• Issue

    Hepatology: Volume 66, Issue 4

    1013-1366
    October 2017
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Issue Information

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Masthead

  • First Published: 19 September 2017
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Table of contents

  • First Published: 19 September 2017

Hepatology Highlights

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Hepatology Highlights

Nicholas Russo,  Robert S. Brown Jr.,  Robert E. Schwartz,  Russell Rosenblatt,  Shirley Cohen-Mekelburg,  Monica Saumoy,  Clara Tow,  Yecheskel Schneider,  Vikas Gupta, 
  • Pages: 1013-1015
  • First Published: 19 September 2017

Message from the President

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Comments on cochrane review on direct-acting antivirals for hepatitis C

Anna S. Lok,  Raymond T. Chung,  Hugo E. Vargas,  Arthur Y. Kim,  Susanna Naggie,  William G. Powderly, 
  • Pages: 1016-1019
  • First Published: 16 July 2017

Comments from the Editors

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NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response

Hugo R. Rosen M.D.,  Marc G. Ghany M.D.,  Raymond T. Chung M.D.,  Anna S.F. Lok M.D., 
  • Pages: 1020-1022
  • First Published: 17 July 2017

Editorials

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Is hepatitis B immune globulin still needed after liver transplantation for chronic hepatitis B?

Edward J. Gane M.B. Ch.B., M.D., 
  • Pages: 1023-1025
  • First Published: 26 May 2017
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Mutant PNPLA3 I148M protein as pharmacological target for liver disease

Luca Valenti M.D., M.Sc.,  Paola Dongiovanni B.Sc., 
  • Pages: 1026-1028
  • First Published: 06 June 2017
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The challenge of cholangiocarcinoma diagnosis: The turning point is in extracellular vesicles?

Domenico Alvaro M.D., 
  • Pages: 1029-1031
  • First Published: 12 June 2017
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Linking long noncoding RNA to control bile acid signaling and cholestatic liver fibrosis

John Y.L. Chiang Ph.D., 
  • Pages: 1032-1035
  • First Published: 24 May 2017

Original Articles

VIRAL HEPATITIS

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Long-term outcomes of entecavir monotherapy for chronic hepatitis B after liver transplantation: Results up to 8 years

James Fung,  Tiffany Wong,  Kenneth Chok,  Albert Chan,  Tan-To Cheung,  Jeff Wing-Chiu Dai,  Sui-ling Sin,  Ka-Wing Ma,  Kelvin Ng,  Kevin Tak-Pan Ng,  Wai-Kay Seto,  Ching-Lung Lai,  Man-Fung Yuen,  Chung-Mau Lo, 
  • Pages: 1036-1044
  • First Published: 31 March 2017
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Efficient replication of blood-borne hepatitis C virus in human fetal liver stem cells

Xuan Guo,  Shu Wang,  Zhi-Gang Qiu,  Ya-Ling Dou,  Wei-Li Liu,  Dong Yang,  Zhi-Qiang Shen,  Zhao-Li Chen,  Jing-Feng Wang,  Bin Zhang,  Xin-Wei Wang,  Xiang-Fei Guo,  Xue-Lian Zhang,  Min Jin,  Jun-Wen Li, 
  • Pages: 1045-1057
  • First Published: 13 April 2017
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A potent hepatitis B surface antigen response in subjects with inactive hepatitis B surface antigen carrier treated with pegylated-interferon alpha

Zhenhuan Cao,  Yali Liu,  Lina Ma,  Junfeng Lu,  Yi Jin,  Shan Ren,  Zhimin He,  Chengli Shen,  Xinyue Chen, 
  • Pages: 1058-1066
  • First Published: 13 April 2017
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Vaccines targeting preS1 domain overcome immune tolerance in hepatitis B virus carrier mice

Yingjie Bian,  Zheng Zhang,  Zhichen Sun,  Juanjuan Zhao,  Danming Zhu,  Yang Wang,  Sherry Fu,  Jingya Guo,  Longchao Liu,  Lishan Su,  Fu-Sheng Wang,  Yang-Xin Fu,  Hua Peng, 
  • Pages: 1067-1082
  • First Published: 26 April 2017
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Sofosbuvir-velpatasvir with ribavirin for 24 weeks in hepatitis C virus patients previously treated with a direct-acting antiviral regimen

Edward J. Gane,  Mitchell L. Shiffman,  Kyle Etzkorn,  Giuseppe Morelli,  Catherine A.M. Stedman,  Mitchell N. Davis,  Federico Hinestrosa,  Hadas Dvory-Sobol,  K.C. Huang,  Anu Osinusi,  John McNally,  Diana M. Brainard,  John G. McHutchison,  Alex J. Thompson,  Mark S. Sulkowski,  GS-US-342-1553 Investigators , 
  • Pages: 1083-1089
  • First Published: 12 May 2017
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Safety and efficacy of current direct-acting antiviral regimens in kidney and liver transplant recipients with hepatitis C: Results from the HCV-TARGET study

