Hepatoblastoma is the most common malignant liver tumor in children. In this review, we describe the latest technologies and techniques for the surgical management of hepatoblastoma, including new imaging technologies, minimally invasive approaches, and the application of associating liver partition portal vein ligation for staged hepatectomy. We also discuss the current role of liver transplantation, liver transplant-related surgical techniques, and management of metastatic hepatoblastoma.

The serum TNF-, IL-2R, IL-6, and IL-8 in malignant IPMNs are significantly higher than benign ones. Circulating cytokine score (CCS) was calculated and proved as an independent predictor.A novel nomogram incorporating CCS showed a remarkable diagnostic performance for distinguishing malignant IPMNs.

Detailed methodology diagram of signet ring cell carcinoma of bladder.

TNFAIP3 mutation mainly occurred in adults T-ALL patients. TNFAIP3 mutation was associated with adverse clinical outcomes for T-ALL patients.

Searching for reliable indicators for evaluating prognosis diagnosed with clear cell renal cell carcinoma (ccRCC) is crucial for improving clinical therapies. Our study has demonstrated that combining intratumoral RNF43 expression, CD163⁺ TAM infiltration, and TNM stage could significantly enhance the veracity in forecasting postoperative outcomes.

Determining resectability and prognosis in pancreatic ductal adenocarcinoma (PDAC) can be difficult. We examined the capabilities of 92 circulating proteins for the determination of resectability and prognosis in 273 patients undergoing surgery for PDAC.

Patients with AITL in China are mainly treated with anthracycline-based regimens with low rate of autologous stem cell transplantation and unsatisfactory outcomes. A novel prognostic model combining 3 factors (age 〉 70 years, elevated LDH, and albumin level 〈 35 g/L) was proposed which stratified patients into the low, intermediate, and high-risk subgroups with differing outcomes.

This phase I trial evaluated antitumor activity for plitidepsin plus bortezomib (BTZ) and dexamethasone (DXM) in relapsed/refractory multiple mieloma patients (r/r MM). This triple combination of plitidepsin, BTZ, and DXM showed an acceptable safety profile and had moderate activity in adult patients with r/r MM that have failed to standard common therapeutic options, including BTZ and lenalidomide.

Kaplan-Meier curves for OS (A), LRRFS (B), DMFS (C), and PFS (D) stratified by IC cycles in the matched “SD/PD” group.

To investigate the impact of completion axillary lymph node dissection (ALND) omission in patients with sentinel node micro-metastases, we retrospectively analyzed a large cohort of 1421 patients with SN micro-metastases who underwent breast conservative surgery (BCS) in 15 French academic centers. We used inverse probability of treatment weighting (IPTW) to obtain adjusted Kaplan-Meier estimators representing the experience in the analysis cohort. Weighted log-rank test comparing adjusted Kaplan-Meier survival curve showed significant difference for overall survival according to completion axillary lymph node dissection (cALND) or no cALND.

Among patients newly diagnosed with colon cancer, gastric cancer, breast cancer, and non-small cell lung cancer at the stages where adjuvant chemotherapy is generally required, adjuvant chemotherapy was less likely performed in hemodialysis (HD) patients than for non-HD patients. HD patients tended not to receive the standard regimens compared to non-HD patients partly due to the characteristics of each drug handling. Since the appropriate regimens for HD patients remain unclear, even in the adjuvant setting, future studies should evaluate the efficacy and safety of adjuvant chemotherapy and suggest appropriate adjuvant chemotherapy regimens for patients with HD.

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Hemodialysis (HD) patients were less likely to receive adjuvant chemotherapy than non-HD patients.

A larger proportion of non-HD patients underwent standard chemotherapy regimens compared with HD patients.

