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CASE REPORT
A case of glyphosate poisoning with falsely elevated creatinine levels measured by dry chemistry methods
- First Published: 01 August 2025

We describe a case of glyphosate poisoning in which creatinine levels were determined to be elevated using dry chemistry. Because the assay uses ammonia to measure creatinine levels, the ammonia generated from the isopropylamine salt in the glyphosate herbicide solution interferes with the assay, resulting in falsely high creatinine levels.
Fulminant myocarditis in immune-mediated thrombotic thrombocytopenic purpura: A case report
- First Published: 16 July 2025
This report describes a case of iTTP complicated by fulminant myocarditis, successfully managed with multidisciplinary treatment, including PE, steroids, and extracorporeal circulation. Recognizing myocarditis as a possible complication in an iTTP case and providing appropriate supportive therapy may contribute to improved prognosis.
ORIGINAL ARTICLE
JAPAN Registry of Self-harm and Suicide Attempts: Study protocol and profile in 2022–2023
- First Published: 13 July 2025
CASE REPORT
Superior-lateral patella dislocation with rotation along its vertical axis
- First Published: 11 July 2025
Gastric anisakiasis suspected by point-of-care ultrasound finding in the emergency department
- First Published: 11 July 2025
ORIGINAL ARTICLE
A predictive model of delayed pseudoaneurysm formation in paediatric patients with isolated blunt splenic injury using logistic regression analysis
- First Published: 11 July 2025

A predictive model of delayed pseudoaneurysm formation after non-operative management in paediatric patients with isolated blunt splenic injury was constructed, showing moderate discrimination and good calibration. Further improvement using different model creation methods, such as machine learning, may be necessary
CASE REPORT
Preoperative interventional radiology in penetrating posterior abdominal trauma with bowel injury: A case report
- First Published: 07 July 2025
ORIGINAL ARTICLE
A stratified approach to hospital surge capacity during the COVID-19 pandemic in Tokyo
- First Published: 07 July 2025
Hydrogen inhalation therapy alone may not alleviate intestinal mucosal damage in NOMI without total-layer necrosis: An experimental swine model study
- First Published: 04 July 2025
CASE IMAGE
Excessive dynamic airway collapse leading to cardiac arrest due to airway obstruction
- First Published: 04 July 2025
CASE REPORT
Bickerstaff brainstem encephalitis developed quickly after COVID-19 infection
- First Published: 02 July 2025
LETTER TO THE EDITOR
Divergent mortality risks associated with lower body temperature and interleukin-6 levels in elderly and non-elderly patients with sepsis
- First Published: 29 June 2025
ORIGINAL ARTICLE
Comparison of bathing-related adverse events, including drowning, between hot spring bathing and general bathing: A single-center retrospective study
- First Published: 23 June 2025

A retrospective single-center study investigating the characteristics of bathing-related adverse events found that patients transported from hot springs had a higher frequency of drowning. This study may inform clinical practices and public health policies to reduce the incidence of bathing-related emergencies.
REVIEW ARTICLE
Gut dysbiosis and its treatment in patients with critical illness
- First Published: 03 June 2025

After severe injury, such as trauma, operation, burn, infection, shock, and bleeding, systemic inflammation progresses in various organs simultaneously. The gut is considered to have an important role in promoting systemic inflammation through bacterial translocation, intestinal lymphatic mediators, gut immunity, etc.
ORIGINAL ARTICLE
Effect of closed negative pressure wound therapy after laparotomy for gastrointestinal perforation: A single-center observational study
- First Published: 03 June 2025

Laparotomy for gastrointestinal perforation is associated with a high risk of surgical site infection (SSI). The application of closed NPWT in patients undergoing laparotomy for gastrointestinal perforation was associated with a lower incidence of SSI compared with that of standard surgical dressing. Closed NPWT may be an option for the prevention of SSI after gastrointestinal perforation.
Current state and challenges of multidisciplinary collaboration by fire defense headquarters in Japan: A nationwide cross-sectional survey
- First Published: 28 May 2025

Of the 529 participating fire defense headquarters, 445 (84.1%) collaborated with long-term care, welfare, and health organizations within the communities, despite facing various challenges. It is essential for fire defense headquarters and community organizations to continue fostering collaboration, addressing challenges, and adopting best practices.
Performance of Universal TOR rule for out-of-hospital cardiac arrest in the Pan-Asian Resuscitation Outcomes Study
- First Published: 22 May 2025

