This guideline has been developed by the Breast Cancer Expert Committee of the National Cancer Quality Control Center. The experts involved in this guideline have thoroughly examined the comprehensive management of bone health in breast cancer, aiming to establish a reference framework for managing bone health and standardizing the diagnosis and treatment of breast cancer patients.

This study found that coagulation subtypes were associated with prognosis and immune microenvironment in clear cell renal cell carcinoma patients. A precise prognostic coagulation-related risk score (CRRS) model was successfully established. The CRRS model revealed a potential prognostic value for the immunotherapy response.

We found that induced pluripotent stem cells (iPSCs) derived from leukemic cells of patients with primary T cell acute lymphoblastic leukemia (T-ALL) have a gene expression profile similar to that of T-ALL cell lines. Results indicate that complete tumor antigens from T-ALL-iPSCs could slow the progression of inoculated tumors in immunocompromised mice without causing acute and long-term toxicity.

This review discusses the vast valuable importance of Tumor microenvironment (TME) recapitulation in cancer research prioritizing individual roles of TME elements in the histopathology of cancer. Further, the review broadly describes of few of the recently developed 3D models that have their main focus restricted to drug development and their screening and/or implications of the approach in preclinical as well as translational research.

Three dimensional (3D) culture is a promising model for tumor research, replicating solid tumor characteristics. Advantages include high throughput and retention of heterogeneity. Traditional matrigel-submerged organoid culture requires exogenous cells to study the tumor microenvironment (TME). A holistic approach using patient-derived tumor fragments (PDTFs), air-liquid interface (ALI), suspension 3D culture, and microfluidic tumor-on-chip (ToC) models better mimic the tumor structure and composition. Organoid co-culture models are useful for studying the TME, immunotherapy, biomarkers, drug screening, and infections. These 3D systems aim to improve therapeutic approaches and patient outcomes.

Accelerated partial breast irradiation (APBI) as a substitute for WBI for patients with early breast cancer is a hot spot in clinical research. The implementation methods of APBI mainly include brachytherapy, external beam radiation therapy, and intraoperative radiotherapy. This article provides a review of the clinical effects and adverse reactions of the main technologies of APBI and prospects for the future development of APBI.

Postmastectomy radiotherapy in breast reconstruction: current controversies and trends in types of breast reconstruction, timing of radiotherapy, and radiotherapy techniques.

Flavonols are one of the most widespread dietary nutrients of the polyphenols-flavonoids and major constituent of Allium and Brassicaceae vegetables. Flavonols present in vegetables of Allium and Brassicaceae family are kaempferol, myricetin, quercetin, and isorhamnetin. These flavonols are claimed to have antiproliferative activity in vivo and in vitro against colorectal cancer.