• Issue

    Hepatology: Volume 69, Issue 2

    469-926
    February 2019
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Cover Image

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Cover Image

  • First Published: 29 January 2019

Issue Information

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Masthead

  • First Published: 29 January 2019
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Table of contents

  • First Published: 29 January 2019

Hepatology Highlights

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Hepatology Highlights

Nicholas Russo,  Robert S. Brown Jr.,  Shawn L. Shah,  Tibor I. Krisko,  Christopher S. Krumm,  Hayley T. Nicholls,  Omar Mousa,  Harmeet Malhi,  Robert E. Schwartz,  Zurabi Lominadze,  Russell Rosenblatt,  Brett E. Fortune,  Joseph F. Pisa,  Arun B. Jesudian,  Vikas Gupta,  Zaid H. Tafesh, 
  • Pages: 469-472
  • First Published: 29 January 2019

Editorials

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Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis

Shi-ying Cai Ph.D.,  James L. Boyer M.D., 
  • Pages: 473-475
  • First Published: 25 September 2018
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Is This the Last Requiem for Simtuzumab?

Peter Fickert M.D., 
  • Pages: 476-479
  • First Published: 10 October 2018
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Cholangiocyte-to-Hepatocyte Differentiation: A Context-Dependent Process and an Opportunity for Regenerative Medicine

Maria J. Perugorria Ph.D.,  Paula Olaizola M.S.,  Jesus M. Banales Ph.D., 
  • Pages: 480-483
  • First Published: 08 October 2018
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Hepatic Stellate Cells and Retinoids: Toward A Much More Defined Relationship

William S. Blaner Ph.D., 
  • Pages: 484-486
  • First Published: 04 October 2018

Original Articles

VIRAL HEPATITIS

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Impact of Sustained Virologic Response with Direct-Acting Antiviral Treatment on Mortality in Patients with Advanced Liver Disease

Lisa I. Backus,  Pamela S. Belperio,  Troy A. Shahoumian,  Larry A. Mole, 
  • Pages: 487-497
  • First Published: 27 July 2017
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Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region

Chiao-Ling Li,  Chen-Yu Li,  You-Yu Lin,  Ming-Chih Ho,  Ding-Shinn Chen,  Pei-Jer Chen,  Shiou-Hwei Yeh, 
  • Pages: 498-512
  • First Published: 02 August 2018
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Frequent Antiviral Treatment Failures in Patients Infected With Hepatitis C Virus Genotype 4, Subtype 4r

Slim Fourati,  Christophe Rodriguez,  Christophe Hézode,  Alexandre Soulier,  Isaac Ruiz,  Lila Poiteau,  Stéphane Chevaliez,  Jean-Michel Pawlotsky, 
  • Pages: 513-523
  • First Published: 19 August 2018

STEATOHEPATITIS/METABOLIC LIVER DISEASE

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Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice

Jun Gong,  Chun Fang,  Peng Zhang,  Pi-Xiao Wang,  Yixing Qiu,  Li-Jun Shen,  Li Zhang,  Xue-Yong Zhu,  Song Tian,  Feng Li,  Zhihua Wang,  Zan Huang,  Aibing Wang,  Xiao-Dong Zhang,  Zhi-Gang She, 
  • Pages: 524-544
  • First Published: 30 January 2018
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Macrophage-Specific Hypoxia-Inducible Factor-1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Xiaojing Wang,  Marcelle de Carvalho Ribeiro,  Arvin Iracheta-Vellve,  Patrick Lowe,  Aditya Ambade,  Abhishek Satishchandran,  Terence Bukong,  Donna Catalano,  Karen Kodys,  Gyongyi Szabo, 
  • Pages: 545-563
  • First Published: 13 August 2018
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Burden of Illness and Economic Model for Patients With Nonalcoholic Steatohepatitis in the United States

Zobair M. Younossi,  Radhika Tampi,  Massoom Priyadarshini,  Fatema Nader,  Issah M. Younossi,  Andrei Racila, 
  • Pages: 564-572
  • First Published: 04 September 2018

HEPATOBILIARY MALIGNANCIES

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Identification and Therapeutic Intervention of Coactivated Anaplastic Lymphoma Kinase, Fibroblast Growth Factor Receptor 2, and Ephrin Type-A Receptor 5 Kinases in Hepatocellular Carcinoma

Xin Wang,  Minmin Zhang,  Fangfang Ping,  Hongchun Liu,  Jingya Sun,  Yueqin Wang,  Aijun Shen,  Jian Ding,  Meiyu Geng, 
  • Pages: 573-586
  • First Published: 21 January 2018

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Dual Targeting of Histone Methyltransferase G9a and DNA-Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma

