This study evaluated the size and fraction of non-research compensation to Japanese board-certified neurologists from the pharmaceutical industry between 2016 and 2020. We found that more than US$45 million were made to 59.2% of all neurologists over the five years. There was an increasing trend in the payments to the neurologists over time.

Host–microbiota interactions play a critical role in cancer progression from bulk to single-cell level. Growing technologies focus on characterizing the host–microbiota interaction. Microbiota-derived metabolites and components and themselves affect the host immune response and the proliferation of cancer cells. Microbiota is emerging as the target for anticancer therapy.

• Cellular atlas in human lung diseases of COPD, NSCLC and SSC was draw to habor PDGFRα⁺ cells and analyzed its subtypes.

• CD34⁺PDGFRα⁺ telocytes in lung tissues of lung diseases had been elaborated.

• Telocytes might communicate with the cells types in the microenvironment by secreted vesicles.

• The key signals such as TIMP1-CD63, VIM-CD44 and et al. were elucidated in telocytes dominated communication.

(1) The presence of clonal haematopoiesis mutations is associated with increased risk of lung cancer after adjusting other risk factors.

(2) The association between clonal haematopoiesis and lung cancer is mainly driven by mutations with high variant allele frequency.

(3) The association between clonal haematopoiesis and lung cancer is further supported by a meta-analysis including three cohorts.

This article highlights DNA methylation-based cancer development and its clinical significance in an early detection approach.

1. The beneficial effects of FA on NAFLD might be the DNA methylation regulation of NAFL-related genes.

2. FA may reduce inflammation and ER stress in the liver through direct or indirect effects.

3. FA may improve NAFLD by enhance the tight junction and reduce intestinal inflammation.

1. Ageing changes, environmental risk factors and genetic susceptibility are the risk factors in wet AMD progression.

2. VEGF plays a vital role in the formation of CNV, the hallmark of wet AMD.

3. To avoid the need for long-term injections of anti-VEGF agents, CRISPR-based gene editing therapy shows great potential to treat wet AMD permanently.

4. Different targets involved in VEGF-related pathway(Hif-1α, VEGF and VEGFR)showed significant differences in the efficacy and targeting VEGFA at the appropriate time is an effective intervention strategy.