• Issue

    Hepatology: Volume 70, Issue 3

    767-1090
    September 2019
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Cover Image

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Cover Image

  • First Published: 31 August 2019

Issue Information

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Masthead

  • First Published: 31 August 2019
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Table of contents

  • First Published: 31 August 2019

Editorial

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Assessing Surgical Risk in Idiopathic Portal Hypertension: Some Answers, an Extrapolation, and More Questions

Douglas A. Simonetto M.D.,  Patrick S. Kamath M.D.,  Vijay H. Shah M.D., 
  • Pages: 767-770
  • First Published: 12 July 2019

Original Articles

VIRAL HEPATITIS

Open Access

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

Sanne Brun Jensen,  Ulrik Fahnøe,  Long V. Pham,  Stéphanie Brigitte Nelly Serre,  Qi Tang,  Lubna Ghanem,  Martin Schou Pedersen,  Santseharay Ramirez,  Daryl Humes,  Anne Finne Pihl,  Jonathan Filskov,  Christina Søhoel Sølund,  Julia Dietz,  Slim Fourati,  Jean-Michel Pawlotsky,  Christoph Sarrazin,  Nina Weis,  Kristian Schønning,  Henrik Krarup,  Jens Bukh,  Judith Margarete Gottwein, 
  • Pages: 771-787
  • First Published: 09 April 2019

STEATOHEPATITIS/METABOLIC LIVER DISEASE

Open Access

The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis

Michael Trauner,  Aliya Gulamhusein,  Bilal Hameed,  Stephen Caldwell,  Mitchell L. Shiffman,  Charles Landis,  Bertus Eksteen,  Kosh Agarwal,  Andrew Muir,  Simon Rushbrook,  Xiaomin Lu,  Jun Xu,  Jen-Chieh Chuang,  Andrew N. Billin,  Georgia Li,  Chuhan Chung,  G. Mani Subramanian,  Robert P. Myers,  Christopher L. Bowlus,  Kris V. Kowdley, 
  • Pages: 788-801
  • First Published: 19 January 2019
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Efficacy of Granulocyte Colony-stimulating Factor in the Management of Steroid-Nonresponsive Severe Alcoholic Hepatitis: A Double-Blind Randomized Controlled Trial

Saggere Muralikrishna Shasthry,  Manoj Kumar Sharma,  Varsha Shasthry,  Apurva Pande,  Shiv Kumar Sarin, 
  • Pages: 802-811
  • First Published: 21 January 2019
Free Access

Association Between Nonalcoholic Fatty Liver Disease and Reduced Bone Mineral Density in Children: A Meta-Analysis

Alessandro Mantovani,  Davide Gatti,  Giacomo Zoppini,  Giuseppe Lippi,  Enzo Bonora,  Christopher D. Byrne,  Valerio Nobili,  Giovanni Targher, 
  • Pages: 812-823
  • First Published: 31 January 2019

HEPATOBILIARY MALIGNANCIES

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Vessels That Encapsulate Tumor Clusters (VETC) Pattern Is a Predictor of Sorafenib Benefit in Patients with Hepatocellular Carcinoma

Jian-Hong Fang,  Li Xu,  Li-Ru Shang,  Chu-Zhi Pan,  Jin Ding,  Yun-Qiang Tang,  Hui Liu,  Chu-Xing Liu,  Jia-Lin Zheng,  Yao-Jun Zhang,  Zhong-Guo Zhou,  Jing Xu,  Limin Zheng,  Min-Shan Chen,  Shi-Mei Zhuang, 
  • Pages: 824-839
  • First Published: 01 December 2018
Open Access

Stereotactic Radiofrequency Ablation of Hepatocellular Carcinoma: a Histopathological Study in Explanted Livers

Reto Bale,  Peter Schullian,  Gernot Eberle,  Daniel Putzer,  Heinz Zoller,  Stefan Schneeberger,  Claudia Manzl,  Patrizia Moser,  Georg Oberhuber, 
  • Pages: 840-850
  • First Published: 05 December 2018
Free Access