Marina Bárcena-Varela,  Stefano Caruso,  Susana Llerena,  Gloria Álvarez-Sola,  Iker Uriarte,  M. Ujue Latasa,  Raquel Urtasun,  Sandra Rebouissou,  Laura Alvarez,  Maddalen Jimenez,  Eva Santamaría,  Carlos Rodriguez-Ortigosa,  Giuseppe Mazza,  Krista Rombouts,  Edurne San José-Eneriz,  Obdulia Rabal,  Xabier Agirre,  Maria Iraburu,  Alvaro Santos-Laso,  Jesus M. Banales,  Jessica Zucman-Rossi,  Felipe Prósper,  Julen Oyarzabal,  Carmen Berasain,  Matías A. Ávila,  Maite G. Fernández-Barrena, 
  • Pages: 587-603
  • First Published: 16 July 2018
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FUN14 Domain-Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Wenhui Li,  Yanjun Li,  Sami Siraj,  Haojie Jin,  Yuyuan Fan,  Xinrong Yang,  Xiaowu Huang,  Xiaohui Wang,  Jun Wang,  Lei Liu,  Lei Du,  Quan Chen, 
  • Pages: 604-621
  • First Published: 27 July 2018
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Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis

Guido Carpino,  Vincenzo Cardinale,  Trine Folseraas,  Diletta Overi,  Krzysztof Grzyb,  Daniele Costantini,  Pasquale Bartolomeo Berloco,  Sabina Di Matteo,  Tom Hemming Karlsen,  Domenico Alvaro,  Eugenio Gaudio, 
  • Pages: 622-638
  • First Published: 13 August 2018
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Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Ryan A. Hlady,  Aishwarya Sathyanarayan,  Joyce J. Thompson,  Dan Zhou,  Qunfeng Wu,  Kien Pham,  Jeong-Heon Lee,  Chen Liu,  Keith D. Robertson, 
  • Pages: 639-652
  • First Published: 22 August 2018
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Characteristics of Immune Response to Tumor-Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma

Yuki Inada,  Eishiro Mizukoshi,  Takuya Seike,  Toshikatsu Tamai,  Noriho Iida,  Masaaki Kitahara,  Tatsuya Yamashita,  Kuniaki Arai,  Takeshi Terashima,  Kazumi Fushimi,  Taro Yamashita,  Masao Honda,  Shuichi Kaneko, 
  • Pages: 653-665
  • First Published: 13 August 2018

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE

Open Access

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab,  Ute Hofmann,  Selahaddin Sezgin,  Nachiket Vartak,  Reham Hassan,  Ayham Zaza,  Patricio Godoy,  Kai Markus Schneider,  Georgia Guenther,  Yasser A. Ahmed,  Aya A. Abbas,  Verena Keitel,  Lars Kuepfer,  Steven Dooley,  Frank Lammert,  Christian Trautwein,  Michael Spiteller,  Dirk Drasdo,  Alan F. Hofmann,  Peter L.M. Jansen,  Jan G. Hengstler,  Raymond Reif, 
  • Pages: 666-683
  • First Published: 13 August 2018
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Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease

Andrew J. Muir,  Cynthia Levy,  Harry L.A. Janssen,  Aldo J. Montano-Loza,  Mitchell L. Shiffman,  Stephen Caldwell,  Velimir Luketic,  Dora Ding,  Catherine Jia,  Bryan J. McColgan,  John G. McHutchison,  G. Mani Subramanian,  Robert P. Myers,  Michael Manns,  Roger Chapman,  Nezam H. Afdhal,  Zachary Goodman,  Bertus Eksteen,  Christopher L. Bowlus,  for the GS-US-321-0102 Investigators , 
  • Pages: 684-698
  • First Published: 28 August 2018
Open Access

Fine-Tuning of Sirtuin 1 Expression Is Essential to Protect the Liver From Cholestatic Liver Disease

Britt A. Blokker,  Monica Maijo,  Marta Echeandia,  Mikel Galduroz,  Angela M. Patterson,  Anna Ten,  Mark Philo,  Rebecca Schungel,  Virginia Gutierrez-de Juan,  Emina Halilbasic,  Claudia Fuchs,  Gwenaelle Le Gall,  Malgorzata Milkiewicz,  Piotr Milkiewicz,  Jesus M. Banales,  Simon M. Rushbrook,  José M. Mato,  Michael Trauner,  Michael Müller,  María Luz Martínez-Chantar,  Marta Varela-Rey,  Naiara Beraza, 
  • Pages: 699-716
  • First Published: 19 September 2018

LIVER FAILURE/CIRRHOSIS/PORTAL HYPERTENSION

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Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension

Guadalupe Garcia-Tsao,  Michael Fuchs,  Mitchell Shiffman,  Brian B. Borg,  Nikolaos Pyrsopoulos,  Kirti Shetty,  Juan F. Gallegos-Orozco,  K. Rajender Reddy,  Eyob Feyssa,  Jean L. Chan,  Mason Yamashita,  James M. Robinson,  Alfred P. Spada,  David T. Hagerty,  Jaime Bosch, 
  • Pages: 717-728
  • First Published: 31 July 2018
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Serum Angiopoietin-2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

