Malignant tumors pose a heavy threat to human health. In article number 2001704, Zhiqing Pang, Wuli Yang, and co-workers present a multifunctional nanoplatform integrating platelet membrane with dual ferroptosis inducers for high-performance ferroptosis-enhanced immunotherapy of tumors. The biomimetic nanoparticles can not only make tumor ablation by ferroptosis, but also further awaken and boost immune cells to join forces to fight tumors.

Gold nanorods (Au NRs) have attracted great attention owing to their significant role in catalysis, imaging, and photothermal therapy. The internal atomic structure control of metallic NRs has long been a challenge. In article number 2001101, Jianfeng Yan and co-workers demonstrate the concept of internal atomic structures tailored with light, and Au NRs with various internal atomic structure are fabricated.

In article number 2000998, Dong Sung Kim and co-workers develop a direct fabrication process of a freestanding nanoporous junction in a microfluidic device through electrolyte-assisted electrospinning followed by impregnating a nanoporous material. The broad applicability of this novel fabrication is demonstrated as two different types of micro-nanofluidic devices performing reverse electrodialysis and ion concentration polarization based on the ion-selectivity.

In article number 2000546, Jiankang He, Xin Zhao, and co-workers report a human-on-leaf#x02010;chip system with biomimetic multiscale vasculature systems connecting vascularized organs, mimicking the complex in vivo architectures of the human cardiovascular system. The native organ-to-organ crosstalk is well recapitulated, implicating a strong potential for harnessing the leaf chip for circulatory-related studies such as metastasis.

Carbon-supported single atoms catalysts (SACs) are the most widely researched electrocatalysts. Polynary metals and polynary heteroatoms doping strategies are the simple and effective ways to modulate the electronic structure of metal sites that play the leading role for catalyzing activity and product distribution. This Review provides a reference for the electronic structure modulation of other SACs.

This Review provides a new horizon for intracellular delivery of extrinsic probes (cell-impermeable), including both biomedical and physical strategies. Borrowed from gene delivery methods, different biomedical agents are used in this case for intracellular delivery of probes mostly through endocytosis. Different physical forces are applied for direct intracellular delivery by cell-membrane disruption, inducing much higher efficiency than biomedical methods.

Organ-on-a-chip technology is slowly maturing as studies begin to focus on establishing a vascular network to maintain organ-to-organ crosstalk and biomimetic variables. To integrate multiple vascularized organs in one human-on-leaf-chip, chambers are edited in computer-aided design of the highly efficient leaf venation network for multiple organ cultures. In this proof-of-concept, liver and bone are co-cultured, which yields encouraging results.

Poly(lactide-co-glycolide) (PLGA) has been widely used for fabricating 3D scaffolds. Previous methods for fabricating PLGA scaffolds do not support direct encapsulation and are not injectable. Here, a method to first fabricate PLGA into microribbon shape building blocks, which are injectable and can intercrosslink into 3D macroporous scaffolds while supporting homogeneous cell encapsulation and minimally invasive delivery, is reported.

Isolated Pt atoms anchored on WO₃ nanoplates exhibit highly active for ambient ammonia electrosynthesis, which is ascribed to facilitated chemisorption and activation of nitrogen and effective suppression for hydrogen evolution reaction (HER), immensely enhancing NH₃ yield rate and Faradic efficiency. This groundbreaking research presents Pt-based nanocatalysts for electroreduction of nitrogen and provides an idea for the HER depression.

This work demonstrates MoS₂ field effect transistors (FETs) with electrolyte gel gating, achieving flexible modulation of carrier concentration and type in MoS₂. The MoS₂ FETs exhibit high-performance negative photoconductive detection, because the deposited Au nanoparticles on the surface of MoS₂ act as traps. Additionally, a MoS₂ homogeneous p–n junction diode with a high rectification ratio is realized.

A 3D-printed, miniaturized reactor is constructed for variable heating up to 3000 K for microscale materials. To demonstrate the utility of the reactor, ultrafine Ru nanoparticles (2 nm) supported on a carbon substrate are prepared by transient heating (1500 K, 500 ms) and show good cycling stability as a cathode for Li-CO₂ batteries.

Dual crosslinked network achieved by a well-controlled, step-by-step crosslinking strategy, leading to an ultrastable dielectric polymer nanocomposite, exhibits a significantly enhanced high-temperature dielectric stability, owing to the strengthened interfaces and reduced molecular chains relaxation. More notably, the high-temperature energy storage properties under the high fields and high-temperature have significantly enhanced.

In article number 1907506, Anjana Devi and co-workers introduce a new, nonpyrophoric zinc precursor for plasma enhanced atomic layer deposition (PEALD) of zinc oxide (ZnO). Here, oxygen plasma is used to react with adsorbed zinc precursor on chemiresistor structures to form highly pure ZnO which is used effectively as a selective gas sensing layer for NO₂ in a functional gas sensor device.

The application of an exciting nonpyrophoric zinc precursor as an alternative for diethyl zinc in a plasma enhanced atomic layer deposition process yielding zinc oxide thin films which can be effectively used as gas barrier as well as semiconducting gas sensing layers for selective NO₂ detection is presented.

