• Issue

    Glia: Volume 67, Issue 12

    2217-2440
    December 2019
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ISSUE INFORMATION - TABLE OF CONTENTS

Free Access

Issue Information - Table of Contents

  • Pages: 2217-2219
  • First Published: 12 October 2019

REVIEW ARTICLE

Full Access

Questions and (some) answers on reactive astrocytes

Carole Escartin,  Océane Guillemaud,  Maria-Angeles Carrillo-de Sauvage, 
  • Pages: 2221-2247
  • First Published: 19 August 2019
Questions and (some) answers on reactive astrocytes
Main Points

  • Astrocytes react to brain homeostasis alteration by morphological and molecular changes.
  • This response is complex, heterogeneous and subject to controversies.
  • New tools, models and concepts will help better understand this widespread reaction.

RESEARCH ARTICLES

Open Access

Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS

Anne-Laure Dubessy,  Elisa Mazuir,  Quentin Rappeneau,  Sokounthie Ou,  Charly Abi Ghanem,  Kevin Piquand,  Marie-Stéphane Aigrot,  Melina Thétiot,  Anne Desmazières,  Eric Chan,  Matt Fitzgibbon,  Mark Fleming,  Raul Krauss,  Bernard Zalc,  Barbara Ranscht,  Catherine Lubetzki,  Nathalie Sol-Foulon, 
  • Pages: 2248-2263
  • First Published: 22 July 2019
Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS
Main Points

  • Oligodendrocyte secreted factors induce prenode formation on hippocampal GABAergic axons.
  • Proteomic analysis of OCM to select clustering candidates.
  • Contactin-1 in association with Tenascin-R or Phosphacan is responsible for prenodal clustering.

Open Access

Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255-257 and regulated by mTOR

Shokoufeh Khakipoor,  Marina Giannaki,  Shefeeq M. Theparambil,  Jana Zecha,  Bernhard Küster,  Stephan Heermann,  Joachim W. Deitmer,  Eleni Roussa, 
  • Pages: 2264-2278
  • First Published: 18 July 2019
Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255-257 and regulated by mTOR
Main Points

  • Long-term metabolic alkalosis regulates NBCe1 activity in astrocytes. S255-257 regulates NBCe1 functional expression.
  • mTOR activation triggers phosphorylation of NBCe1 and restores alkalosis-dependent decreased NBCe1 activity.

Open Access

Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase

Sebastian Ivens,  Gürsel Çalışkan,  Ismini Papageorgiou,  Tiziana Cesetti,  Ansgar Malich,  Oliver Kann,  Uwe Heinemann,  Oliver Stork,  Anne Albrecht, 
  • Pages: 2279-2293
  • First Published: 17 July 2019
Persistent increase in ventral hippocampal long-term potentiation by juvenile stress: A role for astrocytic glutamine synthetase
Main Points

  • Juvenile stress (JS) increases ventral CA1-LTP lastingly
  • Blocking glutamine synthetase mimics LTP after JS, providing its product glutamine normalizes it
  • Glutamine–glutamate cycle in astrocytes regionally mediates allostatic plasticity after JS

Full Access

Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane

Matthew J. E. Maksoud,  Vasiliki Tellios,  Dong An,  Yun-Yan Xiang,  Wei-Yang Lu, 
  • Pages: 2294-2311
  • First Published: 27 August 2019
Nitric oxide upregulates microglia phagocytosis and increases transient receptor potential vanilloid type 2 channel expression on the plasma membrane
Main Points

  • iNOS−/− microglia exhibited reduced phagocytic capacity, without significant changes in TRPV2 or phagocytic receptor mRNA expression.
  • iNOS−/− microglia displayed reduced plasma membrane expression and activity of TRPV2, which was restored by NO-donors.
  • Blocking PKG and/or PI3K activity in mouse microglia significantly reduced the plasma membrane expression and activity of TRPV2.

Full Access

Open chromatin landscape of rat microglia upon proinvasive or inflammatory polarization

Piotr Przanowski,  Shamba S. Mondal,  Aleksandra Cabaj,  Konrad J. Dębski,  Bartosz Wojtas,  Bartłomiej Gielniewski,  Beata Kaza,  Bozena Kaminska,  Michal Dabrowski, 
  • Pages: 2312-2328
  • First Published: 24 July 2019
Main points

  • We report a dataset of DNase-hypersensitive regions for rat microglia stimulated with glioma conditioned medium or LPS. The two treatments differentially affect openness of regions mapped to genes involved in immune functions and axon guidance.

Full Access

A2AR-induced transcriptional deregulation in astrocytes: An in vitro study

Isabel Paiva,  Kévin Carvalho,  Patrícia Santos,  Lucrezia Cellai,  Maria Angeliki S. Pavlou,  Gaurav Jain,  Thorsten Gnad,  Alexander Pfeifer,  Didier Vieau,  André Fischer,  Luc Buée,  Tiago F. Outeiro,  David Blum, 
  • Pages: 2329-2342
  • First Published: 22 July 2019
A2AR-induced transcriptional deregulation in astrocytes: An in vitro study
Main Points

  • A2AR overexpression induces transcriptional alterations in inflammatory and secretion associated pathways in astrocytes.
  • A selective adenosine A2AR antagonist corrects transcriptional alterations associated with A2AR overexpression in astrocytes.