Andrew S. Allegretti,  Xavier Vela Parada,  Guillermo A. Ortiz,  Joshua Long,  Scott Krinsky,  Sophia Zhao,  Bryan C. Fuchs,  Mozhdeh Sojoodi,  Dongsheng Zhang,  S. Ananth Karumanchi,  Sahir Kalim,  Sagar U. Nigwekar,  Ravi I. Thadhani,  Samir M. Parikh,  Raymond T. Chung, 
  • Pages: 729-741
  • First Published: 23 August 2018

LIVER INJURY/REGENERATION

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Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Jacquelyn O. Russell,  Wei-Yu Lu,  Hirohisa Okabe,  Marc Abrams,  Michael Oertel,  Minakshi Poddar,  Sucha Singh,  Stuart J. Forbes,  Satdarshan P. Monga, 
  • Pages: 742-759
  • First Published: 14 September 2018
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Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort

Rachel J. Church,  Gerd A. Kullak-Ublick,  Jiri Aubrecht,  Herbert L. Bonkovsky,  Naga Chalasani,  Robert J. Fontana,  Jens C. Goepfert,  Frances Hackman,  Nicholas M. P. King,  Simon Kirby,  Patrick Kirby,  John Marcinak,  Sif Ormarsdottir,  Shelli J. Schomaker,  Ina Schuppe-Koistinen,  Francis Wolenski,  Nadir Arber,  Michael Merz,  John-Michael Sauer,  Raul J. Andrade,  Florian van Bömmel,  Thierry Poynard,  Paul B. Watkins, 
  • Pages: 760-773
  • First Published: 22 January 2018
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The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose

Anselm Wong,  Richard McNulty,  David Taylor,  Marco Sivilotti,  Shaun Greene,  Naren Gunja,  Zeff Koutsogiannis,  Andis Graudins, 
  • Pages: 774-784
  • First Published: 19 August 2018

LIVER BIOLOGY/PATHOBIOLOGY

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Retinoic Acid Receptor-β Is Downregulated in Hepatocellular Carcinoma and Cirrhosis and Its Expression Inhibits Myosin-Driven Activation and Durotaxis in Hepatic Stellate Cells

Ernesto Cortes,  Dariusz Lachowski,  Alistair Rice,  Antonios Chronopoulos,  Benjamin Robinson,  Stephen Thorpe,  David A Lee,  Lucia A Possamai,  Haiyun Wang,  David J Pinato,  Armando E. del Río Hernández, 
  • Pages: 785-802
  • First Published: 28 July 2018
Open Access

DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera

Pengfei Pang,  Xiaojun Hu,  Bin Zhou,  Junjie Mao,  Yu Liang,  Zaibo Jiang,  Mingsheng Huang,  Ruihong Liu,  Youyong Zhang,  Jiesheng Qian,  Jinsong Liu,  Jinxin Xu,  Yaqin Zhang,  Maoheng Zu,  Yiming Wang,  Huanhuan He,  Hong Shan, 
  • Pages: 803-816
  • First Published: 31 July 2018

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Effects of Endotoxin on Type 3 Inositol 1,4,5-Trisphosphate Receptor in Human Cholangiocytes

Andressa Franca,  Antonio Carlos Melo Lima Filho,  Mateus T. Guerra,  Jittima Weerachayaphorn,  Marcone Loiola dos Santos,  Basile Njei,  Marie Robert,  Cristiano Xavier Lima,  Paula Vieira Teixeira Vidigal,  Jesus M. Banales,  Meenakshisundaram Ananthanarayanan,  M. Fatima Leite,  Michael H. Nathanson, 
  • Pages: 817-830
  • First Published: 23 August 2018

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Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin)

George B. McDonald,  James W. Freston,  James L. Boyer,  Laurie D. DeLeve, 
  • Pages: 831-844
  • First Published: 18 August 2018
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NLR Family Pyrin Domain-Containing 3 Inflammasome Activation in Hepatic Stellate Cells Induces Liver Fibrosis in Mice

Maria Eugenia Inzaugarat,  Casey D. Johnson,  Theresa Maria Holtmann,  Matthew D. McGeough,  Christian Trautwein,  Bettina G. Papouchado,  Robert Schwabe,  Hal M. Hoffman,  Alexander Wree,  Ariel E. Feldstein, 
  • Pages: 845-859
  • First Published: 04 September 2018
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mTOR Signaling in X/A-Like Cells Contributes to Lipid Homeostasis in Mice