Tumor Microenvironment Regulation by the Endoplasmic Reticulum Stress Transmission Mediator Golgi Protein 73 in Mice

Congwen Wei,  Xiaoli Yang,  Ning Liu,  Jin Geng,  Yanhong Tai,  Zhenyu Sun,  Gangwu Mei,  Pengyu Zhou,  Yumeng Peng,  Chenbin Wang,  Xiaoli Zhang,  Pingping Zhang,  Yunqi Geng,  Yujie Wang,  Xiaotong Zhang,  Xin Liu,  Yanhong Zhang,  Feixiang Wu,  Xiang He,  Hui Zhong, 
  • Pages: 851-870
  • First Published: 05 February 2019

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

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Bile-Derived Organoids From Patients With Primary Sclerosing Cholangitis Recapitulate Their Inflammatory Immune Profile

Carol J. Soroka,  David N. Assis,  Leina S. Alrabadi,  Scott Roberts,  Laura Cusack,  Ariel B. Jaffe,  James L. Boyer, 
  • Pages: 871-882
  • First Published: 18 December 2018
Free Access

Aging-Related Expression of Twinfilin-1 Regulates Cholangiocyte Biological Response to Injury

Luca Maroni,  Claudio Pinto,  Debora Maria Giordano,  Stefania Saccomanno,  Jesus M. Banales,  Daniele Spallacci,  Maria Cristina Albertini,  Fiorenza Orlando,  Mauro Provinciali,  Malgorzata Milkiewicz,  Espen Melum,  Ibone Labiano,  Piotr Milkiewicz,  Chiara Rychlicki,  Luciano Trozzi,  Marina Scarpelli,  Antonio Benedetti,  Gianluca Svegliati Baroni,  Marco Marzioni, 
  • Pages: 883-898
  • First Published: 18 December 2018
Free Access

Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome

John-Paul Berauer,  Anya I. Mezina,  David T. Okou,  Aniko Sabo,  Donna M. Muzny,  Richard A. Gibbs,  Madhuri R. Hegde,  Pankaj Chopra,  David J. Cutler,  David H. Perlmutter,  Laura N. Bull,  Richard J. Thompson,  Kathleen M. Loomes,  Nancy B. Spinner,  Ramakrishnan Rajagopalan,  Stephen L. Guthery,  Barry Moore,  Mark Yandell,  Sanjiv Harpavat,  John C. Magee,  Binita M. Kamath,  Jean P. Molleston,  Jorge A. Bezerra,  Karen F. Murray,  Estella M. Alonso,  Philip Rosenthal,  Robert H. Squires,  Kasper S. Wang,  Milton J. Finegold,  Pierre Russo,  Averell H. Sherker,  Ronald J. Sokol,  Saul J. Karpen,  for the Childhood Liver Disease Research Network (ChiLDReN) , 
  • Pages: 899-910
  • First Published: 21 January 2019

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Abdominal Surgery in Patients With Idiopathic Noncirrhotic Portal Hypertension: A Multicenter Retrospective Study

Laure Elkrief,  José Ferrusquia-Acosta,  Audrey Payancé,  Lucile Moga,  Luis Tellez,  Michael Praktiknjo,  Bogdan Procopet,  Oana Farcau,  Victor De Lédinghen,  Rustam Yuldashev,  Nicolas Tabchouri,  Louise Barbier,  Jérôme Dumortier,  Benjamin Menahem,  Marta Magaz,  Virginia Hernández-Gea,  Agustin Albillos,  Jonel Trebicka,  Laurent Spahr,  Andrea De Gottardi,  Aurélie Plessier,  Dominique Valla,  Laura Rubbia-Brandt,  Christian Toso,  Christophe Bureau,  Juan-Carlos Garcia-Pagan,  Pierre-Emmanuel Rautou,  for VALDIG, an EASL consortium , 
  • Pages: 911-924
  • First Published: 29 March 2019
Free Access