Hemodialysis (HD) patients were less likely to receive adjuvant chemotherapy than non-HD patients. This trend was consistent among the respective cancer types that we assessed: the odds of HD patients receiving adjuvant chemotherapy was approximately 0.1-0.18 times less than non-HD patients (colon cancer: OR = 0.15, 95% CI: 0.13-0.19, P < 60; 0.001; gastric cancer: OR = 0.12, 95% CI: 0.09-0.16, P < 60; 0.001; NSCLC: OR = 0.14, 95% CI: 0.09-0.20, P < 60; 0.001; and breast cancer: OR = 0.17, 95% CI: 0.09-0.31, P < 60; 0.001)

This is a study of the application of cytologic cell block samples for comprehensive next generation sequencing. It demonstrates the usefulness of this sample type in the clinical setting and the importance of utilizing these samples for improved clinical outcomes.

We report results of a retrospective real-world multicenter study including all patients with metastatic castration resistant prostate cancer (mCRPC) treated with radium-223 in all five university hospitals in Finland since the introduction of the treatment. In our cohort, PSA decrease, ALP normalization and pain relief correlated with improved survival. Our results support using radium-223 for mCRPC patients with symptomatic bone metastases even in the era of new generation androgen signaling targeting agents.

This is the first large population study for LCNEC patients with BM. The related prognostic model based on these factors can guide clinical treatment decisions and prognostic judgments.

Patients with early discontinuation of VEGFR-TKIs had a worse survival rate, regardless of the cause of cessation. Axitinib was administered with a safe profile. Patients with IMDC poor risk was at risk for early disease progression. The quantification of response as early as three months of treatment allows a prognostic stratification.

In this prospective multi-centers study, HER2 in serum-derived exosome (Exo HER2) from patients with advanced or metastatic gastric adenocarcinoma (AGC) were analyzed for its diagnostic value and predictive value for trastuzumab therapy. The results showed Exo HER2 is a promissing biomarker for assessing tissue HER2 status in AGC and predicting clinical benefits of trastuzumab based therapy.

Systemic SOX and intraperitoneal high-dose paclitaxel is an effective first-line treatment for patients with peritoneal metastatic gastric cancer and patients with sPCI≤12 scores might be recommended crowd for this regimen as conversion therapy.

Generally, the complete remission rate of the RCDOP group was significantly higher than that of the RCdOP group. For elderly diffuse large B-cell lymphoma patients with cardiovascular disease, the effect benefit brought by pegylated liposomal doxorubicin dose was more obvious, and the progression-free survival of the RCDOP group was significantly longer than that of the RCdOP group (p = 0.043).

The Systemic Inflammatory Response Index (SIRI) is a novel prognostic biomarker based on peripheral blood counts of neutrophils, monocytes, and lymphocytes. However, the predictive value of the SIRI in non-muscle-invasive bladder cancer (NMIBC) patients treated with intravesical Bacillus Calmette-Guerin (BCG) immunotherapy remains elusive. Therefore, this study aimed to evaluate the potential of SIRI as a prognostic factor in these patients. A total of 540 patients with NMIBC who underwent BCG immunotherapy following transurethral resection of bladder tumor (TURBT) were enrolled in this study. Using receiver operating characteristic (ROC) curves and the Youden index, patients were divided into high and low SIRI groups based on the cutoff values. Univariable and multivariable logistic regression analyses were performed to identify independent predictors of BCG non-response. Thereafter, propensity score matching (PSM) was used to eliminate bias due to confounding factors between the low and high SIRI groups. Finally, the Kaplan-Meier method was used to compare recurrence-free survival (RFS) and progression-free survival (PFS) between the two groups. Multivariable logistic regression analysis revealed that high SIRI (p = 0.001), high MLR (p = 0.015), and high tumor pathological T stage (p = 0.015) were significantly correlated with non-response to BCG therapy. In addition, both RFS and PFS were shorter in the high SIRI group than in the other group before and after PSM (both p < 0.05). Pretreatment peripheral blood SIRI can be employed to predict the response to BCG immunotherapy and the prognosis of NMIBC patients. The combination of T stage and SIRI demonstrated robust performance in predicting the response to BCG immunotherapy in NMIBC patients.