Full Access

SIRPα deficiency accelerates the pathologic process in models of Parkinson disease

Jin Wang,  Xin Ding,  Xiangyu Wu,  Jing Liu,  Rui Zhou,  Pingxuan Wei,  Qipeng Zhang,  Chenyu Zhang,  Ke Zen,  Liang Li, 
  • Pages: 2343-2359
  • First Published: 19 July 2019
SIRPα deficiency accelerates the pathologic process in models of Parkinson disease
Main Points

  • SIRPα expression is downregulated in microglia during aging or inflammatory challenge.
  • SIRPα reduction leads to enhanced inflammatory response and dysregulated phagocytic ability in microglia, which facilitates DA neuron loss in PD mice models.

Full Access

GemC1 is a critical switch for neural stem cell generation in the postnatal brain

Maria-Eleni Lalioti,  Konstantina Kaplani,  Georgia Lokka,  Theodore Georgomanolis,  Christina Kyrousi,  Weilai Dong,  Ashley Dunbar,  Evangelia Parlapani,  Eleni Damianidou,  Nathalie Spassky,  Kristopher T. Kahle,  Argyris Papantonis,  Zoi Lygerou,  Stavros Taraviras, 
  • Pages: 2360-2373
  • First Published: 22 July 2019
GemC1 is a critical switch for neural stem cell generation in the postnatal brain
Main Points

  • A novel mutation in GemC1 as a cause of congenital hydrocephalus in humans.
  • The absence of GemC1 leads to a neural stem cell-like fate.
  • GemC1 remodels the chromatin landscape of radial glial cells

Open Access

Drosophila ClC-a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits

Haritz Plazaola-Sasieta,  Qi Zhu,  Héctor Gaitán-Peñas,  Martín Rios,  Raúl Estévez,  Marta Morey, 
  • Pages: 2374-2398
  • First Published: 03 September 2019
Drosophila ClC-a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits
Main Points

  • ClC-a chloride channel is expressed in glia of the stem cell niche and regulates neurogenesis in a non-autonomous fashion.
  • ClC-a mutants have reduced neurogenesis, and consequently, smaller brains.
  • ClC-a mutants also display wiring defects.

Open Access

Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions

Martine Eilert-Olsen,  Jarand B. Hjukse,  Anna E. Thoren,  Wannan Tang,  Rune Enger,  Vidar Jensen,  Klas H. Pettersen,  Erlend A. Nagelhus, 
  • Pages: 2399-2409
  • First Published: 27 July 2019
Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions
Main Points

  • Hypoosmotic stress elicits different types of Ca2+ signals in astrocytes.
  • Subpial endfeet show rapid Ca2+ oscillations.
  • Ca2+ signals in endfeet depend on IP3R2, dystrophin/AQP4 and TRPV4, while those in fine processes are IP3R2-independent.

Full Access

Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

Rafael Franco,  Irene Reyes-Resina,  David Aguinaga,  Alejandro Lillo,  Jasmina Jiménez,  Iu Raïch,  Dasiel O. Borroto-Escuela,  Carlos Ferreiro-Vera,  Enric I. Canela,  Verónica Sánchez de Medina,  Anna del Ser-Badia,  Kjell Fuxe,  Carlos A. Saura,  Gemma Navarro, 
  • Pages: 2410-2423
  • First Published: 19 August 2019
Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists
Main Points

  • Adenosine A2A/cannabinoid CB2 receptor heteromers, expressed in microglia from Alzheimer's disease (AD) models, allow enhanced cannabinoid signaling upon A2A blockade.
  • A2AR antagonists are promising to combat AD and other neurodegenerative diseases.

Full Access

Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth

Jiping Wang,  Jianmei W. Leavenworth,  Anita B. Hjelmeland,  Reed Smith,  Neha Patel,  Ben Borg,  Ying Si,  Peter H. King, 
  • Pages: 2424-2439
  • First Published: 10 August 2019
Deletion of the RNA regulator HuR in tumor-associated microglia and macrophages stimulates anti-tumor immunity and attenuates glioma growth
Main Points

  • HuR deletion in tumor-associated microglia/macrophages (TAMs) reduces malignant glioma growth and prolongs survival.
  • HuR-deleted TAMs are reduced in glioma tumors and develop an M1-like phenotype and an alteration of cytokine and chemokine profiles.
  • HuR-deleted TAMs alter the glioma microenvironment with an increase in Infiltrating cytotoxic CD4+ and CD8+ T cells and a decrease in polymorphonuclear myeloid derived suppressor cells (PMN-MDSC).

ERRATUM

Free Access

Erratum

  • Page: 2440
  • First Published: 04 September 2019