Intestinal Immune Dysregulation Driven by Dysbiosis Promotes Barrier Disruption and Bacterial Translocation in Rats With Cirrhosis

Leticia Muñoz,  María-José Borrero,  María Úbeda,  Elisa Conde,  Rosa del Campo,  Macarena Rodríguez-Serrano,  Margaret Lario,  Ana-María Sánchez-Díaz,  Oscar Pastor,  David Díaz,  Laura García-Bermejo,  Jorge Monserrat,  Melchor Álvarez-Mon,  Agustín Albillos, 
  • Pages: 925-938
  • First Published: 10 November 2018
Free Access

Human Immunodeficiency Virus/Hepatitis C Virus (HCV) Co-infected Patients With Cirrhosis Are No Longer at Higher Risk for Hepatocellular Carcinoma or End-Stage Liver Disease as Compared to HCV Mono-infected Patients

Dominique Salmon-Ceron, Pierre Nahon, Richard Layese, Valérie Bourcier, Philippe Sogni, Firouze Bani-Sadr, Etienne Audureau, Laurence Merchadou, François Dabis, Linda Wittkop, Françoise Roudot-Thoraval, ; for the ANRS CO12 CirVir and ANRS CO13 HEPAVIH study groups , 
  • Pages: 939-954
  • First Published: 19 December 2018
Free Access

Deficiency of Both Farnesoid X Receptor and Takeda G Protein–Coupled Receptor 5 Exacerbated Liver Fibrosis in Mice

Jessica M. Ferrell,  Preeti Pathak,  Shannon Boehme,  Tricia Gilliland,  John Y. L. Chiang, 
  • Pages: 955-970
  • First Published: 21 January 2019
Free Access

Low Risk of Variceal Bleeding in Patients With Cirrhosis After Variceal Screening Stratified by Liver/Spleen Stiffness

Grace Lai-Hung Wong,  Lilian Yan Liang,  Raymond Kwok,  Aric Josun Hui,  Yee-Kit Tse,  Henry Lik-Yuen Chan,  Vincent Wai-Sun Wong, 
  • Pages: 971-981
  • First Published: 25 January 2019
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Prognostic Role of Ammonia in Patients With Cirrhosis

Shalimar,  Mohammed Faisal Sheikh,  Rajeshwar P. Mookerjee,  Banwari Agarwal,  Subrat Kumar Acharya,  Rajiv Jalan, 
  • Pages: 982-994
  • First Published: 31 January 2019

LIVER INJURY/REGENERATION

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Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock–Induced Liver Injury

Yang Xie,  Meishu Xu,  Meihong Deng,  Zhigang Li,  Pengcheng Wang,  Songrong Ren,  Yan Guo,  Xiaochao Ma,  Jie Fan,  Timothy R. Billiar,  Wen Xie, 
  • Pages: 995-1010
  • First Published: 30 April 2019

LIVER BIOLOGY/PATHOBIOLOGY

Open Access

Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms

Hui Chen,  Feng Gao,  Mian He,  Xiao Fan Ding,  Aikha M. Wong,  Siu Ching Sze,  Allen C. Yu,  Tingting Sun,  Anthony W-H. Chan,  Xin Wang,  Nathalie Wong, 
  • Pages: 1011-1025
  • First Published: 13 January 2019

Concise Reviews

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The Role of Innate Immune Cells in Nonalcoholic Steatohepatitis

Jingjing Cai,  Xiao-Jing Zhang,  Hongliang Li, 
  • Pages: 1026-1037
  • First Published: 17 January 2019
Free Access

A Call to Standardize Definitions, Data Collection, and Outcome Assessment to Improve Care in Alcohol-Related Liver Disease