Asian countries have a rapidly aging population and as a result, the number of older individuals transported emergently following out-of-hospital cardiac arrest (OHCA) has increased in recent years. The purpose of this study was to evaluate the characteristics and outcomes of OHCA cases in Japan, Korea, Singapore, and Taiwan in relation to the Universal TOR rule.
CASE REPORT
Rapidly progressive dementia due to superior sagittal sinus dural arteriovenous fistula: A case report
- First Published: 21 May 2025

This case highlights the importance of considering dural arteriovenous fistula (dAVF) as a differential diagnosis in patients presenting with cognitive decline, particularly when accompanied by progressive neurological symptoms. Our report may help clinicians broaden their differential diagnoses when faced with similar clinical presentations.
A case report: Efficacy of thoracic MRA for ischemic stroke due to acute aortic dissection
- First Published: 19 May 2025
ORIGINAL ARTICLE
Incidence and risk stratification of caller noncompliance with dispatcher instructions for cardiopulmonary resuscitation
- First Published: 14 May 2025

A model assigning 1 point for each of the following: patient age of ≥65 years, a familial relationship between the caller and the patient, and cardiac arrest in the bathroom, and effectively stratified the probability of caller noncompliance with dispatcher cardiopulmonary resuscitation instructions.
LETTER TO THE EDITOR
Letter to ‘Automated CT image prescription of the gallbladder using deep learning: Development, evaluation, and health promotion’
- First Published: 14 May 2025
ORIGINAL ARTICLE
Outcomes of blunt trauma patients in police versus ground ambulance transport across US trauma centers
- First Published: 08 May 2025
LETTER TO THE EDITOR
Beyond respiratory distress: The impact of H1N1 influenza on circulatory failure
- First Published: 02 May 2025
ORIGINAL ARTICLE
Hemostatic technique using cyanoacrylate for fingertip cut injury: A review of 21 cases
- First Published: 29 April 2025

A woman in her 70s cut the tip of her right thumb with a slicer, resulting in skin loss. Despite compression, hemostasis was not achieved. A cyanoacrylate sealing method was performed to achieve hemostasis. Six days later, the Aron Alpha A® coating detached, and the wound was nearly completely epithelialized.
Multiple trauma and shock vital signs as potential for improved outcome in patients with severe head trauma
- First Published: 25 April 2025
LETTER TO THE EDITOR
Response to “Letter to Early do-not-attempt resuscitation orders and neurological outcomes in older out-of-hospital cardiac arrest patient”
- First Published: 25 April 2025
CASE IMAGE
Unilateral temporal lobe atrophy after massive caffeine overdose
- First Published: 24 April 2025
CASE REPORT
Bronchiolitis obliterans due to toxic epidermal necrolysis with structural evaluation using computed tomography bronchography: A case report
- First Published: 14 April 2025

Awareness of bronchiolitis obliterans development after the acute phase of toxic epidermal necrolysis is crucial. CT bronchography in bronchiolitis obliterans is superior to conventional CT in visualizing bronchial changes and may be a valuable tool for early detection and monitoring of bronchiolitis obliterans in toxic epidermal necrolysis.
ORIGINAL ARTICLE
mRNA–miRNA integration analysis of T-cell exhaustion in sepsis from community-acquired pneumonia
- First Published: 02 April 2025

mRNA–miRNA integration analysis in community-acquired pneumonia-associated sepsis revealed immune dysregulation with T-cell exhaustion, highlighting the activation of PD-1/PD-L1 and suppression of Th1 pathways. These findings provide insights into sepsis pathogenesis and potential therapeutic targets.
Association of blood carboxyhemoglobin levels with mortality and neurological outcomes in out-of-hospital cardiac arrest
- First Published: 23 March 2025
Early lymphopenia as a predictor of COVID-19 outcomes: A multicenter cohort study
- First Published: 21 March 2025
CASE IMAGE
Pediatric pharyngeal foreign body with a difficult diagnosis
- First Published: 17 March 2025
ORIGINAL ARTICLE
Clinical characteristics and outcomes of patients with out-of-hospital cardiac arrest treated by repeated extracorporeal cardiopulmonary resuscitation: A multicenter retrospective cohort study
- First Published: 13 March 2025
Efficacy of near-infrared spectroscopy in diagnosing skin and soft tissue infections: A single-center retrospective study
- First Published: 13 March 2025
Medical validity and layperson interpretation of emergency visit recommendations by the GPT model: A cross-sectional study
- First Published: 12 March 2025