A Novel Integrated Biomarker Index for the Assessment of Hematological Responses during Treatment with Hydroxyurea and Interferon-alpha2. This novel tool convincingly displays the superiority of interferon-alpha2 versus hydroxyurea in normalizing elevated cell counts.

Based on meta-analysis and TSA, the association between the expression of AFAP1-AS1 and the prognosis of gastric cancer was estimated. GC tissue and non-cancer tissues were determined by qRT-PCR and verified GEPIA. Kaplan–Meier and Cox proportional hazards modelswere conducted to analyze the correlation between AFAP1-AS1 expression and gastric cancer prognosis. The pooled analysisrevealed that the AFAP1-AS1 expression was significantly associated with gastric cancer OS.Compared with non-cancer tissues, AFAP1-AS1 expression level of gastric cancer tissues were significantlyupregulated, which was confirmed by the results of GEPIA. The high expressionof AFAP1-AS1 was correlated withpoor prognosis in patients with gastric cancer. Clinical grade, pTNM LODDS andAFAP1-AS1 expression were independent prognosticfactors for gastric cancer revealed by multivariate Cox-regression analysis. This study demonstrated that the AFAP1-AS1 may be a novel biomarker for the diagnosis and prognosis of gastriccancer.

LMB-100 is an immunotoxin directed against mesothelin, a surface protein expressed by over 85% of pancreatic adenocarcinomas as well as an estimated 30% of all solid tumors. Immunotoxin therapies, while potentially promising, are limited by their side effect profiles, most notably capillary leak syndrome (CLS). This study provides the most detailed assessment to date of the systemic immune and inflammatory changes occurring in patients following LMB-100 treatment and identifies those specific to patients who develop CLS. These findings illuminate the systemic effects of immunotoxin treatment in patients and could ultimately lay the groundwork for new combinations capable of harnessing the immune activating effects of immunotoxin therapy while avoiding dangerous toxicities such as CLS.

The hepatocellular carcinoma modified Gustave Roussy Immune score (HCC-GRIm-Score), which was based on the combination of the albumin level, lactate dehydrogenase, neutrophil-to-lymphocyte ratio, aspartate aminotransferase-to-alanine aminotransferase ratio, and total bilirubin level, serves as a novel prognostic score for HCC patients treated with atezolizumab and bevacizumab.

We utilized whole-exome sequencing and PCR validation with colorectal and pancreatic cancer patient data in order to identify novel biomarkers that may be predictive of adverse effects associated with irinotecan-containing chemotherapy, such as FOLFIRI, FOLFOXIRI, and modified FOLFIRINOX therapies. Among the variations identified, we found that a single nucleotide polymorphism in R3HCC1 showed a significant linear relationship with toxicity and may explain the adverse effects in patients who did not harbor known susceptibility-conferring polymorphisms in UGT1A. Our findings offer a new target to test for when deciding on chemotherapy regimen choice and dosages and improves our approach of precision medicine in colorectal and pancreatic cancer patients.

Differentially expressed genes (DEGs) between ERG_high and ERG_low tumors revealed clustering of most of the non-BCR cases into de ERG_high group and most of the BCR cases in ERG_low group. Subsequent analyses confirmed an association between ERG status with BCR, showing a worst BCR-free survival for ERG_low patients compared to the ERG_high group. Enrichment pathway analysis of the 150 DEGs identified an important participation of metabolic-related pathways in the BCR progression.

Preoperative staging of superficial gastrointestinal tumors is crucial for choosing the most appropriate treatment. Our findings suggested that endoscopic ultrasonography (EUS) was a reliable and easy-to-use diagnostic tool in decision-making regarding appropriate endoscopic treatment for gastrointestinal tumors. However, the diagnostic accuracy of EUS appeared questionable in the presence of ulceration.

