• Issue

    Annals of Neurology: Volume 98, Issue 2

    C1, 205-423
    August 2025
Previous Issue
Export Citation(s)Download PDF(s)

Cover Image

Free Access

Annals of Neurology: Volume 98, Number 2, August 2025

  • Page: C1
  • First Published: 21 July 2025

Issue Information

Free Access

Issue Information

  • Pages: 205-210
  • First Published: 21 July 2025

Review

Open Access

AI in Neurology: Everything, Everywhere, All at Once Part 1: Principles and Practice

Matthew Rizzo MD,  Jeffrey D. Dawson ScD, 
  • Pages: 211-230
  • First Published: 19 June 2025
AI in Neurology: Everything, Everywhere, All at Once Part 1: Principles and Practice

Brief Communication

Open Access

Characterization of Neuropsychiatric Conditions in United States Resettled Refugees at a Single Academic Center

Noor F. Shaik MD, PhD,  Uttara Gadde MD,  Aba Y. Barden-Maja MD, 
  • Pages: 231-235
  • First Published: 16 June 2025

Research Article

Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts

Julien Lagarde MD, PhD,  Piyush Maiti MS,  Daniel R. Schonhaut PhD,  Ganna Blazhenets PhD,  Jiaxiuxiu Zhang MS,  Ani Eloyan PhD,  Maryanne Thangarajah MS,  Alexander Taurone MS,  Isabel Elaine Allen PhD,  David N. Soleimani-Meigooni MD,  Ehud Zeltzer MD,  Charles Windon MD,  Maison Abu Raya MD,  Agathe Vrillon MD, PhD,  Karen Smith BS,  Ranjani Shankar BS,  Alinda Amuiri BS,  Salma Rocha BA,  Dustin B. Hammers PhD,  Jeffrey L. Dage PhD,  Kelly N. Nudelman PhD,  Kala Kirby BS,  Paul Aisen MD,  Robert Koeppe PhD,  Susan M. Landau PhD,  Maria C. Carrillo PhD,  Alexandra Touroutoglou PhD,  Michael Brickhouse BS,  Prashanthi Vemuri PhD,  Laurel Beckett PhD,  Rema Raman PhD,  Alireza Atri MD, PhD,  Gregory S. Day MD,  Ranjan Duara MD,  Neill R. Graff-Radford MD,  Lawrence S. Honig MD, PhD,  David T. Jones MD,  Joseph C. Masdeu MD, PhD,  Mario F. Mendez MD, PhD,  Kyle Womack MD,  Erik Musiek MD, PhD,  Chiadi U. Onyike MD,  Meghan Riddle MD,  Ian M. Grant MD,  Emily Rogalski PhD,  Erik C. B. Johnson MD, PhD,  Stephen Salloway MD,  Sharon Sha MD,  R. Scott Turner MD, PhD,  Thomas S. Wingo MD,  David A. Wolk MD,  Bradford C. Dickerson MD,  Liana G. Apostolova MD,  Renaud La Joie PhD,  Gil D. Rabinovici MD,  the LEADS Consortium for the Alzheimer's Disease Neuroimaging Initiative , 
  • Pages: 236-248
  • First Published: 17 March 2025
Amyloid PET in Sporadic Early- Versus Late-Onset Alzheimer's Disease: Comparison of the LEADS and ADNI Cohorts

Higher amyloid positivity rate and amyloid load in patients with a clinical diagnosis of early-onset Alzheimer's disease (Longitudinal early-onset Alzheimer's disease study [LEADS], n = 399) than late-onset AD (Alzheimer's disease neuroimaging initiative [ADNI], n = 450).

Prevalence of Cerebral Amyloid Angiopathy and Associated Risk of Subsequent Ischemic and Hemorrhagic Stroke and Mortality in a Nationwide Cohort

Samuel S. Bruce MD, MA,  Cenai Zhang MS,  Ava L. Liberman MD,  Alexander E. Merkler MD, MS,  Babak B. Navi MD, MS,  Gloria C. Chiang MD,  Costantino Iadecola MD,  Hooman Kamel MD, MS,  Santosh B. Murthy MD, MPH, 
  • Pages: 249-257
  • First Published: 01 May 2025

Cerebral Edema Progression and Outcomes in Large Infarct Patients Undergoing Endovascular Thrombectomy

Ximing Nie MD,  Jinjie Liu MD,  Bernard Yan DMedSci,  Felix C. Ng MBBS,  Sibo Liu MD,  Yongle Wang MD,  Mengxing Wang PhD,  Lina Zheng MD, PhD,  Zan Wang MD,  Yuying Wang MD,  Yuesong Pan PhD,  Xiaochuan Huo MD, PhD,  Zhongrong Miao MD, PhD,  Stephen M. Davis MD,  Liping Liu MD, PhD,  for the ANGEL-ASPECT Study Group , 
  • Pages: 258-269
  • First Published: 11 March 2025

