including mass balance, fundamental kinetic parameters, and appropriate controls such as system measurements in the absence of catalyst.

The stability of catalysts must be tested, preferably at intermediate conversion levels, and a deactivation path should be proposed. To this end, heterogeneous catalysts should be characterized both before and after reaction.

Catalyst recycling should be tested for at least five cycles and time-on-stream should be provided for industrially relevant catalysts. Although reporting product yield as a function of cycle is acceptable, reaction rates as a measure of recycling efficiency are preferred.

For synthetic methods, a selection of substrates illustrative of the scope of the reaction should be made, and the isolated yields of the corresponding purified products should be reported. Product yields determined by HPLC or GC are considered indicative of a preliminary catalytic study. To illustrate the applicability of the method, one reaction on a gram scale should be included.

Enantiomeric purity can be expressed either as enantiomeric excess (ee) or enantiomeric ratio (e.r.). The proportions of diastereomers are expressed as a diastereomeric ratio (d.r.).

If computational results are part of the work, they must be complementary to the experimental results and should offer significant insight into the topic under investigation.

For manuscripts dealing with the use of enzymes in biocatalysis, the following information must be provided: supplier of commercially available enzymes (company name, city, country) accompanied with information about purity, and preferably units and activity test information. For recombinantly produced enzymes, please provide DNA and/or protein sequences, the vector and expression host used (add reference number if deposited on a database; see Appendix G. Data Deposition). Additionally, the method for production and isolation of the enzyme, purification method, proof of purity, and the activity test used should be stated.

Benchmarking of photo- and electrocatalysts: Where possible, the performance of photocatalysts and electrocatalysts should be benchmarked against known standards; e.g., the electrocatalytic hydrogen evolution and oxygen evolution reactions over Pt/C and RuO₂, respectively. If a platinum counter electrode has been used in electrocatalysis experiments, particularly at potentials below 0V, it should be demonstrated that no Pt contamination has occurred at the working electrode and evidence must be provided.

D. Energy Storage and Conversion

In these systems small changes in sample geometry, weight, preparation, and measurement setup can have a dramatic influence on the results. With record amounts of data published each year, it is mandatory that such claims are not only reproducible but also comparable to similar systems. Hence, authors are encouraged to report the experimental factors influencing the properties and the experimental setup as accurately as possible. This includes, but is not limited to, supplier and purity of chemicals, synthesis method, electrodes used, applied bias, scan rates, irradiation type and intensity, and device structure.

To make data comparable, it is essential that the material is compared to the current state-of-the-art material. Where possible and applicable, the data should be normalized. This can be done using weight, surface area, time, any combination of these, or any other suitable means. However, it is important to provide unambiguous information about how specific data were calculated, either in the manuscript itself or in the Supporting Information. Useful information also includes stability tests, reporting C rates (rather than currents), or gas evolution rates.

E. Electrochemistry

The setup of electrochemical cells and all electrochemical methods, as well as all other relevant experimental parameters, should be detailed either in the main text of the article or in the Supporting Information. The cell setup should include the type of cell (one or two compartments and, if applicable, information about the separator or salt bridge) as well as the electrode setup (two or three electrodes). Details of the working electrode (WE), counter electrode (CE) and, if used, reference electrode (RE) should be provided, as well as any pretreatments (e.g., polishing). For electrochemical methods, preset parameters should be reported (e.g., scan rate, direction, and starting potential; applied voltage/bias; frequency/rotation rates; stir/flow rate). Additional parameters that should be reported include, but are not limited to, the concentration(s) of electrolyte(s), supporting electrolyte, and anolyte, temperature, distance between WE/CE and WE/RE (bulk electrolysis), IR correction, and equipment utilized (i.e., manufacturer, model).

Electrochemistry is used in a wide range of research, and the guidelines in Appendix A. Synthesis Procedures and Appendix B. Characterization also apply for electrosynthesis manuscripts, for example, Appendix C. Catalysis applies for electrocatalysis experiments, and Appendix D. Energy Storage and Conversion should also be considered for electrochemical energy storage and conversion. Raw data should be made available in accordance with Wiley′s Data Sharing Policy, see Appendix G. Data Deposition.

F. Computational Chemistry

For manuscripts that include the results of computational chemistry, the authors should include all the details that will enable other scientists to reproduce the results, that is: x,y,z coordinates, nuclear repulsion energy, and total energy. In case enthalpy and entropy were calculated, enthalpic and entropic corrections should be reported. Results obtained from methods that are neither described in the manuscript nor in previous published reports are not acceptable for publication. Computational details, including data such as force field parameters and equations defining the model, can be included in the paper itself or in the Supporting Information. Alternatively, references to the location of these data in the open literature can also be provided. Software used for calculations must be properly cited. References to the methods upon which the software is based must be provided. Submissions, including the results of electronic structure calculations, should include the geometries of all the stationary points reported, which should be reported with their relative energies (as Cartesian coordinates in the manuscript or as Z matrices in the Supporting Information), along with their computed absolute energies (Hartree). When appropriate, the number of imaginary frequencies should be reported to enable identification of stable structures.

