• Issue

    Hepatology: Volume 68, Issue 5

    1665-2048
    November 2018
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Cover Image

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Cover Image

  • First Published: 27 October 2018

Issue Information

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Masthead

  • First Published: 27 October 2018
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Table of contents

  • First Published: 27 October 2018

Hepatology Highlights

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Hepatology Highlights

Norihiro Imai,  Tibor I. Krisko,  Zaid H. Tafesh,  Catherine Lucero,  Michele Alves-Bezerra,  Hayley T. Nicholls,  Sandra Steensels,  Baran A. Ersoy,  Russell Rosenblatt,  Robert E. Schwartz,  Vikas Gupta,  Zurabi Lominadze,  Brett E. Fortune, 
  • Pages: 1665-1667
  • First Published: 27 October 2018

Editorials

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Ad Libitum Mediterranean or Low-Fat Diets as Treatments for Nonalcoholic Fatty Liver Disease?

Giovanni Targher , M.D.,  Christopher D. Byrne , M.B. B.Ch., Ph.D, 
  • Pages: 1668-1671
  • First Published: 02 August 2018
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Vascular Immunotargeting: Take the Highway to the First Exit

Vladimir R. Muzykantov , M.D., Ph.D.,  Jacob S. Brenner , M.D., Ph.D., 
  • Pages: 1672-1674
  • First Published: 02 August 2018
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AKTions by Cytoplasmic lncRNA CASC9 Promote Hepatocellular Carcinoma Survival

Ji Heon Noh,  Myriam Gorospe, 
  • Pages: 1675-1677
  • First Published: 16 July 2018
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Oxidized Albumin—A Trojan Horse for p38 MAPK-Mediated Inflammation in Decompensated Cirrhosis

Francesca Cingolani,  Mark J. Czaja, 
  • Pages: 1678-1680
  • First Published: 16 July 2018

Original Articles

VIRAL HEPATITIS

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Efficacy and Safety of Peginterferon Alfa-2a (40KD) in Children With Chronic Hepatitis B: The PEG-B-ACTIVE Study

Stefan Wirth,  Hongfei Zhang,  Winita Hardikar,  Kathleen B. Schwarz,  Etienne Sokal,  Weibo Yang,  Huimin Fan,  Vyacheslav Morozov,  Qing Mao,  Hong Deng,  Yang Huang,  Lei Yang,  Nicolas Frey,  Clare Nasmyth-Miller,  Vedran Pavlovic,  Cynthia Wat, 
  • Pages: 1681-1694
  • First Published: 24 April 2018
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Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes

Eloi R. Verrier,  Seung-Ae Yim,  Laura Heydmann,  Houssein El Saghire,  Charlotte Bach,  Vincent Turon-Lagot,  Laurent Mailly,  Sarah C. Durand,  Julie Lucifora,  David Durantel,  Patrick Pessaux,  Nicolas Manel,  Ivan Hirsch,  Mirjam B. Zeisel,  Nathalie Pochet,  Catherine Schuster,  Thomas F. Baumert, 
  • Pages: 1695-1709
  • First Published: 20 April 2018
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CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling

Huixia Zhang,  Chao Zhang,  Hong Tang,  Shanshan Gao,  Fang Sun,  Yuan Yang,  Weiping Zhou,  Yu Hu,  Changshu Ke,  Yu Wu,  Zeyang Ding,  Lin Guo,  Rongjuan Pei,  Xinwen Chen,  Man-Sun Sy,  Bixiang Zhang,  Chaoyang Li, 
  • Pages: 1710-1725
  • First Published: 05 May 2018
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Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition

Raymond Wu,  Ramachandran Murali,  Yasuaki Kabe,  Samuel W. French,  Yi-Ming Chiang,  Siyu Liu,  Linda Sher,  Clay C. Wang,  Stan Louie,  Hidekazu Tsukamoto, 
  • Pages: 1726-1740
  • First Published: 05 May 2018

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial

Catherine Properzi,  Therese A. O'Sullivan,  Jill L. Sherriff,  Helena L. Ching,  Garry P. Jeffrey,  Rachel F. Buckley,  Jonathan Tibballs,  Gerry C. MacQuillan,  George Garas,  Leon A. Adams, 
  • Pages: 1741-1754
  • First Published: 05 May 2018
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Relationship Between Relative Skeletal Muscle Mass and Nonalcoholic Fatty Liver Disease: A 7-Year Longitudinal Study

Gyuri Kim,  Seung-Eun Lee,  You-Bin Lee,  Ji Eun Jun,  Jiyeon Ahn,  Ji Cheol Bae,  Sang-Man Jin,  Kyu Yeon Hur,  Jae Hwan Jee,  Moon-Kyu Lee,  Jae Hyeon Kim, 
  • Pages: 1755-1768
  • First Published: 20 April 2018
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TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice

Chang-Jiang Yu,  Qiu-Shi Wang,  Ming-Ming Wu,  Bin-Lin Song,  Chen Liang,  Jie Lou,  Liang-Liang Tang,  Xiao-Di Yu,  Na Niu,  Xu Yang,  Bao-Long Zhang,  Yao Qu,  Yang Liu,  Zhi-Chao Dong,  Zhi-Ren Zhang, 
  • Pages: 1769-1785
  • First Published: 27 April 2018
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Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6

Pengcheng Luo,  Cong Qin,  Lihua Zhu,  Chun Fang,  Yan Zhang,  Hai Zhang,  Fei Pei,  Song Tian,  Xue-Yong Zhu,  Jun Gong,  Qing Mao,  Chengcheng Xiao,  Yang Su,  Haizhou Zheng,  Tao Xu,  Jingxiao Lu,  Jie Zhang, 
  • Pages: 1786-1803
  • First Published: 26 April 2018

HEPATOBILIARY MALIGNANCIES

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Phenomenon of Endothelial Antibody Capture: Principles and Potential for Locoregional Targeting of Hepatic Tumors

Nora Winkler,  Felix Strübing,  Wolfgang Groß,  Walter Mier,  Eduard Ryschich, 
  • Pages: 1804-1816
  • First Published: 07 May 2018
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The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling

Marcel Klingenberg,  Matthias Groß,  Ashish Goyal,  Maria Polycarpou-Schwarz,  Thilo Miersch,  Anne-Sophie Ernst,  Jörg Leupold,  Nitin Patil,  Uwe Warnken,  Heike Allgayer,  Thomas Longerich,  Peter Schirmacher,  Michael Boutros,  Sven Diederichs, 
  • Pages: 1817-1832
  • First Published: 23 May 2018
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Hepatocellular Carcinoma-Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element-Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth

Chenchen Wang,  Ying Tong,  Yankai Wen,  Jie Cai,  Han Guo,  Lifeng Huang,  Min Xu,  Mingxuan Feng,  Xiaosong Chen,  Jianjun Zhang,  Hailong Wu,  Xiaoni Kong,  Qiang Xia, 
  • Pages: 1833-1850
  • First Published: 16 April 2018
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Oxidatively Modified Protein-Disulfide Isomerase–Associated 3 Promotes Dyskerin Pseudouridine Synthase 1–Mediated Malignancy and Survival of Hepatocellular Carcinoma Cells

Eunkyong Ko,  Jong-Seo Kim,  Soomi Ju,  Hyun-Wook Seo,  Yeonji Chang,  Jung-Ah Kang,  Sung-Gyoo Park,  Guhung Jung, 
  • Pages: 1851-1864
  • First Published: 19 April 2018
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CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein–Coupled Receptor–Mediated Signaling in Hepatocellular Carcinoma

Yin Yin,  Xiaoliang Xu,  Junwei Tang,  Wenjie Zhang,  Guangyan Zhangyuan,  Jie Ji,  Lei Deng,  Shuai Lu,  Han Zhuo,  Beicheng Sun, 
  • Pages: 1865-1878
  • First Published: 27 April 2018
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Impact of the Treating Hospital on Care Outcomes for Hepatocellular Carcinoma

Ronald T. Cotton,  Hop S. Tran Cao,  Abbas A. Rana,  Yvonne H. Sada,  David A. Axelrod,  John A. Goss,  Mark A. Wilson,  Steven A. Curley,  Nader N. Massarweh, 
  • Pages: 1879-1889
  • First Published: 02 August 2018

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Cytokine-Producing B Cells Promote Immune-Mediated Bile Duct Injury in Murine Biliary Atresia

Joseph Bednarek,  Brianna Traxinger,  Dania Brigham,  Jonathan Roach,  David Orlicky,  Dong Wang,  Roberta Pelanda,  Cara L. Mack, 
  • Pages: 1890-1904
  • First Published: 20 April 2018
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Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis

Amy E. Taylor,  Alexandra N. Carey,  Ramesh Kudira,  Celine S. Lages,  Tiffany Shi,  Simon Lam,  Rebekah Karns,  Julia Simmons,  Kumar Shanmukhappa,  Maha Almanan,  Claire A. Chougnet,  Alexander G. Miethke, 
  • Pages: 1905-1921
  • First Published: 26 April 2018
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The Immunobiology of Receptor Activator for Nuclear Factor Kappa B Ligand and Myeloid-Derived Suppressor Cell Activation in Immunoglobulin G4–Related Sclerosing Cholangitis

Min Lian,  Qixia Wang,  Xiang Jiang,  Jun Zhang,  Yiran Wei,  Yanmei Li,  Bo Li,  Weihua Chen,  Haiyan Zhang,  Qi Miao,  Yanshen Peng,  Xiao Xiao,  Li Sheng,  Weici Zhang,  Jingyuan Fang,  Ruqi Tang,  M. Eric Gershwin,  Xiong Ma, 
  • Pages: 1922-1936
  • First Published: 18 May 2018

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen-Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis

José Alcaraz-Quiles,  Mireia Casulleras,  Karl Oettl,  Esther Titos,  Roger Flores-Costa,  Marta Duran-Güell,  Cristina López-Vicario,  Marco Pavesi,  Rudolf E. Stauber,  Vicente Arroyo,  Joan Clària, 
  • Pages: 1937-1952
  • First Published: 02 August 2018
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“Normal” Creatinine Levels Predict Persistent Kidney Injury and Waitlist Mortality in Outpatients With Cirrhosis

Giuseppe Cullaro,  Meyeon Park,  Jennifer C. Lai, 
  • Pages: 1953-1960
  • First Published: 26 April 2018

LIVER INJURY/REGENERATION

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Fibroblast Growth Factor 15–Dependent and Bile Acid–Independent Promotion of Liver Regeneration in Mice

Bo Kong,  Runbin Sun,  Mingxing Huang,  Monica D. Chow,  Xiao-Bo Zhong,  Wen Xie,  Yi-Horng Lee,  Grace L. Guo, 
  • Pages: 1961-1976
  • First Published: 19 April 2018
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Intrahepatic T-Cell Receptor β Immune Repertoire Is Essential for Liver Regeneration

Qing Liang,  Zeyuan Liu,  Chao Zhu,  Bin Wang,  Xiaoke Liu,  Yanan Yang,  Xue Lv,  Haiyu Mu,  Kejia Wang, 
  • Pages: 1977-1990
  • First Published: 27 April 2018
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Excessive Plasmin Compromises Hepatic Sinusoidal Vascular Integrity After Acetaminophen Overdose

Siqi Gao,  Robert Silasi-Mansat,  Amanda R. Behar,  Florea Lupu,  Courtney T. Griffin, 
  • Pages: 1991-2003
  • First Published: 05 May 2018

Special Article

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Pay It Forward: Building Capacity to Treat Hepatitis C by Training Our Own Residents

Thomas Couri,  Tanmayi Gupta,  George Weyer,  Andrew Aronsohn, 
  • Pages: 2004-2007
  • First Published: 23 May 2018

Concise Review

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Cirrhotic Cardiomyopathy After Transplantation: Neither the Transient Nor Innocent Bystander

Manhal Izzy,  Jae Oh,  Kymberly D. Watt, 
  • Pages: 2008-2015
  • First Published: 19 April 2018

Review

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Potential Clinical Targets in Hepatopulmonary Syndrome: Lessons From Experimental Models

Sarah Raevens,  Michael B. Fallon, 
  • Pages: 2016-2028
  • First Published: 05 May 2018

Hepatology Elsewhere

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Multiplatform Genomic Roadmap of Hepatocellular Carcinoma: A Matter of Molecular Heterogeneity

Hyun Goo Woo M.D., Ph.D.,  Yoon Jun Kim M.D., Ph.D., 
  • Pages: 2029-2032
  • First Published: 10 April 2018
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Utilizing Mechanistic Biomarkers in Treating Paracetamol Hepatotoxicity

Rowan F. van Golen M.D., Ph.D.,  Megan J. Reiniers M.D., Ph.D.,  Jacqueline van Gorp M.D.,  Maarten E. Tushuizen M.D., Ph.D.,  Bart van Hoek M.D., Ph.D., 
  • Pages: 2032-2035
  • First Published: 16 April 2018
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Hepatitis C in Patients With RenalDisease: A Deeper Dive Into the KDIGO Guideline

Norah A. Terrault M.D., M.P.H., 
  • Pages: 2035-2038
  • First Published: 19 April 2018

Clinical Observations in Hepatology

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A Case of Immune-Mediated Liver Injury Induced by Olaparib

Manuel Tufoni,  Carmen Serena Ricci,  Giacomo Zaccherini, 
  • Pages: 2039-2041
  • First Published: 02 August 2018
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Liver Metastases From Gastric Adenocarcinoma Mimicking Multinodular Hepatocellular Carcinoma

Álvaro Díaz-González,  Ester Monclús,  Anna Darnell,  Manel Solé,  Jordi Bruix, 
  • Pages: 2042-2044
  • First Published: 25 July 2018

Correspondence

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Diminishing Kidney Reserve and the “Pseudo”normal Creatinine

Abhilash Koratala M.D.,  Kawther F. Alquadan M.D., 
  • Page: 2045
  • First Published: 18 July 2018
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Acute-on-Chronic Liver Failure defined by NACSELD: The Impact on Prognosis and Futility of Care

Filipe S. Cardoso , M.D., M.Sc., 
  • Page: 2046
  • First Published: 10 September 2018
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Reply:

Jacqueline G. O’Leary , M.D. M.P.H.,  K. Rajender Reddy , M.D.,  Florence Wong , M.D.,  Guadalupe Garcia-Tsao , M.D.,  Patrick S. Kamath , M.D.,  Leroy R. Thacker , Ph.D.,  Jasmohan S. Bajaj , M.D., M.S., 
  • Pages: 2046-2048
  • First Published: 10 September 2018

Issue Information

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Notices

  • First Published: 27 October 2018
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Instructions to Authors

  • First Published: 27 October 2018