Nicole T. Shen,  Annaheta Salajegheh,  Robert S. Brown Jr., 
  • Pages: 1038-1044
  • First Published: 25 February 2019

Review

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The Role of Hepatitis B Surface Antigen in Nucleos(t)ide Analogues Cessation Among Asian Patients With Chronic Hepatitis B: A Systematic Review

Jiaye Liu Ph.D.,  Tao Li,  Li Zhang,  Aiqiang Xu, 
  • Pages: 1045-1055
  • First Published: 18 December 2018

Hepatology Elsewhere

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A Tale of Two Complications of Obesity: NASH and Hepatocellular Carcinoma

Renumathy Dhanasekaran M.D.,  Dean W. Felsher M.D., Ph.D., 
  • Pages: 1056-1058
  • First Published: 08 April 2019
Free Access

The Gut-Liver Axis in Primary Sclerosing Cholangitis: Are Pathobionts the Missing Link?

Steven P. O’Hara Ph.D.,  Nicholas F. LaRusso M.D., 
  • Pages: 1058-1060
  • First Published: 23 April 2019
Free Access

Acute Intermittent Porphyria: Novel Etiologic and Pathogenic Therapies Based on RNA Transfer to the Liver

Jesus Prieto M.D., Ph.D.,  Gloria Gonzalez-Aseguinolaza Ph.D., 
  • Pages: 1061-1063
  • First Published: 26 April 2019

Clinical Observations in Hepatology

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Severe Hemochromatosis Arthropathy in the Absence of Iron Overload

Samer Chehade,  Paul C. Adams, 
  • Pages: 1064-1065
  • First Published: 18 December 2018
Free Access

Expanding and Underscoring the Hepato-Encephalopathic Phenotype of QIL1/MIC13

Bianca E. Russell,  Kaitlin G. Whaley,  Kevin E. Bove,  Anatalia Labilloy,  Rachel C. Lombardo,  Robert J. Hopkin,  Nancy D. Leslie,  Carlos Prada,  Zahra Assouline,  Giulia Barcia,  Juliette Bouchereau,  Maryline Chomton,  Dominique Debray,  Imen Dorboz,  Philippe Durand,  Pauline Gaignard,  Dalila Habes,  Claude Jardel,  François Labarthe,  Jonathan Lévy,  Anne Lombès,  Claire Mehler-Jacob,  Judith Melki,  Laura Menvielle,  Arnold Munnich,  Charlotte Mussini,  Samia Pichard,  Marlène Rio,  Agnès Rötig,  Samira Sissaoui,  Abdelhamid Slama,  Alexander G Miethke,  Manuel Schiff, 
  • Pages: 1066-1070
  • First Published: 26 March 2019
Free Access

Treating Hepatitis C in Homeless Veterans at the Greater Los Angeles Veterans' Affairs Medical Center

Omar Bakr,  Lillian Gelberg,  Shinobu Seragaki,  Sarah Youn,  Jenna Kawamoto,  Marcie Hoppe,  Lisa Altman,  Kristin Kopelson,  Folasade P. May,  Brianna Cowan,  Debika Bhattacharya, 
  • Pages: 1071-1073
  • First Published: 04 April 2019

Correspondence

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Letter to the Editor: Characterization of CD169+ Macrophages in Liver Regeneration: Tissue Distribution and Fate?

Yeni Ait-Ahmed,  Adrien Guillot,  Fouad Lafdil, 
  • Page: 1074
  • First Published: 04 March 2019
Free Access

Reply

Kristina Behnke Ph.D.,  Yuan Zhuang M.Sc.,  Haifeng C. Xu Ph.D.,  Balamurugan Sundaram M.Sc.,  Maria Reich Ph.D.,  Prashant V. Shinde Ph.D. ,  Jun Huang Ph.D.,  Nastaran Fazel Modares M.Sc.,  Alexei V. Tumanov Ph.D.,  Robin Polz M.Sc.,  Jürgen Scheller Ph.D.,  Carl F. Ware Ph.D.,  Klaus Pfeffer Ph.D.,  Verena Keitel M.D.,  Dieter Häussinger M.D.,  Aleksandra A. Pandyra Ph.D.,  Karl S. Lang Ph.D.,  Philipp A. Lang Ph.D., 
  • Pages: 1074-1075
  • First Published: 04 March 2019
Free Access