In this cross-sectional study, we assessed the medical plausibility of ChatGPT's outputs as evaluated by seven experts and the interpretation of these outputs by 157 laypersons. ChatGPT demonstrated high accuracy in advising regarding emergency visits when evaluated by experts, but laypersons frequently misinterpreted its recommendations.
Association between neurological outcomes and prehospital time in patients with out-of-hospital cardiopulmonary arrest
- First Published: 06 March 2025
Difficult-to-transport cases and neurological outcomes of out-of-hospital cardiac arrest: A population-based nationwide study in Japan
- First Published: 03 March 2025
Evaluation of aerosol generation and cooling effects of evaporative plus convective cooling in heat stroke treatment: A simulation study
- First Published: 28 February 2025

Heat stroke treatment simulation was conducted using dolls resembling heat stroke patients, and a greater cooling effect was observed with a typical electric fan than with a handheld fan. Because no aerosol was generated from the body surface by evaporation, there was no risk of aerosol-related viral infection.
Automated CT image prescription of the gallbladder using deep learning: Development, evaluation, and health promotion
- First Published: 27 February 2025

The proposed system achieves state-of-the-art performance in the automatic detection and diagnosis of gallbladder conditions in patients requiring cholecystectomy, with robust accuracy and computational efficiency, such as (A) a patient with acute cholecystitis and gallstones and (B) a healthy participant.
LIST OF REVIEWERS
GUIDELINES
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024
- First Published: 24 February 2025
CASE REPORT
Ruptured abdominal aortic aneurysm managed using resuscitative endovascular balloon occlusion of the aorta with a two-stage approach
- First Published: 21 February 2025
Jesaconitine monitoring in a case of severe aconitum poisoning with torsade de pointes treated via extracorporeal membrane oxygenation
- First Published: 20 February 2025

A male in his 20s with suicidal aconite root ingestion developed refractory TdP, requiring ECMO. His arrhythmia resolved as jesaconitine levels decreased below 1 ng/mL. This case highlights the correlation between jesaconitine concentration and clinical symptoms, suggesting its potential use in guiding treatment for severe Aconitum poisoning.
REVIEW ARTICLE
Sepsis in Global Health: Current global strategies to fight against sepsis
- First Published: 19 February 2025
CASE REPORT
Traumatic internal carotid artery aneurysm distant from facial bone fractures treated with a flow diverter stent: A case report
- First Published: 24 January 2025

A 20-year-old woman with a traumatic internal carotid artery aneurysm, distant from facial fractures, was successfully treated with a flow diverter stent, resulting in aneurysm occlusion and improved neurological symptoms. Early screening for cerebrovascular injury is critical in severe head trauma cases.
ORIGINAL ARTICLE
Factors influencing the delivery of automated external defibrillators by lay rescuers to the scene of out-of-hospital cardiac arrests in schools
- First Published: 24 January 2025

We investigated factors affecting whether lay rescuers bring AEDs to nontraumatic OHCAs in Japanese schools. From 2008 to 2021, overall AED delivery rates improved significantly, but incidents involving female students and those occurring during non-sport activities still show lower AED delivery rates. Further efforts are necessary to address these disparities.
Impact of COVID-19 on resuscitation after hospital arrival for patients with out-of-hospital cardiac arrest: An interrupted time series analysis
- First Published: 24 January 2025
CASE REPORT
Inadvertent insertion of dialysis catheter into subclavian artery treated with a covered stent: A case report
- First Published: 16 January 2025

This report describes a subclavian artery injury caused by inadvertent cannulation of a dialysis catheter, successfully treated with GORE VIABAHN stentgraft using pull-through technique. Covered stents offer an effective solution for major vessel injuries requiring immediate hemostasis, particularly when direct surgery is complicated by underlying medical or anatomical conditions.
Warfarin overdose successfully treated using prophylactic vitamin K infusion without severe coagulopathy: A case report
- First Published: 09 January 2025

Prophylactic vitamin K2 infusion successfully managed a warfarin overdose in a non-warfarin-dependent patient, preventing severe coagulopathy and hemorrhage despite the high initial warfarin concentration. This case suggests that early VK administration may be effective in avoiding complications in similar overdose scenarios.
CASE IMAGE
ORIGINAL ARTICLE
Hypothermia-associated acute pancreatitis: A multicenter prospective observational study
- First Published: 03 January 2025

This study comprised a post hoc analysis of data from a multicenter prospective observational study (ICE-CRASH study). The incidence of acute pancreatitis was 3.8% in patients with accidental hypothermia ≤32°C. Patients who developed pancreatitis appeared to have been influenced by alcohol consumption. No strong predictors of pancreatitis were identified.