Advanced T stage, submandibular gland location, and unpaired lesions were associated with lymph node involvement. The prognosis of SDC patients with PLNR ≤ 0.48 was better than that of SDC patients with PLNR > 0.48. PLNR can reflect both the effect of lymph node dissection and the number of positive lymph nodes, and its prognostic value for major SDC exceeds the number of positive lymph node number. Patients with high PLNR should be followed closely after surgery.

This prospective study showed that updated knowledge regarding the management modalities of PAC is a prerequisite for accurate histopathological assessment and good surgical outcomes. Furthermore, histopathological analysis helps clinicians to select effective postoperative therapies for greater improvement in survival outcomes.

Potential Gastro-enteric Virulence Associated Genes in environmental Non-pathogenic Vibrio cholerae revealing potential Public Health concerns.

(1) With the advance in digital pathology and AI-powered approaches, we proposed an automatic workflow to quantify necrosis tumor ratio of colorectal cancer on whole-slide images. (2) The two-category necrosis tumor ratio was an independent prognostic factor and necrosis-low was associated with significant prolonged disease-free survival and overall survival in two cohorts. (3) Furthermore, a stratified analysis showed that necrosis-high was a high risk with adjuvant chemotherapy for overall survival in stage II colorectal cancer (p = 0.047). This finding might assist with changes in risk stratification and affect consequent precision medicine.

This article provides a comprehensive review of the dysregulation of immunometabolism and epigenetics as well as the multilevel regulatory mechanisms underlying the autoimmunity in ALDs.

Role of Nanomaterials in Photodynamic therapy of Cancer.

This article presents a rare case of metastatic pancreatic cancer mimicking medication related osteonecrosis of the jaw highlighting the clinical dilemma and challenges encountered when the presenting clinical symptoms and signs are ambiguous.