Volume 46, Issue 9 e14347
ORIGINAL ARTICLE

Pharmacologically active chemical composite of Musa balbisiana ameliorates oxidative stress, mitochondrial cellular respiration, and thereby metabolic dysfunction

Partha Pratim Sarma

Partha Pratim Sarma

Institute of Advanced Study in Science and Technology, Guwahati, Assam, India

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

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Nonibala Gurumayum

Nonibala Gurumayum

Institute of Advanced Study in Science and Technology, Guwahati, Assam, India

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Suman Kumar Samanta

Suman Kumar Samanta

Institute of Advanced Study in Science and Technology, Guwahati, Assam, India

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Puspanjali Khound

Puspanjali Khound

Institute of Advanced Study in Science and Technology, Guwahati, Assam, India

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Sima Kumari

Sima Kumari

Institute of Advanced Study in Science and Technology, Guwahati, Assam, India

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Diptimayee Devi

Diptimayee Devi

Gauhati Medical College and Hospital, Guwahati, Assam, India

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Jayanta Barman

Jayanta Barman

Government Ayurvedic College, Guwahati, Assam, India

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Sanjay Kumar Banerjee

Corresponding Author

Sanjay Kumar Banerjee

Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India

Correspondence

Sanjay Kumar Banerjee, Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, Assam, India.

Email: [email protected]

Rajlakshmi Devi, Life Sciences Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati-781035, Assam, India.

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Rajlakshmi Devi

Corresponding Author

Rajlakshmi Devi

Institute of Advanced Study in Science and Technology, Guwahati, Assam, India

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India

Correspondence

Sanjay Kumar Banerjee, Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Guwahati 781101, Assam, India.

Email: [email protected]

Rajlakshmi Devi, Life Sciences Division, Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati-781035, Assam, India.

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First published: 30 July 2022
Citations: 5

Abstract

The ripe fruit pulp of different Musa species is known for its excellent source of nutrient contents. Musa balbisiana (MB) is one such variety of Musa species, mainly found in the southern part of Asia, especially in the North-eastern part of India, remains unexplored despite its continuous use by the local traditional healers. The present study focuses on identifying and quantifying the active chemicals present in the ripe fruit pulp of Musa balbisiana (RFPMB) to understand its combined efficacy and nutritional benefit to control human metabolic complications specially related to diabetes and cardiovascular disorder. Characterization and confirmation through targeted LC-MS and HPLC-PDA based assays followed by quantitative analysis led us to identify the major bioactive compounds in RFPMB as shikimic acid, p-hydroxybenzoic acid, vanillic acid, ferulic acid, sinapic acid, caffeic acid, syringic acid, chlorogenic acid, trans-cinnamic acid, and two essential fatty acids; linolenic acid and linoleic acid. The ripe fruit pulp is further analyzed to understand the nutritional and mineral content and found a substantial presence of calcium and potassium (15.74 ± 0.43 and 395.20 ± 9.5 mg/100 g of raw pulp, respectively) compared to other reported varieties. The active portion of RFPMB reduces the production of ROS, the expression of inflammatory marker genes TNF-α and TGF-β, and accelerates the mitochondrial oxygen consumption rate (OCR) by enhancing the basal respiration, maximal respiration, and ATP production capacity of the targeted cells. The present study concluded that, a particular phytopharmaceutical composition of RFPMB with 11-biomarker compounds might be an efficacious formulation for developing a value-added nutraceutical product in managing metabolic complications and its related oxidative stress.

Practical applications

This study has provided the prior information regarding the potential nutraceutical and phytochemical advantages of Musa balbisiana (MB) fruit pulp over other reported banana varieties. The HPLC-based quantification will give a clear understanding of the food values in comparison of bioactive compounds present in the active fraction of RFPMB, which can be an effective phytopharmaceutical in combating metabolic disorders and oxidative stress. Overall this study will help to commercialize a value-added product from this variety of banana with proper scientific validation.

CONFLICT OF INTEREST

The authors declared that there is no known conflict of interest.

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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