Corrosion behavior and biocompatibility evaluation of a novel zinc-based alloy stent in rabbit carotid artery model
Song Lin
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorXiaolin Ran
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorXinhao Yan
Xi'an Advanced Medical Technology Co., Ltd, Xi'an, 710000 China
Search for more papers by this authorWenhua Yan
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorQilong Wang
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorTieying Yin
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorJack G Zhou
Xi'an Advanced Medical Technology Co., Ltd, Xi'an, 710000 China
Search for more papers by this authorCorresponding Author
Tingzhang Hu
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Correspondence to: G. Wang; e-mail: [email protected] or T. Hu; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Guixue Wang
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Correspondence to: G. Wang; e-mail: [email protected] or T. Hu; e-mail: [email protected]Search for more papers by this authorSong Lin
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorXiaolin Ran
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorXinhao Yan
Xi'an Advanced Medical Technology Co., Ltd, Xi'an, 710000 China
Search for more papers by this authorWenhua Yan
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorQilong Wang
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorTieying Yin
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Search for more papers by this authorJack G Zhou
Xi'an Advanced Medical Technology Co., Ltd, Xi'an, 710000 China
Search for more papers by this authorCorresponding Author
Tingzhang Hu
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Correspondence to: G. Wang; e-mail: [email protected] or T. Hu; e-mail: [email protected]Search for more papers by this authorCorresponding Author
Guixue Wang
Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030 China
Correspondence to: G. Wang; e-mail: [email protected] or T. Hu; e-mail: [email protected]Search for more papers by this authorAbstract
Zinc (Zn) and its alloys have been proved to be promising candidate materials for biodegradable cardiovascular stents. In this study, a novel extruded Zn–0.02 Mg–0.02Cu alloy was prepared. Compared with pure Zn, the Zn-based alloy showed higher mechanical properties, and the Zn-based alloy could significantly accelerate Zn2+ release, reaching 0.61 ± 0.11 μg/mL at 15 days of immersion. In vitro biocompatibility studies demonstrated that the Zn-based alloy had excellent cytocompatibility and hemocompatibility, including low hemolysis rate (0.63 ± 0.12%) and strong inhibitory effect on platelet adhesion. Subsequently, the Zn-based alloy stent was implanted into the left carotid arteries of New Zealand white rabbits for 12 months. All the rabbits survived without any adverse clinical events, and all the stented arteries were patent during the study period. Rapid endothelialization at 1 week of implantation was observed, suggesting a low cytotoxicity and thrombosis risk. The stent corroded slowly and no obvious intimal hyperplasia was observed for 6 months, after which corrosion accelerated at 12 months. In addition, no obvious thrombosis and systemic toxicity during implantation period were observed, indicating its potential as the backbone of biodegradable cardiovascular stents. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1814–1823, 2019.
CONFLICT OF INTEREST
The authors declare no conflict of interest.
Supporting Information
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| JBMB34274-sup-0001-Supinfo.docxWord 2007 document , 3.4 MB | Appendix S1: Supplementary Material |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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