Effect of supplementation with polyphenol extract of Thymus atlanticus on paraoxonase-1 activity, insulin resistance, and lipid profile in high-fat diet-fed hamsters
Corresponding Author
Tarik Khouya
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Correspondence
Tarik Khouya, Department of Biology, Faculty of Sciences and Techniques, University Moulay Ismail, Errachidia 52000, Morocco.
Email: [email protected]
Contribution: Conceptualization, Software, Validation, Writing - original draft, Writing - review & editing
Search for more papers by this authorMhamed Ramchoun
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Laboratory of Biotechnology and Sustainable Development of Natural Resources, Polydisciplinary Faculty, University Sultan Moulay Slimane, Beni Mellal, Morocco
Laboratory of Biochemistry and Biotechnologies, Faculty of Sciences, University Mohamed I, Oujda, Morocco
Contribution: Investigation, Methodology, Resources, Validation, Writing - review & editing
Search for more papers by this authorAbdelbassat Hmidani
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Contribution: Software, Validation, Writing - original draft
Search for more papers by this authorSouliman Amrani
Laboratory of Biochemistry and Biotechnologies, Faculty of Sciences, University Mohamed I, Oujda, Morocco
Contribution: Conceptualization, Methodology, Validation
Search for more papers by this authorMohamed Benlyas
Department of Biology, Faculty of Science, Moulay Ismail University, Meknes, Morocco
Contribution: Formal analysis, Investigation, Validation
Search for more papers by this authorFatima Kasbi Chadli
INRAe UMR1280 PhAN, Physiopathology of Nutritional Adaptations, CHU Hôtel Dieu, IMAD, CRNH Ouest, University of Nantes, Nantes Cedex, France
Contribution: Data curation, Methodology, Validation
Search for more papers by this authorKhadija Ouguerram
UMR1280 PhAN, Physiopathology of Nutritional Adaptations, INRAe, University of Nantes, CHU Hôtel Dieu, IMAD, CRNH Ouest, Nantes, France
Contribution: Methodology, Supervision, Validation
Search for more papers by this authorChakib Alem
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Contribution: Conceptualization, Supervision, Validation, Writing - review & editing
Search for more papers by this authorCorresponding Author
Tarik Khouya
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Correspondence
Tarik Khouya, Department of Biology, Faculty of Sciences and Techniques, University Moulay Ismail, Errachidia 52000, Morocco.
Email: [email protected]
Contribution: Conceptualization, Software, Validation, Writing - original draft, Writing - review & editing
Search for more papers by this authorMhamed Ramchoun
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Laboratory of Biotechnology and Sustainable Development of Natural Resources, Polydisciplinary Faculty, University Sultan Moulay Slimane, Beni Mellal, Morocco
Laboratory of Biochemistry and Biotechnologies, Faculty of Sciences, University Mohamed I, Oujda, Morocco
Contribution: Investigation, Methodology, Resources, Validation, Writing - review & editing
Search for more papers by this authorAbdelbassat Hmidani
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Contribution: Software, Validation, Writing - original draft
Search for more papers by this authorSouliman Amrani
Laboratory of Biochemistry and Biotechnologies, Faculty of Sciences, University Mohamed I, Oujda, Morocco
Contribution: Conceptualization, Methodology, Validation
Search for more papers by this authorMohamed Benlyas
Department of Biology, Faculty of Science, Moulay Ismail University, Meknes, Morocco
Contribution: Formal analysis, Investigation, Validation
Search for more papers by this authorFatima Kasbi Chadli
INRAe UMR1280 PhAN, Physiopathology of Nutritional Adaptations, CHU Hôtel Dieu, IMAD, CRNH Ouest, University of Nantes, Nantes Cedex, France
Contribution: Data curation, Methodology, Validation
Search for more papers by this authorKhadija Ouguerram
UMR1280 PhAN, Physiopathology of Nutritional Adaptations, INRAe, University of Nantes, CHU Hôtel Dieu, IMAD, CRNH Ouest, Nantes, France
Contribution: Methodology, Supervision, Validation
Search for more papers by this authorChakib Alem
Team of Biochemistry and Natural Substances, Faculty of Sciences and Techniques, Moulay Ismail University, Errachidia, Morocco
Contribution: Conceptualization, Supervision, Validation, Writing - review & editing
Search for more papers by this authorAbstract
Thymus atlanticus has been used by Moroccan people to treat a variety of health problems, particularly metabolic disorders. In this study, hamsters fed a high-fat diet daily received distilled water (a positive control) or a single dose of Thymus atlanticus polyphenols (Pp) for 63 days. The negative control was fed a normal diet and received distilled water. Results showed that the supplementation of HFD with Pp significantly (p < .001) reduced the levels of MDA and LDL cholesterol, restored insulin level, and increased the activities of serum paraoxonase-1 and HDL cholesterol levels, but did not affect (p > .05) the activity of superoxide dismutase and glutathione peroxidase when compared with the group feeding HFD alone. Thymus atlanticus could be an effective agent against dyslipidemia, oxidative stress, and insulin resistance.
Practical applications
HFD consumption is a risk factor for oxidative stress and the development of metabolic disorders, such as hyperlipidemia and insulin resistance, which may result in atherosclerosis and related cardiovascular diseases, the leading causes of death globally. The management of these alterations is an important strategy to prevent and treat heart complications. Our results showed thatT. atlanticus effectively alleviated HFD-induced hyperlipidemia and insulin resistance and improved PON1 activity. T. atlanticus is a source of biomolecules that may be an effective supplement for controlling HFD-related metabolic disorders. Therefore, the findings of this study may be helpful in the preparation of effective supplements from T. atlanticus to control metabolic disorders and related complications.
CONFLICT OF INTEREST
There is no conflict of interest.
Open Research
DATA AVAILABILITY STATEMENT
All the data used is available from the corresponding author.
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