Letter to the Editor: Acute-on-Chronic Liver Failure: Conceptual Divergences

Ângelo Zambam de Mattos M.D., M.Sc., Ph.D.,  Angelo Alves de Mattos M.D., M.Sc., Ph.D., 
  • Page: 1076
  • First Published: 12 March 2019
Free Access

Letter to the Editor: The Kynurenine Pathway in Hepatic Cirrhosis

Abdulla Badawy Ph.D., F.R.C.Path., F.R.S.B., 
  • Pages: 1077-1078
  • First Published: 29 April 2019
Free Access

Letter to the Editor: Is Emricasan (IDN-6556), an Oral Pan-Caspase Inhibitor, Ready for Controlled Trials?

Sandeep Khurana M.B.B.S.,  Harshit S. Khara M.D., 
  • Pages: 1078-1079
  • First Published: 02 May 2019
Free Access

Reply

David Hagerty M.D.,  Guadalupe Garcia-Tsao M.D.,  Jaime Bosch M.D., Ph.D., 
  • Pages: 1079-1080
  • First Published: 29 April 2019
Free Access

Letter to the Editor: Predicting Postoperative Liver Dysfunction Based on Blood Derived MicroRNA Signatures

Guandou Yuan M.D., Ph.D.,  Jiangfa Li M.D.,  Shuiping Yu M.D.,  Xiaoping Chen M.D., F.A.C.S.,  Songqing He M.D., Ph.D., 
  • Pages: 1080-1081
  • First Published: 29 April 2019
Free Access

Letter to the Editor: Predicting Postoperative Liver Dysfunction Based on Blood-Derived MicroRNA Signatures

Jiangfa Li, 
  • Page: 1081
  • First Published: 29 April 2019
Open Access

Reply

Patrick Starlinger M.D., Ph.D.,  David Pereyra,  Matthias Hackl Ph.D.,  Alice Assinger Ph.D., 
  • Pages: 1082-1083
  • First Published: 29 April 2019
Free Access

Letter to Editor: Prognostic Role of Ammonia in Patients With Cirrhosis

Narendra S. Choudhary D.M.,  Sanjiv Saigal D.M.,  Neeraj Saraf D.N.B.,  Arvinder S. Soin M.S., 
  • Pages: 1083-1084
  • First Published: 11 May 2019
Free Access

Reply

Shalimar D.M.,  Mohammed Faisal Sheikh M.B.B.S.,  Rajeshwar P. Mookerjee Ph.D.,  Banwari Agarwal M.D.,  Subrat Kumar Acharya M.D.,  Rajiv Jalan M.D., Ph.D., 
  • Pages: 1084-1085
  • First Published: 11 May 2019
Free Access

Letter to Editor: Association Between Postoperative Liver Dysfunction and Blood-Derived MicroRNA Signatures

Haisu Dai M.D.,  Kaicheng Shen M.D.,  Xingxing Su M.D.,  Yishi Yang M.D.,  Yan Jiang M.D.,  Zhiyu Chen M.D., Ph.D., 
  • Pages: 1085-1086
  • First Published: 12 May 2019
Open Access

Reply:

Patrick Starlinger M.D., Ph.D.,  Matthias Hackl Ph.D.,  Alice Assinger Ph.D., 
  • Pages: 1086-1088
  • First Published: 13 May 2019

Correction

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Correction

  • Page: 1089
  • First Published: 05 August 2019

Issue Information

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Notices

  • Page: 1090
  • First Published: 31 August 2019
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Instructions to Authors

  • First Published: 31 August 2019