• Issue

    Journal of Biomedical Materials Research Part B: Applied Biomaterials: Volume 107, Issue 6

    1751-2201
    August 2019

Issue Information

Free Access

Issue Information

  • Pages: 1751-1759
  • First Published: 05 July 2019

Original Research Reports

Cartilage/bone interface fabricated under perfusion: Spatially organized commitment of adipose-derived stem cells without medium supplementation

  • Pages: 1833-1843
  • First Published: 21 November 2018
Cartilage/bone interface fabricated under perfusion: Spatially organized commitment of adipose-derived stem cells without medium supplementation

A gradient-based nanocomposite (PLGA/aCaP) was seeded with human ASCs and cultivated in a perfusion flow bioreactor without supplementation. Gene expression of osteocalcin increased toward the bone-mimicking side, while gene expression of Sox9 increased toward the cartilage-mimicking side. Under static cultivation (control), these typical marker genes for osteogenesis (osteocalcin) and chondrogenesis (Sox9) were not influenced by the presence of amorphous calcium phosphate.

Original Research Reports

Original Research Reports