• Issue

    Epilepsia Open: Volume 10, Issue 3

    661-978
    June 2025
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ISSUE INFORMATION

Open Access

Issue Information

  • Pages: 661-668
  • First Published: 13 June 2025

ORIGINAL ARTICLE

Open Access

Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats

Sana Javaid,  Faleh Alqahtani,  Abida Parveen,  Waseem Ashraf,  Zohabia Rehman,  Syed Muhammad Muneeb Anjum,  Tanveer Ahmad,  Imran Imran, 
  • Pages: 669-681
  • First Published: 08 April 2025
Open Access

Self-stigma among people with epilepsy: Comparison between Germany and Japan

Izumi Kuramochi,  Takayuki Iwayama,  Hiroaki Okajima,  Satsuki Watanabe,  Koji Matsuo,  Haruo Yoshimasu,  Christian G. Bien,  Christian Brandt,  Anne Hagemann, 
  • Pages: 682-693
  • First Published: 24 March 2025
Open Access

Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies

Rohin Singh,  Megan M. J. Bauman,  Karimul Islam,  Panagiotis Kerezoudis,  Sanjeet S. Grewal,  Jonathon J. Parker,  Jamie J. Van Gompel,  Kai J. Miller,  Brian N. Lundstrom,  Keith Starnes, 
  • Pages: 694-704
  • First Published: 01 April 2025
Open Access

Antiseizure medication choice in diffuse glioma: A single-center population-based experience

Leena Ollila,  Reina Roivainen, 
  • Pages: 705-716
  • First Published: 30 April 2025
Open Access

Prevalence and factors associated with seizures among patients with dementia: A retrospective clinic-based study

Liz Edenberg Quiles,  Prima Kristina Paola Quintay,  Adrian Espiritu,  Viel Mendoza,  Veeda Michelle Anlacan, 
  • Pages: 717-724
  • First Published: 18 March 2025
Open Access

Phenotype and surgical management of drug-resistant epilepsy in patients with COL4A1 and COL4A2 variants

Jie Shi,  Jiuluan Lin,  Jianjun Bai,  Haixiang Wang,  Bingqing Zhang,  Qian Feng,  Zhaohui Sun,  Yiou Liu,  Jing He,  Xiancheng Song,  Siyu Wang,  Xiaoyan Liu,  Wenjing Zhou, 
  • Pages: 725-735
  • First Published: 08 March 2025
Open Access

Real-world effectiveness and tolerability of cenobamate in drug-resistant epilepsy: A retrospective analysis of the patients included into the Early Access Programs (EAP) in Germany, France, and United Kingdom

Sylvain Rheims,  Bernhard J. Steinhoff,  Edouard Hirsch,  Felix Rosenow,  Arnaud Biraben,  Rhys Thomas,  Alessandro Lovera,  Paola Lipone,  Alessandro Comandini,  Caroline Benoist,  Elena Alvarez Baron,  John Paul Leach,  Karthinathan Thangavelu,  Agnese Cattaneo, 
  • Pages: 736-748
  • First Published: 22 March 2025
Open Access

Transcranial direct current stimulation treatment reduces, while repetitive transcranial magnetic stimulation treatment increases electroencephalography spike rates with refractory occipital lobe epilepsy: A case study

Tine Tronrud,  Marco Hirnstein,  Tom Eichele,  Eivind Kolstad,  Lynn Marquardt, 
  • Pages: 749-757
  • First Published: 28 March 2025
Open Access

Subjective memory complaints in people with epilepsy: Are there “signature” complaints associated with anxiety and depression?

Cassandra Trend,  Isha Puntambekar,  Sallie Baxendale, 
  • Pages: 758-767
  • First Published: 22 March 2025
Open Access

Short-term sick leave due to epilepsy in the Swedish Prospective Regional Epilepsy Database and Biobank for Individualized Clinical Treatment (PREDICT)

Kerstin Andrén,  David Larsson,  Fredrik Asztély,  Johan Zelano, 
  • Pages: 768-777
  • First Published: 28 March 2025
Open Access

A public benchmark for human performance in the detection of focal cortical dysplasia

