Editors-in-Chief: Hongzhou Lu, Yi-Wei Tang, Asakawa Tetsuya & Eric von Hofe
Tsinghua University Press
iLABMED presents the latest developments in the clinical laboratory sciences. We cover key topics in all aspects of laboratory medicine and related multidisciplinary research.
Focusing on computer and data science enabled intelligent medicine, we unite researchers and clinicians from diverse medical subspecialities, including artificial intelligence, bioinformatics, proteomics, materials and more, to enable collaboration and further advance the field.
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What We Cover
iLABMED's selling points:
- Latest developments in the clinical laboratory sciences. iLABMED focuses on basic and applied research and cutting-edge clinical laboratory medicine. You can access to the latest developments in the clinical laboratory sciences.
- A hub for collaboration and communication across disciplines. iLABMED unites researchers and clinicians from diverse medical subspecialities including artificial intelligence, bioinformatics, proteomics, materials etc, providing opportunities to exchange, collaborate, and explore together.
- High quality peer-review. All contributions submitted for publication in iLABMED are single-blind peer reviewed by at least two experts in the field.
Regulatory factors of ILC2 are therapeutic targets for lung inflammation
ILC2s is a significant population of innate immune cells, which are activated by epithelial-derived alarmins IL-25, IL-33 and TSLP to secrete type 2 cytokines, playing important role in the regulation of lung inflammation. This article reviews the various factors regulating ILC2s in lung inflammation, especially in allergic diseases. These studies prove that ILC2s play a key role in the treatment of lung inflammation. Targeting ILC2s and related regulatory factors is expected to become a new direction for the treatment of lung inflammation, and also provides new therapies for the development of more effective treatments for lung inflammation in the future.
A retrospective analysis of the relationship between dermatomyositis-associated interstitial lung disease and disease duration, age, arterial blood gas pH, and serum Cl− levels
This review highlights the role of investigational associations between DM-ILD and arterial blood gas index, serum ion levels, and time to onset of interstitial lung disease, identifying potential predictors of DM-ILD. The main steps of this study are: (1) data analysis, (2) data selection, (3) model building, and (4) ROC validation.
A case of central nervous system infection with Scedosporium boydii
This research described a case of a man with brain abscesses infected with Scedosporium boydii. It emphasized the importance of using multiple methods for early identification, including microscopy, culture combined with Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), internal transcribed spacer (ITS) sequencing, and Metagenomic next-generation sequencing (mNGS) methods.
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Articles
Current Progress in Targeting Human Cytomegalovirus Infection
- 3 July 2025
Graphical Abstract
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection. Additionally, the review discusses the development of therapeutics and vaccines against HCMV.
Recent Advances in DNA‐Based Strategies for the Capture, Detection, and Release of Circulating Tumor Cells
- 2 July 2025
Graphical Abstract
Circulating tumor cell (CTC) analysis has become a powerful tool for the early diagnosis of cancer, monitoring disease progression, and evaluating treatment efficacy. This article reviews the latest progress in CTC detection, capture, and release methods based on DNA materials and provides insights into current development trends and future research directions. We give a comprehensive overview of various strategies and discuss their design principles, characteristics, advantages, and limitations and the challenges faced by the CTC research field.
Analysis of the Clinical Value of Monocyte Human Leukocyte Antigen‐DR, Procalcitonin, and C‐Reactive Protein in Sepsis
- 1 July 2025
Graphical Abstract
This study compared the clinical value of monocytic human leukocyte antigen-DR (mHLA-DR), procalcitonin (PCT), and C-reactive protein (CRP) in diagnosing and predicting sepsis outcomes, providing better guidance for clinical management. The diagnostic efficacy of PCT and CRP for sepsis was superior to that of mHLA-DR, but mHLA-DR demonstrated a significantly better predictive efficacy than PCT in evaluating sepsis prognosis, while there was no significant difference in CRP levels between the survival and non-survival groups.
Extrachromosomal Circular DNA: Emerging Insights Into Cardiovascular Disease Mechanisms and Biomarker Potential
- 29 June 2025
Graphical Abstract
Extrachromosomal circular DNA (eccDNA) has quite recently turned out to be a cardinal component in cardiovascular diseases (CVD), governing the gene expression and mechanisms of disease causation. Studies indicated an upregulation of eccDNA in pulmonary arterial hypertension (PAH), which makes it strikingly potential as a sensitive and specific biomarker. High-throughput sequencing advances enabled the detection of massive amounts of eccDNA from plasma, opening a new horizon in non-invasive diagnosis. Future studies shall elucidate the understanding of functional roles in CVD and provide novel therapies coupled with better clinical outcomes.
Electrical Impedance Tomography in Medical Applications: Brain and Lung
- 28 June 2025
Graphical Abstract
The clinical focus of EIT technology lies in lung function monitoring and neurological diseases, while also exploring new scenarios such as abdominal hemorrhage detection. Technological breakthroughs include the development of wearable devices and the optimization of hardware architecture. However, there are still challenges, such as limited spatial resolution, susceptibility to interference, and motion artifacts. In the future, with the advancement of intelligence and portability, EIT has great potential in personalized medicine and improving the level of intensive care.
The following is a list of the most cited articles based on citations published in the last three years, according to CrossRef.
Bottlenecks and recent advancements in detecting Mycobacterium tuberculosis in patients with HIV
- 44-57
- 10 May 2023
Graphical Abstract
Tuberculosis (TB) is difficult to diagnose, particulally in HIV-positive individuals, leading to a delayed disease treatment and poor prognosis. Herein, we summarize the strengths and limitations of current TB diagnostic methods, and shed light on the obstacles of TB diagnosis in people living with HIV. In addition, we discuss newly-emerging technologies and advocate for combining multiple diagnostic tools to develop alternative strategies for TB diagnosis, especially in cases of HIV/TB co-infection.
Single cell metabolic phenome and genome via the ramanome technology platform: Precision medicine of infectious diseases at the ultimate precision?
- 5-14
- 9 May 2023
Graphical Abstract
At precisely one microbial cell resolution, the SCIVVS strategy enables total live cell counting, rapid species identification, species-resolved in situ vitality and antimicrobial susceptibility test, and source tracking directly from an infected clinical specimen. The integrated workflow is culture-free, fast, cost-effective and can be automated, making it a promising new tool in combating bacterial or fungal infections.
Clinical utility of six serum tumor markers for the diagnosis of lung cancer
- 132-141
- 12 September 2023
Graphical Abstract
This article investigated the clinical utility of the six serum tumor markers in differentiating between lung cancer and benign lung diseases through the comparative analysis of patient samples, and proved that combining the detection of ProGRP, NSE, CYFRA21-1, CEA, and SCCA significantly improves sensitivity when diagnosing lung cancer.
Diagnostic approaches for monkeypox virus
- 6-13
- 7 March 2024
Graphical Abstract
This review highlights the technical details, application scenarios, and the advantages and disadvantages of MPXV-specific diagnostic methods. The main diagnostic techniques include (1) monkeypox virus isolation and culture (2) immunoassays (3) molecular methods (4) electron microscopy. In addition, the types of specimens for MPXV detection and their uses are introduced.
Research progress of CRISPR/Cas systems in nucleic acid detection of infectious diseases
- 58-74
- 13 May 2023
Graphical Abstract
In this review, we presented the development and mechanism of the CRISPR/Cas system together with representative CRISPR/Cas applications in nucleic acid detection. Additionally, the review summarizes future perspectives and trends of the CRISPR/Cas system in nucleic acid detection.
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An official journal of the third People's Hospital of Shenzhen, published on behalf of Tsinghua University Press.
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