17/22 (77%) of patients with histiocytic neoplasms undergoing interruption of targeted therapy experience disease relapse.

Patients with multiple myeloma (MM) undergoing disease-directed therapy are at an increased risk of venous thromboembolism (VTE) compared to the general population. In this setting, current guidelines suggest low-dose direct oral anticoagulants (DOACs) as an alternative to aspirin for primary thromboprophylaxis. Our systematic review and meta-analysis of selected randomised controlled trials and observational studies demonstrated a reduced occurrence of VTE with DOACs in comparison to aspirin, with no associated rise in bleeding events. However, these results should be interpreted with caution, considering the heterogeneous baseline population characteristics and potential biases/confounders from observational studies. Further research is essential to determine the optimal thromboprophylaxis strategy, especially for high-risk individuals.

The median age at diagnosis was 27 years. Housewives represented the largest subset of patients from an occupational point of view constituting 37.44% of the total sample population and 81.72% of the female population, followed by 20.69% patients who were students of which 14.77% were male and 5.91% were female, and 17.24% who were farmers, which constituted 31.81% of the male population. Similarly, 64.53% of the individuals received standard 7 + 3 induction regimen, 10.68% of those received 5 + 2 re-induction chemotherapy, 10.84% who were diagnosed with acute promyelocytic leukaemia received all-trans-retinoic acid + arsenic trioxide, while 5.42% of patients defaulted chemotherapy.

XPO1 mutations, conceivably through increased miR-155 levels, may enhance BCR signalling leading to higher proliferation and shorter TTFT in early stage CLL.

The transformation of a tumour immune surveillance system into a tumour-supportive state is one of the critical events in disease development, progression, and the acquisition of therapy resistance against immunochemotherapy in multiple myeloma. In this scenario, in combination with several soluble factors secreted by myeloma cells, miR-106a-5p and miR-146a-5p contained in myeloma cell-derived exosomes play essential roles in modulating gene expression patterns, such as genes involved in interferon response, inflammation, and TNF-α signalling, and, to direct normal peripheral blood mononuclear cells to differentiate into monocytic myeloid-derived suppressor cells.

The association between graft-versus-lymphoma (GVL) effect and graft-versus-host disease (GVHD)s varied between different lymphoma subtypes and their pre-transplant controls (C, D). Meanwhile, the negative impact of severe GVHDs on survival via their contribution to transplant-related mortality was still significant (A, B). Since GVL effect and GVHDs have not yet been successfully separated in the clinical settings, transplant outcomes were still a consequence of the balance between GVL and GVHDs. However, it was clear that the management of GVHDs within a limited activity should be prioritized regardless of the cases.

A sample of children with sickle cell anaemia (SCA) and sibling/family controls in Uganda were tested for four blood-based biomarkers. Neurofilament light chain (NfL) strongly correlated with SCA MRI-detected cerebral infarcts.