The cover image is based on the Case Report Paraquat induced acute kidney and liver injury: case report of a survivor from Bangladesh by Dr. ASADUZZAMAN et al., https://doi.org/10.1002/ccr3.5020.

We report a case of atypical parkinsonism and self-mutilation.

With appropriate interprofessional collaboration, dental schools have the capacity to facilitate the dental management of patients with head and neck cancer who are facing multiple barriers to care.

Surgical excision is the most common treatment option for keratoacanthomas. However, the topical application of the imiquimod 5% cream is a safe and effective option, especially for patients who refuse surgical removal.

Gallstone ileus is a very rare cause of mechanical bowel obstruction with often-delayed presentation and nonspecific symptoms. Aerobilia is found in approximately 50% of patients with gallstone ileus.

Intestinal infestation with Enterobius vermicularis is common, especially in the developing countries. However, its migration in the bile ducts is rare, often diagnosed after cholecystectomy. More investigations are needed to define its involvement in symptoms presented by patients and the likelihood of complications.

Nontuberculous mycobacterial disease presenting as a solitary pulmonary nodule (NTM-SPN) is often indistinguishable from malignancy. Although surgical resection is sometimes chosen for the diagnosis and treatment, the mass in this case shrank spontaneously. Careful observation is required to avoid unnecessary interventions.

Some psychosomatic diseases, like Takotsubo cardiomyopathy, may occur because of exposure to a stressful event like COVID-19. The simultaneous development of psychosis and Takotsubo cardiomyopathy suggests a field of vulnerability. Specific measures need to be taken to help vulnerable people to manage these stressful events.

Abdominal pain in children in COVID-19 era should be carefully evaluated and weighing risk-benefit of surgical procedure in suspected cases should be more discussed. Surgery in patients with high suspicious to MIS-C should be delayed for preventing critical outcomes.

Renal cell carcinoma can have lung metastasis even after a long interval of radical nephrectomy (16 years after nephrectomy in our case). If any pulmonary nodule is diagnosed with a history of RCC, pulmonary metastasis of RCC should be suspected and should be appropriately treated.

Despite high fatality following paraquat ingestion, a few percentages of patients survive even after organ damage appears. We need to focus more on careful clinical and laboratory monitoring. Early diagnosis and Supportive therapy are crucial.

Immune mediated thrombocytopenia should be considered as a differential in patients who present with thrombocytopenia post COVID-19 vaccination. Some patients may be refractory to standard treatment with steroids and intravenous immunoglobulin, necessitating more aggressive management.

Administration of molecular hydrogen dissolved in water to patient with COVID-19-like symptoms may improve oxygen levels and exercise capacity.

Hyperglycemic hyperosmolar syndrome (HHS) is a rare complication of diabetes mellitus among pediatric patients. Since its treatment differs from diabetic ketoacidosis (DKA), hence, pediatricians should be aware of its diagnosis and management.

Health policymakers and clinicians should also prioritize mental, emotional, and social health while treating SARS-CoV-2/COVID-19, and for this, different treatment varieties of eastern medicine would be a better option to integrate into western medicine so that we could have a better result in all dimensions of health.

We recommend testing for SARS-CoV-2 in a patient with an unexplained thromboembolic event, even in the absence of fever or respiratory symptoms.

Although eslicarbazepine is an anti-seizure medication, it may result in seizure worsening if its use is complicated by severe hyponatremia, even long time after commencing this medication. The treatment is a replacement for another ASM.

In the cases of acute rivaroxaban overdose, conservative management without prothrombin complex concentrate or other coagulation factors may be sufficient if renal function is normal and there is no bleeding.

Adrenergic cardiomyopathy is uncommon but can be fulminant and life-threatening. Nowadays, the need to exclude the possibility of COVID-19 pneumonia in patients with acute dyspnea in a previously healthy adult may cause a delay in the diagnosis.

Overdiagnosis of papillary thyroid hyperplasia which may mimic papillary thyroid carcinoma in fine-needle aspiration and frozen section has a serious impact on the patient. Therefore, it is important to know the difference between them to avoid over or undertreatment.

Splenic arteriovenous torsion causes splenomegaly and ischemic necrosis of the spleen. The recommended treatment for wandering spleen with hypersplenism is considered to be splenectomy.

The combination of the STRAW technique and coronary artery fenestration using a cutting balloon could be effective in SCAD patients, especially with dissection to the distal end of the coronary artery.

This case of Gastric Adenocarcinoma had progressed following failure of several prior lines of standard of care regimens. Multi-analyte profiling of freshly biopsied tumor sample indicated FGFR3 amplification along with sensitivity of tumor cells towards various chemotherapy drugs. The patient received personalized combination regimen of Pazopanib with Gemcitabine and Pemetrexed which yielded significant regression of metastatic deposits.