Evaluation of the impact of lenvatinib treatment on health-related quality-of-life was a secondary objective of the phase 2 double-blinded Study 211. This study compared a starting dose of lenvatinib 18 mg/day with the approved starting dose of 24 mg/day in patients with radioiodine-refractory differentiated thyroid cancer. Health-related quality-of-life of patients in the 18 mg/day arm was not statistically different from that of patients in the 24 mg/day arm. These data, combined with results from the primary analysis (where the lenvatinib starting dose of 18 mg/day did not demonstrate noninferiority to the approved starting dose of lenvatinib 24 mg/day), support the use of the approved lenvatinib starting dose of 24 mg/day in patients with radioiodine-refractory differentiated thyroid cancer.

A randomized, double-blind placebo-controlled prospective clinical trial. Oral magnesium-L-threonate enhances the analgesia and reduces the dosage of opioids needed in advanced cancer patients. Magnesium-L-threonate inhibits or eases morphine tolerance. Magnesium-L-threonate relieves opioid-induced constipation

The comparison of SP and SE in various methods using a fixed cut-point was affected by point selection. So we proposed the utilization of AUC for displaying the overall capabilities of those methods regardless of cut-points.

ERß, the predominant estrogen receptor expressed in both normal and non-malignant colonic epithelium, has a protective role in colon carcinogenesis. ERß may exert the anti-tumor effect through selective activation of pro-apoptotic signaling, increasing DNA repair, inhibiting expression of oncogenes, regulating cell cycle progression, and also by changing the micro-RNA pool and DNA-methylation.

1. Bioinformatics reveals that m6A regulators are generally elevated in PC. 2. IGF2BP2 enhances the stability of B3GNT6 mRNA via m6A methylation. 3. IGF2BP2 plays a carcinogenic role, promoting tumor formation in vivo.

This paper elaborately explored the role of lncRNA HOXA11-AS and miR-148b-3p in glycolysis and proliferation of lung adenocarcinoma, and demonstrated that the lncRNA HOXA11-AS is involved in the regulation of PKM2, a key protein of glycolysis, through sponging miR-148b-3p, which in turn affects the proliferation and glycolysis of lung adenocarcinoma.

Low-dose apatinib normalizes tumor blood vessels and significantly ameliorate intratumor hypoxic level in lung cancer. Meanwhile, low-daose apatinib can sensitize radiotherapy in the xenograft mouse model, likely due to vascular normalization and hypoxia reduction.

We identified 51 amplified genes that potentially progression from a high-grade intramucosal lesion (HGIL) to an invasive submucosal lesion (ISL) and 6 amplified genes involved in the progression from ISL to an invasive front lesion (IFL) within the same colorectal cancer tumor.

Amuvatinib (MP-470) inhibits lung cancer cell proliferation following βIII-tubulin suppression as demonstrated by decreased Ki67 and BrdU-incorporation using ELISA. These data show that suppressing the survival factor βIII-tubulin, the activity of Amuvatinib (MP-470) is enhanced.

Our study demonstrate that BMAL1 plays a critical role in cell migration and invasion of CRC cells via MAPK-c-Myc pathway. Our results may deepen our understanding in the relationship of BMAL1 and tumorigenic phenotypes and be developed into a promised therapeutic target for the BMAL1-overexpression CRC.

Provided a comprehensive profile of HRR gene mutations in Chinese SCLC. Illuminated the relationships of HRR gene mutation patterns with TMB and PD-L1.

Nerve-derived galanin (GAL) could activate GALR2 and promote epithelial-to-mesenchymal transition in salivary adenoid cystic carcinoma (SACC) cells, thereby enhancing the perineural invasion (PNI) process. Interruption of the GAL/GALR2 axis might be a novel strategy for anti-PNI therapy for SACC.

