• Autonomic nervous system plays a role in immunomodulation but poor is known about its activity in cirrhosis.
• IL-6, OPN, IL-1Ra and IL-22 concentrations are associated with indirect signs of portal hypertension and its main complications.
• Alteration of sympathovagal balance assessed by heart rate variability (HRV) is related to IL-6, IL-22, osteopontin and IL-1Ra concentrations and accompanies inflammation across the progression of cirrhosis and portal hypertension

Graphical Highlights

Intranasal administration (INA) has emerged as an unconventional method for drug delivery, offering distinct advantages such as non-invasiveness and enhanced pharmacokinetic characteristics within the brain.

INA route effectively delivers therapeutic agents through the olfactory and/or trigeminal nerve systems.

With introducing appropriate improvements to the drug formulation, such as the incorporation of nanocarriers, the efficacious delivery via the INA approach has gained considerable traction for the treatment of neurological disorders.

With introducing appropriate improvements to the drug formulation, such as the incorporation of nanocarriers, the efficacious delivery via the INA approach has gained considerable traction for the treatment of neurological disorders.

ZBOLT is a comprehensive analysis system that incorporates both software and hardware advancements, making it an appropriate choice for large-scale population genomic studies.

ZBOLT's calling accuracy is comparable to GATK Best Practices.

ZBOLT is able to analyze 100Tbp of raw sequencing data per day.

ZBOLT consumes 1 kWh per 100Gbp sequenced sample.

In this commentary, we briefly introduce the ubiquitin-proteasome system and the potential targets for drug discovery in this system. We then outline the classification and function of deubiquitinating enzymes (DUBs) and discuss the molecular mechanism by which OTUB1 regulates the deubiquitination and function of cellular communication network factor 6, a specific tumour suppressor in breast cancer. Finally, we summarise the strategies for the regulation of DUBs at different levels.

By utilizing the Bayesian network method and integrating the analysis of tumor immune microenvironment, the molecular mechanism of gene regulation in lung adenocarcinoma was discovered. Two key genes, CD36 and ADRA1A, were identified, providing insights and theoretical basis for targeted therapy in lung cancer.