Percutaneous vertebroplasty with the Spine Jack^® system .

After an acupuncture treatment 24 times, the symptoms are recovered right shoulder both active and passive full range of movement in all directions and pain-free. Furthermore, no adverse effects were observed.

Many exaggerated skin reactions after insect bites have been described, and due to global warming, the incidence of these cases will increase. This clinical video promotes its recognition by showing an unusual cutaneous phenomenon after an insect bite.

Toxocariasis is a relatively common parasitic disease that can rarely affect the heart. Cardiac toxocariasis may lead to restrictive cardiomyopathy secondary to hypereosinophilia. CMR is a valuable diagnostic method in hypereosinophilic syndrome.

Sarcomatoid change in a renal tumor should undergo cytogenetic analysis of t(x;18) to prevent a missed diagnosis of synovial sarcoma. Surgeons should be vigilant regarding pathological correlation.

Diagnosis of hepatopulmonary syndrome complicated by interstitial pneumonia and obesity is difficult because these complications can cause hypoxia. Such patients may not present with typical contrast echocardiography findings.

Urgent response is required in suspected pulmonary tuberculosis (PTB) cases for infection control, and chest image is the first step to suspect PTB. This case shows an unexpected exception and importance of molecular testing for definite diagnosis.

Burkitt's lymphoma (BL) is defined as a highly invasive B-cell lymphoma with a poor prognosis. Primary bilateral ovarian mass without involvement of other organs is a rare manifestation of BL. Our report was a case of an EBV-positive Burkitt's lymphoma, which initially presented with ovarian mass and adnexal torsion.

Isolated TLA is an extremely rare condition, but should always be considered in a patient presented with liver abscess, especially from an endemic area. Diagnosis depends on histological identification, with treatment being quadruple therapy.

A hand-held doppler device reaveals a continuous machinery bruit due to a tibial A-V fistula

The association between UC and SLE is a rare incidence. We expect polyclonal hypergammaglobulinemia in serum protein analysis in patients with SLE; however, the results showed monoclonal gammopathy. This observation added even more peculiarity.

Clinicians should be aware of the potential for the pharmacologic activity of SGLT2 inhibitors to persist long after the standard drug clearance period of five half-lives, the typical duration used to guide pre-operative medication recommendations.

We describe a novel modified intranasal approach to minimize the complications of the impacted mesiodens surgical extraction. Also, it can be performed under local anesthesia with proper preoperative workup.

Pneumorarchis is a rare condition of low back pain. It is usually asymptomatic and secondary to trauma. Spontaneous pneumorrachis is scarce.

Vagal schwannomas are rare peripheral nerve sheath tumors arising from the vagus nerve. They are typically diagnosed in adulthood. We describe an atypical case in terms of size of the lesion, patient age, surgical approach, and molecular pathology.

Prostate abscesses in developed countries are becoming increasingly less common. Left untreated these abscesses can lead to numerous complications, including some which are very rare.

Intraoperative management is possible using continuous central venous pressure monitoring through inferior vena cava in situations where hemodynamic change is expected, such as in infant's huge mass resection surgery.

Adult-type granulosa cell tumors are extremely rare. Albeit mostly benign, 10% have malignant potential associated with unfavorable pathological features. The present case with the longest history duration shows that size alone may not necessarily be unfavorable prognosticator when not associated with other factors.

Lymphangioleiomyomatosis (LAM) is an unusual lung disease which can be diagnosed by its characteristic appearance on a high-resolution CT, and may not always require a biopsy.

Carotid artery dissection, which accounts for up to 20% of strokes in young patients, usually extends distally and leads to acute stenosis, occlusion, and aneurysmal changes with increased risk for thromboembolic events, especially in young people.

Treatment of pit viper envenomated puppies (≤6 months old) with antivenom was well tolerated, similar to adult dogs. However, therapeutic guidelines should be established to direct use and prove efficacy in this population.

At present, as there is no proper treatment for COVID-19–related anosmia, we recommend the use of B-complex vitamins and olfactory training for treating COVID-19–related anosmia.

After years of discontinuation of lanthanum carbonate, depositions can still be found in the gastric mucosa with associated gastrointestinal symptoms.

Presacral dermoid cysts are rare, benign tumors of developmental origin that primarily affect women. Surgical resection is the mainstay of treatment for these cysts, even if asymptomatic, with the laparoscopic approach being safer and more efficient.

