• Issue

    Epilepsia Open: Volume 10, Issue 2

    371-660
    April 2025
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ISSUE INFORMATION

Open Access

Issue Information

  • Pages: 371-379
  • First Published: 22 April 2025

NARRATIVE REVIEW

Open Access

Voxel-based and surface-based cortical morphometric MRI applications for identifying the epileptogenic zone: A narrative review

Jacob Bunyamin,  Benjamin Sinclair,  Meng Law,  Patrick Kwan,  Terence J. O'Brien,  Andrew Neal, 
  • Pages: 380-397
  • First Published: 28 February 2025

SYSTEMATIC REVIEW

Open Access

The use of steroids in adult epilepsy: A systematic review

Ruth Walsh,  Colin P. Doherty,  Elisabeth Doran, 
  • Pages: 398-410
  • First Published: 12 February 2025

SPECIAL REPORT

Open Access

Three cases of atypical Rasmussen's encephalitis with delayed-onset seizures

Hongru Guo,  Pan Gong,  Guojing Yu,  Chongyang Tang,  Guoming Luan,  Qingzhu Liu,  Lixin Cai,  Taoyun Ji, 
  • Pages: 411-426
  • First Published: 21 February 2025

ORIGINAL ARTICLE

Open Access

Quantitative EEG signatures in patients with and without epilepsy development after a first seizure

Marysol Segovia-Oropeza,  Erik Hans Ulrich Rauf,  Ev-Christin Heide,  Niels K. Focke, 
  • Pages: 427-440
  • First Published: 04 March 2025
Open Access

The role of ubiquitin C–terminal hydrolase (UCH-L1) and protein S100B in differentiating patients with epileptic and psychogenic non-epileptic seizures – Pilot study

Biljana Dapic Ivancic,  Zeljka Petelin Gadze,  Lana Ganoci,  Petra Nimac Kozina,  Dunja Rogic,  Maja Zivkovic, 
  • Pages: 441-449
  • First Published: 02 March 2025
Open Access

Communicating a diagnosis of Dravet syndrome to parents/caregivers: An international Delphi consensus

Andreas Brunklaus, Susanne Schubert-Bast, Francesca Darra, Katherine Nickels, Delphine Breuillard, Andrea Giuffrida, Claire Eldred, Silke Flege, Elena Cardenal-Muñoz,  Rocío Sánchez-Carpintero, 
  • Pages: 450-465
  • First Published: 01 February 2025
Open Access

Ictal scalp EEG patterns are shaped by seizure etiology in temporal lobe epilepsy

Sha Xu,  Qianwen Zhu,  Jinqi Zhou,  Lingqi Ye,  Hongyi Ye,  Chunhong Shen,  Zhe Zheng,  Hongjie Jiang,  Shan Wang,  Yao Ding,  Cong Chen,  Yi Guo,  Zhongjin Wang,  Shuang Wang, 
  • Pages: 466-476
  • First Published: 07 February 2025
Open Access

Disparities in the utilization of genetic testing for non-acquired infantile epileptic spasms syndrome in a single healthcare center in North Carolina

Kenza El Marzouki,  Bridley K. Jenkins,  Tamy Moraes Tsujimoto,  Huijun Jiang,  Emma B. Cardwell,  Martin Arhin,  Unwana Eyo,  Cristian Gonzalez-Rodriguez,  Stephanie Peck,  Feng-Chang Lin,  Senyene E. Hunter, 
  • Pages: 477-486
  • First Published: 17 February 2025
Open Access

Diagnostic yield of utilizing 24–72-hour video electroencephalographic monitoring in the diagnosis of seizures presenting as paroxysmal events in resource-limited settings

Chukwudi Nwogu,  Chukwuma Nwaze,  Adaeze Avah,  Benjamin Anyanwu,  Chinekwu Anyanwu, 
  • Pages: 487-493
  • First Published: 19 February 2025
Open Access

HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study

Irma Wati Ngadimon,  Devi Mohan,  Mohd Farooq Shaikh,  Ching Soong Khoo,  Hui Jan Tan,  Yu Mey Lee,  Nor Syazwani Chamhuri,  Farizal Fadzil,  Nursyazwana Zolkafli,  Alina Arulsamy,  Jegan Thanabalan,  Angel Aledo-Serrano,  Wing Loong Cheong, 
  • Pages: 494-507
  • First Published: 12 February 2025
Open Access

Intrinsic brain network stability during kainic acid-induced epileptogenesis

Nastaran Jafari,  Lingna He,  Charbel Bou Khalil,  Hsiang J. Yeh,  Neil G. Harris,  John M. Stern,  Jerome Engel Jr.,  Anatol Bragin,  Lin Li, 
  • Pages: 508-520
  • First Published: 20 February 2025
Open Access

