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Graphical Abstract: Human gut harbors complex microbiota ecosystem, and the multi-kingdom microbiota are critical in the development of CRC. Diet intervention and different therapies regulated multi-kingdom microbiota influencing the development of CRC.

Pancreatic tissues' tumors exhibited three different situations. (A) Several glandular tubular adenocarcinoma structures could be seen in pancreatic tissue. (B) Tubular area could be seen in the pancreas, exhibiting papillary growth in the area. (C) The ductal epithelium in the pancreas was replaced by high columnar mucous cells, which showed pseudostratified columnar epithelial cells.

This paper examines the impact of COVID-19 on colorectal cancer diagnosis and management in Australia and New Zealand by comparing patients receiving colorectal cancer surgery during the pandemic against averages from the same period over the preceding three years. The key findings are a significant reduction in total colorectal cancer operations, particularly in rectal cancers, cancers presented at a more advanced stage and operations were more likely to be emergencies. The response to COVID-19 has had measurably negative effects on the diagnosis and management of colorectal cancer in two countries that have had significantly fewer COVID-19 cases than many other countries.

Sarcopenia as assessed on computed tomography was investigated as a predictor of outcomes following colorectal cancer resection. Associations were found with length of stay, complications and recurrence at 1 year. Sarcopenia was found to be a better predictive factor for recurrence and morbidity than other traditional measures of nutrition.

Pictorial essay on MRI local staging of rectal carcinoma: An easy approach

Multiple effects of berberine (BBR) as a gastrointestinal (GI) cancer therapeutic agent. BBR acts as a potential anti-GI cancer agent by inducing apoptosis, autophagy, and cell-cycle arrest, as well as metastasis and angiogenesis inhibition. It plays an important role in suppressing GI cancer cells.

Prevalence of gastrointestinal cancers was positively correlated with national human development index levels, but negatively with hypertension and diabetes rates. Age-specific trends were observed in stomach cancer and esophagus cancer for incidence and in liver cancer and pancreatic cancer for mortality, as well as sex-specific trends for stomach cancer and pancreatic cancer in the elder.These findings suggest that future research has to focus on the specific etiology of gastrointestinal cancers behind these epidemiologic transitions and improve therapeutic strategies for patients with comorbid metabolic diseases.

We have performed subcloning of metastatic intestinal tumor-derived organoids from single cells. Notably, approximately 30% of subclones showed loss of metastatic ability associated with growth suppression, although driver mutations were not affected. The results suggest that cancer evolution is regulated not only by positive selection but also by negative selection.

RUVBL1 is a direct downstream target gene of SETD1A. High expression of both SETD1A and RUVBL1 is an independent prognostic factor not only for disease-free survival but also for overall survival.

Graphical Headlights

• Small extracellular vesicles (sEVs) released from pancreatic ductal carcinoma (PDAC) are enriched in pancreatic juice (PJ).
• PJ-derived sEVs are promising for the early diagnosis of PDAC.
• PJ-derived sEVs could be promising therapeutic targets.

1. LINC01606 functions as an oncogene to facilitate malignant phenotypes of colon cancer cells by enhancing tumour cell stemness and anti-ferroptosis by Wnt/β-catenin signalling;

2. LINC01606 protects colon cancer cells from ferroptotic cell death by increasing the formation of monounsaturated fatty acids;

3. LINC01606–Wnt/β-catenin–TFE3 positive feedback regulatory loop signalling blocks ferroptosis and promotes stemness.

• An in-depth proteomic and phosphoproteomic resource on metformin signaling in colorectal cancer (CRC).
• The phosphoproteomic response to metformin was highly heterogeneous in CRC cell lines.
• Establishing a phosphorylation site-specific MetScore, which identified 55 most significant metformin signature sites.
• Leveraging the phosphoproteomics to discover potential metformin∼drug interactions in CRC, e.g., navitoclax.

Flow diagram of included and excluded studies.

Disease burden estimation allows clinicians and policymakers to plan for future healthcare needs. Our study provides comprehensive estimates of the burden of gastrointestinal diseases in a super-aging society focusing on cancers and other chronic gastrointestinal diseases. Currently, colorectal, gastric, pancreatic, and liver cancers are the focus of early detection and treatment.