Ultrasonogram can be considered as the imaging of choice when there is a contraindication to CT or conventional radiograph by reducing the overall amount of radiation. Which also can be the another treatment modalities for the surgical management of close reduction of zygomatic arch fracture.

Celiac disease is an autoimmune disease that is associated with different conditions. Cardiomyopathy associated with celiac disease needs high degree of clinical suspicion to make the diagnosis, as a gluten-free diet can improve heart function.

A successful alternative technique to resolve the catheter knotting during radial access using balloon internal fixation of 5F angiographic catheter in the cath laboratory.

Systemic mastocytosis with associated primitive myelofibrosis is a rare and complex disease with a difficult therapeutic management. The release of several inflammation mediators can trigger acute cardiovascular events.

Complex regional pain syndrome (CRPS) has rarely been reported in the setting of snakebite but might be more common than previously reported. We present the third case of CRPS reported in North America and the first resulting from a pit-viper's bite.

Postoperative permanent hypoparathyroidism can exhibit extensive intracranial calcifications involving basal ganglia, thalamus, cerebellum, and cerebral cortex.

In this report, we provide guidance to a challenging clinical situation in a low-resource setting environment. We present an approach to the treatment of helminths in infants presenting with a cutaneous form of the disease.

Hair regrowth with no adverse effects following nonablative 2940-nm Er:YAG laser treatment in alopecia universalis patient resulted in high patient satisfaction and compliance. As the main challenge in alopecia universalis is maintenance of regrown hair, patient compliance associated with this treatment might represent an advantage over traditional treatment modalities.

Identification of risk factors for postoperative delirium in patients planning to undergo total knee arthroplasty is important for perioperative management and prevention of fall-related complications.

Soft-tissue extramedullary plasmacytoma are rare and with unpredictable prognosis tumors. Radiotherapy, however, should be considered as the main therapeutic approach for these tumors due to their proven radiosensitivity.

Pneumocystis jirovecii pneumonia in primary immunodeficiency (ID) should be considered in slowly progressing cyanotic infants. Prenatal genetic counseling is crucial to prevent fatal infection in X-linked anhidrotic ectodermal dysplasia with ID.

Emphysematous gastritis caused by gas-producing bacteria have been reported to be cured without surgery by early and appropriate medical treatment, which should be widely recognized by general physicians.

Screening the MC4R gene showed one rare mutation p.Met215Ile in a Moroccan patient with morbid obesity, which leads to a change in the protein structure. The analysis of MC4R variants may be useful for future therapeutic approaches.

This clinical report underlines the importance of appropriate investigations when endocarditis is suspected. The timing of therapy changes the outcome. Adequate indications need to be followed also to limit the emergence of resistant microorganisms.

Venlafaxine has potential as a therapeutic option for patients with depressive disorder, migraine, and pruritus unresponsive to antihistamines.

In rare cases, dumping-like symptoms might be related to an intermittent gastric volvulus. In our patient, solid-phase gastric emptying scintigraphy led to the diagnosis and was essential in treating the patient.

Malnourished individuals are at increased risk of acetaminophen hepatotoxicity. The ratio of formation and clearance of the metabolites in relation to the clinical symptoms of hepatotoxicity should be further investigated, to better predict acetaminophen hepatotoxicity.

Any suspicion for PBOS needs a comprehensive pathological evaluation including IHC and excluding metaplastic carcinoma as well as phyllodes tumor. Then, it should be managed similar to an extra-skeletal sarcoma consisting of surgery or chemoradiation.

This report describes delayed presentation of rectal stenosis associated with Down's syndrome and hypothyroidism at 17 years of age. A thick membrane separated the rectum from the anal canal in the presence of a normal anus.

Surgeons must be investigative about the feature of inflammed appendix for the possibility of uncommon findings that can reveal extraordinary disease such as granulomatous.

As public COVID-19 vaccination programs are being implemented, it is possible that more rare and serious adverse effects such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) may occur

Lysergic acid diethylamide (LSD) is a potent hallucinogenic drug affecting the mood and perception of an individual. Although LSD-induced self-inflicted cut-throat wounds and self-harm injuries are extremely rarely reported behaviors, some reports are coming out in recent days that may complicate the depiction of scenarios in forensic psychiatry settings.

Fine-needle aspiration cytology is an excellent diagnostic tool for breast tuberculosis. Proper diagnosis enables appropriate management earlier in the course of the disease, which prevents widespread infection.

This report highlights that the genetic causes of FSGS, including NUP93 gene variant, such as the one described in this report, progress to end-stage renal disease rapidly and that the risk of recurrence post-renal transplantation is less likely.