Palladin was identified to be specifically expressed in the cytomembrane of patients with NSCLC, suggesting its potential as a cell surface marker for LCSCs identification. More importantly, we demonstrated that Palladin might serve as a tumor oncogene and promote the biological properties of LCSCs, possibly by activating the Wnt/β-catenin signaling in NSCLC for the first time. The elucidation of this new molecular mechanism for Palladin and Wnt/β-catenin signaling activation is conducive to understand the pathogenesis of NSCLC, providing a novel possibility of the development of novel therapeutic target for CSCs targeted therapy.

CEACAM6 in the CSF was higher in LUAD-LM than benign diseases. LUAD-LM patients had a higher level of serum CAECAM6 than healthy controls and non-LM LUAD patients. Serum CEACAM6 had a higher AUC than CEA in differentiating LM from non-LM in LUAD. CEACAM6 may serve as a potential biomarker in diagnosing LUAD-LM.

We found that compared with normal-weight breast cancer patients, serum vaspin levels in overweight patients were significantly increased, and vaspin could promote the progression of triple-negative breast cancer by regulating the miR-33a-5p/ABHD2 pathway

We evaluated the growth inhibitory effect of 1271 FDA-approved compounds by MTS assay and identified vorinostat, a histone deacetylase inhibitor, as one of the therapeutic candidates. Vorinostat showed a remarkable anti-cancer effect both in vitro and in vivo by inducing ferroptosis.

Dirty necrosis (DN) in renal cell carcinoma (RCC) is morphologically characterized by abundant neutrophil infiltration and has significant potential as an unfavorable prognostic indicator. In addition, DN in RCC is characterized by neutrophil extracellular traps production and systemic inflammation.

Our study suggests that deregulation of PRDM5 promotes the proliferation of lung adenocarcinoma cells by downregulating SOCS1 and then upregulating the JAK2/STAT3 signaling pathway. The findings will provide significant clues and evidence for targeted treatment of lung adenocarcinoma in the clinic.

In the present study, the applicability of Trastuzumab-based NIR-PIT in HER2-positive breast cancer was examined. As a result, we found Tra-IR700 accumulates BT-474 xenograft tumors and the tumors were induced diffuse necrosis by NIR-PIT.

miR-31 mediated QKI-5 downregulation promoted tumor growth of NSCLC through regulating p21 protein and CDK4/6 mRNAs.

Retinoblastoma is a rare malignancy involving the retina, although more common among children, with genetic inheritance explaining the incidence as well as acquired forms. The incidence varies among race and sex as well as mortality and survival. The current study aimed to assess retinoblastoma cumulative incidence, mortality, and survival by sex. In a representative sample of pediatric retinoblastoma, there was a sex differential in survival with excess risk of dying identified among males relative to females, which may be explained in X-linkage in males.

Given that this study cohort is primarily senior citizens, it is especially troubling that an active working status seems to be an important requirement for managing cancer treatment without severe financial hardship. In the absence of more robust financial support for these patients, financial planning has become a vital part of the treatment process for cancer patients. Until the introduction of legislation that makes cancer treatment financially viable, health systems have a responsibility to direct resources toward the education and assistance of these patients.

Our results suggest that the 2021 USPSTF recommendation on lung cancer screening may not reduce disparities associated with socioeconomic status. These factors include educational attainment, poverty level, employment history, and transportation for medical care.

This study, based on a large ongoing case-control study (the DACHS study) on CRC in Germany, adds to the limited evidence of the individual and joint association of PA and polygenic risk score (PRS) with CRC risk and compares these associations using a novel metric of GRE for effective risk communication. We found that leisure time PA, in particular sports, was associated with reduced CRC risk regardless of PRS levels. The high GREs suggest that adequate sports activity can compensate for a large share of predetermined polygenic risk for CRC.

The impact of low-dose CT on smoking behavior among non-smokers, former-smokers and smokers.