Neuro-Images

Intracranial Intra-Aneurysm Thrombi Vegetation After Flow Diverter Implantation

Jiabao Yang MD,  Ning Ma MD, 
  • Pages: 270-272
  • First Published: 30 May 2025

Research Article

Open Access

Association Between Vascular NOTCH3 Aggregation and Disease Severity in a CADASIL Cohort – Implications for NOTCH3 Variant-Specific Disease Prediction

Minne N. Cerfontaine MD,  Gido Gravesteijn MD, PhD,  Remco J. Hack MD, PhD,  Kyra L. Dijkstra BSc,  Mar Rodríguez-Girondo PhD,  Benno Gesierich PhD,  Marie-Noëlle W. Witjes-Ané PhD,  Remco van Doorn MD, PhD,  Marco Duering MD,  Julie W. Rutten MD, PhD,  Saskia A. J. Lesnik Oberstein MD, PhD, 
  • Pages: 273-285
  • First Published: 23 April 2025
Open Access

Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis

Rosario Vasta MD, PhD,  Emanuele Koumantakis MD,  Antonio Canosa MD, PhD,  Umberto Manera MD, PhD,  Maurizio Grassano MD, PhD,  Francesca Palumbo MD,  Sara Cabras MD,  Enrico Matteoni MD,  Francesca Di Pede MD,  Filippo De Mattei MD,  Filippo Vergnano,  Jessica Mandrioli MD,  Cecilia Simonini BSc,  Ilaria Martinelli MD,  Fabiola De Marchi MD, PhD,  Letizia Mazzini MD,  Cristina Moglia MD, PhD,  Andrea Calvo MD, PhD,  Adriano Chiò MD, FAAN, 
  • Pages: 286-293
  • First Published: 26 April 2025
Open Access

Effectiveness of Autologous Hematopoietic Stem Cell Transplantation versus Alemtuzumab and Ocrelizumab in Relapsing Multiple Sclerosis: A Single Center Cohort Study

Paolo Antonio Muraro MD, PhD,  Antonio Zito MD,  Alessio Signori MD, PhD,  Maria Pia Sormani PhD,  Eleonora Rigoni MD, PhD,  Federica Pollidoro MD,  Roberto Bergamaschi MD,  Alice Mariottini MD,  Omar Malik MD, PhD,  Ashwini Nandoskar MD,  Victoria Singh-Curry MD,  Varun Mehra MD, PhD,  Majid Kazmi MD,  Ian Gabriel MD,  Eli Silber MD,  Richard Nicholas MD, PhD,  Antonio Scalfari MD, PhD, 
  • Pages: 294-307
  • First Published: 19 April 2025
Open Access

Detecting New Lesions Using a Large Language Model: Applications in Real-World Multiple Sclerosis Datasets

Shane Poole BS,  Nikki Sisodia BS,  Kanishka Koshal MPH,  Kyra Henderson BA,  Jaeleene Wijangco BS,  Danelvis Paredes MD,  Chelsea Chen BA,  William Rowles BS,  Amit Akula BA,  Jens Wuerfel MD, PhD,  Vishakha Sharma PhD,  UCSF Multiple Sclerosis and Neuroinflammation Center clinicians ,  Andreas M. Rauschecker MD, PhD,  Roland G. Henry PhD,  Riley Bove MD, 
  • Pages: 308-316
  • First Published: 25 April 2025

Review

Open Access

New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Joseph J. Sabatino Jr. MD, PhD,  Bruce A. C. Cree MD, PhD, MAS,  Stephen L. Hauser MD, 
  • Pages: 317-328
  • First Published: 06 June 2025
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond

Research Article

Open Access

Punctate White Matter Abnormality in Moderate-to-Late Preterm Infants

Eleanor Kennedy PhD,  Ting Guo PhD,  Sian Williams PhD,  Thiviya Selvanathan MD, PhD,  Jane M. Alsweiler MBChB, PhD,  Frank H. Bloomfield MBChB, PhD,  Malcolm Battin MBChB, MD,  David Dubowitz MD, PhD,  Steven P. Miller MDCM, MAS,  Catherine Morgan PhD,  David Perry MBChB,  Ngaire Susan Stott MBChB, PhD,  Jane E. Harding MBChB, DPhil,  for the MR DIAMOND and MoPED Study Groups , 
  • Pages: 329-340
  • First Published: 09 June 2025
Open Access

Regional and Global Changes in Brain Structure 1-Year Post Pediatric “Mild” Traumatic Brain Injury

Upasana Nathaniel PhD,  Tracey V. Wick MS,  Josef L. Ling BA,  Jessica R. McQuaid BS,  Divyasree Sasi Kumar MS,  Samuel D. Miller BS,  Jingshu Wu BS,  Vadim Zotev PhD,  Timothy B. Meier PhD,  Harm J. van der Horn MD, PhD,  John P. Phillips MD,  Richard A. Campbell PhD,  Robert E. Sapien MD, PhD,  Rahsan Keskin MD,  Andrei A. Vakhtin PhD,  Andrew R. Mayer PhD, 
  • Pages: 341-353
  • First Published: 06 June 2025

Neuro-Images

Open Access

Pediatric RNS Lead Migration: Wandering Eyes or Electrode?

