Chimeric antigen receptor-T (CAR-T) design and deployment for B-cell lymphomas.

Due to mutations in exon 12 of NPM1, the C-terminal nuclear localization signal (NoLs) is disrupted, leading to the formation of a novel nuclear export signal (NES). Exportin 1 interacts with NPM1c⁺ carrying NES and facilitates its transportation into the cytoplasm. The FLT3-ITD mutation leads to elevated expression of BCAT1, subsequently upregulating the expression of the MYC gene, thereby exerting biological functions that promote the occurrence and development of AML.

In chronic lymphocytic leukemia (CLL), the activation of B-cell receptor and other signalling pathways promote the activation of focal adhesion kinase (FAK) and its subsequent calpain-mediated cleavage following calcium (Ca²⁺) mobilization. FAK activation, together with HS1 and cortactin, two essential cytoskeletal proteins, lead to an aggressive phenotype in CLL. These effects can be attenuated by Defactinib, a selective active FAK inhibitor.

ETS1 phosphorylation at threonine 38 isa marker for ETS1 activation, regulated by MEK. p-ETS1 is detected in activated B cell-like (ABC) diffuse large B cell lymphoma (DLBCL) , not in germinal centre B-cell-like (GCB) DLBCL cell lines and, accordingly, it is more common in ABC than GCB DLBCL diagnostic biopsies. Removal of the phosphorylation of ETS1 at threonine 38 affects the growth and the BCR-mediated transcriptome program in DLBCL cell lines.

Pre-transplant and longitudinal changes in faecal microbiome are associated with risk of chronic graft-versus-host disease.

Maximum platelet count changes from baseline during initial response assessment. (A) Waterfall plot shows maximum platelet count changes. Each column represents an individual patient. (B) Median platelet count changes were calculated for each group. Patients in the obese group showed the least change in platelet count (median count × 10^9/L, underweight vs. normal. vs. overweight vs. obese: 86.5 vs. 91.0 vs. 76.0 vs. 41.0, p = 0.006).

Bleeding risk with concurrent use of anticoagulants and ibrutinib: A population-based nested case-control study.

A case-control study nested in the CADRE multinational African cohort was conducted in Bamako and Dakar in 235 patients with sickle cell anemia (SCA) to test multiple biological and functional markers as potential markers of six different SCA-related chronic organ damage.