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The aims were to assess attitudes to and understanding of safety culture (SC) and incident learning systems (ILSs) in two closely-linked radiation oncology departments using a customised survey. Sixty-three per cent of staff participated. Barriers identified in one department prompted a quality improvement project to develop a new radiation oncology-specific reporting system, with a focus on improving departmental learning and modifying the overall ILS.

Changes within the department were followed by an increasing number of reported incidents. Proactive measures should be undertaken prior to the implementation of major changes within the department to aid in the minimisation of incident occurrence.

Shared, disease specific, and comprehensive survivorship care programs all have their own strengths in aspects including the cost of time, money, and human resources. And it's worth noting that oncology nurses all played indispensable significant roles in these different models.

Overall, the epidemiological results of our neuroendocrine tumor (NET) cohort were comparable with findings in literature. Gastrointestinal NETs met most of the requirements of qualitative pathology reporting and diagnostic imaging as listed in the European Neuroendocrine Tumor Society consensus guidelines. Discussing treatment strategies in specialized multidisciplinary tumor boards would facilitate regional care.

With the vigorous development of intelligent medical care and interdisciplinary science, innovative flexible bioelectronics (FBEs) are emerging in health monitoring, disease diagnosis and treatment, and even cancer therapy. This work comments on the recent progress of FBEs in personalized health management, emphasizing its innovative role in cancer therapy. Future perspectives on the challenges and opportunities for the next-generation innovative FBEs are also proposed.

In this review, we highlight the latest progress in the CAR-NK cell-based immunotherapy. We also discuss major roadblocks facing the clinical translation of CAR-NK cell therapy, and present potential strategies to surmount these challenges.

Pathophysiology and main treatment options for myeloma bone disease.

In ITP, Treg cells play an important role in pathogenesis. Treg cells decrease as their output from thymus decreased and their plasticity in peripheral blood. Meanwhile, Treg cells' function impaired. New treatment may develop focusing on the abnormality of Treg cells.

• Find a new lysosomotropic drug V8.
• The characteristics of targeting lysosome HSP70 are clarified.
• Disturbance of lysosomal lipid metabolism is a new approach for T cell malignancies.
• The HSP70-ASM axis regulates lysosomal stability.

Graphic working model illustrates that SFRS8 reduces CACYBP isoform1 (NM_014412.3) and increases CACYBP isoform2 (NM_001007214.1) by mediating the alternative splicing of CACYBP, thereby altering the ubiquitination degradation of β-catenin and exosome-based cellular communication to promote MM malignancy and bone lesion.

Multiple myeloma (MM) is the second-ranking malignancy in hematological tumors. There has been a significant change in the paradigm for the management of MM. In this review, we summarize the pathogenesis and current treatment options of MM, then overview recent advances in nanomedicine-based systems, aiming to provide more insights into the treatment of MM.

1. Mammalian FAM46C is a unique non-canonical poly(A) polymerase (PAP) with a bacterial-like protein fold.
2. FAM46C differs from its homolog FAM46B in PAP activity due to the divergence of amino acid residues at several critical sites.
3. The structural-functional characterization of MM-related FAM46C mutations that may be used for prognosis in the future.

miR-195-5p, miR-4505, miR-22-3p and miR-148a-3p were selected as hub microRNAs in microRNA-Gene ontology regulatory network and their aberrant expression might be closely associated with myelodysplastic syndromes pathogenesis. Their target genes mainly participated in the process of signal transduction, blood coagulation, apoptotic process, cell proliferation, transmembrane transport and angiogenesis