Varun Saxena,  Vandana Khungar,  Elizabeth C. Verna,  Josh Levitsky,  Robert S. Brown Jr,  Mohamed A. Hassan,  Mark S. Sulkowski,  Jacqueline G. O'Leary,  Farrukh Koraishy,  Joseph S. Galati,  Alexander A. Kuo,  Monika Vainorius,  Lucy Akushevich,  David R. Nelson,  Michael W. Fried,  Norah Terrault,  K. Rajender Reddy MD, 
  • Pages: 1090-1101
  • First Published: 15 May 2017
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Sofosbuvir and ribavirin in adolescents 12-17 years old with hepatitis C virus genotype 2 or 3 infection

Stefan Wirth,  Philip Rosenthal,  Regino P. Gonzalez-Peralta,  Maureen M. Jonas,  William F. Balistreri,  Chuan-Hao Lin,  Winita Hardikar,  Kathryn Kersey,  Benedetta Massetto,  Bittoo Kanwar,  Diana M. Brainard,  Jiang Shao,  Evguenia Svarovskaia,  Brian Kirby,  Ronen Arnon,  Karen F. Murray,  Kathleen B. Schwarz, 
  • Pages: 1102-1110
  • First Published: 22 May 2017

STEATOHEPATITIS/METABOLIC LIVER DISEASE

Open Access

The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation

Soumik BasuRay,  Eriks Smagris,  Jonathan C. Cohen,  Helen H. Hobbs, 
  • Pages: 1111-1124
  • First Published: 18 May 2017

HEPATOBILIARY MALIGNANCIES

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Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma

Ander Arbelaiz,  Mikel Azkargorta,  Marcin Krawczyk,  Alvaro Santos-Laso,  Ainhoa Lapitz,  Maria J. Perugorria,  Oihane Erice,  Esperanza Gonzalez,  Raul Jimenez-Agüero,  Adelaida Lacasta,  Cesar Ibarra,  Alberto Sanchez-Campos,  Juan P. Jimeno,  Frank Lammert,  Piotr Milkiewicz,  Marco Marzioni,  Rocio I.R. Macias,  Jose J.G. Marin,  Tushar Patel,  Gregory J. Gores,  Ibon Martinez,  Félix Elortza,  Juan M. Falcon-Perez,  Luis Bujanda,  Jesus M. Banales, 
  • Pages: 1125-1143
  • First Published: 26 May 2017
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Biases in the reporting of hepatocellular carcinoma tumor sizes on the liver transplant waiting list

Mariya L. Samoylova,  Mark J. Nigrini,  Jennifer L. Dodge,  John P. Roberts, 
  • Pages: 1144-1150
  • First Published: 18 May 2017
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Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

Dan Han,  Jiangxue Li,  Huamin Wang,  Xiaoping Su,  Jin Hou,  Yan Gu,  Cheng Qian,  Yun Lin,  Xiang Liu,  Mingyan Huang,  Nan Li,  Weiping Zhou,  Yizhi Yu,  Xuetao Cao, 
  • Pages: 1151-1164
  • First Published: 18 May 2017
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aPKC-ι/P-Sp1/Snail signaling induces epithelial–mesenchymal transition and immunosuppression in cholangiocarcinoma

Yawei Qian,  Wei Yao,  Tao Yang,  Yan Yang,  Yan Liu,  Qi Shen,  Jian Zhang,  Weipeng Qi,  Jianming Wang, 
  • Pages: 1165-1182
  • First Published: 02 June 2017

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule

Yongfeng Song,  Chune Liu,  Xia Liu,  Jocelyn Trottier,  Michele Beaudoin,  Li Zhang,  Chad Pope,  Guangyong Peng,  Olivier Barbier,  Xiaobo Zhong,  Linheng Li,  Li Wang, 
  • Pages: 1183-1196
  • First Published: 13 April 2017
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TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Tatyana V. Masyuk,  Anatoliy I. Masyuk,  Maria Lorenzo Pisarello,  Brynn N. Howard,  Bing Q. Huang,  Pui-Yuen Lee,  Xavier Fung,  Eduard Sergienko,  Robert J. Ardecky,  Thomas D.Y. Chung,  Anthony B. Pinkerton,  Nicholas F. LaRusso, 
  • Pages: 1197-1218
  • First Published: 23 May 2017

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Stratifying risk in the prevention of recurrent variceal hemorrhage: Results of an individual patient meta-analysis

