Acheta domesticus (AD) in high-fat and -fructose diet (HFFD) reduces body weight gain and visceral adipose tissue accumulation.

AD in HFFD decreases the serum triglycerides and improves insulin resistance, measured by the HOMA-IR index.

The effects of the addition of AD in an HFFD were related to a greater lipid excretion in feces, and the partial inhibition of pancreatic lipase by the aqueous extract and the hydrolyzed protein obtained from AD.

• New alternatives from sustainable sources to wheat in bakery foods as an approach that affects human health.
• Alternatives from sustainable sources are important source of nutrients and bioactive compounds.
• Alternatives from sustainable sources are rising due to nutritional and consumer demand in bakery industry.
• New alternatives from sustainable sources improve physicochemical, pasting, and rheological properties of dough.
• Non-wheat-based foods from non-traditional grains have a potential to increase consumer market acceptance.

Most plant-based foods (e.g., cereals and legumes) contain thermosensitive anti-nutritional factors such as trypsin inhibitors, lectins, urease and lipoxygenase, the presence of which can cause damage to human such as reduced trypsin activity, decreased appetite, gastro-intestinal wall damage, interference with digestive enzyme secretion and compromised absorption rate of nutrients. Now physical, biological and chemical methods are being used to passivate anti-nutritional factors in foods and improve people health. In this paper, we reviewed the research progress on thermosensitive anti-nutritional factors.

Kaempferol had comparable anti-Helicobacter pylori capacities to clarithromycin and amoxicillin. Crabapple flowers containing abundant kaempferol may benefit humans by inhibiting the growth of H. pylori in a manner distinct from antibiotics.

Major royal jelly proteins (MRJPs) were applied to study its effects on improving NAFLD in the NAFLD mouse model. Herein, we demonstrated that intaking of 250–500 mg/kg/day MRJPs significantly decreased the rate of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. TOF to MRM widely targeted metabolomics indicated that MRJPs alleviated lipid metabolism, oxidative stress, and inflammation mainly by regulating the metabolisms of alpha-linolenic acid, linoleic acid, arachidonic acid, and biosynthesis of unsaturated fatty acids.

In the present study, the effect of postmortem pH decline rate on mitochondria-dependent apoptosis and bovine muscle tenderness was investigated. The fast pH decline promoted sarcoplasmic protein denaturation and ROS accumulation, which further enhanced mitochondrial dysfunction and cytochrome c oxidation, thereby increasing the proportion of apoptotic nuclei and caspase-3 activity. Thus, the fast postmortem pH decline contributed to the tenderization of bovine muscle via caspase-3 activation.

The various extracts of self-fermented Bovistella sinensis (BS) Lloyd showed stronger anti-proliferation of MDA-MB-231 cells than that of untreated. Then the ethyl acetate extract of self-fermented BS was further separated and purified to obtain the main component F, which showed the low toxicity in normal cell line, while high cytotoxicity in breast cancer cell line. Apoptosis of MDA-MB-231 cells was found to be taken place in the mitochondrial pathway induced by reactive oxygen species.

The molecular docking and molecular dynamics simulations of carotenoids against multiple SARS-CoV-2 druggable targets revealed that carotenoids are promising therapeutic candidates for COVID-19. Particularly, crocin showed strong binding affinity against multiple drug targets and thus can be considered as a dietary supplement option in the prevention and treatment of COVID-19.

Electrochemical assays confirmed the antioxidant power of jabuticaba seed extracts. Extracts prevented lipid peroxidation induced by Fe²⁺ in phospholipids. Jabuticaba seed extracts prevented AAPH-induced oxidative damages in erythrocytes.

Protective effects of epigallocatechin-3-o-gallate combined with organic selenium against transforming growth factor-beta 1-induced fibrosis in LX-2 cells Mechanisms of TGF-β1-induced fibrosis of LX-2 cells improved by EGCG combined with organic selenium.

Sixty-three days of supplementation with a polyphenol-rich extract from Thymus atlanticus prevented diabetes, hyperlipidemia, and oxidative stress induced by a high-fat diet (HFD) in hamsters via improving insulin signaling, decreasing the levels of LDL cholesterol and VLDL triglycerides, increasing HDL cholesterol level, and enhancing serum paraoxonase-1 activity.

To investigate the effects of 63 secondary metabolites from Salvia species on cell viability and apoptosis were examined using MTT and Western Blot methods. Acetyl royleanone, 6,7-dehydroroyleanone, carnosic acid and cryptotanshinone were found to have anticancer potential based on their modulating effects on the expression levels of Bax and Bcl-2 proteins which play important roles in the regulation of apoptosis.

Blueberry extract improves vascular remodeling.

Genistein is widely distributed in soy or soy-based products. It has potential therapeutic benefits against several diseases due to its antioxidant, antineoplastic, anti-inflammatory, antiobesity, cardioprotective and antidiabetic activities.

The antithrombotic, antistroke, anti-inflammatory, pro-angiogenic, and cardioprotective activities of phospholipids from shrimp heads, codfish roe, and squid gonads were comprehensively evaluated and compared using the zebrafish model. There were significant differences among these distinct phospholipids in activities. The results lay a foundation for the development of phospholipids in marine byproducts in the future.

Lung cancer is one of the most common malignancies in the world with a high fatality rate. Several studies have found that Baicalein is an important candidate for treating lung cancer. Its mechanism of action includes regulation of oxidative stress, cell proliferation, metastasis, apoptosis, cell cycle, autophagy, and inflammation. Baicalein could be used as a novel anti-cancer drug for the treatment of lung carcinoma.

