Literature Watch

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Literature Watch, written by Xian C. Li, is a monthly section in AJT that highlights new basic science research. Dr. Li scours the highest quality basic science journals for findings and discoveries, then introduces and provides brief commentary on those topics that might stimulate new ideas for applications in transplantation or entice readers to look beyond their usual sources of information. The feature is not designed to be comprehensive, but rather to be somewhat idiosyncratic, drawing from journals and areas with which the Editorial Board has sensed a potential link to transplantation. It also will venture into speculation as to what fields may emerge in the coming years as relevant to AJT's readers. Above all, it will strive to be informative and even provocative, with the hope that it will stimulate readers to pursue avenues they might not have otherwise considered.

2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011

2022

Sep: MICA is a histocompatibility antigen in transplantation
Aug: Induction of fetomaternal tolerance? Suppressing B cells!
Jul: Allograft rejection: Be aware of tissue-resident T cells
Jun: Control of tertiary lymphoid tissue revealed
May: A new VISTA on kidney fibrosis
Apr: T cells with stem cell-like properties mediate type 1 diabetes
Mar: NK cells are caught in human kidney allograft rejection
Feb: Group 2 innate lymphoid cells join the memory club
Jan: Engineering IL-2 to steer immune responses



2021

Dec: The xenobiotic receptor CAR directs T cell response to bile acids
Nov: A new type of programmed inflammatory cell death: PANoptosis
Oct: B cells are going innate in human renal allografts
Sep: Stronger bone and better immune protection? Exercise more!
Aug: Senescence and aging of solid organs? Blame the immune system!
Jul: Taking AIM2 at regulatory T cells to modulate autoimmune diseases
Jun: Dissecting CMV latency and reactivation: BETing on the epigenetic regulators
May: Breaking the NF‐kB barriers to promote interspecies organogenesis
Apr: Fecal microbiota transplant boosts cancer immunotherapy in patients
Mar: Engineering smart Tregs to promote transplant survival
Feb: The entangled world of T cell memory and exhaustion
Jan: When aging meets tregs: It’s all about ROS stress



2020

Dec: The 2020 Vision of “Infectious Tolerance” in Transplantation
Nov: The brain controls intestinal Tregs remotely via a liver–brain–gut neural arc
Oct: MDSCs paralyze T cells via one‐way intercellular transfer of a toxic metabolite
Sep: Innate Myeloid Cells Remember and Reject Allogeneic Nonself in Transplantation
Aug: Atypical monocytes conspire with nuclear exosomes to promote organ fibrosis
July: Metabolomic profiling reveals clinically relevant microbiota‐linked metabolites
June: The anti‐inflammatory function of the apoptotic secretome
May: Liver Protection by ILC1s
Apr: Immune impact of commensals versus pathobionts
Mar: Giving effector/memory T cells a new (suppressive) purpose
 Feb: In vivo and in vitro differences in CD8+ T cell metabolism
 Jan: The initiation of graft‐versus‐host disease

2019

 Dec: Confounding Virus in Mouse Facilities
 Nov: DeTOXifying exhausted T cells
 Oct: Innate lymphoid cells coming of age
 Sep: Fibroblasts can have subsets too!
 Aug: Teamwork by IL‐10+ and IL‐35+ Tregs
 July: Lymph node segregation for tolerance or inflammation
 June: Neuroimmunology and the control of T cell migration
 May: Harnessing the commensal microbiota to improve immune responses
 Apr: Treg Respiration
 Mar: A New Ligand for LAG‐3
 Feb: A molecular pathway for indirect presentation?
 Jan: The Importance of Inflammation‐induced NETS

2018

 Dec: Th17 Cells Changing Colors
 Nov: Creating a Niche
 Oct: Danger, Metabolism and T Cell Memory
 Sep: The Adaptive NK Cell Response
 Aug: Metabolic Control of T Cell Memory
 Jul: Preventing PTLD?
 Jun: A Cause for Leaky Guts
 May: Immune Regulation of Lung Fibrosis
 Apr: Sweet T Cell Dysfunction
 Mar: Mind the GAP, for Tolerance to Gut Bacteria
 Feb: DC Metabolism Controls Lung T Cell Polarization
 Jan: Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth

 

2017

 Dec: Stealing Tregs’ Identity (by Deleting NF-κB)
 Nov: Making Therapeutic Antibodies in Vitro
 Oct: Predicting TCR Specificity?
 Sep: The Unbearable Lightness of Breathing
 Aug: Immune-Electrical Connection
 Jul: The Bugs That Keep Us Safe
 Jun: Timing is Everything
 May: Anti-Inflammatory Effects of Nonprofessional Phagocyte
 Apr: The Tpm Subset of the CD8+ T Cell Memory Family
 Mar: Dendritic Cell Identification for Dummies
 Feb: The Multiple Molecular Paths of Antibody Suppression by TFR Cells
 Jan: Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy

 