G. Data Deposition

Angewandte Chemie expects that data supporting the results in the paper will be archived in a community-trusted, subject-based, public repository. For examples of community-trusted repositories, consult the list in this section, and visit the Registry of Research Data Repositories or FAIRsharing to help identify registered and certified data repositories relevant to your subject area. Authors are required to provide a data availability statement to describe the availability or the absence of shared data (for more information and for a list of our template Data Availability Statements, please see Wiley′s Data Sharing Policy).

When data have been shared, authors are required to include in their Data Availability Statement a link to the repository they have used, and to cite in the reference section of their manuscript the data they have shared (see Section 3.5). Whenever possible the scripts and other artefacts used to generate the analyses presented in the paper should also be publicly archived. If sharing data compromises ethical standards or legal requirements then authors are not expected to share it. This can be indicated by choosing the appropriate Data Availability Statement from our template list, available under Wiley′s Data Sharing Policy.

If the repository allows a user to place the data under an embargo until publication or allows a user to place the release of the data on hold until publication, please ensure that the appropriate steps are taken to ensure that data release is coordinated with publication of the associated article.

If the repository allows reviewers to access the data during peer review, please provide details in the manuscript. Validation reports should be provided for peer-review purposes.

Please consider depositing your data in one of the subject-specific repositories listed below. If a subject-specific database is not available, please consider depositing your data in a generic or multidisciplinary repository, for example, Figshare, Zenodo, Dryad, RADAR, Open Science Framework, Science Data Bank Science Data Bank, and Qresp.

Biological and medicinal chemistry:

Bioactivity data of drugs and drug-like small molecules: ChEMBL.

Biological activities of chemical substances listed in PubChem Substance: PubChem BioAssay.

Biological data (general): BioStudies

Biological imaging: BioImage Archive, Image Data Resource (IDR), Electron Microscopy Public Image Archive (EMPIAR), and EMPIAR-PDBJ.

Chemical probes: The Chemical Probes Portal.

DNA, RNA, and protein sequences: Genbank, DDBJ, UniProt (UniProt SPIN and European Nucleotide Archive (ENA) for nucleotide sequences), Addgene.

Enzymology: Strenda DB.

Proteomics: Members of ProteomeXchange (PRIDE, PeptideAtlas, MassIVE, JPOST, iProX, and PanoramaWeb).

Structures of biological macromolecules: Worldwide Protein Data Bank (wwPDB) members (RCSB PDB, PDBj, PDBe, Biological Magnetic Resonance Data Bank (BMRB), and Electron Microscopy Data Bank (EMRB), EMDataResource.

Catalysis:

Catalyst discovery and optimization: SwissCAT+.

Computational catalysis: Catalysis-Hub.org.

Organic reaction data: Open Reaction Database.

Small-molecule characterization data and reactions: Chemotion.

Computational chemistry:

Computational catalysis: Catalysis-Hub.org.

Computational chemistry: io-Chem-BD.

Computational materials data: NOMAD.

Quantum chemistry: QCArchive.

Organic and inorganic chemistry:

Chemical substances and their physicochemical properties: PubChem Substance (linked to PubChem BioAssay and PubChem Compound).

Intermolecular interaction data: SupraBank.

Organic reaction data: Open Reaction Database.

Raw and processed NMR data: nmrXiv.

Small-molecule characterization data and reactions: Chemotion.

Small-molecule structures and their physicochemical properties and characterization data: ChemSpider.

Synthetic chemistry methods: ChemSpider Synthetic Pages.

X-ray crystallographic data for organic, metal–organic, and inorganic compounds:

Deposit your data online to the joint CCDC and FIZ Karlsruhe deposition service (for support on using this service e-mail the CCDC) and select to run the checkCIF service during the deposition process.

The data will be assigned a registry number, which should be included with the following standard text as a reference in the main manuscript: "Deposition Number ######...contain(s) the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."

Organic, metal–organic, and inorganic crystal structure data can be freely obtained from the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service by searching for the Deposition Number quoted in the publication or by searching for the publication itself.

During the peer-review process referees are able to obtain unpublished organic, metal–organic, and inorganic crystal structure data for peer-review purposes from the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Referee Service. Referees will need to provide the Deposition Number(s) and an author surname to enable access.