For the treatment and prognosis of primary central nervous system lymphoma (PCNSL), an early and precise diagnosis is critical, but brain biopsy and cerebrospinal fluid (CSF) cytology are invasive and has poor diagnostic accuracy, respectively. In our study, NMR-based analysis of CSF in PCNSL patients revealed a different metabolic profile. This is significantly correlated with magnetic resonance imaging characteristics. This approach could reduce costs, avoid invasive diagnostic procedures, and allow treatment to begin immediately for PCNSL patients.

Spanish-preferring Latina breast cancer survivors had high positive beliefs about genetic counseling and their reported benefits and barriers for genetic counseling were similar for survivors residing in Florida and Puerto Rico. The study findings highlight the factors that should be considered when designing culturally sensitive interventions for Latina breast cancer survivors and suggest that similar intervention contents to promote uptake of genetic counseling could be implemented in Florida and Puerto Rico.

This retrospective observational study used medical claims data in Japan to examine the effects of different COVID-19 periods and magnitudes of its spread on in-hospital cancer operations. We confirmed that cancer operations were significantly reduced in hospitals where in-hospital treatments for patients with COVID-19 were provided during the COVID-19 pandemic. Our findings suggest that a statement of emergency by the government as well as the spread of COVID-19 both have an influence on the number of cancer operations performed in Yamagata prefecture during the COVID-19 era.

In this large, prospective cohort study, we found no strong associations of protein and amino acid intakes with prostate cancer incidence or mortality. Nonetheless, the results suggested weak positive associations for dairy and yogurt protein with prostate cancer risk, and possibly for egg protein with prostate cancer death. These results deserve further investigation in large-scale, pooled analyses aimed at clarifying these associations.

In this national survey, a relatively high prevalence of FT was observed in patients with lung cancer in China. Patients with high FT are more likely to use coping actions. Keen attention must be paid to reducing the disproportionate high financial risks of those patients with low SES.

Using genotype, gene expression, and survival data, we analyzed the relationship between race/ethnicity and survival in pediatric B-cell acute lymphoblastic leukemia (B-ALL), when accounting for genes associated with genetic ancestry. Our results suggest that genetic ancestry and its associated genes play meaningful roles in the occurrence and magnitude of racial/ethnic disparities in B-ALL.

In an analysis of National Health Interview Survey (NHIS) data from 2020, we found nearly 1/3 of patients reportedly requiring cancer treatment or other cancer care experienced disruptions due to the COVID-19 pandemic. Patients experiencing disruptions were significantly more likely to be younger or female, as well as reported higher rates of anxiety. The long term impact of these care disruptions on outcomes merits further study.

It is important to acknowledge that Chinese mainland culture and medical practice are distinct which presents a number of issues that need to be considered in more detail. Understanding how these distinctions influence regret and outcomes may enable us to develop patient education programs and to promote participation.

We explored the relationship between depression/anxiety status and adverse events induced by adjuvant chemotherapy. Patients with depression were more likely to develop myelosuppression. Monitoring the psychological status of breast cancer patients before chemotherapy may help to optimize the management of adverse events.

Prognostic awareness and its association with helth outcomes in the last year of life.

A population-based descriptive study using linked health administrative data in Ontario, Canada, described where patients dying of cancer spent their last 100 days of life. From 2013 to 2017, patients dying with cancer spent most of their time in either institutions (25.9 days) or at home without any care (48.3 days).

This study reported about pre-treatment cancer-related cognitive impairment between newly diagnosed AYAC and age-matched healthy control. There were higher proportions of subjects with impairment and elevated inflammatory marker levels among AYAC compared to controls. At the same time, lower levels of self-perceived impairment and lower baseline BDNF levels were reported in this patient group.

Findings of the current study highlight PC-related anxiety as a burden of survivors many years after diagnosis and treatment. The respective disease-specific anxiety was the strongest predictor of this anxiety 5 years later, which emphasizes the need of screening and monitoring in a timely manner for PC-related anxiety. Treating urologists should screen, identify, and monitor patients at risk for targeted referrals to psychosocial services.