2016

Dec: Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression
Nov: B Cells Gasping for Air
Oct: Select Effects of IL-13 in Driving Tissue Repair and Fibrosis
Sep: Standardizing Mouse Models to Account for Host–Microbial Interactions
Aug: Of (Dirty) Mice, Men and Memory
Jul: Tregs Hold On To Ceramide
Jun: Micromanaging B Cell Tolerance
May: ABO-Incompatible Kidney Transplants: Twice as Expensive, Half as Good
Apr: Robo-Immunity: Neuroendocrine Regulation of Inflammation in the Lung
Mar: How Brains Are Drained: Discovery of Lymphatics WIthin the CNS
Feb: Single-Cell Transcriptomics Comes of Age
Jan: Of Bugs and Drugs: How the Microbiome Controls Responsiveness to Antitumor Immunotherapy

 

2015

Dec: Signals From Succinate: Elucidating the Primordial Trigger of Ischemia–Reperfusion Injury
Nov: Generating High-Affinity, Class-Switched Antibody Responses: LEF-1 and TCF-1 Get With the Program
Oct: Too Pooped To Pop: T Cell Exhaustion Portends Better Outcomes in Autoimmunity
Sep: New Tricks for an Old Dog: How CMV Shapes NK Cell Immunity
Aug: Total Virome Immunity Scan: Transplant Diagnostic of the Future?
Jul: The Jekyll and Hyde of TH17 Immunity During Inflammation
Jun: Gut–Immune Crosstalk: How IL-6 Signaling Links Inflammation to Epithelial Regeneration
May: AN IMMUNOLOGIC HEX: Novel Insights Into Mechanisms of Complement Activation
Apr: Living Off the Fat of the Land: How Specialized Adipose Tissue–Resident Tregs Control Inflammation and Metabolism
Mar: Identifying Diversity Within Memory B Cell Populations
Feb: The Circadian Clock and Transplantation
Jan: Designing Donors: Nuclease-Based Genome Editing in Pigs

 

2014

Dec: Genomic Approaches to Unraveling the Diversity and Dynamics of the Human Virome
Nov: CTLA4: Emerging Concepts and Potential Therapies
Oct: How mTOR Inhibition Increases Cross-Protective Immunity Following Influenza Vaccination
Sep: Fueling Memory: How Cellular Metabolism Drives T Cell Immunity
Aug: Adding Complexity to Immune Regulation by mTOR
Jul: Foxp3+ Cells by Any Other Name?
Jun: Bridging the Gap: Innate Lymphoid Cells and Tissue Repair
May: Cell-Permeable Peptides as Potential Diagnostics and Therapeutics
Apr: The Elusive Role of mTOR in Treg Functions
Mar: Aryl Hydrocarbon Receptor: Is the Environment Playing a Role in Transplant Outcomes?
Feb: A Skulk of Foxes Controls Treg Cell Development and Function
Jan: Transplantation of a Recellularized Rat Renal Scaffold

 

2013

Dec: Lung Macrophages Influence Regulatory T Cells in Asthma Models
Nov: New Insights Into Tolerogenic Functions of Skin Langerhans Cells
Oct: Lymphoid Neogenesis in Allografts: Bad, Good or Neither?
Sep: Lineage Determination and Epigenetics of Regulatory T Cells
Aug: Inflaming Alloreactivity Through Infection, Tissue Damage and Inflammasomes
Jul: Mesenchymal Stromal Cells: What’s In the Name? (and For What?)
Jun: Blastocyst Complementation For Chimeras For Xenotransplantation
May: A Closer Look at B Cell Memory
Apr: From Infection to Colonization: The Role of Microbiota in Transplantation
Mar: The House That Jack Built: Expanding the Concept of Plasma Cell Niches
Feb: ENCODE: Life, the Universe and Everything
Jan: System Network: Tackling the Complexity of the Immune System

 

2012

Dec: Molecular Assassins From Within: Intracellular DAMPs From Injured Cells Initiate Tissue Inflammation
Nov: CCR9+ Plasmacytoid Dendritic Cells Are “Central” to Tolerance
Oct: Alarmin’ Findings: IVIGs Suppress Infl ammation Through the “Alarmin” IL-33
Sep: Mast Cells: Infl ammatory, Immunoregulatory or Something In Between?
Aug: Commensal Microbiota Determine Intestinal iTreg
Jul: Leukocyte: Tempus Fugit Vel Carpe Diem
Jun: Memory T Cells: New Insights Into the Molecular Basis of Sensitivity and Heterogeneity
May: Transmissible Fatty Liver Disease
Apr: AHR and Tryptophan Catabolism: Putting the Effector T-Cell Response to Sleep
Mar: Fetal T Cells and Immunological Tolerance
Feb: Initiating Immune Responses in States of Sterile Inflammation
Jan: The Anti-Infectious Role of the IL -17 Pathway

 

2011

Dec: Adoptive Treg Therapy: Closer to the Clinic
Nov: Anatomy of Tolerance
Oct: Searching for Pathogens
Sep: GWAS, Gee Whiz
Aug: The Genetics of Renal Failure
Jul: IFNαβ, NF-κB, TLR, TNFα, S1P: The αβγs of Endogenous Ligands
Jun: Microbial Pathophysiology and Opportunistic Infections: Surprises Ahead
May: Stimulation of Beta Cells: Trying to Reap What We Grow
Apr: Markers of Organ Function: If You Search, What Will You Find?
Mar: What’s in a Name? Type 1 and Type 2 Responses
Feb: The Inflammasome: The Heart of Transplant Morbidity?
Jan: Fundamental Findings in Tissue Injury and Repair: New Insights Into the Etiology of Renal Fibrosis