Statins' protective effects on focal epilepsy are independent of LDL-C

Zhen Sun,  Jing Zhang,  Yulong Li,  Miao Tuo,  Limin Yu,  Yun Wang,  Yanping Sun, 
  • Pages: 521-528
  • First Published: 07 March 2025
Open Access

Radiofrequency thermocoagulation in focal epilepsy: A retrospective cohort study

Alejandra Vasquez,  Karimul Islam,  Madeline R. Cross,  Kai J. Miller,  Jamie J. Van Gompel,  Brian Nils Lundstrom,  Anthony L. Fine, 
  • Pages: 529-538
  • First Published: 28 February 2025
Open Access

Interim analysis of the long-term efficacy and safety of azetukalner in an ongoing open-label extension study following a phase 2b clinical trial (X-TOLE) in adults with focal epilepsy

Jacqueline A. French, Roger J. Porter, Emilio Perucca, Martin J. Brodie, Michael A. Rogawski, Cynthia Harden, Jenny Qian, Constanza Luzon Rosenblut, Christopher Kenney, Gregory N. Beatch,  for the X-TOLE Study Group , 
  • Pages: 539-548
  • First Published: 07 March 2025
Open Access

Early rehabilitation and improved outcomes in patients with status epilepticus: Evidence from cases presenting to the emergency department

Hidetaka Onda,  Shoji Yokobori, 
  • Pages: 549-556
  • First Published: 28 February 2025
Open Access

Frequency-specific network changes in mesial temporal lobe epilepsy: Analysis of chronic and transient dysfunctions in the temporo-amygdala-orbitofrontal network using magnetoencephalography

Tomotaka Ishizaki,  Satoshi Maesawa,  Takahiro Suzuki,  Miki Hashida,  Yoshiki Ito,  Hiroyuki Yamamoto,  Takafumi Tanei,  Jun Natsume,  Minoru Hoshiyama,  Ryuta Saito, 
  • Pages: 557-570
  • First Published: 06 March 2025
Open Access

Bromodomain-containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia

Diah Kurnia Mirawati, Muhana Fawwazy Ilyas, Muhammad Hafizhan, Stefanus Erdana Putra, Suroto Suroto, Subandi Subandi,  Rivan Danuaji,  Pepi Budianto,  Yetty Hambarsari,  Baarid Luqman Hamidi,  Hanindia Riani Prabaningtyas,  Ervina Arta Jayanti Hutabarat,  Ira Ristinawati,  Teddy Tejomukti,  Raden Andi Ario Tedjo,  Faris Khairuddin Syah, 
  • Pages: 571-580
  • First Published: 07 March 2025

SHORT RESEARCH ARTICLE

Open Access

NORSE secondary to anti-GAD65 antibody-positive encephalitis treated with novel adjunctive rapid titration VNS protocol

Mingyu Li,  Nilufer Yalcin,  Danielle L. Weiss,  Leila A. T. Hill,  Manan Shah,  Klepper Alfredo Garcia,  Fernando L. Vale Diaz,  Luis G. Rueda Carrillo,  Hunter Smith,  Debra T. Moore-Hill, 
  • Pages: 581-586
  • First Published: 13 January 2025
Open Access

Harmonization of MRI sequences across ERN EpiCARE centers

Sophie Adler,  Felice D'Arco,  Kshitij Mankad,  Martin Kyncl,  Alexis Arzimanoglou,  Petr Marusic, 
  • Pages: 587-592
  • First Published: 12 February 2025
Open Access

PAK3 pathogenic variant associated with sleep-related hypermotor epilepsy in a family with parental mosaicism

Antonio Gambardella,  Yu-Chi Liu,  Mark F. Bennett,  Timothy E. Green,  John A. Damiano,  Francesco Fortunato,  Matthew J. Coleman,  Jacqueline Cherfils,  Jean-Vianney Barnier,  Jozef Gecz,  Melanie Bahlo,  Samuel F. Berkovic,  Michael S. Hildebrand, 
  • Pages: 593-601
  • First Published: 13 January 2025
Open Access

The impact of ketogenic diet on the frequency of psychogenic non-epileptic seizures (PNES): A feasibility randomized pilot study

Reinhard Janssen-Aguilar,  Juan Galindez-de la Portilla,  Iris E. Martínez-Juárez,  Claudia Mimiaga-Hernandez,  Gabriel Alvarado-Luis,  Andrea Aguilar-Hernandez,  Kevin Alan Garcia-Esparza,  Mariel Hernadez-Palestina,  Daniel Crail-Meléndez, 
  • Pages: 602-608
  • First Published: 22 January 2025
Open Access

