Desferrioxamine treatment enhanced hypoxia inducible factor-1α and vascular endothelial growth factor expression in encapsulated human islets and improved their ability to function when transplanted into diabetic recipients.

B cell help for alloreactive T cells promotes their proliferation and survival to generate optimal numbers of functional memory T cells.

CsA, MPA and Rapa each have distinct effects on NK-cell phenotype and function in vitro, which may have important implications for NK-cell function in vivo after transplantation and for their use in GVHD prophylaxis.

Machine perfusion and simple cold storage of DCD kidneys produce equivalent transplant outcome in a UK multicentre randomised controlled trial.
See editorial by Irish & Katz on page 1955.

This report presents the results of a large series of dual kidney transplantation from ECD, with a detailed description of an advantageous surgical technique of unilateral placement.
See editorial by Shapiro et al on page 1959.

The previously documented association between waiting time on dialysis and reduced kidney transplant outcomes is predominantly explained by time to placement on the waiting list.

This study of 105 renal biopsies after liver, lung, heart and bone marrow transplantation addresses whether or not calcineurin-inhibitor toxicity is the only cause of renal insufficiency after non-renal transplantation.

In a retrospective analysis of 127 Finnish CMV D⁺/R⁻ kidney transplant recipients who received 6 months valganciclovir prophylaxis, 37% developed late-onset CMV infection after the end of prophylaxis and 43/47 of these infections were symptomatic.

This study demonstrates successful transplantation of crossmatch-positive deceased donor kidney allograft recipients using a protocol of peri-transplant immunoadsorption for rapid alloantibody depletion immediately before transplant surgery.

Comparing the frequency of colorectal neoplasia among renal transplant with that of the healthy subjects, this work could found that the renal transplant cohort had an apparent increase in their risk of advanced colorectal neoplasia.

In a retrospective study, the presence of lupus anticoagulant at the time of transplantation was associated with a high rate of thrombosis, the hallmark lesions of antiphospholipid syndrome associated nephropathy, an increase in chronic vascular scores and a faster decline in mGFR.

A renal transplant recipient with life threatening post parathyroidectomy hypocalcemia was successfully treated with an allotransplant using cryopreserved parathyroid tissue from a third party.

A more global assessment of inflammation in kidney allograft biopsies to include inflammation in atrophic areas may provide critical insight into the prognosis of late graft injury.

Inferior pancreas and kidney graft survival in African American SPK patients

Carefully selected patients with T1DM can be rendered insulin independent after a single islet infusion with a novel efalizumab-based immunosuppressive regimen.

This multicenter, prospective study showed benefit of orthotopic liver transplantation in patients exceeding Milan Criteria based on preoperative imaging.

In a center experienced in live liver donation, anonymous donors are altruistic individuals who can successfully enhance the donor pool with acceptable morbidity similar to that of living-related liver donors.

Assessing 105 endomyocardial allograft biopsies by Affymetrix microarrays revealed that the current ISHLT system for diagnosing rejection does not reflect the molecular phenotype and lacks clinical relevance; and that the interpretation of Quilty lesions are more strongly associated with the molecular phenotype than current ISHLT rejection grades.
See editorial by Marboe on page 1957.

This multi-center study of pediatric heart transplant recipients suggests a complex relationship between recipient socioeconomic position and graft loss

Solid organ transplantation has historically been contentious in systemic AL amyloidosis because of the multisystem nature of the condition as well as the theoretical risk of graft amyloid recurrence, but this series highlights the outcomes and feasibility of transplantation in selected individuals.

This prospective study examines the contribution of thymopoiesis versus homeostatic proliferation to immune reconstitution following rATG and the influence of rATG on the emergence of Treg in renal transplant recipients.