Pulmonary cryptococcosis might present as multiple cystic shadows after the initiation of treatment. The condition may result in a risk of dyspnea and pneumothorax due to enlarged cystic lesions. Clinicians should follow-up the patient carefully.

In this study, we report a case of a 16-year-old female patient who is a known case of systemic lupus erythematosus (SLE) for 5 months and is on steroids presenting with hypocalcemia and massive pulmonary embolism diagnosed clinically while she has COVID.

Transcatheter tricuspid valve-in-valve for patients with failed tricuspid bio-prosthesis can be performed successfully and safely in broad variety of patients with varied underlying tricuspid valve pathology and patient comorbidities. The procedure opens new option for surgical valve selection in patients that required tricuspid valve surgery at young age.

Priapism as the first manifestation of chronic myeloid leukemia is uncommon. However, given that delay in the treatment onset is associated with erectile dysfunction, urgent management is required.

This simple technique permits simultaneous suspension and stabilization of endobag and adnexa, facilitating the surgeon's work and making the operation safer for the patient.

Mycosis fungoides is an indolent lymphoma, but when it reaches the tumor stage, it can cause cardiac tamponade due to extracardiac invasion, which may lead to arrhythmia and sudden death due to myocardial invasion.

DKA as an early manifestation of monogenic diabetes (eg, Wolcott-Rallison syndrome) in infancy, can be accelerated by COVID-19 infection, so its distinction is imperative in clinical settings.

This is the first report on cataract surgery in a Japanese macaque. Good vision was restored postoperatively by calculating the intraocular lens power and performing the surgery properly even if there was a hypermature cataract.

Aggressive thoracoscopy can help clinicians diagnose dry pleural dissemination, which leads to the appropriate treatment in lung cancer cases with interlobar granular shadows in HRCT even if PET-CT shows negative uptake in pleural dissemination.

More attention of the medical staff to this sign can lead to faster diagnosis and timely treatment of patients.

Complex surgery associated with major hemorrhage presents particular risks for Jehovah's Witnesses who do not accept transfusion of blood products. Intraoperative use of two cell saver machines simultaneously can maximize the yield of salvaged blood from both the operative field and from washed surgical swabs and can potentially be life-saving.

Although ascites leakage to the skin is the most frequent complication after abdominal paracentesis, leakage to the subcutaneous space has not been reported. Here, we report a subcutaneous effusion after paracentesis suggesting ascites leakage. We should be aware of this rare complication due to the potential risk of dissemination.

Bronchopleural fistula should be considered in COVID-19 pneumonia patients suffering from persistent pneumothorax, even in those who have never been placed on mechanical ventilation.

The diagnosis of postorgasmic illness syndrome is essentially clinical. Postorgasmic illness syndrome remains poorly identified and misdiagnosed. There are no recognized or codified treatment modalities for postorgasmic illness syndrome.

Fibroadenomas are the most common benign breast tumors in women, but rarely occur in men. We present a case of fibroadenoma occurring in a young, healthy male without hormonal alterations.

This case report presents bilateral hearing loss after vestibular-evoked myogenic potential (VEMP) testing. The loud acoustic stimulus used in VEMP testing can cause noise-induced hearing loss in some cases with high sensitivity to noise exposure or by exceeding individual cochlear safety thresholds.

Barraquer-Simons syndrome is a rare entity and can be associated with autoimmune conditions such as systemic lupus erythematosus. Close long-term follow-up is required to identify metabolic disturbances and potentially life-threatening renal problems.

This graph represents the daily lamotrigine dose, white blood cell count (WBC) and absolute neutrophil count (ANC) over time. The bottom x-axis represents days of the second admission. The left y-axis represents the daily lamotrigine dose in milligrams and is shown by the vertical bars. The right y-axis represents the WBC and ANC and is shown by the black circles and diamond points, respectively. The neutropenia cutoff is indicated by the dotted line (1.5 × 10⁹/L). Phenytoin and filgrastim therapy days are shown by the two double-arrowed lines in the plot area.

Rehabilitation of severely worn teeth in deep bite patient is considered as a challenging situation. Minimally invasive restorations and occlusal ceramic overlays are presented as a reliable and durable option in treatment of these cases.

The case details the features of colesional cutaneous talaromycosis and Kaposi sarcoma. Prudent histopathological examination and judicious use of adjunct diagnostic test are essential for the diagnosis.

Aplastic anemia is a disorder of bone marrow failure characterized by a hypocellular bone marrow. We report two cases with an initial hypercellular bone marrow at the time of presentation, suggesting a new phase in the pathogenesis of the disease.