Ziru Li,  Ruili Yu,  Wenzhen Yin,  Yan Qin,  Liangxiao Ma,  Michael Mulholland,  Weizhen Zhang, 
  • Pages: 860-875
  • First Published: 23 August 2018
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Tracking Fenestrae Dynamics in Live Murine Liver Sinusoidal Endothelial Cells

Bartlomiej Zapotoczny,  Karolina Szafranska,  Edyta Kus,  Filip Braet,  Eddie Wisse,  Stefan Chlopicki,  Marek Szymonski, 
  • Pages: 876-888
  • First Published: 23 August 2018

Review

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Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long-Term Relationship

Ratna B. Ray,  Ranjit Ray, 
  • Pages: 889-900
  • First Published: 13 August 2018

Hepatology Elsewhere

Open Access

Bis-choline Tetrathiomolybdate as Old Drug in a New Design for Wilson’s Disease: Good for Brain and Liver?

Wolfgang Stremmel M.D., 
  • Pages: 901-903
  • First Published: 02 August 2018
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Old Remedies to Heal the Liver: Novel Effects of Digoxin in Hepatic Sterile Inflammation

Juan P. Arab M.D., Marco Arrese M.D., FAASLD, 
  • Pages: 904-906
  • First Published: 23 July 2018
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Genetics Meets Therapy? Exome-wide Association Study Reveals a Loss-of-Function Variant in 17-Beta-Hydroxysteroid Dehydrogenase 13 That Protects Patients From Liver Damage and Nonalcoholic Fatty Liver Disease Progression

Silvia Sookoian M.D., Ph.D., F.A.A.S.L.D.,  Marco Arrese M.D., F.A.A.S.L.D.,  Carlos J. Pirola Ph.D., F.A.H.A., 
  • Pages: 907-910
  • First Published: 13 August 2018

Clinical Observations in Hepatology

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Hepatocellular Carcinoma as a Complication of Vascular Disease of the Liver After Fontan Procedure

Chiara Mazzarelli,  Mary D. Cannon,  Mark Hudson,  Nigel Heaton,  Debashis Sarker,  Pauline Kane,  Alberto Quaglia,  Abid Suddle, 
  • Pages: 911-913
  • First Published: 28 July 2018

Free Access

Antiprogrammed Cell Death-1 Immunotherapy-Related Secondary Sclerosing Cholangitis

Kohei Ogawa,  Kenya Kamimura,  Shuji Terai, 
  • Pages: 914-916
  • First Published: 23 July 2018
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Herpes Simplex Virus–Associated Acute Liver Failure Often Goes Unrecognized

Lanna Little,  Jody Rule,  Lan Peng,  Michelle Gottfried,  William M. Lee,  the Acute Liver Failure Study Group , 
  • Pages: 917-919
  • First Published: 27 August 2018

Correspondence

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Necessity of More Sensitivity Analyses and Interpretations From Public Health Perspectives

Vasveebye Sonoo M.D.,  Jay V. Kumar M.D.,  Xibei Liu M.D.,  Johnson Ukken M.S.,  Mary Froehlich M.A.,  Ji Won Yoo M.D., 
  • Page: 920
  • First Published: 18 September 2017
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Reply

Barret Rush M.D., M.P.H.,  Keith R. Walley M.D.,  Leo Anthony Celi M.D., M.S., M.P.H.,  Neil Rajoriya M.B.Ch.B., M.R.C.P. U.K., D.Phil.,  Mayur Brahmania M.D., M.P.H., 
  • Pages: 920-921
  • First Published: 18 September 2017
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Comment on Hakvoort et al.

Natalia Qvartskhava M.D.,  Cheng Jun Jin M.D.,  Boris Görg M.D.,  Dieter Häussinger M.D., 
  • Pages: 921-922
  • First Published: 12 December 2017
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Reply

Theodorus B.M. Hakvoort Ph.D.,  Wouter H. Lamers M.D., Ph.D., 
  • Pages: 922-923
  • First Published: 12 December 2017
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Surgical Resection Versus Transarterial Chemoembolization for Intermediate Stage Hepatocellular Carcinoma (BCLC-B): An Unsolved Question

Ismail Labgaa M.D.,  Nicolas Demartines M.D.,  Emmanuel Melloul M.D., 
  • Page: 923
  • First Published: 01 November 2018
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Reply

Young-Sun Lee M.D., Ph.D.,  Myung Han Hyun M.D., Ph.D.,  Sun Young Yim M.D., Ph.D.,  Ji Hoon Kim M.D., Ph.D.,  Jong Eun Yeon M.D., Ph.D.,  Kwan Soo Byun M.D., Ph.D., 
  • Page: 924
  • First Published: 16 October 2018

Correction

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Correction

Sergio Anastasi Ph.D., 
  • Page: 925
  • First Published: 29 January 2019

Issue Information

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Notices

  • Page: 926
  • First Published: 29 January 2019
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Instructions to Authors

  • First Published: 29 January 2019