Dietary habits and risk of hepatocellular carcinoma among hepatitis B surface antigen carriers: A prospective cohort study in China
Cheng Xiao Yu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
These authors contributed equally to this work.
Search for more papers by this authorYong Sheng Chen
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
These authors contributed equally to this work.
Search for more papers by this authorZi Jun Ge
Department of Infection Management, Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu Province, China
Search for more papers by this authorYong Hui Zhang
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
Search for more papers by this authorXin Xu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorTing Tian
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorYang Wen
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorJian Zhu
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
Search for more papers by this authorCi Song
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorCorresponding Author
Jian Guo Chen
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
Affiliated Tumor Hospital/Institute, Nantong University, Nantong, Jiangsu Province, China
Correspondence
Zhi Bin Hu, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu Province 210029, China.
Email: [email protected]
Jian Guo Chen, Department of Epidemiology, Qidong Liver Cancer Institute, 785 Middle Jianghai Road, Qidong, Jiangsu Province 226200, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Zhi Bin Hu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Correspondence
Zhi Bin Hu, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu Province 210029, China.
Email: [email protected]
Jian Guo Chen, Department of Epidemiology, Qidong Liver Cancer Institute, 785 Middle Jianghai Road, Qidong, Jiangsu Province 226200, China.
Email: [email protected]
Search for more papers by this authorCheng Xiao Yu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
These authors contributed equally to this work.
Search for more papers by this authorYong Sheng Chen
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
These authors contributed equally to this work.
Search for more papers by this authorZi Jun Ge
Department of Infection Management, Nanjing Medical University First Affiliated Hospital, Nanjing, Jiangsu Province, China
Search for more papers by this authorYong Hui Zhang
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
Search for more papers by this authorXin Xu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorTing Tian
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorYang Wen
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorJian Zhu
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
Search for more papers by this authorCi Song
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Search for more papers by this authorCorresponding Author
Jian Guo Chen
Qidong Liver Cancer Institute, Qidong People's Hospital, Affiliated Qidong Hospital of Nantong University, Qidong, Jiangsu Province, China
Affiliated Tumor Hospital/Institute, Nantong University, Nantong, Jiangsu Province, China
Correspondence
Zhi Bin Hu, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu Province 210029, China.
Email: [email protected]
Jian Guo Chen, Department of Epidemiology, Qidong Liver Cancer Institute, 785 Middle Jianghai Road, Qidong, Jiangsu Province 226200, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Zhi Bin Hu
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China
Correspondence
Zhi Bin Hu, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu Province 210029, China.
Email: [email protected]
Jian Guo Chen, Department of Epidemiology, Qidong Liver Cancer Institute, 785 Middle Jianghai Road, Qidong, Jiangsu Province 226200, China.
Email: [email protected]
Search for more papers by this authorFunding information: China Postdoctoral Science Foundation, Grant/Award Number: 2019M651900; National Natural Science Foundation of China, Grant/Award Numbers: 81703300, 81903382; Natural Science Foundation of Jiangsu Province, Grant/Award Number: BK20190652
Abstract
Objective
In this prospective cohort study, we aimed to evaluate the association between dietary habits and the risk of developing hepatocellular carcinoma (HCC) in hepatitis B surface antigen (HBsAg)-positive carriers in Qidong, an hepatitis B virus (HBV)-epidemic area in China.
Methods
A total of 3199 HBsAg carriers aged 30-70 years in a prospective cohort in Qidong, China from 2007 to 2011 were included in the study. At baseline, all participants self-reported their dietary habits in a questionnaire interview. A follow-up check-up was performed every 6 months to identify HCC cases until November 2017. Cox’s regression analysis and an interaction analysis were performed to estimate the relative risks of HCC in terms of baseline diet.
Results
Among 3199 HBsAg-positive participants, 270 developed HCC (143.86/100 000 person-years [PYs]). Compared with participants who rarely consume garlic, the risk of HCC in those who consumed it ≥ once per week decreased along with the increase in frequency (HR = 1.00, 0.90 and 0.62 in those who consumed it rarely vs those who consumed it 1-6 times per week and ≥ 7 times per week, respectively). This study found a synergistic effect between garlic and tea consumption on the risk of HCC (P = 0.039 for a multiplicative interaction).
Conclusions
HBsAg carriers should improve their diet. Regular consumption of garlic and tea drinking may reduce the HCC incidence in HBsAg carriers.
CONFLICT OF INTEREST
The authors declare no competing financial interest.
Supporting Information
| Filename | Description |
|---|---|
| cdd12878-sup-0001-FigureS1.tifTIFF image, 25.8 MB | Figure S1 Flow chart for recruiting study participants |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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