SARS-CoV-2 infection may trigger subacute thyroiditis. Doctors should be aware of the potential development of subacute thyroiditis at SARS-CoV-2, which may be masked by dramatic affection of the respiratory system and dexamethasone administration.

Diaphragmatic eventration (DE) is a life-threatening abnormality that leads to one or both hemi-diaphragms being elevated in the thoracic cavity. Congenital DE can fatally hinder lung formation. DE can be easily misdiagnosed, thus recognizing the presentation, and performing accurate interventions can allow for suitable management and favorable outcomes.

Mucopolysaccharidosis type II/Hunter syndrome is an X-linked recessive lysosomal storage disorder. We report a 1-year and 4-month-old boy with coarse facial appearance, macrocephaly, dermal melanocytosis, widened wrists, kyphotic deformity, and left-sided inguinal hernia, consistent with MPS II, subsequently confirmed with genetic tests. There is no family history, parents are counselled.

DRESS syndrome is a rare and potentially life-threatening severe cutaneous adverse reaction that should be quickly diagnosed to guide its management, that implies a perfect knowledge of its clinical features and symptoms. In this context, cheilitis can be initial manifestation of this syndrome as reported in this paper.

The importance of accurate diagnosis that influence the treatment plan. In this case with accurate diagnosis, conservative treatment was substituted for marginal resection.

Although the “zone” approach may be useful for the surgical treatment of injuries to the anterior components of the neck, the “no zone” approach using imaging techniques should be applied when searching for posterior components, including the vertebral artery.

Chorioamnionitis is a fetomaternal condition that can be caused by ESBL-producing E. coli which pose challenging infection control issues and are a serious global threat. Screening strategies to monitor them could be useful in women from endemic areas to prevent perinatal transmission and introduction of multiresistant strains to the maternity wards.

Primary urinary bladder amyloidosis is a rare histopathological finding. Interestingly, it presents clinically and radiologically similar to urothelial carcinoma of the bladder. The only differentiation can be reached by histopathologic examination. Resection of such bladder lesions requires special care as such flat pathological lesions can be complicated by bladder perforation.

Concomitant decalcification of the anterior mitral leaflet via the aortic annulus during aortic valve replacement may be effective in reducing mitral stenosis in high-risk patients with severe aortic and mitral valve stenoses within short aortic cross-clamp time.

It is crucial to consider cervical osteomyelitis as a differential diagnosis for neck pain in patients who underwent radiotherapy for early diagnosis and management, thereby preventing the development of potentially debilitating neurologic symptoms.

An acupuncture point, GV-26, could be used as an analgesic acupoint to treat acute low back pain. Acupuncture can be integrated with allopathic (western) medicine and used in the hospital's emergency department to treat acute painful conditions.

Our case is particularly interesting because it clearly highlights the clinical characteristics of a rare disease whose atopic manifestations have been aggravated by a concurrence of FLG2 and SPINK5 mutations. Furthermore, trichoscopy showing invaginated trichoresis could suggest an early diagnosis of Netherton syndrome.

Utilization of therapeutic plasma exchange in select patients with COVID-19 microangiopathy may provide useful treatment by modulation of inflammatory cytokines and coagulation cascade to maintain homeostasis.

Bronchopleural fistula may develop in a patient with COVID-19 along with pneumothorax and hydropneumothorax.

Because non-Hodgkin lymphomas with mediastinal disease at presentation have a natural tendency for rapid dissemination and worse prognosis when invading the pericardium; hence, minimal delay in diagnosis is essential.

Rapidly destructive coxarthrosis should be in the differential diagnosis for acute hip pain with an elevated CRP level, even if the joint deformity is slight on radiography, and early surgery should be considered.

Odontomas must be removed in time as these can grow in size and eventually cause destruction of the periodontium, tooth mobility, and damage to adjacent structures. Peripheral compound odontomas must be removed as these have a tendency to exfoliate, and during removal, the area must be inspected for any underlying osseous lesions.

In case of severe pectus excavatum, an ultrasound-guided serratus anterior plane block and parasternal block with intermuscular two-incision technique implantation can be useful.

MIS-A should be considered with a sepsis-like syndrome following a recent COVID-19 disease or vaccination and there are no alternative diagnoses. Steroid might be beneficial in suppressing the hyper-immune activation in such population.

Here we present a case with chronic psoriasis developed anogenital condyloma acuminata. The warts originated from normal skin, not from psoriatic plaque. We consider these reactivation of latent HPV unrelated to recent psoriasis therapy.

Pre-operative MRI showed an expansive mass (37 × 33 mm) at the base of the left tongue, involving the body of the tongue, the anterior belly of the digastric muscle, the palatoglossal muscle, and imprinting the homolateral parapharyngeal space.