A new strategy for reinforcing systemic antitumor immunity by using a biomimetic magnetic nanoparticle (Fe₃O₄-SAS@PLT) to trigger ferroptosis is proposed, for enhancing the therapeutic effect of programmed cell death 1 immune checkpoint blockade therapy. Fe₃O₄-SAS@PLT can repolarize tumor-assoicated macrophages and continuously eliminate metastatic tumors by enhancing tumor-related immune response, providing a valuable way of clinically applicable synergistic immunotherapy in cancer.

Gold nanorods (Au NRs) have attracted great attention owing to their significant role in catalysis, imaging, and photothermal therapy. The internal atomic structure control of metallic NRs has long been a challenge. Here, the concept of internal atomic structure tailored with light is demonstrated and Au NRs with various internal atomic structure are fabricated.

A freestanding nanoporous junction is directly fabricated, patterned, and integrated in a microfluidic device through electrolyte-assisted electrospinning followed by impregnating a nanoporous material. The broad applicability of this fabrication is demonstrated as two different types of micro-nanofluidic devices performing reverse electrodialysis and ion concentration polarization based on the ion-selectivity of the nanoporous junction.

This study establishes a high-throughput screening platform based on organoids that is used to evaluate the nephrotoxicity of quantum dots (QDs). Black phosphorus (BP)-QDs have toxic effects on the kidney, as shown by screening on the organoids. The nephrotoxicity of BP-QDs is validated in mice and human renal tubular epithelial cells. Endoplasmic reticulum stress IRE1α signaling is proven to mediate renal toxicity and insulin insensitivity caused by BP-QDs.

It is demonstrated that self-propelling metallo-dielectric Janus particles, under an externally applied electric field, can trap and transport deformable cell organelles in a selective and releasable manner. Moreover, electro-deformation of the trapped nucleus can act as a promising label-free biomechanical marker. Hence, the Janus particle constitutes an ex vivo platform for manipulation and mechanical probing of subcellular components.

Hierarchical porous polymer monoliths are prepared based on Pickering high internal phase emulsion that is stabilized by microporous, cyclodextrin-based polymer agents. The materials are designed to contain hierarchical porosity that comprise macro-channels and small pores, and capable of exhibiting enhanced sorption and photocatalytic activity for the removal of aromatic pollutants.

A multicomponent DNA origami-based rotor is created and characterized using negative stain and cryo electron microscopy. The nanodevice is immobilized on a microfluidic chamber and its Brownian and flow-driven rotational behavior is analyzed in real time by single-molecule fluorescence microscopy. The rotor randomly switches among three different rotational states. Its mobility increases under moderate flow rates.

The role of d⁰ transition-metal (TM) cations in the redox chemistry of model Li-rich cation-disordered rocksalt cathodes is investigated. Although electrochemically inactive, d⁰ TM is found to serve as a modulator for the reversible and irreversible oxygen redox processes. This results in significant differences in chemical, structural, and cycling stabilities of the cathode materials.

Fluorescent molecular rotors (FMRs, viscosity-dependent fluorescence lifetime probes) are combined with time-resolved fluorescence anisotropy imaging for novel multiplex viscosity imaging in model and live cell lipid droplets. All-atom molecular dynamics simulations identify two FMR tilt states which are connected to extracted viscosity parameters, namely FMR lifetime and rotational correlation time.

The influence of quantum capacitance on deviation from the metallic capacitance model (C/C₀) for experimental data from literature as a function of a universal parameter β is presented. This introduces a quantum capacitance-limited transport regime (shaded blue), where the metallic approximation is invalid (shaded red). Inset: β dependence on density of states for different capacitive couplings (surface area to capacitance S/C₀).

The synthesized nanocomposite can degrade into small nanoparticles with the ability of dual cell-tissue penetration. It harbors photothermal and photodynamic properties and demonstrates efficient deep tumor therapy combined with chemotherapy.

An effective intramolecular locking strategy is designed by introducing the central electron-deficient quinoid to unfused ring A₁–D–A₂–D–A₁-type nonfullerene small molecule acceptors (NF-SMAs). The polymer solar cells (PSCs) based on BT2FIDT-4Cl with difluorobenzothiadiazole central unit show a power conversion efficiency (PCE) of 12.5% with V_oc of near 1 V. This is the best result for nonfused ring NF-SMAs with electron-deficient A₂ unit in binary PSCs.

DNA-modified hydrogel microcapsules, cross-linked by glucosamine–boronate ester bridges and duplex nucleic acids and functionalized with Au nanoparticles or Au nanorods, are developed. The microcapsules present switchable ON/OFF thermoplasmonic drug release. The selective triggering release of drugs and selective cytotoxicity toward cancer cells are demonstrated.

Oxygen-deficient ferric oxide (Fe₂O_3−x), prepared by lithiothermic reduction, is proposed as a low-cost and effective cathodic catalyst. The batteries with Fe₂O_3−x deliver a high capacity of 512 mAh g⁻¹ over 500 cycles at 4 C. In addition, a high-loading porous cathode is prepared by freeze-drying and a high areal capacity of 12.24 mAh cm⁻² is achieved.

Unique electron/ion transports paths can simultaneously minimize the four primary resistances to improve the electrochemical stability of Zn anode. Besides, the fabricated Zn–Br₂ battery with maximum areal specific capacity of ≈1.56 mAh cm⁻² is close to the level of commercial Li-ion batteries. The design concept provides a general strategy for next-generation batteries with high reversibility.