We performed a multi-center retrospective study to assess the survival of the elderly esophageal cancer patients. Our finding revealed that age, therapy method, and pathological stage were mainly associated with the survival of esophageal cancer in elderly patients.

The combination of ATR and TOP1 inhibitors in STING-low SCLC triggered activation of the STING-IFN response and expression of pro-inflammatory factors, and thus might transform “cold” tumors into “hot” tumors, which are more likely to respond to systemic immunotherapy.

Expression levels of COL3A1 were correlated with HNSCC differentiation but were found to be independent factors affecting HNSCC patients CloseCurlyQuote; overall survival rates. #10;COL3A1 exhibited good performance in evaluating immune cell infiltrations, immune activities, and immune checkpoint gene expressions in HNSCC.

Prognostic signatures for alternative splicing events and splicing factors in malignant pleural mesothelioma.

Upregulation of ANLN was associated with worse clinical outcomes in most solid tumors. ANLN was positively related with TMB, MSI, immune cells infiltration and immune checkpoint genes in various cancers. Higher ANLN level predicted better immune responses and longer OS in BLCA patients receiving immunotherapy.

This study identified the pyroptosis-related model associated with multiple immune-inflamed characteristics as a reliable tool for predicting clinical benefit and survival outcomes from immunotherapy in melanoma. Preliminary data from four published cohorts consistently suggested better treatment outcomes from immunotherapy in melanoma with high pyroptosis scores, which was characterized as the immune-inflamed phenotype in TME.

This is the first study to elucidate the relationship between CHST11 expression and prognosis as well as immune infiltration in HCC. These findings are potentially valuable in advancing our current understanding of CHST11 as a biomarker for HCC prognosis predicting and a molecular target for HCC immunotherapy.

PDGFRA and IGFBP7 were co-amplifying in glioma. IGFBP7 but not PDGFRA served an ideal prognostic marker and therapeutic target of glioma. IGFBP7 was associated with the glioma immune infiltrations.

Based on a variety of bioinformatics and immune infiltration analyses, we found the expression of inflammation-related genes was associated with the prognosis. And the inflammation-related genes signature can be a potential indicator of the effectiveness of immunotherapy.

In this study, we performed multiplex immunofluorescence to test CD68⁺TAMs, FOXP3⁺ Treg cell, CD4⁺ T cell, CD8⁺ T cell, and PD-L1 expression in MIBC before and after NAC. The results revealed that CD68⁺ and CD68⁺PD-L1⁻ TAM infiltration levels decreased significantly after NAC and pre-treatment TAM infiltration levels were independent prognostic factors for MIBC patients. However, there was no sufficient evidence demonstrating that pre-treatment TILs or TAMs could predict response to NAC in MIBC patients.

Regulatory T cells (Tregs) are well-known immunosuppression factor in most human malignancies. We gave a comprehensive analysis of Tregs disorder and observed that high Tregs accumulation potentially acted as a prognostic indicator for esophageal cancer (EC) and was associated with tumor deterioration.

Using the TARGET-OS database, we developed a risk score prognosis model using the cuproptosis-related lncRNAs. The novel cuproptosis-related lncRNA signature have high reliability and accuracy for predicting outcome and immunotherapy response in osteosarcoma patients.

We developed a machine learning-based model to predict the explore potential risk factors for metastatic disease in osteosarcoma patients according to the tumor features and the treatment duration in this study. As a result, the Random Forest model outperformed all other models in training and validation sets. To improve the interpretability of our machine learning model, we reported the SHAP values and a list of highly influential features.

From bioinformatics analysis aspect, systemic analysis of the expression and prognostic significance of ORCs in lung adenocarcinoma. This article was designed to help understand the roles of ORCs in the formation, development and progression of lung adenocarcinoma for further studies

miR-30c-5p inhibits OvCa progression by inhibiting m6A reader HNRNPA2B. Meanwhile, HNRNPA2B1 might regulate CDK19 mRNA stability to alter m6A level.