Anti-GAD65 musicogenic epilepsy: Bilateral and independent mesial temporal seizures revealed by foramen ovale electrodes

Roberta Di Giacomo,  Giulia Maccanti,  Vadym Gnatkovsky,  Giampaolo Vatti,  Annalisa Parente,  Ambra Dominese,  Davide Rossi Sebastiano,  Fabio Martino Doniselli,  Francesca Andreetta,  Andrea Stabile,  Francesco Deleo,  Chiara Pastori,  Giulia Battaglia,  Dunja Duran,  Giuseppe Didato,  Angelo Del Sole,  Michele Rizzi,  Marco de Curtis, 
  • Pages: 609-614
  • First Published: 21 January 2025
Anti-GAD65 musicogenic epilepsy: Bilateral and independent mesial temporal seizures revealed by foramen ovale electrodes

Open Access

Exploring the effect of valproic acid levels on patients with epilepsy treated with ketogenic diet: An observational study

Stacey Tarrant,  Aurelija Liubauske,  Guangyu Zhu,  Bo Zhang,  Heidi Pfeifer,  Ann Paris,  Ann M. Bergin,  Anna L. Pinto, 
  • Pages: 615-619
  • First Published: 27 February 2025
Open Access

GATAD2B-related developmental and epileptic encephalopathy (DEE): Extending the epilepsy phenotype and a literature appraisal

Giovanna Scorrano,  Giulia Barcia,  Jérôme Champ,  Thomas Courtin,  Nathalie Boddaert,  Anna Kaminska,  Nicole Chemaly,  Rima Nabbout, 
  • Pages: 620-627
  • First Published: 20 February 2025
Open Access

Practical experience and challenges in nutritional management of glucose transporter 1 deficiency syndrome: Provider survey results

Diana Lehner-Gulotta,  Robyn Blackford,  Stacey Bessone,  Wesley Lowman,  Nicole Haggerty,  Chu-Yi Huang,  Erika T. Axeen,  the Ketogenic Dietitians Research Network , 
  • Pages: 628-634
  • First Published: 07 February 2025
Open Access

Self-limited familial focal epilepsy caused by ANK2 variants: A potentially under-recognized condition

Po-Hsi Lin,  Chen-Jui Ho,  Chih-Hsiang Lin,  Ya-Yuan Hou,  Cheng-Han Chan,  Meng-Han Tsai, 
  • Pages: 635-642
  • First Published: 17 February 2025

PRELIMINARY REPORT

Open Access

Efficacy and tolerability of low versus standard daily doses of antiseizure medications in newly diagnosed focal epilepsy. A multicenter, randomized, single-blind, non-inferiority trial (STANDLOW)

Giorgia Giussani,  Elisa Bianchi,  Edoardo Carlando,  Jacopo Cosimo DiFrancesco,  Payam Tabaee Damavandi,  Francesco Pasini,  Giulia Pederzoli,  Stefania Filipponi,  Alessandra Gaiani,  Luca Massacesi,  Eleonora Rosati,  Ginevra Giovannelli,  Teresa Anna Cantisani,  Michela Cecconi,  Rossella Papetti,  Monica Brioschi,  Francesco Aruta,  Elio Clemente Agostoni,  Francesco Paladin,  Filippo Dainese,  Marco Longoni,  Bartolini Yerma,  Sara Gasparini,  Umberto Aguglia,  Edoardo Ferlazzo,  Roberto Cantello,  Gionata Strigaro,  Marta Maschio,  Dario Benincasa,  Angela La Neve,  Giovanni Falcicchio,  Alfonso Giordano,  Lara Buttarelli,  Gabriele Enia,  Maurizio Leone,  Carlo Ferrarese,  Ettore Beghi,  Simone Beretta, 
  • Pages: 643-653
  • First Published: 27 February 2025

LETTER

Open Access

Predictive value of electrographic neonatal seizures for later epilepsy: A call for a broader perspective

Lucia Fusco, 
  • Pages: 654-655
  • First Published: 17 February 2025
Open Access

Epilepsy following neonatal encephalopathy—Future directions

Carol M. Stephens,  Jacopo Proietti,  Sean R. Mathieson,  Vicki Livingstone,  Brian McNamara,  Niamh McSweeney,  Olivia O'Mahony,  Brian H. Walsh,  Deirdre M. Murray,  Geraldine B. Boylan, 
  • Pages: 656-657
  • First Published: 04 March 2025

ANNOUNCEMENT

Open Access

Epilepsia Open – April 2025 Announcements

  • Pages: 658-660
  • First Published: 22 April 2025