Lennart Walger,  Matthias H. Schmitz,  Tobias Bauer,  David Kügler,  Fabiane Schuch,  Christophe Arendt,  Tobias Baumgartner,  Johannes Birkenheier,  Valeri Borger,  Christoph Endler,  Franziska Grau,  Christian Immanuel,  Markus Kölle,  Patrick Kupczyk,  Asadeh Lakghomi,  Sarah Mackert,  Elisabeth Neuhaus,  Julia Nordsiek,  Anna-Maria Odenthal,  Karmele Olaciregui Dague,  Laura Ostermann,  Jan Pukropski,  Attila Racz,  Klaus von der Ropp,  Frederic Carsten Schmeel,  Felix Schrader,  Aileen Sitter,  Alexander Unruh-Pinheiro,  Marilia Voigt,  Martin Vychopen,  Philip von Wedel,  Randi von Wrede,  Ulrike Attenberger,  Hartmut Vatter,  Alexandra Philipsen,  Albert Becker,  Martin Reuter,  Elke Hattingen,  Alexander Radbruch,  Rainer Surges,  Theodor Rüber, 
  • Pages: 778-786
  • First Published: 01 April 2025
Open Access

Noninvasive brain stimulation as focal epilepsy treatment in the hospital, clinic, and home

Karimul Islam,  Keith Starnes,  Kelsey M. Smith,  Thomas Richner,  Nicholas Gregg,  Alejandro A. Rabinstein,  Gregory A. Worrell,  Brian N. Lundstrom, 
  • Pages: 787-795
  • First Published: 10 April 2025
Open Access

Impact of hippocampectomy on seizure freedom in temporal encephaloceles: A systematic review and individual participant data meta-analysis

Panagiota-Eleni Tsalouchidou,  Alexandros Matsingos,  Wiebke Hahn,  Katja Menzler,  Susanne Knake, 
  • Pages: 796-808
  • First Published: 10 April 2025
Open Access

Cardiac structural and molecular alterations in rodent models of temporal lobe epilepsy

Zining Liu,  Shobi Sivathamboo,  Peravina Thergarajan,  Flavia M. Gomes,  Idrish Ali,  Kim L. Powell,  Piero Perucca,  Nigel C. Jones,  Terence J. O'Brien,  Pablo Casillas-Espinosa, 
  • Pages: 809-821
  • First Published: 28 April 2025
Open Access

Effects of perampanel on bone health in adult patients with epilepsy

Mingxing Yu,  Nana Zhang,  Chunyan Chen,  Yuxuan He,  Jing Meng,  Wen Luo,  Yi Liang,  Yi Guo,  Liang Yu, 
  • Pages: 822-830
  • First Published: 07 April 2025
Open Access

A pilot study on the programming protocol of vagus nerve stimulation in children with drug-resistant epilepsy: High pulse amplitude or high duty cycle

Yuying Pan,  Han Xie,  Jiayi Ma,  Taoyun Ji,  Qingzhu Liu,  Lixin Cai,  Yuwu Jiang,  Kai Zhang,  Jianguo Zhang,  Ye Wu, 
  • Pages: 831-841
  • First Published: 22 April 2025
Open Access

The relationship between neuromagnetic networks and cognitive impairment in self-limited epilepsy with centrotemporal spikes

Jing Lu,  Peilin Jiang,  Yingfan Wang,  Minghao Li,  Yinjie Zhu,  Ke Hu,  Xinyi Zhou,  Xiaoshan Wang, 
  • Pages: 842-854
  • First Published: 15 April 2025
Open Access

Facilitators and barriers to neurologist referral of patients for epilepsy surgery evaluation

Chloé E. Hill,  Daniel Hochster,  Jessica E. Baker,  Alison L. Herman,  Nishad Shaheid,  Susanna S. O'Kula,  Jack M. Parent,  Darin B. Zahuranec,  Lesli E. Skolarus, 
  • Pages: 855-865
  • First Published: 19 April 2025
Open Access

Knowledge, attitudes, and practices of epilepsy patients regarding the ketogenic diet therapy: A cross-sectional study

Xiuping Zhang,  Meizhen Sun,  Guofang Xue,  Yongxiong Zhao,  Taotao Du,  Xueying Guan,  Yong Xu, 
  • Pages: 866-879
  • First Published: 05 May 2025
Open Access

Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures

Sylvain Rheims, Fatima Chorfa, Véronique Michel, Edouard Hirsch, Louis Maillard, Luc Valton, Fabrice Bartolomei, Philippe Derambure, Vincent Navarro, Julien Biberon, Arielle Crespel, Anca Nica, Martine Lemesle Martin, Laure Mazzola, Jerome Petit, Vincent Rossero, Sébastien Boulogne, Mathilde Leclercq, Laurent Bezin, Catherine Mercier, Pascal Roy, Philippe Ryvlin,  on behalf of the ENALEPSY Study Group , 
  • Pages: 880-893
  • First Published: 28 April 2025
Open Access

Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi-center retrospective 12-year Veterans Health Administration study