Charuta Joshi MBBS, MSCS,  Daniel Veltkamp MD,  Cathleen Dodez BBA,  Aaron E. L. Warren PhD,  Deepa Sirsi MD,  Afsaneh Talai MD,  Rana Said MD,  Angela Price MD, 
  • Pages: 354-356
  • First Published: 18 June 2025

Research Article

Open Access

Toward a Universal Map of EEG: A Semantic, Low-Dimensional Manifold for EEG Classification, Clustering, and Prognostication

Laura Krumm,  Dominik D. Kranz,  Mustafa Halimeh,  Alexander Nelde,  Edilberto Amorim,  Sahar Zafar,  Jin Jing,  Robert J. Thomas,  M. Brandon Westover,  Christian Meisel, 
  • Pages: 357-368
  • First Published: 20 June 2025

Biallelic Variants in EPG5 Gene Are Associated with Parkinson's Disease

Qi-Ying Sun MD, PhD,  Fu-Liang Tang MD,  Yao Zhou MD,  Hong-Xu Pan MD, PhD,  Xun Zhou MD, PhD,  Yu-Wen Zhao MD, PhD,  Run-Cheng He MD, PhD,  Sheng Zeng MD, PhD,  Jun-Pu Wang PhD,  Wei Lin PhD,  Wei-Qian Zeng PhD,  Dan-dan Wang MSc,  Xue-Jing Wang MD, PhD,  Zhen-Hua Liu MD, PhD,  Qian Xu MD, PhD,  Jin-Chen Li PhD,  Xin-Xiang Yan MD,  Ji-Feng Guo MD,  Jian Qiu PhD,  Bei-Sha Tang MD, 
  • Pages: 369-385
  • First Published: 07 April 2025
Open Access

Neuroimaging Biomarkers for Friedreich Ataxia: A Cross-Sectional Analysis of the TRACK-FA Study

Nellie Georgiou-Karistianis PhD,  Louise A. Corben PhD,  Eric F. Lock PhD,  Helena Bujalka PhD,  Isaac Adanyeguh PhD,  Manuela Corti PhD,  Dinesh K. Deelchand PhD,  Martin B. Delatycki MBBS, PhD,  Imis Dogan PhD,  Jennifer Farmer MS,  Marcondes C. França Jr. MD, PhD,  Anthony S. Gabay PhD,  William Gaetz PhD,  Ian H. Harding PhD,  James Joers PhD,  Michelle A. Lax MSc,  Jiakun Li BS,  David R. Lynch MD, PhD,  Thomas H. Mareci PhD,  Alberto R. M. Martinez MD,  Massimo Pandolfo MD,  Marina Papoutsi PhD,  Richard G. Parker PhD,  Kathrin Reetz MD,  Thiago J.R. Rezende PhD,  Timothy P. Roberts PhD,  Sandro Romanzetti PhD,  David A. Rudko PhD,  Susmita Saha PhD,  Jörg B. Schulz MD,  Sub H. Subramony MD,  Veena G. Supramaniam PhD,  Christophe Lenglet PhD,  Pierre-Gilles Henry PhD, 
  • Pages: 386-397
  • First Published: 22 March 2025
Open Access

Cholinergic Degeneration and Cognitive Function in Early GBA1-Related Parkinson's Disease

Sofie Slingerland MD,  Sygrid van der Zee PhD,  Giulia Carli PhD,  Anne C. Slomp MSc,  Emile d'Angremont PhD,  Jeffrey M. Boertien MD, PhD,  Teus van Laar MD, PhD, 
  • Pages: 398-409
  • First Published: 16 April 2025

Machine Learning Models of Voxel-Level [18F] Fluorodeoxyglucose Positron Emission Tomography Data Excel at Predicting Progressive Supranuclear Palsy Pathology

Addison S. Braun BS,  Ryota Satoh PhD,  Nha Trang Thu Pham BS,  Neha Singh-Reilly PhD,  Farwa Ali MD,  Dennis W. Dickson MD,  Val J. Lowe MD,  Jennifer L. Whitwell PhD,  Keith A. Josephs MD, MST, MSc, 
  • Pages: 410-420
  • First Published: 30 May 2025

Letter/Reply

Enhancing the Evaluation of IVT in DOAC-Treated Stroke Patients: Addressing Methodological Considerations for Future Research

Zhengting Duan MD,  Li Qi MD, 
  • Page: 421
  • First Published: 26 June 2025

Reply to “Enhancing the Evaluation of IVT in DOAC-Treated Stroke Patients: Addressing Methodological Considerations for Future Research”

Marius Matusevicius MD, PhD,  Malin Säflund MD,  Niaz Ahmed MD, 
  • Pages: 421-423
  • First Published: 26 June 2025