REVIEW
Bioactive polysaccharides and their potential health benefits in reducing the risks of atherosclerosis: A review
Chao-Li Jiang,
Xue-Ying Li,
Wen-Di Shen,
Li-Hua Pan,
Qiang-Ming Li,
Jian-Ping Luo,
Xue-Qiang Zha,
Chao-Li Jiang
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorXue-Ying Li
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorWen-Di Shen
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorLi-Hua Pan
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorQiang-Ming Li
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorJian-Ping Luo
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorCorresponding Author
Xue-Qiang Zha
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes, Hefei University of Technology, Hefei, People's Republic of China
Correspondence
Xue-Qiang Zha, Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China.
Email: [email protected]
Search for more papers by this authorChao-Li Jiang,
Xue-Ying Li,
Wen-Di Shen,
Li-Hua Pan,
Qiang-Ming Li,
Jian-Ping Luo,
Xue-Qiang Zha,
Chao-Li Jiang
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorXue-Ying Li
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorWen-Di Shen
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorLi-Hua Pan
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorQiang-Ming Li
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorJian-Ping Luo
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Search for more papers by this authorCorresponding Author
Xue-Qiang Zha
Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China
School of Food and Biological Engineering, Hefei University of Technology, Hefei, People's Republic of China
Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes, Hefei University of Technology, Hefei, People's Republic of China
Correspondence
Xue-Qiang Zha, Engineering Research Centre of Bioprocess of Ministry of Education, Hefei University of Technology, Hefei, People's Republic of China.
Email: [email protected]
Search for more papers by this authorChao-Li Jiang and Xue-Ying Li contributed equally to this work.
Abstract
Atherosclerosis is a kind of lipid-driven chronic inflammatory disease of arteries and is the principal pathological basis of life-threatening cardiovascular disease events, such as strokes and heart attacks. Clinically, statins are the most commonly prescribed drugs for the treatment of atherosclerosis, but prolonged use of these drugs exhibit many adverse reactions and have limited efficacy. Polysaccharides are important natural biomacromolecules widely existing in plants, animals, microorganisms and algae. They have drawn considerable attention worldwide due to their multiple healthy functions, along with their non-toxic property. Importantly, a growing number of studies have demonstrated that bioactive polysaccharides exhibit prominent efficiency in controlling atherosclerotic risk factors like hyperlipemia, hypertension, oxidative stress, and inflammation. In recent decades, various bioactive polysaccharides with different structural features and anti-atherosclerotic potential from natural sources have been isolated, purified, and characterized. The aim of this review is to focus on the research progress of natural polysaccharides in reducing the risks of atherosclerosis based on evidence of in vitro and in vivo studies from 1966 to 2022.
Practical applications
In the future, it is still necessary to strengthen the research on the development and mechanism of polysaccharides with anti-atherosclerotic potential. These anti-atherosclerotic polysaccharides with different structural characteristics and physiochemical properties from different sources will constitute a huge source of materials for future applications, especially in functional foods and drugs. The information summarized here may serve as useful reference materials for further investigation, production, and application of these polysaccharides in functional foods and therapeutic agents.
CONFLICT OF INTEREST
The authors declare that they have no conflict of interests.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing not applicable to this article as no datasets were generated or analysed during the current study.
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