1. OSTN alleviates DOX-induced inflammation, oxidative stress and cardiomyocyte apoptosis in vivo and in vitro. 2. OSTN deficiency exacerbates DOX-induced inflammation, oxidative stress and apoptosis in vitro. 3. OSTN overexpression attenuates DOX-induced acute and chronic cardiotoxicity in mice. 4. The beneficial effects of OSTN against DOX-induced cardiotoxicity are mediated by PKG activation.

A comprehensive review of the different primary technologies used to test for COVID-19 infection. The review indicates the advantages and disadvantages of each technology, describes technologies that have the potential to accelerate SARS-CoV-2 detection in the future, and discusses the remaining challenges in COVID-19 diagnostic testing.

FTO stimulates tumor growth of bladder cancer through regulating MALAT1 methylation.

MALAT1 and MAL2 interact with miR-384 for regulating tumor growth of bladder cancer.

FTO promotes bladder cancer tumor growth via MALAT1/miR-384/MAL2 axis.

Menstrual blood-derived MSC transplantation significantly lowers the mortality of severe and critical SARS-CoV-2-induced COVID-19.

This prospective and systematic report assessed the ability of menstrual blood-derived MSCs to treat both severe and critically ill COVID-19 patients.

MSC-based therapy may serve in future clinical applications as an alternative way for the treatment of COVID-19

Exosomes derived from UMSCs exhibited the ability to transfer lncRNA H19 to chondrocytes.

Exosomal H19 was found to promote chondrocyte migration, matrix secretion, apoptosis suppression, as well as senescence suppression, both in vitro and in vivo.

The specific mechanism lies in the fact that exosomal H19 acts as a ceRNA against miR-29b-3p to upregulate FoxO3 in chondrocytes.

Integrated single-cell RNA sequencing technologies reveal a high-resolution immune landscape of colorectal primary tumors and liver metastasis, identifying major immune cell types and distinct cell functional states of T and B cells as well as predictions of complex cell-cell interactions.

Serum or plasma assay of lncRNAs in blood can be used as a novel detection method to assist low dose CT scan (LDCT) while improving the accuracy of early lung cancer screening. LncRNAs can be used as predictive markers for chemosensitivity, radiosensitivity, and sensitivity to epidermal growth factor receptor (EGFR)-targeted therapy, and as well markers of prognosis. Different lncRNAs have been implicated to regulate chemosensitivity, radiosensitivity and sensitivity to EGFR-targeted therapy through diverse mechanisms.

1. USP35 is abundant in human lung cancer tissues and cell lines.

2. USP35 modulates iron homeostasis and ferroptosis in lung cancer tissues and cell lines.

3. USP35 directly interacts with ferroportin and maintain its protein stability to prevent iron overload and ferroptosis.

1. PCAT6 is upregulated in bone metastasis-positive prostate cancer and PCAT6 upregulation correlates with poor prognosis in patients with prostate cancer.

2. PCAT6 promotes prostate cancer bone metastasis by stabilizing IGF1R mRNA through interacting with IGF2BP2.

3. METTL3-mediated m⁶A modification leads to the upregulation of PCAT6 in an IGF2BP2-dependent manner.