Agustín Albillos,  Javier Zamora,  Javier Martínez,  David Arroyo,  Irfan Ahmad,  Joaquin De-la-Peña,  Juan-Carlos Garcia-Pagán,  Gin-Ho Lo,  Shiv Sarin,  Barjesh Sharma,  Juan G. Abraldes,  Jaime Bosch,  Guadalupe Garcia-Tsao,  on behalf of the Baveno Cooperation , 
  • Pages: 1219-1231
  • First Published: 25 May 2017
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Plasma cystatin C is a predictor of renal dysfunction, acute-on-chronic liver failure, and mortality in patients with acutely decompensated liver cirrhosis

Daniel Markwardt,  Lesca Holdt,  Christian Steib,  Andreas Benesic,  Flemming Bendtsen,  Mauro Bernardi,  Richard Moreau,  Daniel Teupser,  Julia Wendon,  Frederik Nevens,  Jonel Trebicka,  Elisabet Garcia,  Marco Pavesi,  Vicente Arroyo,  Alexander L. Gerbes, 
  • Pages: 1232-1241
  • First Published: 25 May 2017

LIVER INJURY/REGENERATION

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Targeting CCl4-induced liver fibrosis by RNA interference–mediated inhibition of cyclin E1 in mice

Jörg-Martin Bangen,  Linda Hammerich,  Roland Sonntag,  Maike Baues,  Ute Haas,  Daniela Lambertz,  Thomas Longerich,  Twan Lammers,  Frank Tacke,  Christian Trautwein,  Christian Liedtke, 
  • Pages: 1242-1257
  • First Published: 18 May 2017
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Loss of L-selectin-guided CD8+, but not CD4+, cells protects against ischemia reperfusion injury in a steatotic liver

Vasantha L. Kolachala,  Sirish Palle,  Ming Shen,  Alayna Feng,  Dmitry Shayakhmetov,  Nitika A. Gupta, 
  • Pages: 1258-1274
  • First Published: 20 May 2017
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Death and liver transplantation within 2 years of onset of drug-induced liver injury

Paul H. Hayashi,  Don C. Rockey,  Robert J. Fontana,  Hans L. Tillmann,  Neil Kaplowitz,  Huiman X. Barnhart,  Jiezhan Gu,  Naga P. Chalasani,  K. Rajender Reddy,  Averell H. Sherker,  Jay H. Hoofnagle,  for the Drug-Induced Liver Injury Network (DILIN) Investigators , 
  • Pages: 1275-1285
  • First Published: 23 May 2017

LIVER BIOLOGY/PATHOBIOLOGY

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FIB-4 stage of liver fibrosis predicts incident heart failure among HIV-infected and uninfected patients

Kaku A. So-Armah,  Joseph K. Lim,  Vincent Lo Re,  Janet P. Tate,  Chung-Chou H. Chang,  Adeel A. Butt,  Cynthia L. Gibert,  David Rimland,  Vincent C. Marconi,  Matthew B. Goetz,  Maria C. Rodriguez-Barradas,  Matthew J. Budoff,  Hilary A. Tindle,  Jeffrey H. Samet,  Amy C. Justice,  Matthew S. Freiberg,  for the Veterans Aging Cohort Study Project Team , 
  • Pages: 1286-1295
  • First Published: 24 May 2017

Consensus Statement

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Hepatitis B cure: From discovery to regulatory approval

Anna S. Lok,  Fabien Zoulim,  Geoffrey Dusheiko,  Marc G. Ghany, 
  • Pages: 1296-1313
  • First Published: 01 August 2017

Concise Review

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Acute hepatic porphyrias: Recommendations for evaluation and long-term management

Manisha Balwani,  Bruce Wang,  Karl E. Anderson,  Joseph R. Bloomer,  D. Montgomery Bissell,  Herbert L. Bonkovsky,  John D. Phillips,  Robert J. Desnick,  for the Porphyrias Consortium of the Rare Diseases Clinical Research Network , 
  • Pages: 1314-1322
  • First Published: 12 June 2017

Review

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Large-scale computational models of liver metabolism: How far from the clinics?

Tanja Cvitanović,  Matthias C. Reichert,  Miha Moškon,  Miha Mraz,  Frank Lammert,  Damjana Rozman, 
  • Pages: 1323-1334
  • First Published: 18 May 2017

Hepatology Elsewhere

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Kidney transplant recipients with hepatitis C virus experienced 100% sustained virologic response at 12 weeks when treated with sofosbuvir–ledipasvir

Meghan E. Sise M.D., M.S., 
  • Pages: 1335-1337
  • First Published: 26 June 2017
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Transintestinal cholesterol excretion: A secondary, nonbiliary pathway contributing to reverse cholesterol transport

David Q.-H. Wang M.D., Ph.D.,  Piero Portincasa M.D., Ph.D.,  Patrick Tso Ph.D., 
  • Pages: 1337-1340
  • First Published: 27 June 2017

