We analyzed data from the phase III NETTER-1 study of ¹⁷⁷Lu‑DOTATATE for patients with advanced midgut neuroendocrine tumors to explore whether tumor shrinkage is associated with durable efficacy. Although patients receiving ¹⁷⁷Lu‑DOTATATE had a progression-free survival (PFS) benefit, no obvious association between best tumor shrinkage and PFS or overall survival was evident. Our results suggest that disease stabilization is an acceptable outcome of ¹⁷⁷Lu‑DOTATATE treatment and should not lead to early termination of peptide receptor radionuclide therapy.

There are scarce data about integrin glycosylation in head and neck squamous cell carcinoma. In this study, glycosylation of ITGA2, ITGA3, ITGA5, ITGA6, ITGB1, and ITGB4 was investigated in intraoperative tissue samples using lectin-bioaffinity assays. While integrin glycovariants are abundant in HNSCC tumors and ITGB1-WFL was associated with invasiveness, integrin glycovariants did not directly correlate with metastatic behavior.

TBS proves to be a valuable predictor for the long-term outcomes of HCC patients meeting Milan criteria after MWA. A higher TBS is associated with a lower long-term survival rate. Notably, among HCC patients meeting Milan criteria, those with TBS > 3 exhibited an extended median RFS time after LMWA treatment.

We identified 156 novel miRNAs through de novo prediction in the newly discovered genomic regions of T2T-CHM13. These miRNAs target 345 protein-coding genes that are downregulated in collecting duct renal cell carcinoma (cdRCC). The miRNAs may play a role in the disease by altering several key tumor suppressor pathways and targeting multiple tumor suppressor genes.

To improve access to comprehensive pain management, an interdisciplinary team developed a 90-min, single-session, telehealth intervention that combines medical education with behavioral pain treatment modified for patients with cancer. In an open, single-arm pilot study, the intervention was found to be moderately feasible, highly acceptable, and participants described reduced fear regarding opioid use, increased adoption of behavioral pain management strategies, and appreciation for the convenience of telehealth.

A comprehensive outline of the study, detailing the process from DNA extraction to the evaluation of RB1 mutations in relation to clinical features and patient outcomes.

Hypoxia and hypoxia-reoxygenation upregulate CEACAM6. It potentiates ROS generation via NOX4. Moreover, CEACAM6 upregulation facilitates H. pylori adhesion to hypoxic gastric epithelial cells, establishes infection leading to the aggressiveness of gastric cancer.

We examined routine health care (no routine checkup in the past year) among a nationally representative sample of childhood, adolescent, and young adult (CAYA) cancer survivors at different life stages. A higher proportion of young adults did not receive routine health care or have a personal doctor, compared to middle-aged or older CAYA survivors. In multivariable models, being a young adult was strongly associated with (1) not receiving routine health care and (2) not having a personal doctor.

Key barriers to OS implementation in non-gynecological surgeries include unclear invoicing and increased workload, while significant facilitators are the availability of counseling materials and education on counseling and technical performance of OS. Addressing these barriers and leveraging facilitators could enhance OS adoption, potentially reducing ovarian cancer incidence.

Evaluation of New-Onset Diabetes Mellitus (NODM) for Pancreatic Ductal Adenocarcinoma at the onset of NODM and subsequent surveillance for 3–12 years would be a potential strategy for early diagnosis and improved outcomes in patients with pancreatic cancer.

This study found no difference in cardiovascular disease (CVD) medication use between cancer and the general population. Despite no differences in medication use, the study found higher health service utilisation in individuals with cancer and CVD, suggesting higher need burden and/or limited care integration.

Exosomes are small extracellular vesicles that facilitate cellular communication and play a significant role in cancer progression by transferring molecules like miRNA and lncRNA within the tumor microenvironment. This review explores how exosomes derived from various cells influence solid cancer growth by activating pathways critical to tumor proliferation and metastasis. Understanding these interactions may reveal new therapeutic approaches for treating solid tumors.

Exercise interventions for survivors of childhood cancer focus on improving cardiovascular fitness and muscle strength but often do not consider personality factors that influence longitudinal maintenance of function. In this study of longitudinal performance change after participation in exercise intervention in survivors, associations were observed between higher levels of conscientiousness and improvement in walking speed ~4 years post-exercise intervention.

The COVID19 pandemic caused significant diagnostic delay for patients presenting with curative gastroesophageal and gastric cancer. The lack of correlation of pre-diagnostic interval with OS may reflect underlying tumor biology as the driving force that determines prognosis.

Tfh lymphomas, including angioimmunoblastic T-cell lymphoma, often present with symptoms resembling autoimmune conditions. The p.Gly17Val RHOA (G17V) mutation is commonly found in these lymphomas and can aid diagnosis, offering faster results, especially in patients with specific clinical features like lymphadenopathy, fever, and skin rash.

The results of our investigation have shown that patients with newly diagnosed malignant disease with acute PE and patients with known malignant disease and PE had much higher hospital mortality and more severe acute PE presentation than patients without malignant disease. We have also shown that patients with known malignant disease had a lower chance of thrombolysis treatment than patients without malignant disease.