Given that the severe acute respiratory syndrome coronavirus 2 (SRAS-CoV-2) virus keeps mutating during the COVID-19 pandemic, there is an urgent need to develop a quick and convenient test method to detect real-life samples for mass on-site screening. Zhang et al. proposed a novel strategy for rapid detection and discrimination of SARS-CoV-2 and its variants at rather low cost utilizing a subtly designed DNA probe. By combining with a paper-based colorimetric amplification platform, the results could be analyzed by the naked eyes or a widely used smartphone.

Nanobiotechnology-mediated radioimmunotherapy is mainly applied to the local controlled release of immunotherapeutic drugs in tumors, enhancement of radiosensitization and avoidance of systemic toxic reaction, which is explored new options for clinical treatment of TNBC.

Specific mature cell membrane camouflaging facilitated the internalization of nanothylakoids through homologous targeting and membrane fusion. Under red light irradiation, the biomimetic nanothylakoids (cell membrane-camouflaged nanoparticulate thylakoids, CM-NTUs) would provide sufficient ATP and increase nicotinamide adenine dinucleotide phosphate (NADPH) to correct energy imbalance to improve metabolic homeostasis through enhancing anabolism in degenerated cells. Consequently, CM-NTUs promoted cartilage homeostasis and remarkedly ameliorated osteoarthritis progression in animals, offering therapeutic avenues for various degenerative diseases.

Dendrimers can prolong precorneal retention, enhance corneal permeation, allow multidrug loading, allow hierarchical structure construction and targeting, and inhibit inflammation, making them multifunctional topical drug delivery systems (TDDS) for the eye. Dendrimer nanogels combine the advantages of dendrimers, hydrogels, and nanoparticles. Dendrimer gel-derived drug delivery systemsmight overcome bottlenecks in topical delivery of glaucoma medications.

Amphiphilic PhA-PEG₅₀₀₀ polymer can self-assemble into nanoparticles to perform as not only a photosensitizer but also a drug carrier to deliver chemotherapeutic drugs, achieving photo-chemo combination therapy. The design of the PhA-PEG₅₀₀₀ is the key-point to significantly improve the total drug loading of the nanomedicine for enhanced combination therapy.

Scanning ion conductance microscope has strong potentials in various living biological samples, such as the real-time and high-resolution imaging of living cell, monitoring the volume and movements of living cell.

Lipopeptides are surface active molecules with hydrophilic and hydrophobic regions and are kenned to be engendered by different species of Bacillus and Pseudomonas. These lipopeptides can be applied in different domains because of their remarkable properties like antibacterial, antifungal, anticorrosion, antitumor, and antiviral. They act by engendering pores in the cell membrane to perforate and conclusively disrupt them.

Nontoxic, biocompatible UV filter agents by integrating the chemical and physical functionality of the rare-earths and organic Lawsone with excellent sun protection value.