Clinical Observations in Hepatology

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Direct-acting antivirals during or after immunochemotherapy in hepatitis C virus–positive diffuse large B-cell lymphomas

Michele Merli,  Marco Frigeni,  Manuel Gotti,  Paolo Grossi,  Raffaele Bruno,  Francesco Passamonti,  Luca Arcaini, 
  • Pages: 1341-1343
  • First Published: 05 April 2017
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Persisting risk of hepatocellular carcinoma after hepatitis C virus cure monitored by a liver transcriptome signature

Atsushi Ono,  Nicolas Goossens,  Richard S. Finn,  Warren N. Schmidt,  Swan N. Thung,  Gene Y. Im,  Yujin Hoshida,  on behalf of Precision Liver Cancer Prevention Consortium , 
  • Pages: 1344-1346
  • First Published: 08 April 2017
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Coil-assisted retrograde transvenous obliteration and partial splenic artery embolization for hepatic encephalopathy

Frank Kuo,  Jonathan Park,  Alice Chen, 
  • Pages: 1347-1350
  • First Published: 13 April 2017

Correspondence

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Molecular classification of hepatoblastoma and prognostic value of the HB 16-gene signature

Marie-Annick Buendia Ph.D.,  Carolina Armengol Ph.D.,  Stefano Cairo Ph.D., 
  • Pages: 1351-1352
  • First Published: 16 May 2017
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Is antibody to surface antigen associated with hepatitis B reactivation in patients with resolved hepatitis B?

Yi-Hsiang Huang M.D., Ph.D.,  Shou-Dong Lee M.D., 
  • Page: 1353
  • First Published: 07 July 2017
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Reply

Sonali Paul M.D., M.S., 
  • Page: 1354
  • First Published: 07 July 2017
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Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial

Benjamin H. Mullish M.B., B.Chir.,  Julie A. K. McDonald Ph.D.,  Mark R. Thursz M.D.,  Julian R. Marchesi Ph.D., 
  • Pages: 1354-1355
  • First Published: 17 July 2017
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Reply

Jasmohan S. Bajaj M.D.,  Zain Kassam M.D.,  I. Jane Cox Ph.D.,  Thomas Gurry Ph.D.,  Roger Williams M.D.,  Eric Alm Ph.D.,  Binu John M.D.,  Mark Smith Ph.D.,  Simon D. Taylor-Robinson M.D.,  Patrick M. Gillevet Ph.D., 
  • Pages: 1355-1356
  • First Published: 17 July 2017
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Rediscussion on linearity between fibrosis stages and mortality risk in nonalcoholic fatty liver disease patients

Zhengtao Liu Ph.D.,  Shuping Que M.D.,  Adil Mardinoglu Ph.D., 
  • Pages: 1357-1358
  • First Published: 20 July 2017
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Comments on “Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta-analysis”

Saeid Safiri Ph.D.,  Salman Khazaei M.Sc.,  Kamyar Mansori M.Sc.,  Erfan Ayubi Ph.D., 
  • Pages: 1358-1359
  • First Published: 20 July 2017
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Reply

Siddharth Singh M.D., M.S.,  Rohit Loomba M.D., M.H.Sc., 
  • Pages: 1359-1360
  • First Published: 20 July 2017
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The royal free hospital cirrhosis glomerular filtration rate: Validation in a danish cohort

Julie Steen Pedersen M.D.,  Nina Kimer Ph.D.,  Jens H. Henriksen Dm. Sci.,  Flemming Bendtsen Dm. Sci.,  Søren Møller Dm. Sci., 
  • Pages: 1360-1361
  • First Published: 20 July 2017
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Reply

Maria Kalafateli Ph.D.,  Emmanuel A. Tsochatzis Ph.D., 
  • Pages: 1361-1362
  • First Published: 20 July 2017
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Continuation of nonselective beta-blockers for patients with liver cirrhosis and hemodynamic nonresponse?

Tilman Sauerbruch M.D., 
  • Pages: 1362-1363
  • First Published: 22 July 2017
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Reply

Càndid Villanueva M.D.,  Isabel Graupera M.D.,  Edilmar Alvarado M.D., 
  • Pages: 1363-1364
  • First Published: 24 July 2017

Correction

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Correction

  • Page: 1365
  • First Published: 04 September 2017

Retraction

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Retraction statement: Equilibrative nucleoside transporter (ENT)-1-dependent elevation of extracellular adenosine protects the liver during ischemia and reperfusion

  • Page: 1366
  • First Published: 23 August 2017

Issue Information

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Notices

  • First Published: 19 September 2017
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Instructions to authors and Information for readers

  • First Published: 19 September 2017