• LGG fermentation further enhanced the anti-digestive properties, NIAC, and SCFAs production of dietary fiber in bamboo shoot.
• There was no significant difference in bread quality when adding 3% FTDF-LGG to bread and it had great CAC and more than 25% reduced the release of reducing sugar.

Kidney bean cysteine protease was characterized as a major cross-reacting allergen by in silico and in vitro methods. In computational assessment cross-reactivity and allergenicity of allergen was determined using sequence homology approach. This was followed by cloning and purification of allergen using recombinant DNA technology and affinity chromatography, respectively. Finally, in vitro analysis using food hypersensitive patients' sera validated in silico data, thereby representing cysteine protease as a potential allergen.

Piper retrofractum extract (PRE) and piperine promoted the proliferation, migration, and tube formation of human dermal lymphatic microvascular endothelial cells (HDLECs). PRE- and piperine-induced lympangiogenesis is AKT and ERK signaling dependent mechanism. PRE has the potential to be used as a novel functional food for improving lymphedema.

Kidney bean cysteine protease was characterized as a major cross-reacting allergen by in silico and in vitro methods. In computational assessment cross-reactivity and allergenicity of allergen was determined using sequence homology approach. This was followed by cloning and purification of allergen using recombinant DNA technology and affinity chromatography, respectively. Finally, in vitro analysis using food hypersensitive patients' sera validated in silico data, thereby representing cysteine protease as a potential allergen.

OCP-3, purification from O. corniculata polysaccharide with DEAE Cellulose-52 and Sephadex G-100, was an acidic heteropolysaccharide with 31.5 kDa and exhibited strong antioxidants for scavenging free radical, anti-lipid peroxidation, protecting plasmid DNA, HEK 293 cell, and Caenorhabditis elegans from oxidative damage.

We developed a new dual protein functional yogurt fermented by Bacillus natto and Lactobacillus plantarum with milk and soy as substrates. Our results demonstrated that Natto yogurt could improve blood lipid by inhibiting the de novo synthesis of fatty acids, accelerating the catabolism of fatty acids, reducing liver damage, and increasing the richness of beneficial intestinal microorganisms. Therefore, it is possible that Natto yogurt could prevent and treat hyperlipidemia and obesity as a functional food.

• L. draba extract due has remarkable anti-oxidant and anti-inflammatory properties.
• L. draba extract can protects the Oxymetholone-induced kidney and liver injuries.
• L. draba extract contains phenolic and flavonoid components.

1 ASTE suppressed the secretion and mRNA expression of inflammatory cytokines in LPS-primed THP-1 macrophages treated with MSU; 2 ASTE suppressed NLRP3 inflammasome priming and activation; 3 Activating Nrf2 signaling pathway was involved in the negative regulation of ASTE on gout inflammation.

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• Chemical and natural toxic agents affect human health.
• Phenolic antioxidant compounds can suppress free radical production.
• Chlorogenic acid exerts strong antioxidant properties that can effectively help in the treatment of various toxicities.

This study shows that after 10 weeks of gavage, the level of INS in DT3 (inactivated cellular content of L. plantarum SCS4) significantly increased and the level of ROS and MDA returned to normal level. The activities of SOD, CAT, and GPx increased. In addition, there is no significant lesion of pancreas in the DT3 group. The results indicate that the inactivated cellular content of L. planetarum SCS4 is more effective in improving oxidative stress in the pancreas of hyperglycemic mice.

• Whole forms of cereals, like brown rice, wheat, maize, barley, and millets, like finger, foxtail, proso, kodo, and their effect on inhibition of biochemical markers of adipogenesis and inflammation.
• Role of grain phytochemicals like phenolics, tocopherols, tocotrienols, carotenoids, antioxidants, dietary fiber in obesity-associated biochemical markers of inflammation.

• The COX2 is a key target of LE on cancer.
• Indole, 2-methyl-3-phenyl from LE is a key inhibitor on COX-2 against cancer.
• The inactivation of pathways in cancer, and activation in PPAR signaling pathway are significant pathways of LE against cancer.

Effect of dragon fruit extract on indomethacin-induced ulcer. Malondialdehyde (MDA), caspase 3 (Cas-3) and Cyclooxygenase 2 (Cox-2) levels was increased, while Glutathione (GSH) and Cyclooxygenase 1 (Cox-1) levels was decreased in indomethacin-induced ulcer. On the other hand, when Dragon Fruit Extract (DFE) was given as a protective agent, the levels of MDA, Cas-3 and Cox-2 decreased, while the levels of (GSH) and Cox-1 decreased. As a result, DFE reduced ulcer foci and shows gastro-protective activity in the stomach.

The aim of this review is to focus on the research advances of natural polysaccharides in reducing the risks of atherosclerosis based on evidence of in vitro and in vivo studies.

The present study focuses on the identification and quantification of bioactive chemicals present in the ripe fruit pulp of Musa balbisiana (RFPMB) and to develop a phytopharmaceutical composition for the treatment of different metabolic complications.

The reversed micelle system consisting of n-hexanol/isooctane and CTAB was an appropriate decolorized method for Ramaria flava polysaccharide. Decolorized R. flava polysaccharide was virtually undegraded after digestion in vitro. Decolorized R. flava polysaccharide stimulated Lactobacillus rhamnosus proliferation and improved SCFA production.

A pectin polysaccharide (AP2-c) was extracted, purified and identified from the lignified okra. The physicochemical characteristics of AP2-c were systematically studied for the first time. The anti-inflammatory activity of AP2-c was explored by the NF-κB inflammatory pathway.

Antisickling effect of C. cajan and G. max blend