Maximillian S. Feygin,  Autumn Smith,  Sruthi Gopinath Karicheri,  Khadar Haroun,  Omar Khan,  Maria R. Lopez,  Stephan Eisenschenk,  John Jones,  Stephanie Reeder,  Alan R. Towne,  Christopher Ransom,  Karen Medin,  James Chen,  Tung Tran,  Nina I. Garga,  Noemi Rincon-Flores,  Marissa Kellogg,  Steven Tobochnik,  Zulfi Haneef,  the Veterans Epilepsy Learning, Collaborative Research, and Operations (VELCRO) investigators , 
  • Pages: 894-905
  • First Published: 29 April 2025
Open Access

Cerebral blood flow increases in idiopathic generalized epilepsy and its relationship with mood dysfunction

Yun Lien,  Ayushe A. Sharma,  William R. Willoughby,  Anna Moyana,  Jennifer Pilkington,  Ja’ Kaiya Bryant,  Adam M. Goodman,  Goutham Selladurai,  Lawrence W. Ver Hoef,  Jerzy P. Szaflarski,  Jane B. Allendorfer, 
  • Pages: 906-917
  • First Published: 28 April 2025
Open Access

Utility and limitations of homemade videos in differentiating functional seizures from other paroxysmal events: An Italian cohort study

Sara Gasparini,  Giorgia Giussani,  Elisa Bianchi,  Adriana Magaudda,  Angelo Labate,  Angela Laganà,  Chiara Martellino,  Marina Casazza,  Giuseppe Didato,  Valentina Chiesa,  Maria Paola Canevini,  Vincenzo Belcastro,  Tommaso Bocci,  Elisabetta Domina,  Angela La Neve,  Stefano Meletti,  Marco Poloni,  Ettore Salsano,  Vittorio Velucci,  Stefano Martini,  Valentina Bova,  Anna Mammì,  Angelo Pascarella,  Vittoria Cianci,  Edoardo Ferlazzo,  Umberto Aguglia,  Giuseppe Erba, 
  • Pages: 918-929
  • First Published: 28 April 2025
Open Access

Building a dashboard to inform policy and clinical practice using the Irish epilepsy electronic patient record: Towards a learning health system

Ian A. J. Darragh,  Laura Brady,  Norman Delanty,  Colin Doherty,  David Lewis-Smith,  Kathleen E. Bennett, 
  • Pages: 930-941
  • First Published: 05 May 2025

SHORT RESEARCH ARTICLE

Open Access

Compound heterozygosity of a De novo 16q24.1 deletion and missense mutation in COX4I1 leads to developmental regression, intellectual disability, and seizures

Zhen Liu,  Mei He,  Xuan Luo,  Hu Pan,  Xiao Mao,  Jinping Su, 
  • Pages: 942-947
  • First Published: 17 March 2025
Open Access

Efficacy of phenobarbital is maintained after exposure to mild-to-moderate seizures in neonates

Cynthia Sharpe,  Charlotte-Rose Rennie-Younger,  Dug Yeo Han,  Suzanne L. Davis,  Mark Nespeca,  Francesco Pisani,  Jeffrey J. Gold,  Gail E. Reiner,  Sonya Wang,  Richard H. Haas, 
  • Pages: 948-956
  • First Published: 05 April 2025
Open Access

Calpastatin, a calpain specific inhibitor, reduce seizures in a mouse model of temporal lobe epilepsy

Philip M. Lam,  Mala V. Rao,  Ralph A. Nixon,  Marco I. González, 
  • Pages: 957-964
  • First Published: 28 April 2025
Open Access

Decreased homovanillic acid and 5-hydroxyindoleacetic acid levels in the cerebrospinal fluid of patients with Dravet syndrome with parkinsonism

Ryo Sugiyama,  Takashi Saito,  Atsuko Katsumoto,  Shota Yoneno,  Tomoyuki Akiyama,  Hirofumi Komaki, 
  • Pages: 965-970
  • First Published: 04 April 2025

LETTER

Open Access

Perampanel monotherapy in pediatric epilepsy: Emphasizing the need for comprehensive safety evaluation

Gabriel Christian de Farias Morais,  Guilherme Bastos Alves,  Shahina Akter,  Shopnil Akash,  Md. Aktaruzzaman,  Md. Sakib Al Hasan,  Umberto Laino Fulco,  Edilson Dantas da Silva Junior,  Jonas Ivan Nobre Oliveira, 
  • Pages: 971-975
  • First Published: 08 April 2025

ANNOUNCEMENT

Open Access

Epilepsia Open – June 2025 Announcements

  • Pages: 976-978
  • First Published: 13 June 2025